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profilePeng Yin, PH.D.

TitleProfessor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressCenter for Life Science
Wyss Institute, Room 543
3 Blackfan Circle
Boston MA 02115
Phone617/432-5166
Fax617/432-7828
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
DNA Nanotechnology for Programmable Drug Targeting and Localization to Cancer Cells
Summer, 06/01/11 - 08/17/11

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01MH106011     (BATHE, MARK)Sep 26, 2014 - Jun 30, 2017
NIH/NIMH
Ultra-Multiplexed Nanoscale In Situ Proteomics for Understanding Synapse Types
Role: Co-Principal Investigator

R01EB018659     (YIN, PENG)Sep 25, 2013 - Aug 31, 2018
NIH/NIBIB
Super-resolution imaging via programmable autonomous blinking
Role: Principal Investigator

R21HD072481     (YIN, PENG)Apr 1, 2012 - Mar 31, 2014
NIH/NICHD
Programmable metafluorophores for quantitative multiplex in situ imaging of mRNA
Role: Principal Investigator

DP2OD007292     (YIN, PENG)Sep 30, 2010 - Jun 30, 2015
NIH
Engineering Bioimaging Probes Based on Triggered Molecular Geometry
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Grun C, Werfel J, Zhang DY, Yin P. DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology. J R Soc Interface. 2015 Oct 6; 12(111):20150580. PMID: 26423437; PMCID: PMC4614494.
  2. Knudsen JB, Liu L, Bank Kodal AL, Madsen M, Li Q, Song J, Woehrstein JB, Wickham SF, Strauss MT, Schueder F, Vinther J, Krissanaprasit A, Gudnason D, Smith AA, Ogaki R, Zelikin AN, Besenbacher F, Birkedal V, Yin P, Shih WM, Jungmann R, Dong M, Gothelf KV. Routing of individual polymers in designed patterns. Nat Nanotechnol. 2015 Oct; 10(10):892-8. PMID: 26322946.
    View in: PubMed
  3. Scheible MB, Ong LL, Woehrstein JB, Jungmann R, Yin P, Simmel FC. A Compact DNA Cube with Side Length 10 nm. Small. 2015 Oct 21; 11(39):5200-5. PMID: 26294348.
    View in: PubMed
  4. Beliveau BJ, Boettiger AN, AvendaƱo MS, Jungmann R, McCole RB, Joyce EF, Kim-Kiselak C, Bantignies F, Fonseka CY, Erceg J, Hannan MA, Hoang HG, Colognori D, Lee JT, Shih WM, Yin P, Zhuang X, Wu CT. Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Nat Commun. 2015 May 12; 6:7147. PMID: 25962338; PMCID: PMC4430122.
  5. Wei B, Vhudzijena MK, Robaszewski J, Yin P. Self-assembly of complex two-dimensional shapes from single-stranded DNA tiles. J Vis Exp. 2015 May 08; (99):e52486. PMID: 25993048.
    View in: PubMed
  6. Yin P. 75 DNA nanotech and super-resolution imaging. J Biomol Struct Dyn. 2015; 33 Suppl 1:49. PMID: 26103287.
    View in: PubMed
  7. Green AA, Silver PA, Collins JJ, Yin P. Toehold switches: de-novo-designed regulators of gene expression. Cell. 2014 Nov 6; 159(4):925-39. PMID: 25417166; PMCID: PMC4265554.
  8. Pardee K, Green AA, Ferrante T, Cameron DE, DaleyKeyser A, Yin P, Collins JJ. Paper-based synthetic gene networks. Cell. 2014 Nov 6; 159(4):940-54. PMID: 25417167; PMCID: PMC4243060.
  9. Ke Y, Ong LL, Sun W, Song J, Dong M, Shih WM, Yin P. DNA brick crystals with prescribed depths. Nat Chem. 2014 Nov; 6(11):994-1002. PMID: 25343605; PMCID: PMC4238964.
  10. Sun W, Boulais E, Hakobyan Y, Wang WL, Guan A, Bathe M, Yin P. Casting inorganic structures with DNA molds. Science. 2014 Nov 7; 346(6210):1258361. PMID: 25301973; PMCID: PMC4260265.
  11. Wei B, Ong LL, Chen J, Jaffe AS, Yin P. Complex reconfiguration of DNA nanostructures. Angew Chem Int Ed Engl. 2014 Jul 14; 53(29):7475-9. PMID: 24899518; PMCID: PMC4235524.
  12. Jin Z, Sun W, Yin P, Strano MS. Nanolithography based on metalized DNA templates for graphene patterning. Curr Protoc Chem Biol. 2014; 6(2):53-64. PMID: 24903883.
    View in: PubMed
  13. Sadowski JP, Calvert CR, Zhang DY, Pierce NA, Yin P. Developmental self-assembly of a DNA tetrahedron. ACS Nano. 2014 Apr 22; 8(4):3251-9. PMID: 24720462; PMCID: PMC4004324.
  14. Iinuma R, Ke Y, Jungmann R, Schlichthaerle T, Woehrstein JB, Yin P. Polyhedra self-assembled from DNA tripods and characterized with 3D DNA-PAINT. Science. 2014 Apr 4; 344(6179):65-9. PMID: 24625926; PMCID: PMC4153385.
  15. Wu Y, Zhang DY, Yin P, Vollmer F. Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity. Small. 2014 May 28; 10(10):2067-76. PMID: 24585636; PMCID: PMC4096343.
