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David Christopher Christiani, M.D.

TitleElkan Blout Professor of Environmental Genetics
InstitutionHarvard School of Public Health
DepartmentEH - Environmental + Occupational Medicine + Epi
AddressHarvard School of Public Health
Building 1, 1401
665 Huntington Ave
Boston MA 02115
Phone617/432-3323
Fax617/726-2932
vCardDownload vCard (login for email)
Other Positions
TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
DivisionPulmonary/Critical Care


 Overview 
 overview
David Christiani, MD, MPH, MS, is a Professor of Occupational Medicine and Epidemiology with the School’s Departments of Environmental Health and Epidemiology. He earned his MD in 1976 from Tufts University, and an MS and MPH from the Harvard School of Public Health. He did his post-graduate medical training at Boston City Hospital and the Massachusetts General Hospital in Boston.
Professor Christiani’s major research interest lies in the interaction between human genes and the environment. In the emerging field of molecular epidemiology, he studies the impact of humans’ exposure to pollutants on health, as well as the how genetic and acquired susceptibility to these diseases along with environmental exposures can lead to acute and chronic pulmonary and cardiovascular disease. He is also developing new methods for assessing health effects after exposure to pollutants and has is very active in environmental and occupational health studies internationally.
In Asia, Africa, and North America, Dr. Christiani and his wide network of collaborators are studying of the reproductive effects of exposure to chemicals, in China; arsenic exposure and bladder and skin cancer, in Taiwan and Bangladesh; exposure to indoor combustion products in respiratory disease in Central America; petrochemical exposures, brain tumors, and leukemia in Taiwan; and the respiratory effects of paraquat exposure in Africa. Preventing these diseases is an ultimate goal.
With his HSPH colleagues, Professor Christiani has developed biologic markers useful for examining pollutant-induced diseases such as lung cancer, bladder cancer, skin cancer, and upper-respiratory-tract inflammation. He led a large molecular and genetic analysis of lung cancer, looking at genetic factors that make people susceptibility to lung cancer and help predict the outcome of treatment. He has also led studies of the acute respiratory effects of toxins in the particles produced by coal-burning power plants. This study is also evaluating molecular markers in nasal and lung fluids of exposed and unexposed workers. With collaborators at the Mass. General Hospital, Professor Christiani isl examining the role of genetic susceptibility in ARDS, as well as biomarkers predictive of outcome and survival for this disorder.
Christiani oversees a landmark 27-year-long study of respiratory disease in cotton-textile workers in Shanghai, China. This study has determined the rate of loss in lung function among dust-exposed workers and uses molecular biology’s tools to evaluate the relationship between exposure to endotoxins produced by bacteria in cotton and acute and chronic lung disease.


 Mentoring 
 completed student projects
Association of Google Trends data and cancer incidence in the United States from 2004 to 2009: the predictive power of search engine data
Summer, 06/11/15 - 08/17/13
Research in the Department of Occupational Medicine, Tongji Medical College School of Public Health
International, 06/16/06 - 08/11/06

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Environmental Genomics Service Facility (HSPH) - Core services (3) and Instruments (9)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Bledsoe JR, Christiani DC, Kradin RL. Smoking-associated fibrosis and pulmonary asbestosis. Int J Chron Obstruct Pulmon Dis. 2015; 10:31-7.
    View in: PubMed
  2. Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DC. Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health. 2014; 14:1279.
    View in: PubMed
  3. Song Q, Christiani DC, Ren J. The global contribution of outdoor air pollution to the incidence, prevalence, mortality and hospital admission for chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Environ Res Public Health. 2014; 11(11):11822-32.
    View in: PubMed
  4. Liao SY, Lin X, Christiani DC. Occupational exposures and longitudinal lung function decline. Am J Ind Med. 2015 Jan; 58(1):14-20.
    View in: PubMed
  5. Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. Eur J Endocrinol. 2014 Nov; 171(5):X4.
    View in: PubMed
  6. Huang YT, Hsu T, Christiani DC. TEGS-CN: A Statistical Method for Pathway Analysis of Genome-wide Copy Number Profile. Cancer Inform. 2014; 13(Suppl 4):15-23.
