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profileDavid Thomas Scadden, M.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressDepartment of Stem Cell and Regenerative Biology
Sherman Fairchild Biochemistry Building; Rm 258B
7 Divinity Ave
Cambridge MA 02138
Phone617/726-5615
Fax617/724-2662
vCardDownload vCard (login for email)
Other Positions
TitleGerald and Darlene Jordan Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
DivisionHematology/Oncology

TitleCo-Chair of the Department of Stem Cell & Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology


Collapse Mentoring 
Collapse completed student projects
Survival Roles for RagA and RagB in Acute Myeloid and T-Cell Acute Lymphoblastic Leukemias
Summer, 06/08/15 - 08/10/15
Identification of genes regulating hematopoietic stem cell homing
Summer, 06/20/11 - 08/12/11
An in vitro culture system to maintain and expand haematopoietic stem cells for bone marrow transplantation
Summer, 06/01/05 - 08/31/05
Modification of Stem Cell Self-renewal by miR-125a
Full Time, 04/04/08 - 08/08/08

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK107784     (KHARCHENKO, PETER V)Jan 1, 2016 - Dec 31, 2020
NIH/NIDDK
Deconvoluting the hematopoietic niche under stress
Role: Co-Principal Investigator

R21HL126070     (SCADDEN, DAVID T)Sep 1, 2015 - Apr 30, 2017
NIH/NHLBI
In vivo tracking of the hematopoietic stem cell clonal dynamics using a novel multi-fluorescent transgenic mouse model
Role: Principal Investigator

R24DK103074     (SCADDEN, DAVID T)Aug 1, 2015 - Jun 30, 2019
NIH/NIDDK
Cell and Molecular Dynamics of Hematopoiesis In Vivo
Role: Principal Investigator

U54CA193461     (HOLLAND, ERIC C.)May 19, 2015 - Apr 30, 2020
NIH/NCI
Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies
Role: Co-Principal Investigator

R01CA194596     (LIN, CHARLES P.)May 18, 2015 - Apr 30, 2019
NIH/NCI
(PQC2) Localization as a determinant of cancer dormancy
Role: Co-Principal Investigator
Collapse research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Harvard Stem Cell Institute - Research opportunities (1)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MC. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 Sep 15; 63(6):1006-20. PMID: 27635760.
    View in: PubMed
  2. Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22; 167(1):171-186.e15. PMID: 27641501.
    View in: PubMed
  3. Yu VW, Lymperi S, Oki T, Jones A, Swiatek P, Vasic R, Ferraro F, Scadden DT. Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem Cell Reports. 2016 Aug 9; 7(2):220-35. PMID: 27453006.
    View in: PubMed
  4. Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Jul 20; 538(7624):274. PMID: 27437586.
    View in: PubMed
  5. Yu VW, Scadden DT. Heterogeneity of the bone marrow niche. Curr Opin Hematol. 2016 Jul; 23(4):331-8. PMID: 27177311.
    View in: PubMed
  6. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016 Jul; 34(7):738-45. PMID: 27272386.
    View in: PubMed
  7. Hoggatt J, Kfoury Y, Scadden DT. Hematopoietic Stem Cell Niche in Health and Disease. Annu Rev Pathol. 2016 May 23; 11:555-81. PMID: 27193455.
    View in: PubMed
  8. Scadden DT. Blood and Bone. N Engl J Med. 2016 May 12; 374(19):1891-3. PMID: 27168440.
    View in: PubMed
  9. Mercier FE, Sykes DB, Scadden DT. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016 Jun 14; 6(6):985-92. PMID: 27185283.
    View in: PubMed
  10. Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016 Apr 21; 532(7599):323-8. PMID: 27074509.
    View in: PubMed
  11. Yu VW, Scadden DT. Hematopoietic Stem Cell and Its Bone Marrow Niche. Curr Top Dev Biol. 2016; 118:21-44. PMID: 27137653.
    View in: PubMed
  12. Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N, Scadden DT. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 Apr 1; 126(4):1300-10. PMID: 26927669.
    View in: PubMed
  13. Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA. Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-?B inflammatory pathway. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1871-6. PMID: 26831087.
    View in: PubMed
  14. Mercier FE, Scadden DT. Not All Created Equal: Lineage Hard-Wiring in the Production of Blood. Cell. 2015 Dec 17; 163(7):1568-70. PMID: 26687347.
    View in: PubMed
  15. Krause DS, Scadden DT. A hostel for the hostile: the bone marrow niche in hematologic neoplasms. Haematologica. 2015 Nov; 100(11):1376-87. PMID: 26521296.
    View in: PubMed
  16. Ren X, Moser PT, Gilpin SE, Okamoto T, Wu T, Tapias LF, Mercier FE, Xiong L, Ghawi R, Scadden DT, Mathisen DJ, Ott HC. Engineering pulmonary vasculature in decellularized rat and human lungs. Nat Biotechnol. 2015 Oct; 33(10):1097-102. PMID: 26368048.
    View in: PubMed
  17. Wang YH, Scadden DT. Harnessing the apoptotic programs in cancer stem-like cells. EMBO Rep. 2015 Sep; 16(9):1084-98. PMID: 26253117; PMCID: PMC4576979 [Available on 09/01/16].
  18. Yu VW, Scadden DT. Global transcriptome analysis of T-competent progenitors in the bone marrow. Genom Data. 2015 Sep; 5:100-2. PMID: 26484235; PMCID: PMC4583637.
  19. Yu VW, Lymperi S, Ferraro F, Scadden DT. Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model. Genom Data. 2015 Sep; 5:318-9. PMID: 26484277; PMCID: PMC4583650.
  20. Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu VW, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden DT, Stanley P, Lowe JB, Huang AY, Siebel CW, Zhou L. Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells. 2015 Jul; 33(7):2280-93. PMID: 25851125; PMCID: PMC4478168 [Available on 07/01/16].
  21. Wang YH, Scadden DT. Targeting the Warburg effect for leukemia therapy: Magnitude matters. Mol Cell Oncol. 2015 Jul-Sep; 2(3):e981988. PMID: 27308458.
    View in: PubMed
  22. Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med. 2015 May 4; 212(5):759-74. PMID: 25918341; PMCID: PMC4419348.
  23. Kfoury Y, Scadden DT. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell. 2015 Mar 5; 16(3):239-53. PMID: 25748931.
    View in: PubMed
  24. Méndez-Ferrer S, Scadden DT, Sánchez-Aguilera A. Bone marrow stem cells: current and emerging concepts. Ann N Y Acad Sci. 2015 Jan; 1335:32-44. PMID: 25573321.
    View in: PubMed
  25. Kfoury Y, Scadden DT. Cellular thrust and parry in the leukemic niche. Blood. 2014 Oct 30; 124(18):2760-1. PMID: 25359983.
    View in: PubMed
  26. Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014 Sep 11; 158(6):1309-23. PMID: 25215489; PMCID: PMC4197056.
  27. Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood. 2014 Nov 6; 124(19):2937-47. PMID: 25202142; PMCID: PMC4224192.
  28. Kalaitzidis D, Scadden DT. Deep diving in the blood stem cell-ome. EMBO J. 2014 Oct 16; 33(20):2281-2. PMID: 25190519; PMCID: PMC4253519.
  29. Choi YJ, Saez B, Anders L, Hydbring P, Stefano J, Bacon NA, Cook C, Kalaszczynska I, Signoretti S, Young RA, Scadden DT, Sicinski P. D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Dev Cell. 2014 Aug 11; 30(3):255-67. PMID: 25087893; PMCID: PMC4134362.
  30. Baryawno N, Scadden DT. Blood loses it when nerves go bad. Cell Res. 2014 Oct; 24(10):1151-2. PMID: 25070156; PMCID: PMC4185357.
  31. Kfoury Y, Mercier F, Scadden DT. SnapShot: The hematopoietic stem cell niche. Cell. 2014 Jul 3; 158(1):228-228.e1. PMID: 24995988.
    View in: PubMed
  32. Cho J, Yusuf R, Kook S, Attar E, Lee D, Park B, Cheng T, Scadden DT, Lee BC. Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest. 2014 Jul; 124(7):3159-71. PMID: 24937426; PMCID: PMC4071372.
  33. Park D, Spencer JA, Lin CP, Scadden DT. Sequential in vivo imaging of osteogenic stem/progenitor cells during fracture repair. J Vis Exp. 2014 May 23; (87). PMID: 24894331; PMCID: PMC4206246.
  34. Kharchenko PV, Silberstein L, Scadden DT. Bayesian approach to single-cell differential expression analysis. Nat Methods. 2014 Jul; 11(7):740-2. PMID: 24836921; PMCID: PMC4112276.
  35. Kalaitzidis D, Scadden DT. Tic-TACs: refreshing hair growth. Cell. 2014 May 8; 157(4):769-70. PMID: 24813602; PMCID: PMC4123451.
  36. Scadden DT. Nice neighborhood: emerging concepts of the stem cell niche. Cell. 2014 Mar 27; 157(1):41-50. PMID: 24679525; PMCID: PMC4161226.
  37. Schajnovitz A, Scadden DT. Bone's dark side: mutated osteoblasts implicated in leukemia. Cell Res. 2014 Apr; 24(4):383-4. PMID: 24589711; PMCID: PMC3975504.
