Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Deborah Tan Hung, M.D., Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19AI142780 (HUNG, DEBORAH T) Aug 7, 2019 - Jul 31, 2024
    Innovative technologies to transform antibiotic discovery.
    Role: Principal Investigator
  2. R01AI132300 (HUNG, DEBORAH T) Jul 1, 2017 - Jun 30, 2022
    New targets against tuberculosis
    Role: Principal Investigator
  3. R21AI119296 (HUNG, DEBORAH T) Jul 1, 2015 - Jun 30, 2017
    Exploiting bacterial uptake as a universal platform for antibacterial development
    Role: Principal Investigator
  4. R21AI112945 (HUNG, DEBORAH T) Jun 15, 2015 - May 31, 2017
    Chemical biological studies of pyroptotic cell death
    Role: Principal Investigator
  5. R01AI117043 (HUNG, DEBORAH T) Feb 15, 2015 - Jan 31, 2020
    RNA based diagnostics for rapid pathogen identification and drug resistance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Joung J, Ladha A, Saito M, Kim NG, Woolley AE, Segel M, Barretto RPJ, Ranu A, Macrae RK, Faure G, Ioannidi EI, Krajeski RN, Bruneau R, Huang MW, Yu XG, Li JZ, Walker BD, Hung DT, Greninger AL, Jerome KR, Gootenberg JS, Abudayyeh OO, Zhang F. Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing. N Engl J Med. 2020 10 08; 383(15):1492-1494. PMID: 32937062.
    Citations: 1     Fields:    
  2. Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani AC, Sade-Feldman M, Baron RM, Goldberg MB, Blainey PC, Hacohen N. Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19. bioRxiv. 2020 Sep 02. PMID: 32908980.
  3. Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nat Med. 2020 Aug; 26(8):1307. PMID: 32587394.
    Citations:    Fields:    
  4. Ackerman CM, Myhrvold C, Thakku SG, Freije CA, Metsky HC, Yang DK, Ye SH, Boehm CK, Kosoko-Thoroddsen TF, Kehe J, Nguyen TG, Carter A, Kulesa A, Barnes JR, Dugan VG, Hung DT, Blainey PC, Sabeti PC. Massively multiplexed nucleic acid detection with Cas13. Nature. 2020 06; 582(7811):277-282. PMID: 32349121.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nat Med. 2020 05; 26(5):705-711. PMID: 32284589.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. An immune-cell signature of bacterial sepsis. Nat Med. 2020 03; 26(3):333-340. PMID: 32066974.
    Citations: 4     Fields:    Translation:HumansCells
  7. Betin V, Penaranda C, Bandyopadhyay N, Yang R, Abitua A, Bhattacharyya RP, Fan A, Avraham R, Livny J, Shoresh N, Hung DT. Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis. Sci Rep. 2019 12 17; 9(1):19244. PMID: 31848386.
    Citations: 1     Fields:    
  8. Johnson EO, Office E, Kawate T, Orzechowski M, Hung DT. Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria. ACS Infect Dis. 2020 01 10; 6(1):56-63. PMID: 31721551.
    Citations: 1     Fields:    
  9. Bhattacharyya RP, Bandyopadhyay N, Ma P, Son SS, Liu J, He LL, Wu L, Khafizov R, Boykin R, Cerqueira GC, Pironti A, Rudy RF, Patel MM, Yang R, Skerry J, Nazarian E, Musser KA, Taylor J, Pierce VM, Earl AM, Cosimi LA, Shoresh N, Beechem J, Livny J, Hung DT. Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination. Nat Med. 2019 12; 25(12):1858-1864. PMID: 31768064.
    Citations: 9     Fields:    Translation:Humans
  10. Johnson EO, Hung DT. A Point of Inflection and Reflection on Systems Chemical Biology. ACS Chem Biol. 2019 12 20; 14(12):2497-2511. PMID: 31613592.
    Citations:    Fields:    Translation:Humans
  11. Romano KP, Warrier T, Poulsen BE, Nguyen PH, Loftis AR, Saebi A, Pentelute BL, Hung DT. Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 09; 63(9). PMID: 31235628.