    View in: PubMed
  7. Liu Y, Rong Y, Steenland K, Christiani DC, Huang X, Wu T, Chen W. Long-term Exposure to Crystalline Silica and Risk of Heart Disease Mortality. Epidemiology. 2014 Sep; 25(5):689-96.
    View in: PubMed
  8. Gaughan DM, Piacitelli CA, Chen BT, Law BF, Virji MA, Edwards NT, Enright PL, Schwegler-Berry DE, Leonard SS, Wagner GR, Kobzik L, Kales SN, Hughes MD, Christiani DC, Siegel PD, Cox-Ganser JM, Hoover MD. Exposures and Cross-shift Lung Function Declines in Wildland Firefighters. J Occup Environ Hyg. 2014 Sep; 11(9):591-603.
    View in: PubMed
  9. El-Zein RA, Lopez MS, D'Amelio AM, Liu M, Munden RF, Christiani D, Su L, Tejera-Alveraz P, Zhai R, Spitz MR, Etzel CJ. The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: extension of a lung cancer risk prediction model. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2462-70.
    View in: PubMed
  10. Gleason K, Shine JP, Shobnam N, Rokoff LB, Suchanda HS, Ibne Hasan MO, Mostofa G, Amarasiriwardena C, Quamruzzaman Q, Rahman M, Kile ML, Bellinger DC, Christiani DC, Wright RO, Mazumdar M. Contaminated turmeric is a potential source of lead exposure for children in rural bangladesh. J Environ Public Health. 2014; 2014:730636.
    View in: PubMed
  11. Zhao Y, Wei Q, Hu L, Chen F, Hu Z, Heist RS, Su L, Amos CI, Shen H, Christiani DC. Polymorphisms in MicroRNAs Are Associated with Survival in Non-Small Cell Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2503-11.
    View in: PubMed
  12. Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC. Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):262-72.
    View in: PubMed
  13. Lee MS, Eum KD, Fang SC, Rodrigues EG, Modest GA, Christiani DC. Oxidative stress and systemic inflammation as modifiers of cardiac autonomic responses to particulate air pollution. Int J Cardiol. 2014 Sep; 176(1):166-70.
    View in: PubMed
  14. Liao SY, Lin X, Christiani DC. Genome-wide Association and Network Analysis of Lung Function in the Framingham Heart Study. Genet Epidemiol. 2014 Sep; 38(6):572-8.
    View in: PubMed
  15. Gaughan DM, Siegel PD, Hughes MD, Chang CY, Law BF, Campbell CR, Richards JC, Kales SF, Chertok M, Kobzik L, Nguyen PS, O'Donnell CR, Kiefer M, Wagner GR, Christiani DC. Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters. Am J Ind Med. 2014 Jul; 57(7):748-56.
    View in: PubMed
  16. Bruno Garza J, Zhang J, Fang S, Wong J, Christiani D, Cavallari J. 0231 Acute inflammatory response to secondhand smoke exposure among non-smoking construction workers: a repeated measures study0231 Acute inflammatory response to secondhand smoke exposure among non-smoking construction workers: a repeated measures study. Occup Environ Med. 2014 Jun; 71 Suppl 1:A31-2.
    View in: PubMed
  17. Mattioli S, Gori D, Di Gregori V, Farioli A, Pia Fantini M, Christiani D, Curti S, Violante F. 0408 PubMed search strings for the study of putative environmental determinants of disease. Occup Environ Med. 2014 Jun; 71 Suppl 1:A115.
    View in: PubMed
  18. Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, Zong X, Laplana M, Wei Y, Han Y, Lloyd A, Delahaye-Sourdeix M, Chubb D, Gaborieau V, Wheeler W, Chatterjee N, Thorleifsson G, Sulem P, Liu G, Kaaks R, Henrion M, Kinnersley B, Vallée M, LeCalvez-Kelm F, Stevens VL, Gapstur SM, Chen WV, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Lener M, Lubinski J, Johansson M, Vineis P, Agudo A, Clavel-Chapelon F, Bueno-de-Mesquita HB, Trichopoulos D, Khaw KT, Johansson M, Weiderpass E, Tjønneland A, Riboli E, Lathrop M, Scelo G, Albanes D, Caporaso NE, Ye Y, Gu J, Wu X, Spitz MR, Dienemann H, Rosenberger A, Su L, Matakidou A, Eisen T, Stefansson K, Risch A, Chanock SJ, Christiani DC, Hung RJ, Brennan P, Landi MT, Houlston RS, Amos CI. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 2014 Jul; 46(7):736-41.