  38. Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem Cells. 2014 Mar; 32(3):791-801. PMID: 24549639; PMCID: PMC3930080.
  39. Lee BC, Scadden DT. From quiescence to senescence. Cell Cycle. 2014; 13(22):3469-70. PMID: 25493411; PMCID: PMC4614945 [Available on 12/10/15].
  40. Catic A, Suh CY, Hill CT, Daheron L, Henkel T, Orford KW, Dombkowski DM, Liu T, Liu XS, Scadden DT. Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation. Cell. 2013 Dec 5; 155(6):1380-95. PMID: 24315104; PMCID: PMC4068507.
  41. Silberstein L, Scadden DT. Blood scent. Cell. 2013 Nov 21; 155(5):981-2. PMID: 24267883.
    View in: PubMed
  42. Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7. PMID: 24162813; PMCID: PMC3827980.
  43. Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. PMID: 23996087; PMCID: PMC3811179.
  44. Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12774-9. PMID: 23861493; PMCID: PMC3732948.
  45. Kook SH, Cho JS, Morrison A, Wiener E, Lee SB, Scadden D, Lee BC. The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity. Cell Death Dis. 2013 Jul 04; 4:e703. PMID: 23828566; PMCID: PMC3730399.
  46. Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell. 2013 Jul 8; 24(1):45-58. PMID: 23770013; PMCID: PMC3746037.
  47. Sykes SM, Scadden DT. Modeling human hematopoietic stem cell biology in the mouse. Semin Hematol. 2013 Apr; 50(2):92-100. PMID: 24216169; PMCID: PMC3826087.
  48. Ruiz-Riol M, Mothe B, Gandhi RT, Bhardwaj N, Scadden DT, Sanchez-Merino V, Brander C. Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients. Eur J Immunol. 2013 Jun; 43(6):1545-54. PMID: 23504637.
    View in: PubMed
  49. Roccaro AM, Sacco A, Maiso P, Azab AK, Tai YT, Reagan M, Azab F, Flores LM, Campigotto F, Weller E, Anderson KC, Scadden DT, Ghobrial IM. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest. 2013 Apr; 123(4):1542-55. PMID: 23454749; PMCID: PMC3613927.
  50. Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, Zhang D, Scadden DT, Chen D. SIRT3 reverses aging-associated degeneration. Cell Rep. 2013 Feb 21; 3(2):319-27. PMID: 23375372; PMCID: PMC3582834.
  51. Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ß-catenin. EMBO Mol Med. 2013 Mar; 5(3):430-40. PMID: 23364955; PMCID: PMC3598082.
  52. Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, Santo L, Cirstea D, Hideshima T, Schirtzinge L, Kuhstoss S, Anderson KC, Munshi N, Scadden D, Kronenberg HM, Raje N. In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. Bone. 2013 Apr; 53(2):487-96. PMID: 23333523; PMCID: PMC4163545.
  53. Krause DS, Scadden DT, Preffer FI. The hematopoietic stem cell niche--home for friend and foe? Cytometry B Clin Cytom. 2013 Jan-Feb; 84(1):7-20. PMID: 23281119; PMCID: PMC3691061.
  54. Van Etten RA, Mauro M, Radich JP, Goldman JM, Saglio G, Jamieson C, Soverini S, Gambacorti-Passerini C, Hehlmann R, Martinelli G, Perrotti D, Scadden DT, Skorski T, Tefferi A, Mughal TI. Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. Leuk Lymphoma. 2013 Jun; 54(6):1151-8. PMID: 23121619; PMCID: PMC3612371.
  55. Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P. Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Blood. 2013 Feb 7; 121(6):930-9. PMID: 23160461; PMCID: PMC3567340.
  56. Yusuf RZ, Scadden DT. Fate through fat: lipid metabolism determines stem cell division outcome. Cell Metab. 2012 Oct 3; 16(4):411-3. PMID: 23040066; PMCID: PMC4045100.
  57. Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41):16636-41. PMID: 23012470; PMCID: PMC3478612.
  58. Hoggatt J, Scadden DT. The stem cell niche: tissue physiology at a single cell level. J Clin Invest. 2012 Sep; 122(9):3029-34. PMID: 22945635; PMCID: PMC3428076.
  59. Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012 Aug 7; 109(32):13076-81. PMID: 22826226; PMCID: PMC3420209.
  60. Scadden DT. Rethinking stroma: lessons from the blood. Cell Stem Cell. 2012 Jun 14; 10(6):648-9. PMID: 22704500; PMCID: PMC4020272.
  61. Yusuf RZ, Wang YH, Scadden DT. The secrets of the bone marrow niche: Metabolic priming for AML. Nat Med. 2012 Jun 06; 18(6):865-7. PMID: 22673998; PMCID: PMC4013790.
  62. Mosam A, Shaik F, Uldrick TS, Esterhuizen T, Friedland GH, Scadden DT, Aboobaker J, Coovadia HM. A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-associated Kaposi sarcoma in South Africa. J Acquir Immune Defic Syndr. 2012 Jun 1; 60(2):150-7. PMID: 22395672; PMCID: PMC3360837.
  63. Krause DS, Scadden DT. Deconstructing the complexity of a microenvironmental niche. Cell. 2012 Mar 30; 149(1):16-7. PMID: 22464318; PMCID: PMC3652249.
  64. Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012 Mar 2; 10(3):259-72. PMID: 22385654; PMCID: PMC3652251.
  65. Scadden D, Srivastava A. Advancing stem cell biology toward stem cell therapeutics. Cell Stem Cell. 2012 Feb 3; 10(2):149-50. PMID: 22305564; PMCID: PMC4020273.
  66. Park D, Sykes DB, Scadden DT. The hematopoietic stem cell niche. Front Biosci (Landmark Ed). 2012 Jan 01; 17:30-9. PMID: 22201730; PMCID: PMC4020275.
  67. Mercier FE, Ragu C, Scadden DT. The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol. 2011 Dec 23; 12(1):49-60. PMID: 22193770; PMCID: PMC4013788.
  68. Lo Celso C, Scadden DT. The haematopoietic stem cell niche at a glance. J Cell Sci. 2011 Nov 1; 124(Pt 21):3529-35. PMID: 22083139; PMCID: PMC3215569.
  69. Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT. Diabetes impairs hematopoietic stem cell mobilization by altering niche function. Sci Transl Med. 2011 Oct 12; 3(104):104ra101. PMID: 21998408; PMCID: PMC3754876.
  70. Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA. Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood. 2011 Sep 8; 118(10):2849-56. PMID: 21765021; PMCID: PMC3172801.
  71. Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 2011 Aug 4; 118(5):1264-73. PMID: 21653327; PMCID: PMC3152494.
  72. Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DA. Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9607-12. PMID: 21606370; PMCID: PMC3111279.
  73. Vallet S, Pozzi S, Patel K, Vaghela N, Fulciniti MT, Veiby P, Hideshima T, Santo L, Cirstea D, Scadden DT, Anderson KC, Raje N. A novel role for CCL3 (MIP-1a) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function. Leukemia. 2011 Jul; 25(7):1174-81. PMID: 21403648; PMCID: PMC4142423.
  74. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 5; 117(18):4915-23. PMID: 21393479; PMCID: PMC3100698.
  75. Guo S, Scadden DT. A microRNA regulating adult hematopoietic stem cells. Cell Cycle. 2010 Sep 15; 9(18):3637-8. PMID: 20855952.
    View in: PubMed
  76. Lane AA, Scadden DT. Stem cells and DNA damage: persist or perish? Cell. 2010 Aug 6; 142(3):360-2. PMID: 20691895.
    View in: PubMed
  77. Jeanson NT, Scadden DT. Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen. Blood. 2010 Nov 18; 116(20):4126-9. PMID: 20664059; PMCID: PMC2993619.
  78. Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5124-9. PMID: 20194748; PMCID: PMC2841922.
  79. Lymperi S, Ferraro F, Scadden DT. The HSC niche concept has turned 31. Has our knowledge matured? Ann N Y Acad Sci. 2010 Mar; 1192:12-8. PMID: 20392212; PMCID: PMC4091621.
  80. Wu JY, Scadden DT, Kronenberg HM. Role of the osteoblast lineage in the bone marrow hematopoietic niches. J Bone Miner Res. 2009 May; 24(5):759-64. PMID: 19257832; PMCID: PMC3276348.
  81. Lane SW, Scadden DT, Gilliland DG. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood. 2009 Aug 6; 114(6):1150-7. PMID: 19401558; PMCID: PMC2723012.
  82. Yusuf RZ, Scadden DT. Homing of hematopoietic cells to the bone marrow. J Vis Exp. 2009; (25). PMID: 19295497; PMCID: PMC2762899.
  83. Ali N, Karlsson C, Aspling M, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood. 2009 Apr 16; 113(16):3690-5. PMID: 19188664; PMCID: PMC2670788.
  84. Raje N, Hideshima T, Mukherjee S, Raab M, Vallet S, Chhetri S, Cirstea D, Pozzi S, Mitsiades C, Rooney M, Kiziltepe T, Podar K, Okawa Y, Ikeda H, Carrasco R, Richardson PG, Chauhan D, Munshi NC, Sharma S, Parikh H, Chabner B, Scadden D, Anderson KC. Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma. Leukemia. 2009 May; 23(5):961-70. PMID: 19151776.