    Citations: 4     Fields:    Translation:Cells
  12. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 Jul; 17(7):460. PMID: 31036919.
    Citations: 2     Fields:    
  13. Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A. Definitions and guidelines for research on antibiotic persistence. Nat Rev Microbiol. 2019 07; 17(7):441-448. PMID: 30980069.
    Citations: 49     Fields:    Translation:Cells
  14. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78. PMID: 31217586.
    Citations: 6     Fields:    Translation:Cells
  15. Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A. Conservation of the structure and function of bacterial tryptophan synthases. IUCrJ. 2019 Jul 01; 6(Pt 4):649-664. PMID: 31316809.
    Citations: 2     
  16. Poulsen BE, Yang R, Clatworthy AE, White T, Osmulski SJ, Li L, Penaranda C, Lander ES, Shoresh N, Hung DT. Defining the core essential genome of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10072-10080. PMID: 31036669.
    Citations: 9     Fields:    Translation:Cells
  17. Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, Han J, Pierce VM, Cosimi LA, Shoresh N, Livny J, Beechem J, Hung DT. Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA. Sci Rep. 2019 03 14; 9(1):4516. PMID: 30872641.
    Citations:    Fields:    Translation:Cells
  18. Penaranda C, Hung DT. Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions. ACS Infect Dis. 2019 03 08; 5(3):336-344. PMID: 30702856.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). PMID: 30266803.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Ma P, Laibinis HH, Ernst CM, Hung DT. Carbapenem Resistance Caused by High-Level Expression of OXA-663 ß-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate. Antimicrob Agents Chemother. 2018 11; 62(11). PMID: 30126962.
    Citations: 1     Fields:    Translation:HumansCells
  21. Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors. Bioorg Med Chem Lett. 2018 12 01; 28(22):3529-3533. PMID: 30316633.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Bhattacharyya RP, Thakku SG, Hung DT. Harnessing CRISPR Effectors for Infectious Disease Diagnostics. ACS Infect Dis. 2018 09 14; 4(9):1278-1282. PMID: 30113801.
    Citations: 5     Fields:    Translation:HumansCells
  23. Clatworthy AE, Romano KP, Hung DT. Whole-organism phenotypic screening for anti-infectives promoting host health. Nat Chem Biol. 2018 04; 14(4):331-341. PMID: 29556098.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Wellington S, Hung DT. The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infect Dis. 2018 05 11; 4(5):696-714. PMID: 29412643.
    Citations: 5     Fields:    Translation:HumansCells
  25. Kim M, Wu L, Kim B, Hung DT, Han J. Continuous and High-Throughput Electromechanical Lysis of Bacterial Pathogens Using Ion Concentration Polarization. Anal Chem. 2018 01 02; 90(1):872-880. PMID: 29193960.
    Citations: 1     Fields:    Translation:Cells
  26. Avital G, Avraham R, Fan A, Hashimshony T, Hung DT, Yanai I. scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing. Genome Biol. 2017 10 27; 18(1):200. PMID: 29073931.
    Citations: 9     Fields:    Translation:AnimalsCells
  27. Piantadosi A, Mukerji SS, Chitneni P, Cho TA, Cosimi LA, Hung DT, Goldberg MB, Sabeti PC, Kuritzkes DR, Grad YH. Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. Open Forum Infect Dis. 2017; 4(3):ofx138. PMID: 28761901.
    Citations: 3     
  28. Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017 Sep; 13(9):943-950. PMID: 28671682.
    Citations: 20     Fields:    Translation:Cells
  29. Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. PLoS Pathog. 2017 May; 13(5):e1006363. PMID: 28505176.
    Citations: 18     Fields:    Translation:AnimalsCells
  30. Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science. 2017 04 28; 356(6336):438-442. PMID: 28408723.
    Citations: 159     Fields:    Translation:HumansCells
  31. Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 2017 02 21; 6. PMID: 28220755.
    Citations: 9     Fields:    Translation:Cells
  32. Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1135-1140. PMID: 28096418.
    Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
  33. Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT. Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis. Antimicrob Agents Chemother. 2016 11; 60(11):6600-6608. PMID: 27572408.
