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David H. Sachs, M.D.

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Institution
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Mentoring
HHMI
Full Time/Year Long, 07/01/98 - 06/30/99
Vascularized Thymic Transplantation as a Strategy for Tolerance Induction
Summer, 06/18/00 - 08/31/00
Vascularized Thymic Transplantation as a Strategy for Tolerance Induction
Part Time/Continuation, 01/03/01 - 03/15/01

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19AI102405 (COSIMI, A BENEDICT) Aug 1, 2012 - Jul 31, 2017
    NIH/NIAID
    Approaches to Tolerance of Allogeneic Kidney and Islet Transplants
    Role: Co-Principal Investigator
  2. R41AI082853 (MTANGO, NAMDORI RACHEL) Feb 15, 2010 - May 14, 2012
    NIH/NIAID
    GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts
    Role: Co-Principal Investigator
  3. R01AI086134 (SACHS, DAVID H) Jan 15, 2010 - Dec 31, 2014
    NIH/NIAID
    Thymic Rejuvenation for the Induction of Transplantation Tolerance
    Role: Principal Investigator
  4. R42AI082853 (MTANGO, NAMDORI RACHEL) Apr 1, 2009 - Apr 30, 2015
    NIH/NIAID
    GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts
    Role: Co-Principal Investigator
  5. U01DK080653 (SACHS, DAVID H) Aug 20, 2007 - Oct 31, 2012
    NIH/NIDDK
    TOLERANCE TO COMPOSITE ISLET-KIDNEY TRANSPLANTS IN BABOONS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL, Madsen JC, Sachs DH, Wang Z. Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in Non-Human Primates. Mol Oncol. 2018 Jun 05. PMID: 29873181.
    View in: PubMed
  2. Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Lennan B, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study. Transpl Int. 2018 May 02. PMID: 29722117.
    View in: PubMed
  3. Fishman JA, Sachs DH, Yamada K, Wilkinson RA. Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo. Xenotransplantation. 2018 Apr 06; e12395. PMID: 29624743.
    View in: PubMed
  4. Navarro-Alvarez N, Goncalves B, Andrews AR, Wang Z, Wang Z, Harrington E, Shah J, Sachs DH, Eliaz I, Huang CA. The effects of galectin-3 depletion apheresis on induced skin inflammation in a porcine model. J Clin Apher. 2018 Mar 23. PMID: 29572917.
    View in: PubMed
  5. Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake-Alper DK, Boyd LK, Louras NJ, Asfour A, Danton MA, Ho SH, Arn SJ, Hawley RJ, Shimizu A, Nagayasu T, Ayares D, Lorber MI, Sykes M, Sachs DH, Yamada K. GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels. Xenotransplantation. 2018 Mar 12. PMID: 29527745.
    View in: PubMed
  6. Michel SG, Madariaga MLL, LaMuraglia GM, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC. The effects of brain death and ischemia on tolerance induction are organ-specific. Am J Transplant. 2018 May; 18(5):1262-1269. PMID: 29377632.
    View in: PubMed
  7. Møller R, Schwarz TM, Noriega VM, Panis M, Sachs D, Tortorella D, tenOever BR. miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2. Proc Natl Acad Sci U S A. 2018 Jan 30; 115(5):1069-1074. PMID: 29339472.
    View in: PubMed
  8. Yamada K, Sykes M, Sachs DH. Tolerance in xenotransplantation. Curr Opin Organ Transplant. 2017 Dec; 22(6):522-528. PMID: 28937406.
    View in: PubMed
  9. Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR. Miscellaneous. Xenotransplantation. 2017 11; 24(6). PMID: 29193342.
    View in: PubMed
  10. Sasaki H, Oura T, Spitzer TR, Chen YB, Madsen JC, Allan J, Sachs DH, Cosimi AB, Kawai T. Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach. Hum Immunol. 2018 May; 79(5):258-265. PMID: 29175110.
    View in: PubMed
  11. Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation. Cell Transplant. 2017 Nov; 26(11):1755-1762. PMID: 29338381.
    View in: PubMed
  12. Ng ZY, Lellouch AG, Drijkoningen T, Chang IA, Sachs DH, Cetrulo CL. Vascularized Composite Allotransplantation-An Emerging Concept for Burn Reconstruction. J Burn Care Res. 2017 Nov/Dec; 38(6):371-378. PMID: 28328655.
    View in: PubMed
  13. Gao B, Gu Y, Rong C, Moore C, Porcheray F, Wong W, Preffer F, Saidman SL, Fu Y, Cosimi B, Sachs DH, Kawai T, Sykes M, Zorn E. Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients. Transplantation. 2017 11; 101(11):2722-2730. PMID: 28422925.
    View in: PubMed
  14. Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials. 2017 Dec; 147:116-132. PMID: 28942128.
    View in: PubMed
  15. Sachs DH. Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S220-S225. PMID: 28945472.
    View in: PubMed
  16. Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. Cell Rep. 2017 Aug 15; 20(7):1503-1512. PMID: 28813663.
    View in: PubMed
  17. Cooper DKC, Pierson RN, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH. Regulation of Clinical Xenotransplantation-Time for a Reappraisal. Transplantation. 2017 08; 101(8):1766-1769. PMID: 28737658.
    View in: PubMed
  18. Fulton BO, Sachs D, Schwarz MC, Palese P, Evans MJ. Transposon Mutagenesis of the Zika Virus Genome Highlights Regions Essential for RNA Replication and Restricted for Immune Evasion. J Virol. 2017 08 01; 91(15). PMID: 28515302.
    View in: PubMed
  19. Aguado LC, Schmid S, May J, Sabin LR, Panis M, Blanco-Melo D, Shim JV, Sachs D, Cherry S, Simon AE, Levraud JP, tenOever BR. RNase III nucleases from diverse kingdoms serve as antiviral effectors. Nature. 2017 07 06; 547(7661):114-117. PMID: 28658212.
    View in: PubMed
  20. Mayourian J, Cashman TJ, Ceholski DK, Johnson BV, Sachs D, Kaji DA, Sahoo S, Hare JM, Hajjar RJ, Sobie EA, Costa KD. Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity. Circ Res. 2017 Aug 04; 121(4):411-423. PMID: 28642329.
    View in: PubMed
  21. Leonard DA, Mallard C, Albritton A, Torabi R, Mastroianni M, Sachs DH, Kurtz JM, Cetrulo CL. Skin grafts from genetically modified a-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts. Burns. 2017 Dec; 43(8):1717-1724. PMID: 28602591.