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  85. Scadden DT, Komaroff AL. Will stem cells finally deliver? Newsweek. 2008 Dec 15; 152(24):57-8. PMID: 19105310.
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  86. Raaijmakers MH, Scadden DT. Divided within: heterogeneity within adult stem cell pools. Cell. 2008 Dec 12; 135(6):1006-8. PMID: 19070570.
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  87. Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM. Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16976-81. PMID: 18957542; PMCID: PMC2579363.
  88. Larsson J, Ohishi M, Garrison B, Aspling M, Janzen V, Adams GB, Curto M, McClatchey AI, Schipani E, Scadden DT. Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture. Cell Stem Cell. 2008 Aug 7; 3(2):221-7. PMID: 18682243; PMCID: PMC4197168.
  89. Raaijmakers MH, Scadden DT. Evolving concepts on the microenvironmental niche for hematopoietic stem cells. Curr Opin Hematol. 2008 Jul; 15(4):301-6. PMID: 18536566.
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  90. Orford K, Kharchenko P, Lai W, Dao MC, Worhunsky DJ, Ferro A, Janzen V, Park PJ, Scadden DT. Differential H3K4 methylation identifies developmentally poised hematopoietic genes. Dev Cell. 2008 May; 14(5):798-809. PMID: 18477461.
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  91. Papayannopoulou T, Scadden DT. Stem-cell ecology and stem cells in motion. Blood. 2008 Apr 15; 111(8):3923-30. PMID: 18398055; PMCID: PMC2288715.
  92. Scadden DT. Circadian rhythms: stem cells traffic in time. Nature. 2008 Mar 27; 452(7186):416-7. PMID: 18368105.
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  93. Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA. Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood. 2008 May 1; 111(9):4716-22. PMID: 18299447; PMCID: PMC2343601.
  94. Daley GQ, Scadden DT. Prospects for stem cell-based therapy. Cell. 2008 Feb 22; 132(4):544-8. PMID: 18295571.
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  95. Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008 Feb; 118(2):491-504. PMID: 18219387; PMCID: PMC2213372.
  96. Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet. 2008 Feb; 9(2):115-28. PMID: 18202695.
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  97. Spitzer TR, Ambinder RF, Lee JY, Kaplan LD, Wachsman W, Straus DJ, Aboulafia DM, Scadden DT. Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant. 2008 Jan; 14(1):59-66. PMID: 18158962; PMCID: PMC4524737.
  98. Craiu A, Scadden D. Flow electroporation with pulsed electric fields for purging tumor cells. Methods Mol Biol. 2008; 423:301-10. PMID: 18370208.
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  99. Scadden DT. The weight of cell identity. J Clin Invest. 2007 Dec; 117(12):3653-5. PMID: 18060026; PMCID: PMC2096442.
  100. Adams GB, Scadden DT. A niche opportunity for stem cell therapeutics. Gene Ther. 2008 Jan; 15(2):96-9. PMID: 18004404.
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  101. Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood. 2008 Feb 1; 111(3):1302-5. PMID: 17993613; PMCID: PMC2214740.
  102. Lo Celso C, Klein RJ, Scadden DT. Analysis of the hematopoietic stem cell niche. Curr Protoc Stem Cell Biol. 2007 Nov; Chapter 2:Unit 2A.5. PMID: 18785177.
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  103. Friel AM, Sergent PA, Patnaude C, Szotek PP, Oliva E, Scadden DT, Seiden MV, Foster R, Rueda BR. Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells. Cell Cycle. 2008 Jan 15; 7(2):242-9. PMID: 18256549.
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  104. Purton LE, Scadden DT. Limiting factors in murine hematopoietic stem cell assays. Cell Stem Cell. 2007 Sep 13; 1(3):263-70. PMID: 18371361.
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  105. Lo Celso C, Scadden DT. Stem cells remember their grade. Cell Stem Cell. 2007 Aug 16; 1(2):132-4. PMID: 18371344.
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  106. Bihl F, Mosam A, Henry LN, Chisholm JV, Dollard S, Gumbi P, Cassol E, Page T, Mueller N, Kiepiela P, Martin JN, Coovadia HM, Scadden DT, Brander C. Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma. AIDS. 2007 Jun 19; 21(10):1245-52. PMID: 17545700.
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  107. Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May; 81(9):4904-8. PMID: 17329344; PMCID: PMC1900166.
  108. Lo Celso C, Scadden D. Isolation and transplantation of hematopoietic stem cells (HSCs). J Vis Exp. 2007; (2):157. PMID: 18830434; PMCID: PMC2532946.
  109. Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol. 2007 Mar; 25(3):317-8. PMID: 17322871.
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  110. Duda DG, Cohen KS, Scadden DT, Jain RK. A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat Protoc. 2007; 2(4):805-10. PMID: 17446880; PMCID: PMC2686125.
  111. Chen T, Bai H, Shao Y, Arzigian M, Janzen V, Attar E, Xie Y, Scadden DT, Wang ZZ. Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells. 2007 Feb; 25(2):392-401. PMID: 17038674.
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  112. Scadden DT, Muse VV, Hasserjian RP. Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy. N Engl J Med. 2006 Sep 28; 355(13):1358-68. PMID: 17005954.
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  113. Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res. 2006 Sep 15; 66(18):9054-64. PMID: 16982747.
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  114. Fleming HE, Scadden DT. Embryonic stem cells make human T cells. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12213-4. PMID: 16894150; PMCID: PMC1567857.
  115. Scadden DT. The stem-cell niche as an entity of action. Nature. 2006 Jun 29; 441(7097):1075-9. PMID: 16810242.
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  116. Purton LE, Scadden DT. Osteoclasts eat stem cells out of house and home. Nat Med. 2006 Jun; 12(6):610-1. PMID: 16761001.
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  117. Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol. 2006 Apr; 7(4):333-7. PMID: 16550195.
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  118. Robertson P, Means TK, Luster AD, Scadden DT. CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus. Exp Hematol. 2006 Mar; 34(3):308-19. PMID: 16543065.
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  119. Larsson J, Scadden D. Nervous activity in a stem cell niche. Cell. 2006 Jan 27; 124(2):253-5. PMID: 16439198.
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  120. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006 Feb 2; 439(7076):599-603. PMID: 16382241.
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  121. Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 2006 Apr 1; 107(7):2774-6. PMID: 16339405; PMCID: PMC1895376.
  122. Dong HY, Scadden DT, de Leval L, Tang Z, Isaacson PG, Harris NL. Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am J Surg Pathol. 2005 Dec; 29(12):1633-41. PMID: 16327436.
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  123. Scadden D. Interview with David Scadden. Interview by Joseph Glorioso and Jenny Jacoby. Gene Ther. 2005 Dec; 12(23):1663-6. PMID: 16121202.
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  124. Robertson P, Scadden DT. Differentiation and characterization of T cells. Curr Protoc Immunol. 2005 Nov; Chapter 22:Unit 22F.8. PMID: 18432955.
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  125. Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 1; 23(31):8136-9. PMID: 16258121.
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  126. Miyake N, Brun AC, Magnusson M, Miyake K, Scadden DT, Karlsson S. HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency. Stem Cells. 2006 Mar; 24(3):653-61. PMID: 16210402.
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  127. Zhang J, Attar E, Cohen K, Crumpacker C, Scadden D. Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells. Gene Ther. 2005 Oct; 12(19):1444-52. PMID: 15877047.
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  128. Woodberry T, Suscovich TJ, Henry LM, August M, Waring MT, Kaur A, Hess C, Kutok JL, Aster JC, Wang F, Scadden DT, Brander C. Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. J Immunol. 2005 Oct 1; 175(7):4355-62. PMID: 16177076.
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  129. Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander C. Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. J Infect Dis. 2005 Nov 1; 192(9):1513-24. PMID: 16206065.
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  130. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005 Jul 29; 122(2):303-15. PMID: 16051153.
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  131. Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander C. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. J Infect Dis. 2005 Aug 15; 192(4):622-9. PMID: 16028131.
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  132. Sipkins DA, Wei X, Wu JW, Runnels JM, Côté D, Means TK, Luster AD, Scadden DT, Lin CP. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature. 2005 Jun 16; 435(7044):969-73. PMID: 15959517; PMCID: PMC2570168.
  133. Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, Bonventre JV. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest. 2005 Jul; 115(7):1743-55. PMID: 16007251; PMCID: PMC1159124.
  134. Li ZJ, Wang ZZ, Zheng YZ, Xu B, Yang RC, Scadden DT, Han ZC. Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation. J Cell Biochem. 2005 Jun 1; 95(3):559-70. PMID: 15786495.
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  135. Kaplan LD, Lee JY, Ambinder RF, Sparano JA, Cesarman E, Chadburn A, Levine AM, Scadden DT. Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood. 2005 Sep 1; 106(5):1538-43. PMID: 15914552; PMCID: PMC1895225.
  136. Mark Stroh, John P Zimmer, Dan G Duda, Tatyana S Levchenko, Kenneth S Cohen, Edward B Brown, David T Scadden, Vladimir P Torchilin, Moungi G Bawendi, Dai Rukumura & Rakesh K Rain. . Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Advance publication online. 2005.