    Citations: 4     Fields:    Translation:HumansCells
  34. Avraham R, Hung DT. A perspective on single cell behavior during infection. Gut Microbes. 2016 11; 7(6):518-525. PMID: 27658058.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J. Accelerating global innovation to address antibacterial resistance: introducing CARB-X. Nat Rev Drug Discov. 2016 09; 15(9):589-590. PMID: 27469032.
    Citations: 9     Fields:    Translation:Humans
  36. Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT. A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes. Nat Protoc. 2016 08; 11(8):1477-91. PMID: 27442864.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chem Biol. 2016 06 23; 23(6):666-77. PMID: 27321573.
    Citations: 10     Fields:    Translation:Cells
  38. Wivagg CN, Wellington S, Gomez JE, Hung DT. Loss of a Class A Penicillin-Binding Protein Alters ß-Lactam Susceptibilities in Mycobacterium tuberculosis. ACS Infect Dis. 2016 02 12; 2(2):104-10. PMID: 27624961.
    Citations: 2     Fields:    Translation:Cells
  39. Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT. Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell. 2015 Sep 10; 162(6):1309-21. PMID: 26343579.
    Citations: 66     Fields:    Translation:AnimalsCells
  40. Hou HW, Bhattacharyya RP, Hung DT, Han J. Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics. Lab Chip. 2015 May 21; 15(10):2297-307. PMID: 25882432.
    Citations: 21     Fields:    Translation:HumansCells
  41. Shishkin AA, Giannoukos G, Kucukural A, Ciulla D, Busby M, Surka C, Chen J, Bhattacharyya RP, Rudy RF, Patel MM, Novod N, Hung DT, Gnirke A, Garber M, Guttman M, Livny J. Simultaneous generation of many RNA-seq libraries in a single reaction. Nat Methods. 2015 Apr; 12(4):323-5. PMID: 25730492.
    Citations: 53     Fields:    Translation:Cells
  42. Wivagg CN, Bhattacharyya RP, Hung DT. Mechanisms of ß-lactam killing and resistance in the context of Mycobacterium tuberculosis. J Antibiot (Tokyo). 2014 Sep; 67(9):645-54. PMID: 25052484.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  43. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159.
    Citations: 78     Fields:    Translation:AnimalsCells
  44. Slater LH, Clatworthy AE, Hung DT. Bacterial toxins and small molecules elucidate endosomal trafficking. Trends Microbiol. 2014 Feb; 22(2):53-5. PMID: 24370463.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6052-9. PMID: 24103299.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  46. Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem Biol. 2013 Oct 18; 8(10):2224-34. PMID: 23898841.
    Citations: 20     Fields:    Translation:Cells
  47. Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11565-70. PMID: 23798446.
    Citations: 29     Fields:    Translation:AnimalsCells
  48. Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9932-7. PMID: 23716698.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Wright GD, Hung DT, Helmann JD. How antibiotics kill bacteria: new models needed? Nat Med. 2013 May; 19(5):544-5. PMID: 23652106.
    Citations: 6     Fields:    Translation:HumansCells
  50. Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun; 9(6):398-405. PMID: 23603659.
    Citations: 30     Fields:    Translation:AnimalsCells
  51. Grant SS, Hung DT. Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 2013 May 15; 4(4):273-83. PMID: 23563389.
    Citations: 51     Fields:    Translation:HumansCells
  52. Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol. 2013 Apr 19; 8(4):812-22. PMID: 23343607.
    Citations: 5     Fields:    Translation:AnimalsCells
  53. Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):E3629-30. PMID: 23479789.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  54. Chand NS, Clatworthy AE, Hung DT. The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence. J Bacteriol. 2012 Dec; 194(23):6537-47. PMID: 23024348.
    Citations: 7     Fields:    Translation:Cells
  55. McMahon TC, Stanley S, Kazyanskaya E, Hung D, Wood JL. The first synthesis of an epidiselenodiketopiperazine. Org Lett. 2012 Sep 07; 14(17):4534-6. PMID: 22913407.
    Citations:    Fields:    Translation:Cells
  56. Grant SS, Kaufmann BB, Chand NS, Haseley N, Hung DT. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12147-52. PMID: 22778419.