    View in: PubMed
  19. Grashow R, Zhang J, Fang SC, Weisskopf MG, Christiani DC, Cavallari JM. Toenail metal concentration as a biomarker of occupational welding fume exposure. J Occup Environ Hyg. 2014 Jun; 11(6):397-405.
    View in: PubMed
  20. Lai P, Hang JQ, Zhang FY, Zheng BY, Valeri L, Eisen E, Christiani D. 0031 Lung Function Improvement is Sustained after Work Cessation in Shanghai Cotton and Silk Textile Workers. Occup Environ Med. 2014 Jun; 71 Suppl 1:A3.
    View in: PubMed
  21. Wang X, Lin S, Yano E, Yu IT, Courtice M, Lan Y, Christiani DC. Exposure-specific lung cancer risks in Chinese chrysotile textile workers and mining workers. Lung Cancer. 2014 Aug; 85(2):119-24.
    View in: PubMed
  22. Pu X, Hildebrandt MA, Lu C, Roth JA, Stewart DJ, Zhao Y, Heist RS, Ye Y, Chang DW, Su L, Minna JD, Lippman SM, Spitz MR, Christiani DC, Wu X. Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapy. Clin Pharmacol Ther. 2014 Sep; 96(3):360-9.
    View in: PubMed
  23. Kile ML, Rodrigues EG, Mazumdar M, Dobson CB, Diao N, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh. Environ Health. 2014; 13(1):29.
    View in: PubMed
  24. Wang T, Liu Z, Wang Z, Duan M, Li G, Wang S, Li W, Zhu Z, Wei Y, Christiani DC, Li A, Zhu X. Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study. PLoS One. 2014; 9(4):e94124.
    View in: PubMed
  25. Souza K, Cantley LF, Slade MD, Eisen EA, Christiani D, Cullen MR. Individual-level and plant-level predictors of acute, traumatic occupational injuries in a manufacturing cohort. Occup Environ Med. 2014 Jul; 71(7):477-83.
    View in: PubMed
  26. Grashow R, Zhang J, Fang SC, Weisskopf MG, Christiani DC, Kile ML, Cavallari JM. Inverse association between toenail arsenic and body mass index in a population of welders. Environ Res. 2014 May; 131:131-3.
    View in: PubMed
  27. Park SL, Fesinmeyer MD, Timofeeva M, Caberto CP, Kocarnik JM, Han Y, Love SA, Young A, Dumitrescu L, Lin Y, Goodloe R, Wilkens LR, Hindorff L, Fowke JH, Carty C, Buyske S, Schumacher FR, Butler A, Dilks H, Deelman E, Cote ML, Chen W, Pande M, Christiani DC, Field JK, Bickebller H, Risch A, Heinrich J, Brennan P, Wang Y, Eisen T, Houlston RS, Thun M, Albanes D, Caporaso N, Peters U, North KE, Heiss G, Crawford DC, Bush WS, Haiman CA, Landi MT, Hung RJ, Kooperberg C, Amos CI, Le Marchand L, Cheng I. Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia. J Natl Cancer Inst. 2014 Apr 1; 106(4):dju061.
    View in: PubMed
  28. Kim CH, Lee YC, Hung RJ, McNallan SR, Cote ML, Lim WY, Chang SC, Kim JH, Ugolini D, Chen Y, Liloglou T, Andrew AS, Onega T, Duell EJ, Field JK, Lazarus P, Le Marchand L, Neri M, Vineis P, Kiyohara C, Hong YC, Morgenstern H, Matsuo K, Tajima K, Christiani DC, McLaughlin JR, Bencko V, Holcatova I, Boffetta P, Brennan P, Fabianova E, Foretova L, Janout V, Lissowska J, Mates D, Rudnai P, Szeszenia-Dabrowska N, Mukeria A, Zaridze D, Seow A, Schwartz AG, Yang P, Zhang ZF. Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO). Int J Cancer. 2014 Oct 15; 135(8):1918-30.