  137. Tonia Woodberry, Todd J. Suscovich, Leah M. Henry, Jeff N. Martin, Sheila Dollard, Paula G. O’Connor, Jennifer K. Davis, Dennis Osmond, Tzong-Hae Lee, Dean H. Kedes, Ashok Khatri, Jeannette Lee, Bruce D. Walker, David T. Scadden, Christian Brander. . T cell responses to KSHV ORF73 and ORF65. J. Inf. Dis. 2005; (in press).
  138. Tonia Woodberry, Todd J. Suscovich, Leah M. Henry, Jennifer K. Davis, Nicole Frahm, Bruce D. Walker, David T. Scadden, Frederick Wang, Christian Brander. . Differential targeting and shifts in the immunodominanace of EBV specific CD8 and CD4 T cell responses from acute to persistent infection. J. Inf. Dis. 2005; (in press).
  139. Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood. 2005 Jul 15; 106(2):477-84. PMID: 15811962.
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  140. Mosam A, Cassol E, Page T, Bodasing U, Cassol S, Dawood H, Friedland GH, Scadden DT, Aboobaker J, Jordaan JP, Lalloo UG, Esterhuizen TM, Coovadia HM. Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa. AIDS. 2005 Mar 4; 19(4):441-3. PMID: 15750399.
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  141. Fangman JJ, Scadden DT. Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management. Curr Hematol Rep. 2005 Mar; 4(2):95-102. PMID: 15720957.
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  142. Kutok JL, Yang X, Folkerth RD, Imitola J, Raddassi K, Yano Y, Salahuddin S, Lawitts J, Imboden H, Chinami M, Shirakawa T, Turner H, Khoury S, Sayegh MH, Scadden D, Adra C. The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. J Mol Histol. 2005 Feb; 36(1-2):77-87. PMID: 15704002.
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  143. Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, ... Scadden DT. Matrix glycoprotein, osteopontin, is a niche constituent that negatively regulates hematopoietic stem cell pool size. J Exp Med (in press). 2005.
  144. Scadden DT. Book Review. Am J Transplant. 2005; 5(1):193.
  145. Noy A, Scadden DT, Lee J, Dezube BJ, Aboulafia D, Tulpule A, Walmsley S, Gill P. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10; 23(5):990-8. PMID: 15598977.
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  146. Attar EC, Scadden DT. Regulation of hematopoietic stem cell growth. Leukemia. 2004 Nov; 18(11):1760-8. PMID: 15457182.
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  147. Craiu A, Saito Y, Limon A, Eppich HM, Olson DP, Rodrigues N, Adams GB, Dombkowski D, Richardson P, Schlossman R, Choi PS, Grogins J, O'Connor PG, Cohen K, Attar EC, Freshman J, Rich R, Mangano JA, Gribben JG, Anderson KC, Scadden DT. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood. 2005 Mar 1; 105(5):2235-8. PMID: 15292069.
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  148. Cheng T, Scadden DT. Cell Cycle Regulators in Stem Cells. Handbook of Stem Cells: Adult and Fetal Volume. 2004; 2:73-82.
  149. Scadden DT. Cancer stem cells refined. Nat Immunol. 2004 Jul; 5(7):701-3. PMID: 15224098.
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  150. Chabner KT, Adams GB, Qiu J, Moskowitz M, Marsters ES, Topulos GP, Scadden DT. Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment. Blood. 2004 Jun 15; 103(12):4685-6. PMID: 15178586.
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  151. Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C. Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leuk Lymphoma. 2004 Jun; 45(6):1223-38. PMID: 15360006.
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  152. Yuan Y, Shen H, Franklin DS, Scadden DT, Cheng T. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol. 2004 May; 6(5):436-42. PMID: 15122268.
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  153. Qiu J, Takagi Y, Harada J, Rodrigues N, Moskowitz MA, Scadden DT, Cheng T. Regenerative response in ischemic brain restricted by p21cip1/waf1. J Exp Med. 2004 Apr 5; 199(7):937-45. PMID: 15067031; PMCID: PMC2211886.
  154. Adams G, Scadden D. Defining the hematopoietic stem cell niche. Discov Med. 2004 Apr; 4(21):118-9. PMID: 20705006.
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  155. Scadden DT. The malignant side of successful transplantation. Am J Transplant. 2004 Feb; 4(2):153-4. PMID: 14974933.
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  156. O’Connor PG, Scadden DT. Neoplastic Complications of HIV Infection. AIDS & Other Manifestations of HIV Infection. 2004; 21:597-611.
  157. Scadden DT, Groopman JE. AIDS-associated lymphoma. Hematology: Basic Principles and Practice. 2004; 82:1487-1500.
  158. Scadden DT. Cord blood transplantation: the complexity of success. The Hematologist: ASH News and Reports. 2004; 1(4):7.
  159. Adams GB, Scadden DT. Microenvironmental influences on stem cell function. Discovery Medicine. 2004; (in press).
  160. Scadden DT. Cancer stem cells refined. Nat. Immunol. Invited commentary. 2004; 5(7):701-3.
  161. Scadden DT, Attar E. Stem cells. Molecular Haematology. 2004; (in press).
  162. Scadden DT. The malignant side of successful transplantation. American Journal of Transplantation. Invited editorial. 2004; 4:153-4.
  163. Scadden DT. Stem cells and immune reconstitution in AIDS. Blood Rev. 2003 Dec; 17(4):227-31. PMID: 14556777.
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  164. Scadden DT. T-cell differentiation: Notch another step. Blood. Invited commentary. 2003; (102):2316.
  165. Robertson P, Scadden DT. Immune reconstitution in HIV infection and its relationship to cancer. Hematol Oncol Clin North Am. 2003 Jun; 17(3):703-16, vi. PMID: 12852652.
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  166. Fukushima T, Miyazaki Y, Tsushima H, Tsutsumi C, Taguchi J, Yoshida S, Kuriyama K, Scadden D, Nimer S, Tomonaga M. The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. Leuk Res. 2003 May; 27(5):387-92. PMID: 12620289.
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  167. Stier S, Cheng T, Forkert R, Lutz C, Dombkowski DM, Zhang JL, Scadden DT. Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells. Blood. 2003 Aug 15; 102(4):1260-6. PMID: 12702511.
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  168. Anton PA, Mitsuyasu RT, Deeks SG, Scadden DT, Wagner B, Huang C, Macken C, Richman DD, Christopherson C, Borellini F, Lazar R, Hege KM. Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS. 2003 Jan 3; 17(1):53-63. PMID: 12478069.
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  169. Scadden DT. AIDS-Associated Malignancies. Atlas of Diagnostic Oncology. 2003; 17:584-596.
  170. Whelan JP, Scadden DT. Lymphoma and abnormalities of the immune system. Non-Hodgkin’s Lymphomas. 2003; 45:729-748.
  171. Scadden DT. Hematology/Oncology in AIDS. Cecil Textbook of Medicine. 2003; 419:2173-2177.
  172. Scadden DT. Acquired Immunodeficiency Syndrome. Blood: Principles and Practice of Hematology. 2003; 2:713-732.
  173. Friedberg J, Scadden DT. Cancer and the Immunocompromised Host. Clinical Practice of Hematology and Oncology: Presentations, Diagnosis, and Treatment. 2003; 1155-1165.
  174. Scadden DT. Developing Cellular Therapies for HIV Infection. J Hematotherapy and Stem Cell Research. 2003; (in press).
  175. Scadden DT. Stem Cells and Immune Reconstitution in AIDS. Blood Reviews.Invited commentary. 2003; 17 (4):227-31.
  176. Scadden DT. AIDS lymphomas: beginning of an EPOCH?. Blood.Invited commentary. 2003; 101:4647.
  177. Scadden DT. Non-Hodgkin Lymphoma. AIDS Therapy. 2003; 51:696-705.
  178. Miles SA, Testa M, Huang J, Wade M, Carden J, Scadden DT. Lack of antitumor activity and intolerance of interleukin-4 in patients with advanced HIV disease and Kaposi's sarcoma. J Interferon Cytokine Res. 2002 Nov; 22(11):1143-8. PMID: 12513914.
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  179. Scadden DT. Toward cellular-based therapies for HIV infection. J Hematother Stem Cell Res. 2002 Oct; 11(5):759-64. PMID: 12427282.
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  180. Poznansky MC, Luster, AT, Scadden DT, inventors; The General Hospital Corporation assignee. . Purposeful movement of human migratory cells away from an agent source. 2002.
  181. Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP. The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6; 16(13):1743-7. PMID: 12218384.
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  182. Adams GB, Chabner KT, Foxall RB, Weibrecht KW, Rodrigues NP, Dombkowski D, Fallon R, Poznansky MC, Scadden DT. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood. 2003 Jan 1; 101(1):45-51. PMID: 12393569.
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  183. Brander C, Raje N, O'Connor PG, Davies F, Davis J, Chauhan D, Hideshima T, Martin J, Osmond D, Kedes DH, Walker BD, Scadden DT, Anderson KC. Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma. Blood. 2002 Jul 15; 100(2):698-700. PMID: 12091368.