    Citations: 74     Fields:    Translation:Cells
  57. Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012 Aug 17; 7(8):1377-84. PMID: 22577943.
    Citations: 87     Fields:    Translation:Cells
  58. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  59. Weiner B, Gomez J, Victor TC, Warren RM, Sloutsky A, Plikaytis BB, Posey JE, van Helden PD, Gey van Pittius NC, Koehrsen M, Sisk P, Stolte C, White J, Gagneux S, Birren B, Hung D, Murray M, Galagan J. Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region. PLoS One. 2012; 7(2):e26038. PMID: 22347359.
    Citations: 11     Fields:    Translation:Cells
  60. Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3065-70. PMID: 22315421.
    Citations: 109     Fields:    Translation:HumansCellsPHPublic Health
  61. Chindelevitch L, Stanley S, Hung D, Regev A, Berger B. MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis. Genome Biol. 2012 Jan 31; 13(1):r6. PMID: 22292986.
    Citations: 14     Fields:    Translation:Cells
  62. Wivagg CN, Hung DT. Resuscitation-promoting factors are required for ß-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Mar; 56(3):1591-4. PMID: 22155826.
    Citations: 4     Fields:    Translation:HumansCells
  63. Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L. Systematics-guided bioprospecting for bioactive microbial natural products. Antonie Van Leeuwenhoek. 2012 Jan; 101(1):55-66. PMID: 22086462.
    Citations: 7     Fields:    
  64. Chand NS, Hung DT. The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection. Virulence. 2011 Nov-Dec; 2(6):553-8. PMID: 21971182.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  65. Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011 Sep; 81(5):1390-401. PMID: 21797942.
    Citations: 9     Fields:    Translation:AnimalsCells
  66. Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT. The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. J Bacteriol. 2011 Jun; 193(12):2989-99. PMID: 21515773.
    Citations: 17     Fields:    Translation:AnimalsCells
  67. Gomez JE, Clatworthy A, Hung DT. Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Crit Rev Biochem Mol Biol. 2011 Feb; 46(1):41-66. PMID: 21250782.
    Citations: 2     Fields:    Translation:AnimalsCells
  68. Kaufmann BB, Hung DT. The fast track to multidrug resistance. Mol Cell. 2010 Feb 12; 37(3):297-8. PMID: 20159549.
    Citations: 5     Fields:    Translation:Cells
  69. Hett EC, Hung DT. Targeting multiple biofilm pathways. Chem Biol. 2009 Dec 24; 16(12):1216-8. PMID: 20064430.
    Citations: 1     Fields:    Translation:AnimalsCells
  70. Stanley SA, Hung DT. Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Sci Transl Med. 2009 Dec 16; 1(11):11ps13. PMID: 20371455.
    Citations:    Fields:    Translation:HumansAnimals
  71. Stanley SA, Hung DT. Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 2009 Sep 22; 48(37):8776-86. PMID: 19653697.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  72. Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009 Oct; 12(5):490-6. PMID: 19631578.
    Citations: 29     Fields:    Translation:HumansCells
  73. Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009 Apr; 77(4):1293-303. PMID: 19168742.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  74. Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nat Methods. 2009 Jan; 6(1):67-9. PMID: 19079253.
    Citations: 45     Fields:    Translation:Cells
  75. Clatworthy AE, Pierson E, Hung DT. Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007 Sep; 3(9):541-8. PMID: 17710100.
    Citations: 330     Fields:    
  76. Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2372-7. PMID: 17283330.
    Citations: 45     Fields:    Translation:Cells
  77. Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006 Aug; 10(4):321-6. PMID: 16814591.
    Citations: 7     Fields:    Translation:Cells
  78. Hung DT, Zhu J, Sturtevant D, Mekalanos JJ. Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol. 2006 Jan; 59(1):193-201. PMID: 16359328.
    Citations: 53     Fields:    Translation:HumansCells
  79. Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005 Oct 28; 310(5748):670-4. PMID: 16223984.
    Citations: 128     Fields:    Translation:AnimalsCells
  80. Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):3028-33. PMID: 15699331.