    View in: PubMed
  29. Guo H, Huang K, Zhang X, Zhang W, Guan L, Kuang D, Deng Q, Deng H, Zhang X, He M, Christiani D, Wu T. Women are more susceptible than men to oxidative stress and chromosome damage caused by polycyclic aromatic hydrocarbons exposure. Environ Mol Mutagen. 2014 Jul; 55(6):472-81.
    View in: PubMed
  30. Zhang GH, Ye LL, Wang JW, Ren JC, Xu XW, Feng NN, Zhou LF, Ru JG, Hao YH, Tian W, Sun P, Au WW, Christiani DC, Xia ZL. Effect of polymorphic metabolizing genes on micronucleus frequencies among benzene-exposed shoe workers in China. Int J Hyg Environ Health. 2014 Sep; 217(7):726-32.
    View in: PubMed
  31. Liu X, Hamnvik OP, Chamberland JP, Petrou M, Gong H, Christophi CA, Christiani DC, Kales SN, Mantzoros CS. Circulating alanine transaminase (ALT) and ?-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Study. Metabolism. 2014 Jun; 63(6):773-82.
    View in: PubMed
  32. Feng Y, Sun H, Song Y, Bao J, Huang X, Ye J, Yuan J, Chen W, Christiani DC, Wu T, Zhang X. A community study of the effect of polycyclic aromatic hydrocarbon metabolites on heart rate variability based on the Framingham risk score. Occup Environ Med. 2014 May; 71(5):338-45.
    View in: PubMed
  33. Christiani DC. Radiation risk from lung cancer screening: glowing in the dark? Chest. 2014 Mar 1; 145(3):439-40.
    View in: PubMed
  34. Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC. The association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol. 2014 Apr; 38(3):254-64.
    View in: PubMed
  35. Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: A case-control follow-up study. Environ Mol Mutagen. 2014 Jul; 55(6):449-56.
    View in: PubMed
  36. Ahasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS One. 2014; 9(2):e89170.
    View in: PubMed
  37. Alpert HR, Christiani DC, Orav EJ, Dockery DW, Connolly GN. Effectiveness of the cigarette ignition propensity standard in preventing unintentional residential fires in massachusetts. Am J Public Health. 2014 Apr; 104(4):e56-61.
    View in: PubMed
  38. Kile ML, Houseman EA, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Cardenas A, Wright RO, Christiani DC. Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May 1; 9(5):774-82.
    View in: PubMed
  39. Kinsey CM, Estepar RS, Zhao Y, Yu X, Diao N, Heist RS, Wain JC, Mark EJ, Washko G, Christiani DC. Invasive adenocarcinoma of the lung is associated with the upper lung regions. Lung Cancer. 2014 May; 84(2):145-50.
    View in: PubMed
  40. Jia Z, Cheng S, Ma Y, Zhang T, Bai L, Xu W, He X, Zhang P, Zhao J, Christiani DC. Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms. BMC Infect Dis. 2014; 14(1):64.
    View in: PubMed
  41. Zhai R, Yu X, Shafer A, Wain JC, Christiani DC. The Impact of Coexisting COPD on Survival of Patients With Early-Stage Non-small Cell Lung Cancer Undergoing Surgical Resection. Chest. 2014 Feb 1; 145(2):346-53.
    View in: PubMed
  42. Borger DR, Goyal L, Yau T, Poon RT, Ancukiewicz M, Deshpande V, Christiani DC, Liebman HM, Yang H, Kim H, Yen K, Faris JE, Iafrate AJ, Kwak EL, Clark JW, Allen JN, Blaszkowsky LS, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Bardeesy N, Straley KS, Agresta S, Schenkein DP, Ellisen LW, Ryan DP, Zhu AX. Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma. Clin Cancer Res. 2014 Apr 1; 20(7):1884-90.