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  184. Tulpule A, Groopman J, Saville MW, Harrington W, Friedman-Kien A, Espina BM, Garces C, Mantelle L, Mettinger K, Scadden DT, Gill PS. Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma. Cancer. 2002 Jul 1; 95(1):147-54. PMID: 12115328.
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  185. Deeks SG, Wagner B, Anton PA, Mitsuyasu RT, Scadden DT, Huang C, Macken C, Richman DD, Christopherson C, June CH, Lazar R, Broad DF, Jalali S, Hege KM. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther. 2002 Jun; 5(6):788-97. PMID: 12027564.
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  186. Cheng T, Scadden DT. Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors. Int J Hematol. 2002 Jun; 75(5):460-5. PMID: 12095144.
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  187. Scadden DT. AIDS-related lymphoma. 2002; P266-272.
  188. Wang Z, Miura N, Bonelli A, Mole P, Carlesso N, Olson DP, Scadden DT. Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. Blood. 2002 Apr 15; 99(8):2740-7. PMID: 11929761.
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  189. Poznansky MC, Olszak IT, Evans RH, Wang Z, Foxall RB, Olson DP, Weibrecht K, Luster AD, Scadden DT. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J Clin Invest. 2002 Apr; 109(8):1101-10. PMID: 11956248; PMCID: PMC150941.
  190. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002 Apr 1; 99(7):2369-78. PMID: 11895769.
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  191. Poznansky MC, Scadden DT, Luster AD. Chemokine and chemokine receptor analysis. Manual of Clinical Laboratory Immunology. 2002; 357-367.
  192. Preffer FI, Dombkowski D, Sykes M, Scadden D, Yang YG. Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells. 2002; 20(5):417-27. PMID: 12351812.
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  193. Cianfrocca M, Cooley TP, Lee JY, Rudek MA, Scadden DT, Ratner L, Pluda JM, Figg WD, Krown SE, Dezube BJ. Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study. J Clin Oncol. 2002 Jan 1; 20(1):153-9. PMID: 11773164.
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  194. Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN. Human HTm4 is a hematopoietic cell cycle regulator. J Clin Invest. 2002 Jan; 109(1):51-8. PMID: 11781350; PMCID: PMC150822.
  195. Cohen K, Scadden DT. AIDS-related non-Hodgkin’s Lymphoma. ACS Atlas of Clinical Oncology, Malignant Lymphoma. 2002; 241-258.
  196. Jiang Z, Adams GB, Hanash AM, Scadden DT, Levy RB. The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2002; 8(11):588-96. PMID: 12463477.
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  197. Cheng T, Shen H, Rodrigues N, Stier S, Scadden DT. Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1). Blood. 2001 Dec 15; 98(13):3643-9. PMID: 11739168.
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  198. Levine AM, Scadden DT, Zaia JA, Krishnan A. Hematologic aspects of HIV/AIDS. 2001; p463-78.
  199. Scadden DT. AIDS-related malignancies. Annu Rev Med. 2003; 54:285-303. PMID: 12525676.
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  200. Christmas P, Jones JP, Patten CJ, Rock DA, Zheng Y, Cheng SM, Weber BM, Carlesso N, Scadden DT, Rettie AE, Soberman RJ. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. J Biol Chem. 2001 Oct 12; 276(41):38166-72. PMID: 11461919.
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  201. Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J Infect Dis. 2001 Jul 15; 184(2):119-26. PMID: 11424007.
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  202. Poznansky MC, Olszak IT, Foxall RB, Piascik A, Adams GB, Evans RH, Cheng T, Scadden DT. Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells. Exp Hematol. 2001 Jun; 29(6):766-74. PMID: 11378272.
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  203. Ellisen LW, Carlesso N, Cheng T, Scadden DT, Haber DA. The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells. EMBO J. 2001 Apr 17; 20(8):1897-909. PMID: 11296223; PMCID: PMC125233.
  204. Shen H, Cheng T, Olszak I, Garcia-Zepeda E, Lu Z, Herrmann S, Fallon R, Luster AD, Scadden DT. CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells. J Immunol. 2001 Apr 15; 166(8):5027-33. PMID: 11290783.
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  205. Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, Scadden D, Kaplan L, Ambinder R, Levine A, Harrington W, Grochow L, Flexner C, Tan B, Straus D. Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy. J Clin Oncol. 2001 Apr 15; 19(8):2171-8. PMID: 11304769.
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  206. Scadden DT, Shen H, Cheng T. Hematopoietic stem cells in HIV disease. J Natl Cancer Inst Monogr. 2001; (28):24-9. PMID: 11158203.
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  207. Cohen K, Scadden DT. Non-Hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment. Cancer Treat Res. 2001; 104:201-30. PMID: 11191128.
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  208. Levine AM, Scadden DT, Zaia JA, Krishnan A. Hematologic Aspects of HIV/AIDS. Hematology Am Soc Hematol Educ Program. 2001; 463-78. PMID: 11722999.
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  209. Cohen K, Scadden DT. Non-Hodgkin’s lymphoma: pathogenesis, clinical presentation, and treatment. HIV & HTLV-I Associated Malignancies. 2001; 7:201-230.
  210. Scadden DT, Shen H, Cheng T. Hematopoietic stem cells in HIV disease. 2001; 28(J Natl Cancer Inst Monogr):24-9.
  211. O'Connor PG, Scadden DT. AIDS oncology. Infect Dis Clin North Am. 2000 Dec; 14(4):945-65, vii. PMID: 11144646.
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  212. Cheng T, Rodrigues N, Dombkowski D, Stier S, Scadden DT. Stem cell repopulation efficiency but not pool size is governed by p27(kip1). Nat Med. 2000 Nov; 6(11):1235-40. PMID: 11062534.
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  213. Scadden DT. Epstein-Barr virus, the CNS, and AIDS-related lymphomas: as close as flame to smoke. J Clin Oncol. 2000 Oct 1; 18(19):3323-4. PMID: 11013270.
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  214. Brander C, Suscovich T, Lee Y, Nguyen PT, O'Connor P, Seebach J, Jones NG, van Gorder M, Walker BD, Scadden DT. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus. J Immunol. 2000 Aug 15; 165(4):2077-83. PMID: 10925292.
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  215. Mitsuyasu RT, Anton PA, Deeks SG, Scadden DT, Connick E, Downs MT, Bakker A, Roberts MR, June CH, Jalali S, Lin AA, Pennathur-Das R, Hege KM. Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood. 2000 Aug 1; 96(3):785-93. PMID: 10910888.
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  216. Eppich HM, Foxall R, Gaynor K, Dombkowski D, Miura N, Cheng T, Silva-Arrieta S, Evans RH, Mangano JA, Preffer FI, Scadden DT. Pulsed electric fields for selection of hematopoietic cells and depletion of tumor cell contaminants. Nat Biotechnol. 2000 Aug; 18(8):882-7. PMID: 10932160.
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  217. Scadden DT, Baker, KP, Baron WF, inventors; Genentech, Inc. assignee. . Protein tyrosine kinases. 2000.
  218. Whelan P, Scadden DT. New developments in the etiopathogenesis and treatment of HIV-related Kaposi's sarcoma. Clin Dermatol. 2000 Jul-Aug; 18(4):469-77. PMID: 11024314.
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  219. Evans RH, Scadden DT. Haematological aspects of HIV infection. Baillieres Best Pract Res Clin Haematol. 2000 Jun; 13(2):215-30. PMID: 10942622.
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  220. Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT. Active movement of T cells away from a chemokine. Nat Med. 2000 May; 6(5):543-8. PMID: 10802710.
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  221. Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest. 2000 May; 105(9):1299-305. PMID: 10792005; PMCID: PMC315448.
  222. Podestà M, Zocchi E, Pitto A, Usai C, Franco L, Bruzzone S, Guida L, Bacigalupo A, Scadden DT, Walseth TF, De Flora A, Daga A. Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. FASEB J. 2000 Apr; 14(5):680-90. PMID: 10744625.
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  223. Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol. 2000 Apr; 18(4):410-4. PMID: 10748521.
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  224. Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden DT. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. 2000 Mar 10; 287(5459):1804-8. PMID: 10710306.
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  225. Tulpule A, Scadden DT, Espina BM, Cabriales S, Howard W, Shea K, Gill PS. Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma. J Clin Oncol. 2000 Feb; 18(4):716-23. PMID: 10673512.
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  226. Friel TJ, Scadden DT. Hematologic manifestations of HIV infection: Thrombocytopenia and coagulation abnormalities. 2000.
  227. Scadden DT. Non-Hodgkin's lymphoma: Future targets for prevention and therapy. AIDS-related Cancers and their Treatment. 2000; 195-207.
  228. Friel TJ, Scadden DT. Hematologic manifestations of HIV infection: Anemia. 2000.
  229. Evans RH, Scadden DT. Haematological aspects of HIV infection. Bailliere’s Best Practice and Research: Clinical Haematology. 2000; 13:215-230.
  230. Scadden DT. Neoplasms in acquired immunodefiency syndrome. Cancer Medicine. 2000; 37:2099-114.
  231. Scadden DT. AIDS-related neoplasms. UICC Manual of Clinical Oncology. 2000; (in press).
  232. Friel TJ, Scadden DT. Hematologic manifestations of HIV infection: Neutropenia. 2000.
  233. Scadden DT, Freedman A, inventors; Beth Israel Medical Center, Inc. assignee. In-vitro T-lymphopoiesis system. 1999.