    View in: PubMed
  22. Mastroianni M, Ng ZY, Goyal R, Mallard C, Farkash EA, Leonard DA, Albritton A, Shanmugarajah K, Kurtz JM, Sachs DH, Macri LK, Kohn J, Cetrulo CL. Topical Delivery of Immunosuppression to Prolong Xenogeneic and Allogeneic Split-Thickness Skin Graft Survival. J Burn Care Res. 2017 Jun 07. PMID: 28639977.
    View in: PubMed
  23. Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden ES, Eidbo E, Lee WPA, Pomahac B, Brandacher G, Weinstock DM, Elliott G, Nelson D, Acker JP, Uygun K, Schmalz B, Weegman BP, Tocchio A, Fahy GM, Storey KB, Rubinsky B, Bischof J, Elliott JAW, Woodruff TK, Morris GJ, Demirci U, Brockbank KGM, Woods EJ, Ben RN, Baust JG, Gao D, Fuller B, Rabin Y, Kravitz DC, Taylor MJ, Toner M. The promise of organ and tissue preservation to transform medicine. Nat Biotechnol. 2017 06 07; 35(6):530-542. PMID: 28591112.
    View in: PubMed
  24. Shah JA, Patel MS, Elias N, Navarro-Alvarez N, Rosales I, Wilkinson RA, Louras NJ, Hertl M, Fishman JA, Colvin RB, Cosimi AB, Markmann JF, Sachs DH, Vagefi PA. Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade. Am J Transplant. 2017 Aug; 17(8):2178-2185. PMID: 28489305.
    View in: PubMed
  25. Wang Z, Zheng Q, Zhang H, Bronson RT, Madsen JC, Sachs DH, Huang CA, Wang Z. Ontak-like human IL-2 fusion toxin. J Immunol Methods. 2017 09; 448:51-58. PMID: 28551309.
    View in: PubMed
  26. Sadeghipour H, Torabi R, Gottschall J, Lujan-Hernandez J, Sachs DH, Moore FD, Cetrulo CL. Blockade of IgM-Mediated Inflammation Alters Wound Progression in a Swine Model of Partial-Thickness Burn. J Burn Care Res. 2017 May/Jun; 38(3):148-160. PMID: 27801682.
    View in: PubMed
  27. Bichoupan K, Tandon N, Martel-Laferriere V, Patel NM, Sachs D, Ng M, Schonfeld EA, Pappas A, Crismale J, Stivala A, Khaitova V, Gardenier D, Linderman M, Olson W, Perumalswami PV, Schiano TD, Odin JA, Liu LU, Dieterich DT, Branch AD. Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection. World J Hepatol. 2017 Apr 18; 9(11):551-561. PMID: 28469811.
    View in: PubMed
  28. Zheng Q, Wang Z, Zhang H, Huang Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors. Mol Oncol. 2017 05; 11(5):584-594. PMID: 28306193.
    View in: PubMed
  29. Machaidze Z, Yeh H, Wei L, Schuetz C, Carvello M, Sgroi A, Smith RN, Schuurman HJ, Sachs DH, Morel P, Markmann JF, Bühler LH. Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons. Xenotransplantation. 2017 05; 24(3). PMID: 28261903.
    View in: PubMed
  30. Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation. Am J Transplant. 2017 Jul; 17(7):1778-1790. PMID: 28117931.
    View in: PubMed
  31. Shanmugarajah K, Powell H, Leonard DA, Mallard C, Albritton A, Harrington E, Randolph MA, Farkash E, Sachs DH, Kurtz JM, Cetrulo CL. The Effect of MHC Antigen Matching Between Donors and Recipients on Skin Tolerance of Vascularized Composite Allografts. Am J Transplant. 2017 Jul; 17(7):1729-1741. PMID: 28035752.
    View in: PubMed
  32. Tena AA, Sachs DH, Mallard C, Yang YG, Tasaki M, Farkash E, Rosales IA, Colvin RB, Leonard DA, Hawley RJ. Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47. Transplantation. 2017 02; 101(2):316-321. PMID: 27232934.
    View in: PubMed
  33. Eliaz I, Patil A, Navarro-Alvarez N, Wang Z, Eliaz A, Weil E, Wilk B, Sachs DH, Huang CA. Methods for the detection and serum depletion of porcine galectin-3. J Clin Apher. 2017 Oct; 32(5):335-341. PMID: 28083958.
    View in: PubMed
  34. Holzer PW, Leonard DA, Shanmugarajah K, Moulton KN, Ng ZY, Cetrulo CL, Sachs DH. A Comparative Examination of the Clinical Outcome and Histological Appearance of Cryopreserved and Fresh Split-Thickness Skin Grafts. J Burn Care Res. 2017 Jan/Feb; 38(1):e55-e61. PMID: 27606556.
    View in: PubMed
  35. Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Vet Immunol Immunopathol. 2016 Dec; 182:150-158. PMID: 27863545.
    View in: PubMed
  36. Climov M, Matar AJ, Farkash EA, Medeiros E, Qiao J, Harrington E, Gusha A, Al-Musa A, Sachs DH, Randolph M, Bollenbach TJ, Huang CA. Survival of Allogeneic Self-Assembled Cultured Skin. Transplantation. 2016 10; 100(10):2071-8. PMID: 27479166.
    View in: PubMed
  37. Duran-Struuck R, Matar AJ, Crepeau RL, Teague AGS, Horner BM, Pathiraja V, Spitzer TR, Fishman JA, Bronson RT, Sachs DH, Huang CA. Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 11; 22(11):1953-1960. PMID: 27543159.
    View in: PubMed
  38. Pathiraja V, Villani V, Tasaki M, Matar AJ, Duran-Struuck R, Yamada R, Moran SG, Clayman ES, Hanekamp J, Shimizu A, Sachs DH, Huang CA, Yamada K. Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys. Am J Transplant. 2017 01; 17(1):91-102. PMID: 27376692.
    View in: PubMed
  39. Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Induced regulatory T cells in allograft tolerance via transient mixed chimerism. JCI Insight. 2016 Jul 07; 1(10). PMID: 27446989.
    View in: PubMed
  40. Tasaki M, Villani V, Shimizu A, Sekijima M, Yamada R, Hanekamp IM, Hanekamp JS, Cormack TA, Moran SG, Kawai A, Sachs DH, Yamada K. Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation. Am J Transplant. 2016 10; 16(10):2877-2891. PMID: 27145342.