  16. Jungmann R, AvendaƱo MS, Woehrstein JB, Dai M, Shih WM, Yin P. Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT. Nat Methods. 2014 Mar; 11(3):313-8. PMID: 24487583; PMCID: PMC4153392.
  17. Jia J, Zhou A, Wei C, Jia X, Wang F, Li F, Wu X, Mok V, Gauthier S, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese. Alzheimers Dement. 2014 Jul; 10(4):439-47. PMID: 24418053.
    View in: PubMed
  18. Wei B, Dai M, Myhrvold C, Ke Y, Jungmann R, Yin P. Design space for complex DNA structures. J Am Chem Soc. 2013 Dec 4; 135(48):18080-8. PMID: 24256506.
    View in: PubMed
  19. Hochrein LM, Schwarzkopf M, Shahgholi M, Yin P, Pierce NA. Conditional Dicer substrate formation via shape and sequence transduction with small conditional RNAs. J Am Chem Soc. 2013 Nov 20; 135(46):17322-30. PMID: 24219616; PMCID: PMC3842090.
  20. Myhrvold C, Dai M, Silver PA, Yin P. Isothermal self-assembly of complex DNA structures under diverse and biocompatible conditions. Nano Lett. 2013 Sep 11; 13(9):4242-8. PMID: 23978049.
    View in: PubMed
  21. Schaus TE, Yin P. Molecular computing: in situ computation of cell identity. Nat Nanotechnol. 2013 Aug; 8(8):546-8. PMID: 23912106.
    View in: PubMed
  22. Jia J, Wang F, Wei C, Zhou A, Jia X, Li F, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement. 2014 Jan; 10(1):1-9. PMID: 23871765.
    View in: PubMed
  23. Surwade SP, Zhou F, Wei B, Sun W, Powell A, O'Donnell C, Yin P, Liu H. Nanoscale growth and patterning of inorganic oxides using DNA nanostructure templates. J Am Chem Soc. 2013 May 8; 135(18):6778-81. PMID: 23574340.
    View in: PubMed
  24. Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S, Fan J, Zha X. Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines. Mol Cell Biochem. 2013 Apr; 376(1-2):111-9. PMID: 23397112.
    View in: PubMed
  25. Qi H, Ghodousi M, Du Y, Grun C, Bae H, Yin P, Khademhosseini A. DNA-directed self-assembly of shape-controlled hydrogels. Nat Commun. 2013; 4:2275. PMID: 24013352; PMCID: PMC3768014.
  26. Jin Z, Sun W, Ke Y, Shih CJ, Paulus GL, Hua Wang Q, Mu B, Yin P, Strano MS. Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning. Nat Commun. 2013; 4:1663. PMID: 23575667.
    View in: PubMed
  27. Ke Y, Ong LL, Shih WM, Yin P. Three-dimensional structures self-assembled from DNA bricks. Science. 2012 Nov 30; 338(6111):1177-83. PMID: 23197527; PMCID: PMC3843647.
  28. Lin C, Jungmann R, Leifer AM, Li C, Levner D, Church GM, Shih WM, Yin P. Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nat Chem. 2012 Oct; 4(10):832-9. PMID: 23000997; PMCID: PMC3523708.
  29. Shi Y, Yu PW, Lei X, Qian F, Zhao YL, Tang B, Hao YX, Yin P, Li J. [Influence of CO2 pneumoperitoneum pressures on the expression of adhesion molecules of gastric cancer cells]. Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Aug; 15(8):830-3. PMID: 22941688.
    View in: PubMed
  30. Wei B, Dai M, Yin P. Complex shapes self-assembled from single-stranded DNA tiles. Nature. 2012 May 30; 485(7400):623-6. PMID: 22660323; PMCID: PMC4238960.
  31. Zhang DY, Chen SX, Yin P. Optimizing the specificity of nucleic acid hybridization. Nat Chem. 2012 Jan 22; 4(3):208-14. PMID: 22354435; PMCID: PMC4238961.
  32. Uen YH, Ko PH, Yin PH, Liu TY, Chi CW, Lui WY. Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death. Int J Oncol. 2008 Dec; 33(6):1263-70. PMID: 19020760.
    View in: PubMed
  33. Lee HJ, Su Y, Lui WY, Chau GY, Yin PH, Lee HC, Chi CW. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) upregulated E-cadherin expression in HepG2 cells. FEBS Lett. 2008 Mar 5; 582(5):627-34. PMID: 18242180.
    View in: PubMed
  34. Yin P, Choi HM, Calvert CR, Pierce NA. Programming biomolecular self-assembly pathways. Nature. 2008 Jan 17; 451(7176):318-22. PMID: 18202654.
    View in: PubMed
  35. Park SH, Yin P, Liu Y, Reif JH, LaBean TH, Yan H. Programmable DNA self-assemblies for nanoscale organization of ligands and proteins. Nano Lett. 2005 Apr; 5(4):729-33. PMID: 15826117.
    View in: PubMed
  36. Yin P, Yan H, Daniell XG, Turberfield AJ, Reif JH. A unidirectional DNA walker that moves autonomously along a track. Angew Chem Int Ed Engl. 2004 Sep 20; 43(37):4906-11. PMID: 15372637.
    View in: PubMed
  37. Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y. Yin Yang 1 is a negative regulator of p53. Cell. 2004 Jun 25; 117(7):859-72. PMID: 15210108.
    View in: PubMed
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