  234. Godowski PJ, Mark MR, Scadden DT, inventors; New England Deaconess Hospital, Genentech, Inc. assignees. Protein tyrosine kinases. 1999.
  235. Scadden DT . Hematologic aspects of HIV disease and immune reconstitution. 1999.
  236. Cavacini LA, Wisnewski A, Peterson JE, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner MR. A human anti-HIV autoantibody enhances EBV transformation and HIV infection. Clin Immunol. 1999 Dec; 93(3):263-73. PMID: 10600338.
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  237. Scadden DT. Immune reconstitution in AIDS: oncologic implications and hematologic approaches. Curr Opin Oncol. 1999 Nov; 11(6):503-7. PMID: 10550015.
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  238. Scadden DT, inventor; Beth Israel Medical Center, Inc. assignee. Method of screening a compound for hematopoietic activity. 1999.
  239. Poznansky MC, La Vecchio J, Silva-Arietta S, Porter-Brooks J, Brody K, Olszak IT, Adams GB, Ramstedt U, Marasco WA, Scadden DT. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat. Hum Gene Ther. 1999 Oct 10; 10(15):2505-14. PMID: 10543615.
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  240. Gill PS, Tulpule A, Espina BM, Cabriales S, Bresnahan J, Ilaw M, Louie S, Gustafson NF, Brown MA, Orcutt C, Winograd B, Scadden DT. Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma. J Clin Oncol. 1999 Jun; 17(6):1876-83. PMID: 10561228.
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  241. Adams GB, McMullen M, Turner S, Olszak IT, Scadden DT, McClure MO, Poznansky MC. Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors. J Acquir Immune Defic Syndr. 1999 May 1; 21(1):1-8. PMID: 10235508.
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  242. Nikolic B, Gardner JP, Scadden DT, Arn JS, Sachs DH, Sykes M. Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. J Immunol. 1999 Mar 15; 162(6):3402-7. PMID: 10092795.
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  243. Schwartz JD, Howard W, Scadden DT. Potential interaction of antiretroviral therapy with paclitaxel in patients with AIDS-related Kaposi's sarcoma. AIDS. 1999 Feb 4; 13(2):283-4. PMID: 10202837.
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  244. Scadden DT. Hematologic Aspects of HIV Disease and Immune Reconstitution. ASH Education Book, Hematology. 1999.
  245. O'Connor P, Scadden DT. Hodgkin's Disease. Infectious Causes of Cancer: Targets for Intervention. 1999.
  246. Turnbull JL, Patchen ML, Scadden DT. The polysaccharide, PGG-glucan, enhances human myelopoiesis by direct action independent of and additive to early-acting cytokines. Acta Haematol. 1999; 102(2):66-71. PMID: 10529508.
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  247. Scadden DT. AIDS-related non-Hodgkin's Lymphomas. AIDS Therapy. 1999.
  248. Shen H, Cheng T, Preffer FI, Dombkowski D, Tomasson MH, Golan DE, Yang O, Hofmann W, Sodroski JG, Luster AD, Scadden DT. Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression. J Virol. 1999 Jan; 73(1):728-37. PMID: 9847379; PMCID: PMC103880.
  249. Scadden DT, Schenkein DP, Bernstein Z, Luskey B, Doweiko J, Tulpule A, Levine AM. Immunotoxin combined with chemotherapy for patients with AIDS-related non-Hodgkin's lymphoma. Cancer. 1998 Dec 15; 83(12):2580-7. PMID: 9874466.
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  250. Scadden DT, inventor; Beth Israel Deaconess Medical Center, Inc. assignee. . Method of selecting pluripotent hematopoietic progenitor cells. 1998.
  251. Tulpule A, Yung RC, Wernz J, Espina BM, Myers A, Scadden DT, Cabriales S, Ilaw M, Boswell W, Gill PS. Phase II trial of liposomal daunorubicin in the treatment of AIDS-related pulmonary Kaposi's sarcoma. J Clin Oncol. 1998 Oct; 16(10):3369-74. PMID: 9779714.
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  252. Wu CJ, Scadden DT. Posttransplant Kaposi's sarcoma treated with paclitaxel. J Clin Oncol. 1998 Oct; 16(10):3478-9. PMID: 9779728.
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  253. Scadden DT. AIDS-related malignancies. Curr Opin Oncol. 1998 Sep; 10(5):403-4. PMID: 9800109.
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  254. Gardner JP, Rosenzweig M, Marks DF, Harper D, Gaynor K, Fallon RJ, Wall DA, Johnson RP, Scadden DT. T-lymphopoietic capacity of cord blood-derived CD34+ progenitor cells. Exp Hematol. 1998 Sep; 26(10):991-9. PMID: 9728935.
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  255. Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC. Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998 Aug 13; 339(7):444-9. PMID: 9700178.
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  256. Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol. 1998 Jul; 18(7):4301-14. PMID: 9632814; PMCID: PMC109014.
  257. Yamaguchi T, Olozak I, Chattopadhyay N, Butters RR, Kifor O, Scadden DT, Brown EM. Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes. Biochem Biophys Res Commun. 1998 May 19; 246(2):501-6. PMID: 9610391.
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  258. Scadden DT. Mother knows best. Nat Med. 1998 Apr; 4(4):390-1. PMID: 9546778.
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  259. Godowski PJ, Mark MR, Scadden DT, inventors; Genentech, Inc., New England Deaconess Hospital assignees. . Antibodies specific for Rse receptor protein tyrosine kinase. 1998.
  260. Scadden DT. Mother knows best: New developments in Kaposi's sarcoma. Nature Medicine. 1998; 4:390-392.
  261. Scadden DT. Management of AIDS-associated Kaposi's sarcoma: A multidisciplinary Perspective. Center for Bio-Medical Communication. 1998.
  262. Cabriales S, Bresnahan J, Testa D, Espina BM, Scadden DT, Ross M, Gill PS. Extravasation of liposomal daunorubicin in patients with AIDS-associated Kaposi's sarcoma: a report of four cases. Oncol Nurs Forum. 1998 Jan-Feb; 25(1):67-70. PMID: 9460774.
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  263. Scadden DT, Groopman JE. Hematology/Oncology in AIDS. Cecil Textbook in Medicine. 1998.
  264. Scadden DT, Groopman JE. AIDS-associated lymphoma. Hematology: Basic Principles and Practice. 1998.
  265. Scadden DT, Howard WW. AIDS-Related Malignancies. Oncologist. 1998; 3(2):119-123. PMID: 10388093.
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  266. Scadden DT, Howard W. AIDS-related malignancies. The Oncologist. 1998; 3:119-123.
  267. Scadden DT. Non-Hodgkin's lymphoma future targets for prevention and therapy. AIDS-related Cancers and Their Treatment. 1998.
  268. Scadden DT. Cytopenias associated with HIV-1 and other infections. Cytokines in the treatment of hemtopoietic failure. 1998.
  269. Gardner JP, Zhu H, Colosi PC, Kurtzman GJ, Scadden DT. Robust, but transient expression of adeno-associated virus-transduced genes during human T lymphopoiesis. Blood. 1997 Dec 15; 90(12):4854-64. PMID: 9389702.
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  270. Scadden DT, Rosenzweig M, Johnson PR, inventors; President and Fellow of Harvard College assignee. . In vitro differentiation of CD34+ progenitor cells into T lymphocytes. 1997.
  271. Levine AM, Tulpule A, Tessman D, Kaplan L, Giles F, Luskey BD, Scadden DT, Northfelt DW, Silverberg I, Wernz J, Espina B, Von Hoff D. Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial. J Clin Oncol. 1997 Mar; 15(3):1094-103. PMID: 9060550.
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  272. Scadden DT. Cytokine use in the management of HIV disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1997; 16 Suppl 1:S23-9. PMID: 9389312.
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  273. Scadden DT. Cytokine Use in the Management of HIV Disease. J Acq Imm Def Synd & Human Retro. 1997; 16(Supp.1):S23-S29.
  274. Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13158-63. PMID: 8917561; PMCID: PMC24063.
  275. Scadden DT. Hematologic disorders and growth factor support in HIV infection. Hematol Oncol Clin North Am. 1996 Oct; 10(5):1149-61. PMID: 8880202.
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  276. Scadden DT, Pickus O, Hammer SM, Stretcher B, Bresnahan J, Gere J, McGrath J, Agosti JM. Lack of in vivo effect of granulocyte-macrophage colony-stimulating factor on human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 1996 Aug 10; 12(12):1151-9. PMID: 8844019.
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  277. Gill PS, Wernz J, Scadden DT, Cohen P, Mukwaya GM, von Roenn JH, Jacobs M, Kempin S, Silverberg I, Gonzales G, Rarick MU, Myers AM, Shepherd F, Sawka C, Pike MC, Ross ME. Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma. J Clin Oncol. 1996 Aug; 14(8):2353-64. PMID: 8708728.
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  278. Scadden DT. Cytokine use in the management of HIV disease. 1996; 16:pS23.