    View in: PubMed
  41. Climov M, Medeiros E, Farkash EA, Qiao J, Rousseau CF, Dong S, Zawadzka A, Racki WJ, Al-Musa A, Sachs DH, Randolph MA, Huang CA, Bollenbach TJ. Bioengineered Self-assembled Skin as an Alternative to Skin Grafts. Plast Reconstr Surg Glob Open. 2016 Jun; 4(6):e731. PMID: 27482479; PMCID: PMC4956843.
  42. Madariaga ML, Spencer PJ, Shanmugarajah K, Crisalli KA, Chang DC, Markmann JF, Elias N, Cosimi AB, Sachs DH, Kawai T. Effect of tolerance versus chronic immunosuppression protocols on the quality of life of kidney transplant recipients. JCI Insight. 2016 Jun 02; 1(8). PMID: 27336062.
    View in: PubMed
  43. Shah JA, Navarro-Alvarez N, DeFazio M, Rosales IA, Elias N, Yeh H, Colvin RB, Cosimi AB, Markmann JF, Hertl M, Sachs DH, Vagefi PA. A Bridge to Somewhere: 25-day Survival After Pig-to-Baboon Liver Xenotransplantation. Ann Surg. 2016 06; 263(6):1069-71. PMID: 26825261.
    View in: PubMed
  44. Hoffman KW, Sachs D, Bardina SV, Michlmayr D, Rodriguez CA, Sum J, Foster GA, Krysztof D, Stramer SL, Lim JK. Differences in Early Cytokine Production Are Associated With Development of a Greater Number of Symptoms Following West Nile Virus Infection. J Infect Dis. 2016 08 15; 214(4):634-43. PMID: 27142077.
    View in: PubMed
  45. Hamilton JR, Sachs D, Lim JK, Langlois RA, Palese P, Heaton NS. Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3861-6. PMID: 27001854; PMCID: PMC4833272 [Available on 10/05/16].
  46. Buhler L, Illigens BM, Nadazdin O, Tena A, Lee S, Sachs DH, Cooper DK, Benichou G. Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants. Am J Transplant. 2016 06; 16(6):1917-22. PMID: 26718119; PMCID: PMC4874842 [Available on 06/01/17].
  47. Navarro-Alvarez N, Shah JA, Zhu A, Ligocka J, Yeh H, Elias N, Rosales I, Colvin R, Cosimi AB, Markmann JF, Hertl M, Sachs DH, Vagefi PA. The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation. Am J Transplant. 2016 06; 16(6):1715-1725. PMID: 26613235; PMCID: PMC4874924 [Available on 06/01/17].
  48. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19; 44(1):46-58. PMID: 26789921; PMCID: PMC4878455 [Available on 01/19/17].
  49. Sihag S, Haas MS, Kim KM, Guerrero JL, Beaudoin J, Alicot EM, Schuerpf F, Gottschall JD, Puro RJ, Madsen JC, Sachs DH, Newman W, Carroll MC, Allan JS. Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model. Circ Cardiovasc Interv. 2016 Jan; 9(1):e002547. PMID: 26671971; PMCID: PMC4687758 [Available on 01/01/17].
  50. Aguado LC, Schmid S, Sachs D, Shim JV, Lim JK, tenOever BR. microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection. Cell Host Microbe. 2015 Dec 09; 18(6):714-22. PMID: 26651947; PMCID: PMC4683400 [Available on 12/09/16].
  51. Cetrulo CL, Drijkoningen T, Sachs DH. Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application? Curr Opin Organ Transplant. 2015 Dec; 20(6):602-7. PMID: 26536420.
    View in: PubMed
  52. Wang Z, Pratts SG, Zhang H, Spencer PJ, Yu R, Tonsho M, Shah JA, Tanabe T, Powell HR, Huang CA, Madsen JC, Sachs DH, Wang Z. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Mol Oncol. 2016 Apr; 10(4):553-65. PMID: 26643572; PMCID: PMC4826841 [Available on 04/01/17].
  53. Benitez AA, Spanko LA, Bouhaddou M, Sachs D, tenOever BR. Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response. Cell Rep. 2015 Nov 17; 13(7):1456-1466. PMID: 26549455; PMCID: PMC4654977.
  54. Madariaga ML, Spencer PJ, Michel SG, La Muraglia GM, O'Neil MJ, Mannon EC, Leblang C, Rosales IA, Colvin RB, Sachs DH, Allan JS, Madsen JC. Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine. Am J Transplant. 2016 Mar; 16(3):979-86. PMID: 26469344; PMCID: PMC5010442 [Available on 03/01/17].
  55. Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA. Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients. Am J Transplant. 2015 Nov; 15(11):2908-20. PMID: 26461968.
    View in: PubMed
  56. Duran-Struuck R, Huang CA, Orf K, Bronson RT, Sachs DH, Spitzer TR. Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease. Comp Med. 2015 Oct; 65(5):429-43. PMID: 26473348; PMCID: PMC4617335.
  57. Navarro Alvarez N, Zhu A, Arellano RS, Randolph MA, Duggan M, Scott Arn J, Huang CA, Sachs DH, Vagefi PA. Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure. Xenotransplantation. 2015 Sep-Oct; 22(5):368-78. PMID: 26314946.
    View in: PubMed
  58. Vagefi PA, Shah JA, Sachs DH. Progress towards inducing tolerance of pig-to-primate xenografts. Int J Surg. 2015 Nov; 23(Pt B):291-295. PMID: 26296932.
    View in: PubMed
  59. Villani V, Yamada K, Scalea JR, Gillon BC, Arn JS, Sekijima M, Tasaki M, Cormack TA, Moran SG, Torabi R, Shimizu A, Sachs DH. Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model. Am J Transplant. 2016 Jan; 16(1):317-24. PMID: 26260215; PMCID: PMC4718904 [Available on 01/01/17].
  60. Madariaga MLL, Shanmugarajah K, Michel SG, Villani V, Muraglia GM, Torabi R, Leonard DA, Randolph MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL, Sachs DH. Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Transplantation. 2015 Aug; 99(8):1590-1597. PMID: 25757218; PMCID: PMC4551576.
  61. Wang P, Schuetz C, Vallabhajosyula P, Medarova Z, Tena A, Wei L, Yamada K, Deng S, Markmann JF, Sachs DH, Moore A. Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI. Transplantation. 2015 Aug; 99(8):1574-81. PMID: 25806407; PMCID: PMC4551574.
  62. Pakhalé S, Folan P, Neptune E, Sachs D. Retail Tobacco Sale in the Community. Should Pharmacies Sell Tobacco Products? Ann Am Thorac Soc. 2015 Aug; 12(8):1116-7. PMID: 26317269.