    View in: PubMed
  43. Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The Relationship between Inflammatory Biomarkers and Telomere Length in an Occupational Prospective Cohort Study. PLoS One. 2014; 9(1):e87348.
    View in: PubMed
  44. Liu L, Zhong R, Zou L, Fu J, Zhu B, Chen W, Ye X, Gao Y, Yang Y, Christiani DC, Chen S, Miao X. Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers. Cancer Epidemiol. 2014 Feb; 38(1):66-72.
    View in: PubMed
  45. Lin S, Wang X, Yano E, Yu I, Lan Y, Courtice MN, Christiani DC. Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort. Occup Environ Med. 2014 May; 71(5):323-8.
    View in: PubMed
  46. Wong JY, De Vivo I, Lin X, Christiani DC. Cumulative PM2.5 Exposure and Telomere Length in Workers Exposed to Welding Fumes. J Toxicol Environ Health A. 2014; 77(8):441-55.
    View in: PubMed
  47. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577.
    View in: PubMed
  48. Lai PS, Hang JQ, Zhang FY, Lin X, Zheng BY, Dai HL, Su L, Cai T, Christiani DC. Gender differences in the effect of occupational endotoxin exposure on impaired lung function and death: the Shanghai Textile Worker Study. Occup Environ Med. 2014 Feb; 71(2):118-25.
    View in: PubMed
  49. Liao SY, Lin X, Christiani DC. Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health. 2013; 12:101.
    View in: PubMed
  50. Yu S, Christiani DC, Thompson BT, Bajwa EK, Gong MN. Role of diabetes in the development of acute respiratory distress syndrome*. Crit Care Med. 2013 Dec; 41(12):2720-32.
    View in: PubMed
  51. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL. Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Crit Care Med. 2013 Nov; 41(11):2521-31.
    View in: PubMed
  52. Vamvini MT, Aronis KN, Panagiotou G, Huh JY, Chamberland JP, Brinkoetter MT, Petrou M, Christophi CA, Kales SN, Christiani DC, Mantzoros CS. Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans. Eur J Endocrinol. 2013 Dec; 169(6):829-34.
    View in: PubMed
  53. Wei Y, Wang Z, Chang CY, Fan T, Su L, Chen F, Christiani DC. Global metabolomic profiling reveals an association of metal fume exposure and plasma unsaturated fatty acids. PLoS One. 2013; 8(10):e77413.
    View in: PubMed
  54. Moschovis PP, Banajeh S, Macleod WB, Saha S, Hayden D, Christiani DC, Mino G, Santosham M, Thea DM, Qazi S, Hibberd PL. Childhood anemia at high altitude: risk factors for poor outcomes in severe pneumonia. Pediatrics. 2013 Nov; 132(5):e1156-62.
    View in: PubMed
  55. Zhang J, Fang SC, Mittleman MA, Christiani DC, Cavallari JM. Secondhand tobacco smoke exposure and heart rate variability and inflammation among non-smoking construction workers: a repeated measures study. Environ Health. 2013; 12(1):83.
    View in: PubMed
  56. Gaughan DM, Christiani DC, Hughes MD, Baur DM, Kobzik L, Wagner GR, Kales SN. High hsCRP is associated with reduced lung function in structural firefighters. Am J Ind Med. 2014 Jan; 57(1):31-7.
    View in: PubMed
  57. Pan WC, Seow WJ, Kile ML, Hoffman EB, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Association of low to moderate levels of arsenic exposure with risk of type 2 diabetes in bangladesh. Am J Epidemiol. 2013 Nov 15; 178(10):1563-70.
    View in: PubMed
  58. Renouf DJ, Zhai R, Sun B, Xu W, Cheung WY, Heist RS, Kulke MH, Cescon D, Asomaning K, Marshall AL, Li S, Christiani DC, Liu G. Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. J Gastroenterol Hepatol. 2013 Sep; 28(9):1482-8.
    View in: PubMed
  59. Zhai R, Yu X, Wei Y, Su L, Christiani DC. Smoking and smoking cessation in relation to the development of co-existing non-small cell lung cancer with chronic obstructive pulmonary disease. Int J Cancer. 2014 Feb; 134(4):961-70.