  279. Rosenzweig M, Marks DF, Zhu H, Hempel D, Mansfield KG, Sehgal PK, Kalams S, Scadden DT, Johnson RP. In vitro T lymphopoiesis of human and rhesus CD34+ progenitor cells. Blood. 1996 May 15; 87(10):4040-8. PMID: 8639759.
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  280. Scadden DT, Groopman JE. Acquired immune deficiency syndrome. Cecil Textbook of Medicine. 1996; 1870-1875.
  281. Freedman AR, Zhu H, Levine JD, Kalams S, Scadden DT. Generation of human T lymphocytes from bone marrow CD34+ cells in vitro. Nat Med. 1996 Jan; 2(1):46-51. PMID: 8564838.
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  282. Scadden DT, Fairchild PG. HIV-associated malignancies. American Cancer Society (Cancer Manual). 1996; 525-534.
  283. Scadden DT, Freedman AR. GM-CSF in the treatment of AIDS. Marty: Manual of GM-CDF. 1996; 181-193.
  284. Scadden DT, Golde D. Growth factors in the treatment of disease. Immunology of HIV Infection. 1996; 525-531.
  285. Scadden DT, Ellis MH. AIDS-associated malignancies. Mosby-Wolfe Atlas of Diagnostic Oncology. 1996; 577-588.
  286. Golde DW, Neidhart JA, Scadden DT, Nimer SD. The rational use of hematopoietic growth factors. 1995; : Section Seven: Special Topi:p112-118.
  287. Berardi AC, Wang A, Abraham J, Scadden DT. Basic fibroblast growth factor mediates its effects on committed myeloid progenitors by direct action and has no effect on hematopoietic stem cells. Blood. 1995 Sep 15; 86(6):2123-9. PMID: 7662960.
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  288. Columbyova L, Loda M, Scadden DT. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res. 1995 Aug 15; 55(16):3509-12. PMID: 7627956.
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  289. Masood R, Zhang Y, Bond MW, Scadden DT, Moudgil T, Law RE, Kaplan MH, Jung B, Espina BM, Lunardi-Iskandar Y, et al. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma. Blood. 1995 Jun 15; 85(12):3423-30. PMID: 7780129.
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  290. Scadden DT, Levine JD, Bresnahan J, Gere J, McGrath J, Wang Z, Resta DJ, Young D, Hammer SM. In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia. AIDS Res Hum Retroviruses. 1995 Jun; 11(6):731-40. PMID: 7576933.
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  291. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterization of human hematopoietic stem cells. Science. 1995 Jan 6; 267(5194):104-8. PMID: 7528940.
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  292. Price P, Johnson RP, Scadden DT, Jassoy C, Rosenthal T, Kalams S, Walker BD. Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope. Clin Immunol Immunopathol. 1995 Jan; 74(1):100-6. PMID: 7527747.
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  293. Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J Biol Chem. 1994 May 27; 269(21):15092-100. PMID: 8195146.
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  294. Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J Biol Chem. 1994 May 13; 269(19):14211-8. PMID: 8188704.
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  295. Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood. 1994 Apr 15; 83(8):2126-32. PMID: 8161781.
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  296. Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene. 1994 Jan 28; 138(1-2):247-51. PMID: 7510261.
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  297. Scadden DT, Groopman JE. AIDS. Principles and Practice of Hematology. 1994; 697-726.
  298. Scadden DT, Groopman JE. AIDS-associated lymphoma. Hematology: Basic Principles and Practice. 1994; 1344-1353.
  299. Freedman AR, Scadden DT. Viral activity in early HIV disease. Curr Opin Hematol. 1994 Jan; 1(1):19-23. PMID: 9371255.
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  300. Wang Z, Goldberg MA, Scadden DT. HIV-1 suppresses erythropoietin production in vitro. Exp Hematol. 1993 May; 21(5):683-8. PMID: 8390370.
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  301. Scadden DT, Krown SE, Gill PS. Hematologic and oncologic complications of HIV disease. 1992; p120-126.
  302. Avraham H, Scadden DT, Chi S, Broudy VC, Zsebo KM, Groopman JE. Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand. Blood. 1992 Oct 1; 80(7):1679-84. PMID: 1382698.
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  303. Scadden DT. The clinical applications of colony-stimulating factors in acquired immunodeficiency syndrome. Semin Hematol. 1992 Oct; 29(4 Suppl 3):33-7. PMID: 1492232.
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  304. Scadden DT, Wang Z, Groopman JE. Quantitation of plasma human immunodeficiency virus type 1 RNA by competitive polymerase chain reaction. J Infect Dis. 1992 Jun; 165(6):1119-23. PMID: 1583331.
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  305. Scadden DT. The use of GM-CSF in AIDS. Infection. 1992; 20 Suppl 2:S103-6. PMID: 1283604.
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  306. Scadden DT, Feder D, Groopman JE. Scratching the surface. Curr Biol. 1991 Oct; 1(5):301-3. PMID: 15336104.
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  307. Groopman JE, Sakaguchi M, Scadden DT. Pathogenesis of HIV mediated blood cell abnormalities. Retroviruses of human AIDS and related animal diseases. 1991; p5-8.
  308. Scadden DT, Feder D, Groopman JE. Scratching the surface: Kit ligand and hematopoiesis. Current Biology. 1991; 1:301-303.
  309. Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE. GM-CSF as an alternative to dose modification of the combination zidovudine and interferon-alpha in the treatment of AIDS-associated Kaposi's sarcoma. Am J Clin Oncol. 1991; 14 Suppl 1:S40-4. PMID: 2048563.
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  310. Molina JM, Scadden DT, Sakaguchi M, Fuller B, Woon A, Groopman JE. Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus. Blood. 1990 Dec 15; 76(12):2476-82. PMID: 2265244.
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  311. Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE. GM-CSF as an alternative to dose modification of combination Zidovudine and Interferon-a in the treatment of AIDS-associated Kaposi's sarcoma. Cytokines in Tumor Therapy (GM-CSF, G-CSF, and IL-3). 1990; Volume 14 (Am. J. Clin. Oncol.):pS40-S44.
  312. Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman JE. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood. 1990 Jul 15; 76(2):317-22. PMID: 1695109.
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  313. Molina JM, Scadden DT, Amirault C, Woon A, Vannier E, Dinarello CA, Groopman JE. Human immunodeficiency virus does not induce interleukin-1, interleukin-6, or tumor necrosis factor in mononuclear cells. J Virol. 1990 Jun; 64(6):2901-6. PMID: 2335821; PMCID: PMC249473.
  314. Scadden DT. Granulocyte macrophage colony stimulating factor (GM-CSF) in AIDS. Prog Clin Biol Res. 1990; 338:163-76. PMID: 2189138.
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  315. Scadden DT, Fuller B, Cunningham JM. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol. 1990 Jan; 64(1):424-7. PMID: 2152828; PMCID: PMC249120.
  316. Groopman JE, Molina JM, Scadden DT. Hematopoietic growth factors. Biology and clinical applications. N Engl J Med. 1989 Nov 23; 321(21):1449-59. PMID: 2682244.
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  317. Scadden DT, Zon LI, Groopman JE. Pathophysiology and management of HIV-associated hematologic disorders. Blood. 1989 Oct; 74(5):1455-63. PMID: 2676010.
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  318. Molina JM, Scadden DT, Byrn R, Dinarello CA, Groopman JE. Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus. J Clin Invest. 1989 Sep; 84(3):733-7. PMID: 2474573; PMCID: PMC329713.
  319. Albritton LM, Tseng L, Scadden D, Cunningham JM. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell. 1989 May 19; 57(4):659-66. PMID: 2541919.
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  320. Groopman JE, Scadden DT. Interferon therapy for Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Mar 1; 110(5):335-7. PMID: 2644884.
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  321. Groopman JE, Scadden DT. Interferon therapy for AIDS-related Kaposi's sarcoma. Ann Intern Med. 1989; 110:335-337.
  322. Fineberg HV, Scadden D, Goldman L. Care of patients with a low probability of acute myocardial infarction. Cost effectiveness of alternatives to coronary-care-unit admission. N Engl J Med. 1984 May 17; 310(20):1301-7. PMID: 6425687.
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  323. Scadden DT. The stem cell niche in health and leukemic disease. Best Pract Res Clin Haematol. 2007 Mar; 20(1):19-27. PMID: 17336251; PMCID: PMC2748657.
  324. Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE. Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma. J Clin Oncol. 1991 May; 9(5):802-8. PMID: 2016623.
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  325. Scadden DT, Agosti J. No antibodies to granulocyte macrophage colony-stimulating factor with prolonged use in AIDS. AIDS. 1993 Mar; 7(3):438. PMID: 8471211.
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  326. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010 Apr 8; 464(7290):852-7. PMID: 20305640; PMCID: PMC3422863.
  327. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006 Sep 28; 443(7110):421-6. PMID: 16957735.
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  328. Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Nat Med. 1996 Dec; 2(12):1379-82. PMID: 8946840.
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  329. Carlesso N, Aster JC, Sklar J, Scadden DT. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood. 1999 Feb 1; 93(3):838-48. PMID: 9920832.
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  330. Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14229-34. PMID: 20616003; PMCID: PMC2922532.