    View in: PubMed
  63. Matar AJ, Patil AR, Al-Musa A, Hanekamp I, Sachs DH, Huang CA, Duran-Struuck R. Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine. Biol Blood Marrow Transplant. 2015 Oct; 21(10):1732-8. PMID: 26210443.
    View in: PubMed
  64. Madariaga ML, Michel SG, La Muraglia GM, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL, Huang CA, Sachs DH, Madsen JC, Allan JS. Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine. Transplantation. 2015 Jul; 99(7):1372-8. PMID: 25757217; PMCID: PMC4494890.
  65. Benitez AA, Panis M, Xue J, Varble A, Shim JV, Frick AL, López CB, Sachs D, tenOever BR. In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus. Cell Rep. 2015 Jun 23; 11(11):1714-26. PMID: 26074083; PMCID: PMC4586153.
  66. Lei J, Kim JI, Shi S, Zhang X, Machaidze Z, Lee S, Schuetz C, Martins PN, Oura T, Farkash EA, Rosales IA, Smith RN, Stott R, Lee KM, Soohoo J, Boskovic S, Cappetta K, Nadazdin OM, Yamada Y, Yeh H, Kawai T, Sachs DH, Benichou G, Markmann JF. Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model. Am J Transplant. 2015 Oct; 15(10):2739-49. PMID: 26014796.
    View in: PubMed
  67. Fulton BO, Sachs D, Beaty SM, Won ST, Lee B, Palese P, Heaton NS. Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins. Cell Rep. 2015 Jun 09; 11(9):1331-8. PMID: 26004185; PMCID: PMC4464907.
  68. Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang CA, Madsen JC, Sachs DH, Wang Z. Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo. Mol Oncol. 2015 Aug; 9(7):1458-70. PMID: 25958791.
    View in: PubMed
  69. Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS. Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism. Am J Transplant. 2015 Aug; 15(8):2231-9. PMID: 25904524; PMCID: PMC4569127.
  70. Schwarzenböck SM, Gertz J, Souvatzoglou M, Kurth J, Sachs D, Nawroth R, Treiber U, Schuster T, Senekowitsch-Schmidtke R, Schwaiger M, Ziegler SI, Henriksen G, Wester HJ, Krause BJ. Comparison of [¹¹C]choline ([¹¹C]CHO) and S(+)-ß-methyl-[¹¹C]choline ([¹¹C]SMC) as imaging probes for prostate cancer in a PC-3 prostate cancer xenograft model. Mol Imaging Biol. 2015 Apr; 17(2):248-56. PMID: 25163420.
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  71. Madariaga ML, Michel SG, La Muraglia GM, Sekijima M, Villani V, Leonard DA, Powell HJ, Kurtz JM, Farkash EA, Colvin RB, Allan JS, Cetrulo CL, Huang CA, Sachs DH, Yamada K, Madsen JC. Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. Am J Transplant. 2015 Jun; 15(6):1580-90. PMID: 25824550; PMCID: PMC4565499.
  72. Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS. Long-term lung transplantation in nonhuman primates. Am J Transplant. 2015 May; 15(5):1415-20. PMID: 25772308; PMCID: PMC4564890.
  73. Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC. Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression. Am J Transplant. 2015 Mar; 15(3):618-27. PMID: 25693473.
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  74. Tasaki M, Wamala I, Tena A, Villani V, Sekijima M, Pathiraja V, Wilkinson RA, Pratts S, Cormack T, Clayman E, Arn JS, Shimizu A, Fishman JA, Sachs DH, Yamada K. High incidence of xenogenic bone marrow engraftment in pig-to-baboon intra-bone bone marrow transplantation. Am J Transplant. 2015 Apr; 15(4):974-83. PMID: 25676635; PMCID: PMC4407988.
  75. Sachs DH. The Medawar Prize acceptance speech 2014. Transplantation. 2015 Feb; 99(2):254-7. PMID: 25651110.
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  76. Le Bas-Bernardet S, Tillou X, Branchereau J, Dilek N, Poirier N, Châtelais M, Charreau B, Minault D, Hervouet J, Renaudin K, Crossan C, Scobie L, Takeuchi Y, Diswall M, Breimer ME, Klar N, Daha MR, Simioni P, Robson SC, Nottle MB, Salvaris EJ, Cowan PJ, d'Apice AJ, Sachs DH, Yamada K, Lagutina I, Duchi R, Perota A, Lazzari G, Galli C, Cozzi E, Soulillou JP, Vanhove B, Blancho G. Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons. Am J Transplant. 2015 Feb; 15(2):358-70. PMID: 25612490; PMCID: PMC4306235.
  77. Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T. Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant. 2014 Dec; 14(12):2704-12. PMID: 25394378; PMCID: PMC4236265.
  78. Varble A, Albrecht RA, Backes S, Crumiller M, Bouvier NM, Sachs D, García-Sastre A, tenOever BR. Influenza A virus transmission bottlenecks are defined by infection route and recipient host. Cell Host Microbe. 2014 Nov 12; 16(5):691-700. PMID: 25456074; PMCID: PMC4272616.
  79. Leto Barone AA, Mastroianni M, Farkash EA, Mallard C, Albritton A, Torabi R, Leonard DA, Kurtz JM, Sachs DH, Cetrulo CL. Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization. Burns. 2015 May; 41(3):565-74. PMID: 25406888.
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  80. Tena A, Kurtz J, Leonard DA, Dobrinsky JR, Terlouw SL, Mtango N, Verstegen J, Germana S, Mallard C, Arn JS, Sachs DH, Hawley RJ. Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation. Am J Transplant. 2014 Dec; 14(12):2713-22. PMID: 25278264; PMCID: PMC4236244.
  81. Scalea JR, Torabi R, Tena A, Tasaki M, Gillon BC, Moran S, Cormack T, Villani V, Shimizu A, Sachs DH, Yamada K. The rejuvenating effects of leuprolide acetate on the aged baboon's thymus. Transpl Immunol. 2014 Sep; 31(3):134-9. PMID: 25240733; PMCID: PMC4188753.
  82. Scalea JR, Villani V, Gillon BC, Weiner J, Gianello P, Turcotte N, Arn JS, Yamada K, Sachs DH. Development of antidonor antibody directed toward non-major histocompatibility complex antigens in tolerant animals. Transplantation. 2014 Sep 15; 98(5):514-9. PMID: 24933456; PMCID: PMC4149823.
  83. Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z. Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo. Protein Eng Des Sel. 2014 Sep; 27(9):289-95. PMID: 25147093.