    View in: PubMed
  60. Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MH. Prognostic significance of MTOR pathway component expression in neuroendocrine tumors. J Clin Oncol. 2013 Sep 20; 31(27):3418-25.
    View in: PubMed
  61. Wang X, Yano E, Lin S, Yu IT, Lan Y, Tse LA, Qiu H, Christiani DC. Cancer mortality in Chinese chrysotile asbestos miners: exposure-response relationships. PLoS One. 2013; 8(8):e71899.
    View in: PubMed
  62. Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS One. 2013; 8(8):e70792.
    View in: PubMed
  63. Fang SC, Mehta AJ, Hang JQ, Eisen EA, Dai HL, Zhang HX, Su L, Christiani DC. Cotton dust, endotoxin and cancer mortality among the Shanghai textile workers cohort: a 30-year analysis. Occup Environ Med. 2013 Oct; 70(10):722-9.
    View in: PubMed
  64. Applebaum KM, Ray RM, Astrakianakis G, Gao DL, Thomas DB, Christiani DC, LaValley MP, Li W, Checkoway H, Eisen EA. Evidence of a paradoxical relationship between endotoxin and lung cancer after accounting for left truncation in a study of Chinese female textile workers. Occup Environ Med. 2013 Oct; 70(10):709-15.
    View in: PubMed
  65. Kile ML, Fang S, Baccarelli AA, Tarantini L, Cavallari J, Christiani DC. A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders. Environ Health. 2013; 12(1):47.
    View in: PubMed
  66. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910.
    View in: PubMed
  67. Schifano ED, Li L, Christiani DC, Lin X. Genome-wide association analysis for multiple continuous secondary phenotypes. Am J Hum Genet. 2013 May 2; 92(5):744-59.
    View in: PubMed
  68. Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O'Keefe GE, Wurfel MM, Christiani DC, Christie JD. IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist. Am J Respir Crit Care Med. 2013 May 1; 187(9):950-9.
    View in: PubMed
  69. Kirkeleit J, Riise T, Bjørge T, Christiani DC. The healthy worker effect in cancer incidence studies. Am J Epidemiol. 2013 Jun 1; 177(11):1218-24.
    View in: PubMed
  70. Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD. Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. PLoS Genet. 2013 Apr; 9(4):e1003413.
    View in: PubMed
  71. Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MH. Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr Relat Cancer. 2013 Apr; 20(2):187-96.
    View in: PubMed
  72. Zhang R, Zhao Y, Chu M, Mehta A, Wei Y, Liu Y, Xun P, Bai J, Yu H, Su L, Zhang H, Hu Z, Shen H, Chen F, Christiani DC. A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. PLoS One. 2013; 8(3):e59035.
    View in: PubMed
  73. Lin X, Lee S, Christiani DC, Lin X. Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics. 2013 Sep; 14(4):667-81.
    View in: PubMed
  74. Lai PS, Christiani DC. Long-term respiratory health effects in textile workers. Curr Opin Pulm Med. 2013 Mar; 19(2):152-7.
    View in: PubMed
  75. Marshall AL, Christiani DC. Genetic susceptibility to lung cancer--light at the end of the tunnel? Carcinogenesis. 2013 Mar; 34(3):487-502.
    View in: PubMed
  76. Zanardi F, Salvarani R, Cooke RM, Pirastu R, Baccini M, Christiani D, Curti S, Risi A, Barbieri A, Barbieri G, Mattioli S, Violante FS. Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers. Epidemiology. 2013 Jan; 24(1):100-3.
    View in: PubMed
  77. Soto GJ, Frank AJ, Christiani DC, Gong MN. The authors reply. Crit Care Med. 2013 Jan; 41(1):e13.
    View in: PubMed
  78. See KC, Christiani DC. Normal values and thresholds for the clinical interpretation of exhaled nitric oxide levels in the US general population: results from the National Health and Nutrition Examination Survey 2007-2010. Chest. 2013 Jan; 143(1):107-16.