  331. Rodrigues NP, Boyd AS, Fugazza C, May GE, Guo Y, Tipping AJ, Scadden DT, Vyas P, Enver T. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood. 2008 Dec 15; 112(13):4862-73. PMID: 18840712.
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  332. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7. PMID: 14745444; PMCID: PMC2693485.
  333. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003 Oct 23; 425(6960):841-6. PMID: 14574413.
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  334. Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med. 2005 Jun; 11(6):678-82. PMID: 15880117; PMCID: PMC2686110.
  335. Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 7; 11(3):429-39. PMID: 22958934; PMCID: PMC3743253.
  336. Janzen V, Scadden DT. Stem cells: good, bad and reformable. Nature. 2006 May 25; 441(7092):418-9. PMID: 16724049.
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  337. Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 2005 Jun 6; 201(11):1781-91. PMID: 15928197; PMCID: PMC2213260.
  338. Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature. 2011 Jun 08; 474(7350):216-9. PMID: 21654805; PMCID: PMC3725645.
  339. Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK. Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. J Clin Oncol. 2006 Mar 20; 24(9):1449-53. PMID: 16549839; PMCID: PMC2718681.
  340. Vunjak-Novakovic G, Scadden DT. Biomimetic platforms for human stem cell research. Cell Stem Cell. 2011 Mar 4; 8(3):252-61. PMID: 21362565; PMCID: PMC3048803.
  341. Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010 Aug 12; 466(7308):829-34. PMID: 20703299; PMCID: PMC3146551.
  342. Christmas P, Carlesso N, Shang H, Cheng SM, Weber BM, Preffer FI, Scadden DT, Soberman RJ. Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. J Biol Chem. 2003 Jul 4; 278(27):25133-42. PMID: 12709424.
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  343. Lo Celso C, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Côté D, Rowe DW, Lin CP, Scadden DT. Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature. 2009 Jan 1; 457(7225):92-6. PMID: 19052546; PMCID: PMC2820276.
  344. Curley MD, Therrien VA, Cummings CL, Sergent PA, Koulouris CR, Friel AM, Roberts DJ, Seiden MV, Scadden DT, Rueda BR, Foster R. CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells. 2009 Dec; 27(12):2875-83. PMID: 19816957.
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  345. Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007 Jan; 11(1):83-95. PMID: 17222792; PMCID: PMC2748664.
  346. Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM. Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature. 2013 Mar 21; 495(7441):365-9. PMID: 23485965; PMCID: PMC3606692.
  347. Walkley CR, Olsen GH, Dworkin S, Fabb SA, Swann J, McArthur GA, Westmoreland SV, Chambon P, Scadden DT, Purton LE. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007 Jun 15; 129(6):1097-110. PMID: 17574023; PMCID: PMC1974882.
  348. Adams GB, Martin RP, Alley IR, Chabner KT, Cohen KS, Calvi LM, Kronenberg HM, Scadden DT. Therapeutic targeting of a stem cell niche. Nat Biotechnol. 2007 Feb; 25(2):238-43. PMID: 17237769.
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  349. Wang Z, Cohen K, Shao Y, Mole P, Dombkowski D, Scadden DT. Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. Blood. 2004 Jan 1; 103(1):100-9. PMID: 12958066.
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  350. Duvic M, Friedman-Kien AE, Looney DJ, Miles SA, Myskowski PL, Scadden DT, Von Roenn J, Galpin JE, Groopman J, Loewen G, Stevens V, Truglia JA, Yocum RC. Topical treatment of cutaneous lesions of acquired immunodeficiency syndrome-related Kaposi sarcoma using alitretinoin gel: results of phase 1 and 2 trials. Arch Dermatol. 2000 Dec; 136(12):1461-9. PMID: 11115156.
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  351. Janzen V, Fleming HE, Riedt T, Karlsson G, Riese MJ, Lo Celso C, Reynolds G, Milne CD, Paige CJ, Karlsson S, Woo M, Scadden DT. Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. Cell Stem Cell. 2008 Jun 5; 2(6):584-94. PMID: 18522851; PMCID: PMC2991117.
  352. Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N. Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. Exp Hematol. 2008 May; 36(5):545-558. PMID: 18439488; PMCID: PMC3437760.
  353. Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell. 2008 Mar 6; 2(3):274-83. PMID: 18371452; PMCID: PMC2991120.
  354. Lee BC, Cheng T, Adams GB, Attar EC, Miura N, Lee SB, Saito Y, Olszak I, Dombkowski D, Olson DP, Hancock J, Choi PS, Haber DA, Luster AD, Scadden DT. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev. 2003 Jul 1; 17(13):1592-604. PMID: 12842911; PMCID: PMC196132.
  355. Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994 Apr 8; 269(14):10720-8. PMID: 7511603.
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  356. Lo Celso C, Lin CP, Scadden DT. In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow. Nat Protoc. 2011 Jan; 6(1):1-14. PMID: 21212779; PMCID: PMC3382040.
  357. Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 2; 146(5):697-708. PMID: 21884932; PMCID: PMC3826540.
  358. Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010 Dec 2; 468(7324):659-63. PMID: 21124451; PMCID: PMC3037591.
  359. Bungartz G, Land H, Scadden DT, Emerson SG. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood. 2012 Feb 9; 119(6):1380-9. PMID: 22072554; PMCID: PMC3286206.
  360. Jones R, Capen DE, Jacobson M, Cohen KS, Scadden DT, Duda DG. VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI). J Cell Mol Med. 2009 Sep; 13(9B):3720-9. PMID: 19426150; PMCID: PMC2832073.
  361. Ferraro F, Celso CL, Scadden D. Adult stem cels and their niches. Adv Exp Med Biol. 2010; 695:155-68. PMID: 21222205; PMCID: PMC4020242.
  362. Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat Biotechnol. 2000 Jul; 18(7):729-34. PMID: 10888839.
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  363. Scadden DT, Wang A, Zsebo KM, Groopman JE. In vitro effects of stem-cell factor or interleukin-3 on myelosuppression associated with AIDS. AIDS. 1994 Feb; 8(2):193-6. PMID: 7519020.
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  364. Adams GB, Alley IR, Chung UI, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DT. Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature. 2009 May 7; 459(7243):103-7. PMID: 19322176; PMCID: PMC2761017.
  365. Qiu J, Takagi Y, Harada J, Topalkara K, Wang Y, Sims JR, Zheng G, Huang P, Ling Y, Scadden DT, Moskowitz MA, Cheng T. p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. Stem Cells. 2009 Apr; 27(4):920-7. PMID: 19353520; PMCID: PMC2680235.
  366. Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 2013 Feb 14; 152(4):727-42. PMID: 23415223; PMCID: PMC3875356.
  367. Miles SA, Dezube BJ, Lee JY, Krown SE, Fletcher MA, Saville MW, Kaplan L, Groopman J, Scadden DT, Cooley T, Von Roenn J, Friedman-Kien A. Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma. AIDS. 2002 Feb 15; 16(3):421-9. PMID: 11834954.
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  368. Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008 Jun; 14(6):843-53. PMID: 18539114; PMCID: PMC2688789.
  369. Zhang J, Scadden DT, Crumpacker CS. Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest. 2007 Feb; 117(2):473-81. PMID: 17273559; PMCID: PMC1783820.
  370. Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Spencer JA, Celso CL, Scadden DT, Strom TB, Lin CP. Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS One. 2013; 8(8):e69257. PMID: 23990881; PMCID: PMC3753322.
  371. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell. 2013 Nov 11; 24(5):575-88. PMID: 24183681; PMCID: PMC4038627.
  372. Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MA, Scadden DT, Schreiber SL, Ebert BL, Golub TR. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec; 9(12):840-8. PMID: 24161946; PMCID: PMC4009363.
  373. Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014 Jan 16; 505(7483):327-34. PMID: 24429631; PMCID: PMC4514480.
  374. Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature. 2014 Apr 10; 508(7495):269-73. PMID: 24590072; PMCID: PMC3984353.
  375. Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M. Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015 May 7; 16(5):477-87. PMID: 25957903; PMCID: PMC4426344 [Available on 05/07/16].
  376. Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR. Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. J Exp Med. 2014 Nov 17; 211(12):2341-9. PMID: 25332287; PMCID: PMC4235646.
  377. Lee D, Sykes SM, Kalaitzidis D, Lane AA, Kfoury Y, Raaijmakers MH, Wang YH, Armstrong SA, Scadden DT. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 2014 Nov 11; 3(5):832-40. PMID: 25418727; PMCID: PMC4235746.
  378. Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015 Jan 30; 116(3):407-17. PMID: 25362208; PMCID: PMC4312511 [Available on 01/30/16].
  379. Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 2016 Aug 11; 166(4):894-906. PMID: 27518564.
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  380. Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell Stem Cell. 2016 Oct 6; 19(4):530-543. PMID: 27524439.
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  381. Dong L, Yu WM, Zheng H, Loh ML, Bunting ST, Pauly M, Huang G, Zhou M, Broxmeyer HE, Scadden DT, Qu CK. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature. 2016 Oct 26; 539(7628):304-308. PMID: 27783593.
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  382. Yu VW, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 2016 Nov 17; 167(5):1310-1322.e17. PMID: 27863245.
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