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  84. Mathes DW, Solari MG, Gazelle GS, Butler PE, Wu A, Nazzal A, Nielsen GP, Huang CA, Sachs DH, Lee WP, Randolph MA. Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine. Transpl Int. 2014 Oct; 27(10):1086-96. PMID: 24963743.
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  85. Yamada K, Tasaki M, Sekijima M, Wilkinson RA, Villani V, Moran SG, Cormack TA, Hanekamp IM, Hawley RJ, Arn JS, Fishman JA, Shimizu A, Sachs DH. Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model. Transplantation. 2014 Aug 27; 98(4):411-8. PMID: 25243511; PMCID: PMC4176773.
  86. Bichoupan K, Martel-Laferriere V, Sachs D, Ng M, Schonfeld EA, Pappas A, Crismale J, Stivala A, Khaitova V, Gardenier D, Linderman M, Perumalswami PV, Schiano TD, Odin JA, Liu L, Moskowitz AJ, Dieterich DT, Branch AD. Costs of telaprevir-based triple therapy for hepatitis C: $189,000 per sustained virological response. Hepatology. 2014 Oct; 60(4):1187-95. PMID: 25065814; PMCID: PMC4190678.
  87. Heaton NS, Langlois RA, Sachs D, Lim JK, Palese P, tenOever BR. Long-term survival of influenza virus infected club cells drives immunopathology. J Exp Med. 2014 Aug 25; 211(9):1707-14. PMID: 25135297; PMCID: PMC4144728.
  88. Scalea JR, Okumi M, Villani V, Shimizu A, Nishimura H, Gillon BC, Torabi R, Cormack T, Moran S, LeGuern C, Sachs DH, Yamada K. Abrogation of renal allograft tolerance in MGH miniature swine: the role of intra-graft and peripheral factors in long-term tolerance. Am J Transplant. 2014 Sep; 14(9):2001-10. PMID: 25100613; PMCID: PMC4194165.
  89. Yeh H, Machaidze Z, Wamala I, Fraser JW, Navarro-Alvarez N, Kim K, Schuetz C, Shi S, Zhu A, Hertl M, Elias N, Farkash EA, Vagefi PA, Varma M, Smith RN, Robson SC, Van Cott EM, Sachs DH, Markmann JF. Increased transfusion-free survival following auxiliary pig liver xenotransplantation. Xenotransplantation. 2014 Sep-Oct; 21(5):454-64. PMID: 25130043.
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  90. Albritton A, Leonard DA, Leto Barone A, Keegan J, Mallard C, Sachs DH, Kurtz JM, Cetrulo CL. Lack of cross-sensitization between a-1,3-galactosyltransferase knockout porcine and allogeneic skin grafts permits serial grafting. Transplantation. 2014 Jun 27; 97(12):1209-15. PMID: 24798308; PMCID: PMC4407992.
  91. Backes S, Langlois RA, Schmid S, Varble A, Shim JV, Sachs D, tenOever BR. The Mammalian response to virus infection is independent of small RNA silencing. Cell Rep. 2014 Jul 10; 8(1):114-25. PMID: 24953656; PMCID: PMC4096324.
  92. Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio SA, Sayre P, Shonts B, Williams WW, Smith RN, Colvin RB, Sykes M, Cosimi AB. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant. 2014 Jul; 14(7):1599-611. PMID: 24903438.
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  93. Shapiro JS, Schmid S, Aguado LC, Sabin LR, Yasunaga A, Shim JV, Sachs D, Cherry S, tenOever BR. Drosha as an interferon-independent antiviral factor. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7108-13. PMID: 24778219; PMCID: PMC4024876.
  94. Tena A, Sachs DH. Stem cells: Immunology and immunomodulation. Dev Ophthalmol. 2014; 53:122-32. PMID: 24732766.
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  95. Lee PW, Hanekamp JS, Villani V, Vagefi PA, Cina RA, Kamano C, O'Malley PE, Arn S, Yamada K, Sachs DH. Evidence for a gene controlling the induction of transplantation tolerance. Am J Transplant. 2014 Apr; 14(4):952-9. PMID: 24592880; PMCID: PMC4042397.
  96. Shanmugarajah K, Mallard C, Leonard DA, Albritton A, Powell H, Harrington E, Randolph MA, Sachs DH, Kurtz JM, Cetrulo CL. Abstract 104: MHC class I sharing influences the fate of the epidermal component of vascularized composite allografts in mixed chimerism based tolerance protocols in miniature Swine. Plast Reconstr Surg. 2014 Mar; 133(3 Suppl):119. PMID: 25942215.
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  97. Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells. J Immunol Methods. 2014 Mar; 405:57-66. PMID: 24462799; PMCID: PMC4120078.
  98. Leonard DA, Kurtz JM, Mallard C, Albritton A, Duran-Struuck R, Farkash EA, Crepeau R, Matar A, Horner BM, Randolph MA, Sachs DH, Huang CA, Cetrulo CL. Vascularized composite allograft tolerance across MHC barriers in a large animal model. Am J Transplant. 2014 Feb; 14(2):343-55. PMID: 24405666; PMCID: PMC3971524.
  99. Sachs DH, Kawai T, Sykes M. Induction of tolerance through mixed chimerism. Cold Spring Harb Perspect Med. 2014 Jan 01; 4(1):a015529. PMID: 24384815; PMCID: PMC3869282.
  100. Cetrulo CL, Torabi R, Scalea JR, Shimizu A, Leto Barone AA, Gillon BC, Tasaki M, Leonard DA, Cormack TA, Villani V, Randolph MA, Sachs DH, Yamada K. Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis? Transplantation. 2013 Dec 15; 96(11):966-74. PMID: 24056624; PMCID: PMC3902136.
  101. Heaton NS, Sachs D, Chen CJ, Hai R, Palese P. Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20248-53. PMID: 24277853; PMCID: PMC3864309.
  102. Liang F, Wamala I, Scalea J, Tena A, Cormack T, Pratts S, Duran-Struuck R, Elias N, Hertl M, Huang CA, Sachs DH. Increased levels of anti-non-Gal IgG following pig-to-baboon bone marrow transplantation correlate with failure of engraftment. Xenotransplantation. 2013 Nov-Dec; 20(6):458-68. PMID: 24289469; PMCID: PMC3848062.
  103. Wamala I, Matar AJ, Farkash E, Wang Z, Huang CA, Sachs DH. Recombinant anti-monkey CD3 immunotoxin depletes peripheral lymph node T lymphocytes more effectively than rabbit anti-thymocyte globulin in naïve baboons. Transpl Immunol. 2013 Dec; 29(1-4):60-3. PMID: 24157659; PMCID: PMC3938119.