    View in: PubMed
  79. North CM, Christiani DC. Women and Lung Cancer: What is New? Semin Thorac Cardiovasc Surg. 2013; 25(2):87-94.
    View in: PubMed
  80. Chang C, Demokritou P, Shafer M, Christiani D. Physicochemical and toxicological characteristics of welding fume derived particles generated from real time welding processes. Environ Sci Process Impacts. 2013 Jan; 15(1):214-24.
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  581. Xu X, Christiani DC, Dockery DW, Wang L. Exposure-response relationships between occupational exposures and chronic respiratory illness: a community-based study. Am Rev Respir Dis. 1992 Aug; 146(2):413-8.
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  582. Hu H, Christiani D. Reactive airways dysfunction after exposure to teargas. Lancet. 1992 Jun 20; 339(8808):1535.
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  583. Markowitz S, Frank AL, Hessl SM, Christiani D, Robins T, Balmes J. Physicians and occupational medicine. N Engl J Med. 1992 Mar 5; 326(10):713-4.
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  584. Christiani DC. Occupational lung diseases in the industrializing and industrialized world: commonalities and contrasts: measurement tools. Tuber Lung Dis. 1992 Feb; 73(1):7-12.
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  585. LaMontagne AD, Kelsey KT, Ryan CM, Christiani DC. A participatory workplace health and safety training program for ethylene oxide. Am J Ind Med. 1992; 22(5):651-64.
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  586. Hashimoto DM, Brennan TA, Christiani DC. Should asbestos in buildings be regulated on an environmental or occupational basis? Ann N Y Acad Sci. 1991 Dec 31; 643:609-13.
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  587. Yakes B, Kelsey KT, Seitz T, Hashimoto D, Feldman HA, Christiani DC. Occupational skin disease in newspaper pressroom workers. J Occup Med. 1991 Jun; 33(6):711-7.
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  588. Kelsey KT, Christiani DC, Wiencke JK. Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II. Relationship to baseline SCE frequency. Mutat Res. 1991 May; 248(1):27-33.
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  589. Wiencke JK, Christiani DC, Kelsey KT. Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. I. Correlation with chromosomal aberrations. Mutat Res. 1991 May; 248(1):17-26.
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  590. Hashimoto DM, Kelsey KT, Seitz T, Feldman HA, Yakes B, Christiani DC. The presence of urinary cellular sediment and albuminuria in newspaper pressworkers exposed to solvents. J Occup Med. 1991 Apr; 33(4):516-26.
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  591. Sprince NL, Oliver LC, McLoud TC, Eisen EA, Christiani DC, Ginns LC. Asbestos exposure and asbestos-related pleural and parenchymal disease. Associations with immune imbalance. Am Rev Respir Dis. 1991 Apr; 143(4 Pt 1):822-8.
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  592. Kelsey KT, Christiani DC, Wegman DH, Himmelstein JS, Kern DG. Benzene and Hodgkin's disease. J Occup Med. 1991 Mar; 33(3):257.
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  593. Kern DG, Christiani DC, Kelsey KT, Hu H, Frumkin H, Kreiss K, Rose C, Newman LS, Jarvis J, Garabrant D, et al. Asbestos-related diseases. N Engl J Med. 1991 Jan 17; 324(3):195-7.
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  594. Velazquez AM, Christiani DC, McConnell R, Eisen EA, Wilcox M. Respiratory disease in a textile factory in Nicaragua. Am J Ind Med. 1991; 20(2):195-208.
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  595. Olenchock SA, Christiani DC, Mull JC, Ye TT, Lu PL. Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China. Biomed Environ Sci. 1990 Dec; 3(4):443-51.
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  596. Christiani DC, Durvasula R, Myers J. Occupational health in developing countries: review of research needs. Am J Ind Med. 1990; 17(3):393-401.
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  597. Milton DK, Christiani DC, Greaves IA. Airborne endotoxin associated with industrial-scale production of protein products in gram-negative bacteria. Am Ind Hyg Assoc J. 1989 Aug; 50(8):A-594, A-596.
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  598. Christiani DC. Modernization and occupational cancer. J Occup Med. 1988 Dec; 30(12):975-6.
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  599. Schwartz A, Rockoff SD, Christiani D, Hyde J. A clinical diagnostic model for the assessment of asbestosis: a new algorithmic approach. J Thorac Imaging. 1988 Oct; 3(4):29-35.