    Citations: 55     Fields:    Translation:Cells
  81. Hung, D.T.; Lilly, C.M. Hemodynamic monitoring in the intensive care unit. Journal of Critical Illness. 2003; 18((5)):196-297.
  82. Hung, D.T.; Baden L.R. A new era for sepsis treatment? Understanding sepsis as a consequence of host immune response. Expert Opin. Ther. Patents. 2002; 12((2), ):181-192.
  83. Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000 Feb; 292(2):795-802. PMID: 10640320.
    Citations: 27     Fields:    Translation:Animals
  84. Laham RJ, Rezaee M, Post M, Sellke FW, Braeckman RA, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution. Drug Metab Dispos. 1999 Jul; 27(7):821-6. PMID: 10383927.
    Citations: 22     Fields:    Translation:Animals
  85. Laham RJ, Simons M, Hung D. Subxyphoid access of the normal pericardium: a novel drug delivery technique. Catheter Cardiovasc Interv. 1999 May; 47(1):109-11. PMID: 10385173.
    Citations: 6     Fields:    Translation:Animals
  86. Laham RJ, Hung D, Simons M. Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clin Cardiol. 1999 Jan; 22(1 Suppl 1):I6-9. PMID: 9929761.
    Citations: 2     Fields:    Translation:Animals
  87. Laham RJ, Simons M, Tofukuji M, Hung D, Sellke FW. Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation. J Thorac Cardiovasc Surg. 1998 Dec; 116(6):1022-8. PMID: 9832695.
    Citations: 7     Fields:    Translation:Animals
  88. Hung DT, Jamison TF, Schreiber SL. Understanding and controlling the cell cycle with natural products. Chem Biol. 1996 Aug; 3(8):623-39. PMID: 8807895.
    Citations: 29     Fields:    Translation:AnimalsCells
  89. Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996 Apr; 3(4):287-93. PMID: 8807856.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  90. Hung, D.T.; Nerenberg, J.B.; Schreiber, S.L. Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization. J. Am. Chem. Soc. 1996; 118:11054-11080.
  91. Liang, J.; Hung, D.T.; Schreiber, S.L.; Clardy, J. Structure of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin. J. Am. Chem. Soc. 1996; 118:1231.
  92. Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol. 1994 Sep; 1(1):67-71. PMID: 9383372.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  93. Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993 Aug; 13(8):4760-9. PMID: 7687744.
    Citations: 58     Fields:    Translation:HumansCells
  94. Nerenberg, J.B.; Hung, D.T.; Schreiber, S.L. . Total synthesis of the Immunosuppressive Agent (-)-Discodermolide. J. Am. Chem. Soc.,. 1993; 115:12621.
  95. Hung DT, Wong YH, Vu TK, Coughlin SR. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992 Oct 15; 267(29):20831-4. PMID: 1328213.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  96. Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992 Jul 05; 267(19):13146-9. PMID: 1320011.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  97. Hung DT, Schreiber SL. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochem Biophys Res Commun. 1992 Apr 30; 184(2):733-8. PMID: 1374240.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  98. Garboczi DN, Hung DT, Wiley DC. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3429-33. PMID: 1565634.
    Citations: 211     Fields:    Translation:HumansCells
  99. Hung DT, Vu TH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol. 1992 Feb; 116(3):827-32. PMID: 1309820.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  100. Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992 Feb; 89(2):444-50. PMID: 1310695.
    Citations: 12     Fields:    Translation:HumansCells
  101. Coughlin SR, Scarborough RM, Vu TK, Hung DT. Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1992; 57:149-54. PMID: 1339654.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  102. Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature. 1991 Oct 17; 353(6345):674-7. PMID: 1717851.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  103. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22; 64(6):1057-68. PMID: 1672265.
    Citations: 572     Fields:    Translation:HumansAnimalsCells
  104. Evans, D.A.; Chapman, K.T.; Hung, D.T.; Kawaguchi, A.T. . Transition State ?-solvation by Aromatic Rings: An Electronic Contribution to Diels-Alder Reaction Diastereoselectivity. Angew. Chemie, Intl. Ed:. 1987; 26,:1184.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.