  104. Peraino JS, Schenk M, Li G, Zhang H, Farkash EA, Sachs DH, Huang CA, Duran-Struuck R, Wang Z. Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells. J Immunol Methods. 2013 Dec 15; 398-399:33-43. PMID: 24055128; PMCID: PMC3840057.
  105. Varble A, Benitez AA, Schmid S, Sachs D, Shim JV, Rodriguez-Barrueco R, Panis M, Crumiller M, Silva JM, Sachidanandam R, tenOever BR. An in vivo RNAi screening approach to identify host determinants of virus replication. Cell Host Microbe. 2013 Sep 11; 14(3):346-56. PMID: 24034620.
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  106. Vallabhajosyula P, Hirakata A, Shimizu A, Okumi M, Tchipashvili V, Hong H, Yamada K, Sachs DH. Assessing the effect of immunosuppression on engraftment of pancreatic islets. Transplantation. 2013 Aug 27; 96(4):372-8. PMID: 23883972; PMCID: PMC3786704.
  107. Madariaga ML, Michel SG, Tasaki M, Villani V, La Muraglia GM, Sihag S, Gottschall J, Farkash EA, Shimizu A, Allan JS, Sachs DH, Yamada K, Madsen JC. Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation. Am J Transplant. 2013 Oct; 13(10):2558-66. PMID: 24033991; PMCID: PMC3920984.
  108. Kawai T, Sachs DH. Tolerance induction: hematopoietic chimerism. Curr Opin Organ Transplant. 2013 Aug; 18(4):402-7. PMID: 23838644.
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  109. Kawai T, Sachs DH, Sykes M, Cosimi AB. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2013 May 09; 368(19):1850-2. PMID: 23656665; PMCID: PMC3760499.
  110. Shimatsu Y, Yamada K, Horii W, Hirakata A, Sakamoto Y, Waki S, Sano J, Saitoh T, Sahara H, Shimizu A, Yazawa H, Sachs DH, Nunoya T. Production of cloned NIBS (Nippon Institute for Biological Science) and a-1, 3-galactosyltransferase knockout MGH miniature pigs by somatic cell nuclear transfer using the NIBS breed as surrogates. Xenotransplantation. 2013 May-Jun; 20(3):157-64. PMID: 23581451; PMCID: PMC3815503.
  111. Eriksson E, Rohrich RJ, Sachs DH, Pomahac B, Delmonico FL, Caterson EJ, Goldwyn RM. The nobler angels of our nature: a tribute to Joseph E. Murray, M.D., 1919 to 2012. Plast Reconstr Surg. 2013 Apr; 131(4):912-7. PMID: 23542265.
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  112. Brandacher G, Sachs DH, Thomson AW. Immunology of vascularized composite allografts. Clin Dev Immunol. 2013; 2013:689071. PMID: 23573113; PMCID: PMC3618934.
  113. Okumi M, Scalea JR, Gillon BC, Tasaki M, Villani V, Cormack T, Hirakata A, Shimizu A, Sachs DH, Yamada K. The induction of tolerance of renal allografts by adoptive transfer in miniature swine. Am J Transplant. 2013 May; 13(5):1193-202. PMID: 23464595; PMCID: PMC3671754.
  114. Peraino JS, Schenk M, Zhang H, Li G, Hermanrud CE, Neville DM, Sachs DH, Huang CA, Duran-Struuck R, Wang Z. A truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin. J Immunol Methods. 2013 May 31; 391(1-2):103-11. PMID: 23470981; PMCID: PMC3688055.
  115. Leonard DA, Cetrulo CL, McGrouther DA, Sachs DH. Induction of tolerance of vascularized composite allografts. Transplantation. 2013 Feb 15; 95(3):403-9. PMID: 23114532.
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  116. Schwarzenböck S, Sachs D, Souvatzoglou M, Schuster T, Nawroth R, Weirich G, Treiber U, Wester HJ, Ziegler S, Schwaiger M, Senekowitsch-Schmidtke R, Krause BJ. [[¹¹C]choline as a pharmacodynamic marker for docetaxel therapy. Response assessment in a LNCaP prostate cancer xenograft mouse model]. Nuklearmedizin. 2013; 52(4):141-7. PMID: 23396481.
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  117. Bradley JA, Hardy M, Neuberger J, Sachs D, Suthanthiran M, Wood K. Transplantation: a report of progress. Transplantation. 2013 Jan 15; 95(1):1. PMID: 23222822.
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  118. Cosimi AB, Sachs DH, Sykes M, Kawai T. Clinical strategy for induction of transplantation tolerance through mixed chimerism. Clin Transpl. 2013; 127-34. PMID: 25095501.
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  119. Weiner J, Scalea J, Ishikawa Y, Okumi M, Griesemer A, Hirakata A, Etter J, Gillon B, Moran S, Shimizu A, Yamada K, Sachs DH. Tolerogenicity of donor major histocompatibility complex-matched skin grafts in previously tolerant Massachusetts general hospital miniature swine. Transplantation. 2012 Dec 27; 94(12):1192-9. PMID: 23269447; PMCID: PMC3531825.
  120. Matar AJ, Crepeau RL, Pathiraja V, Robson S, Fishman JA, Spitzer TR, Sachs DH, Huang CA, Duran-Struuck R. Effects of mobilization regimens in donors on outcomes of hematopoietic cell transplantation in miniature Swine. Comp Med. 2012 Dec; 62(6):487-94. PMID: 23561882; PMCID: PMC3527753.
  121. Duran-Struuck R, Matar A, Crepeau R, Gusha A, Schenk M, Hanekamp I, Pathiraja V, Spitzer TR, Sachs DH, Huang CA. Lack of antidonor alloantibody does not indicate lack of immune sensitization: studies of graft loss in a haploidentical hematopoietic cell transplantation swine model. Biol Blood Marrow Transplant. 2012 Nov; 18(11):1629-37. PMID: 22892552.
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  122. Crepeau R, Matar A, Spitzer TR, Robson S, Pathiraja V, Sachs DH, Huang CA, Duran-Struuck R. Edema and tetraparesis in a miniature pig after allogeneic hematopoietic cell transplantation. Comp Med. 2012 Aug; 62(4):298-302. PMID: 23043783; PMCID: PMC3415372.
  123. Kim K, Schuetz C, Elias N, Veillette GR, Wamala I, Varma M, Smith RN, Robson SC, Cosimi AB, Sachs DH, Hertl M. Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. Xenotransplantation. 2012 Jul-Aug; 19(4):256-64. PMID: 22909139; PMCID: PMC3655405.