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  600. Shalat SL, Christiani DC, Baker EL. Accuracy of work history obtained from a spouse. Scand J Work Environ Health. 1987 Feb; 13(1):67-9.
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  601. Quinn MM, Punnett L, Christiani DC, Levenstein C, Wegman DH. Modernization and trends in occupational health and safety in the People's Republic of China 1981-1986. Am J Ind Med. 1987; 12(5):499-506.
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  602. Lu PL, Christiani DC, Ye TT, Shi NY, Gong ZC, Dai HI, Zhang WD, Huang JW, Liu MZ. The study of byssinosis in China: a comprehensive report. Am J Ind Med. 1987; 12(6):743-53.
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  603. Kennedy SM, Christiani DC, Eisen EA, Wegman DH, Greaves IA, Olenchock SA, Ye TT, Lu PL. Cotton dust and endotoxin exposure-response relationships in cotton textile workers. Am Rev Respir Dis. 1987 Jan; 135(1):194-200.
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  604. Kelsey KT, Christiani DC, Little JB. Enhancement of benzo[a]pyrene-induced sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. J Natl Cancer Inst. 1986 Aug; 77(2):321-7.
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  605. Christiani DC, Eisen EA, Wegman DH, Ye TT, Gong ZC, Lu PL, Dai HL. Respiratory disease in cotton textile workers in the People's Republic of China. II. Pulmonary function results. Scand J Work Environ Health. 1986 Feb; 12(1):46-50.
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  606. Christiani DC, Eisen EA, Wegman DH, Ye TT, Lu PL, Gong ZC, Dai HL. Respiratory disease in cotton textile workers in the People's Republic of China. I. Respiratory symptoms. Scand J Work Environ Health. 1986 Feb; 12(1):40-5.
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  607. Christiani DC, Kriebel D, Fox NJ, Baker EL. Persistently elevated polychlorinated biphenyl levels from residual contamination of workplace surfaces. Am J Ind Med. 1986; 10(2):143-51.
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  608. Kelsey KT, Christiani DC. Approach to asbestos worker compensation plan alleged to be flawed. J Occup Med. 1985 Nov; 27(11):790-1.
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  609. Frumkin H, Egilman D, Kelly M, Christiani D, Pepper L, Cone J, Sprince N, Himmelstein J. Asbestos-related diseases. JAMA. 1985 Sep 13; 254(10):1307-9.
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  610. Eisen EA, Oliver LC, Christiani DC, Robins JM, Wegman DH. Effects of spirometry standards in two occupational cohorts. Am Rev Respir Dis. 1985 Jul; 132(1):120-4.
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  611. Christiani DC. Occupational health in the People's Republic of China. Am J Public Health. 1984 Jan; 74(1):58-64.
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  612. Olenchock SA, Christiani DC, Mull JC, Shen YE, Lu PL. Airborne endotoxins in a rice production commune in the People's Republic of China. J Toxicol Environ Health. 1984; 13(4-6):545-51.
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  613. Christiani DC. Workers' health on the new "long march": occupational health in the People's Republic of China. Int J Health Serv. 1984; 14(4):605-18.
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  614. Olenchock SA, Christiani DC, Mull JC, Ye TT, Lu PL. Endotoxins in baled cottons and airborne dusts in textile mills in the People's Republic of China. Appl Environ Microbiol. 1983 Oct; 46(4):817-20.
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  615. Christiani DC. Control of cotton dust exposure. JAMA. 1983 May 13; 249(18):2458-9.
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  616. Baker EL, Christiani DC, Wegman DH, Siroky M, Niles CA, Feldman RG. Follow-up studies of workers with bladder neuropathy caused by exposure to dimethylaminopropionitrile. Scand J Work Environ Health. 1981; 7 Suppl 4:54-9.
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  617. Christiani DC. Neglect of occupational disease. Ann Intern Med. 1976 Oct; 85(4):542.
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  618. Christiani DC. Letter: Industrial exposure to vinyl chloride. N Engl J Med. 1976 Jul 22; 295(4):233.
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