  124. Leto Barone AA, Leonard DA, Torabi R, Mallard C, Glor T, Scalea JR, Randolph MA, Sachs DH, Cetrulo CL. The gracilis myocutaneous free flap in swine: an advantageous preclinical model for vascularized composite allograft transplantation research. Microsurgery. 2013 Jan; 33(1):51-5. PMID: 22707437.
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  125. Matar AJ, Pathiraja V, Wang Z, Duran-Struuck R, Gusha A, Crepeau R, Tasaki M, Sachs DH, Huang CA. Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment. Transpl Immunol. 2012 Aug; 27(1):52-4. PMID: 22676970; PMCID: PMC3413771.
  126. Peraino JS, Hermanrud CE, Springett L, Zhang H, Li G, Srinivasan S, Gusha A, Sachs DH, Huang CA, Wang Z. Expression and characterization of recombinant soluble porcine CD3 ectodomain molecules: mapping the epitope of an anti-porcine CD3 monoclonal antibody 898H2-6-15. Cell Immunol. 2012 Mar-Apr; 276(1-2):162-7. PMID: 22672968; PMCID: PMC3641788.
  127. Meltzer AJ, Veillette GR, Aoyama A, Kim KM, Cochrane ME, Wain JC, Madsen JC, Sachs DH, Rosengard BR, Allan JS. Donor brain death inhibits tolerance induction in miniature swine recipients of fully MHC-disparate pulmonary allografts. Am J Transplant. 2012 May; 12(5):1290-5. PMID: 22300400; PMCID: PMC3648993.
  128. Peraino J, Zhang H, Hermanrud CE, Li G, Sachs DH, Huang CA, Wang Z. Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris. Protein Expr Purif. 2012 Apr; 82(2):270-8. PMID: 22326797; PMCID: PMC3319225.
  129. Oku M, Okumi M, Shimizu A, Sahara H, Setoyama K, Nishimura H, Sada M, Scalea J, Ido A, Sachs DH, Tsubouchi H, Yamada K. Hepatocyte growth factor sustains T regulatory cells and prolongs the survival of kidney allografts in major histocompatibility complex-inbred CLAWN-miniature swine. Transplantation. 2012 Jan 27; 93(2):148-55. PMID: 22158517.
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  130. Leonard DA, Gordon CR, Sachs DH, Cetrulo CL. Immunobiology of face transplantation. J Craniofac Surg. 2012 Jan; 23(1):268-71. PMID: 22337423.
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  131. Hermanrud CE, Pathiraja V, Matar A, Duran-Struuck R, Crepeau RL, Srinivasan S, Sachs DH, Huang CA, Wang Z. Expression and purification of non-N-glycosylated porcine interleukin 3 in yeast Pichia pastoris. Protein Expr Purif. 2012 Mar; 82(1):70-4. PMID: 22154875; PMCID: PMC3288236.
  132. Shimizu A, Yamada K, Robson SC, Sachs DH, Colvin RB. Pathologic characteristics of transplanted kidney xenografts. J Am Soc Nephrol. 2012 Feb; 23(2):225-35. PMID: 22114174; PMCID: PMC3269172.
  133. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40. PMID: 22053723; PMCID: PMC3268945.
  134. Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G. Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates. J Immunol. 2011 Nov 01; 187(9):4589-97. PMID: 21957140; PMCID: PMC3197941.
  135. Vallabhajosyula P, Tena A, Yamada K, Sachs DH. Signal joint T-cell receptor excision circle assay in miniature swine. Transplantation. 2011 Sep 27; 92(6):634-40. PMID: 21822172; PMCID: PMC3291197.
  136. Nishimura H, Scalea J, Wang Z, Shimizu A, Moran S, Gillon B, Sachs DH, Yamada K. First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome. Transplantation. 2011 Sep 27; 92(6):641-7. PMID: 21822171; PMCID: PMC3255322.
  137. Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Vallabhajosyula P, Moran S, Sachs DH. Composite islet-kidneys from single baboon donors cure diabetes across fully allogenic barriers. Am J Transplant. 2011 Dec; 11(12):2603-12. PMID: 21929644; PMCID: PMC3226882.
  138. Wang Z, Duran-Struuck R, Crepeau R, Matar A, Hanekamp I, Srinivasan S, Neville DM, Sachs DH, Huang CA. Development of a diphtheria toxin based antiporcine CD3 recombinant immunotoxin. Bioconjug Chem. 2011 Oct 19; 22(10):2014-20. PMID: 21866954; PMCID: PMC3200572.
  139. Sachs DH, Cone JL. A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex. The Journal of Experimental Medicine. 1973. 138: 1289-1304. J Immunol. 2011 Sep 01; 187(5):2045-60. PMID: 21856943.
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  141. Kawai T, Cosimi AB, Sachs DH. Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism. Curr Opin Organ Transplant. 2011 Aug; 16(4):366-71. PMID: 21666482.
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  142. Spitzer TR, Sachs DH, Cosimi B. Multiple myeloma. N Engl J Med. 2011 06 16; 364(24):2364; author reply 2364. PMID: 21675904.
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  143. Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC. Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine. Transplantation. 2011 Jun 15; 91(11):1187-91. PMID: 21512437; PMCID: PMC3232060.
  144. Farris AB, Taheri D, Kawai T, Fazlollahi L, Wong W, Tolkoff-Rubin N, Spitzer TR, Iafrate AJ, Preffer FI, Locascio SA, Sprangers B, Saidman S, Smith RN, Cosimi AB, Sykes M, Sachs DH, Colvin RB. Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts. Am J Transplant. 2011 Jul; 11(7):1464-77. PMID: 21668634.
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  145. Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med. 2011 Jun 08; 3(86):86ra51. PMID: 21653831; PMCID: PMC3261229.
  146. Andreola G, Chittenden M, Shaffer J, Cosimi AB, Kawai T, Cotter P, Locascio SA, Morokata T, Dey BR, Tolkoff-Rubin NT, Preffer F, Bonnefoix T, Kattleman K, Spitzer TR, Sachs DH, Sykes M. Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation. Am J Transplant. 2011 Jun; 11(6):1236-47. PMID: 21645255.
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  148. Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of baboon thymopoiesis in porcine thymokidney xenografts by the signal-joining T-cell receptor excision circle assay. Transplantation. 2011 Mar 27; 91(6):639-44. PMID: 21285918; PMCID: PMC3255479.
  149. Spitzer TR, Sykes M, Tolkoff-Rubin N, Kawai T, McAfee SL, Dey BR, Ballen K, Delmonico F, Saidman S, Sachs DH, Cosimi AB. Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation. 2011 Mar 27; 91(6):672-6. PMID: 21217460.
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  150. Sachs DH. Mark Pescovitz, M.D. (1955-2010). Transplantation. 2011 Mar 15; 91(5):487-8. PMID: 21343875.
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  151. Nguyen BN, Azimzadeh AM, Schroeder C, Buddensick T, Zhang T, Laaris A, Cochrane M, Schuurman HJ, Sachs DH, Allan JS, Pierson RN. Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection. Xenotransplantation. 2011 Mar-Apr; 18(2):94-107. PMID: 21496117; PMCID: PMC3258267.
  152. LoCascio SA, Morokata T, Chittenden M, Preffer FI, Dombkowski DM, Andreola G, Crisalli K, Kawai T, Saidman SL, Spitzer TR, Tolkoff-Rubin N, Cosimi AB, Sachs DH, Sykes M. Mixed chimerism, lymphocyte recovery, and evidence for early donor-specific unresponsiveness in patients receiving combined kidney and bone marrow transplantation to induce tolerance. Transplantation. 2010 Dec 27; 90(12):1607-15. PMID: 21085064.
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  153. Bradley JA, Hardy M, Neuberger J, Sachs D, Suthanthiran M, Wood K, Monaco AP, Morris PJ. Transplantation: a report of progress. Transplantation. 2010 Dec 27; 90(12):1245. PMID: 21160404.
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  154. Lutton BV, Cho PS, Hirsh EL, Ferguson KK, Teague AG, Hanekamp JS, Chi N, Goldman SN, Messina DJ, Houser S, Yeap BY, Popma SH, Sachs DH, Huang CA. Approaches to avoid immune responses induced by repeated subcutaneous injections of allogeneic umbilical cord tissue-derived cells. Transplantation. 2010 Sep 15; 90(5):494-501. PMID: 21451445; PMCID: PMC3740357.
  155. Hirakata A, Okumi M, Griesemer AD, Shimizu A, Nobori S, Tena A, Moran S, Arn S, Boyd RL, Sachs DH, Yamada K. Reversal of age-related thymic involution by an LHRH agonist in miniature swine. Transpl Immunol. 2010 Oct; 24(1):76-81. PMID: 20692342; PMCID: PMC2988885.
  156. Griesemer A, Liang F, Hirakata A, Hirsh E, Lo D, Okumi M, Sykes M, Yamada K, Huang CA, Sachs DH. Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons. Xenotransplantation. 2010 Jul-Aug; 17(4):300-12. PMID: 20723202; PMCID: PMC2942069.
  157. Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G. Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant. 2010 Jun; 10(6):1375-84. PMID: 20486921; PMCID: PMC2893326.
  158. Nadazdin O, Abrahamian G, Boskovic S, Smith RN, Schoenfeld DA, Madsen JC, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Stem cell mobilization and collection for induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys. J Surg Res. 2011 Jun 15; 168(2):294-300. PMID: 20605588; PMCID: PMC2952058.
  159. Weiner J, Yamada K, Ishikawa Y, Moran S, Etter J, Shimizu A, Smith RN, Sachs DH. Prolonged survival of GalT-KO swine skin on baboons. Xenotransplantation. 2010 Mar-Apr; 17(2):147-52. PMID: 20522247; PMCID: PMC2905853.
  160. Duran-Struuck R, Cho PS, Teague AG, Fishman B, Fishman AS, Hanekamp JS, Moran SG, Wikiel KJ, Ferguson KK, Lo DP, Duggan M, Arn JS, Billiter B, Horner B, Houser S, Yeap BY, Westmoreland SV, Spitzer TR, McMorrow IM, Sachs DH, Bronson RT, Huang CA. Myelogenous leukemia in adult inbred MHC-defined miniature swine: a model for human myeloid leukemias. Vet Immunol Immunopathol. 2010 Jun 15; 135(3-4):243-56. PMID: 20079939; PMCID: PMC2879595.
  161. Mulder A, Kardol MJ, Arn JS, Eijsink C, Franke ME, Schreuder GM, Haasnoot GW, Doxiadis II, Sachs DH, Smith DM, Claas FH. Human monoclonal HLA antibodies reveal interspecies crossreactive swine MHC class I epitopes relevant for xenotransplantation. Mol Immunol. 2010 Jan; 47(4):809-15. PMID: 19931911.
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  162. Griesemer AD, Hirakata A, Shimizu A, Moran S, Tena A, Iwaki H, Ishikawa Y, Schule P, Arn JS, Robson SC, Fishman JA, Sykes M, Sachs DH, Yamada K. Results of gal-knockout porcine thymokidney xenografts. Am J Transplant. 2009 Dec; 9(12):2669-78. PMID: 19845583; PMCID: PMC2801602.
  163. Porcheray F, Wong W, Saidman SL, De Vito J, Girouard TC, Chittenden M, Shaffer J, Tolkoff-Rubin N, Dey BR, Spitzer TR, Colvin RB, Cosimi AB, Kawai T, Sachs DH, Sykes M, Zorn E. B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans. Am J Transplant. 2009 Sep; 9(9):2126-35. PMID: 19624570.
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  164. Hanekamp JS, Okumi M, Tena A, Arn S, Yamada K, Sachs DH. Cytoplasmic inheritance of transplantation antigens in animals produced by nuclear transfer. Transplantation. 2009 Jul 15; 88(1):30-7. PMID: 19584677; PMCID: PMC2936509.
  165. Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates. Transplantation. 2009 Jun 15; 87(11):1659-66. PMID: 19502957; PMCID: PMC2746764.
  166. Knosalla C, Yazawa K, Behdad A, Bodyak N, Shang H, Bühler L, Houser S, Gollackner B, Griesemer A, Schmitt-Knosalla I, Schuurman HJ, Awwad M, Sachs DH, Cooper DK, Yamada K, Usheva A, Robson SC. Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant. 2009 May; 9(5):1006-16. PMID: 19422330; PMCID: PMC2824173.
  167. Sachs DH, Galli C. Genetic manipulation in pigs. Curr Opin Organ Transplant. 2009 Apr; 14(2):148-53. PMID: 19469029; PMCID: PMC2687522.
  168. Weiss MJ, Guenther DA, Mezrich JD, Sahara H, Ng CY, Meltzer AJ, Sayre JK, Cochrane ME, Pujara AC, Houser SL, Sachs DH, Rosengard BR, Allan JS, Benichou G, Madsen JC. The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts. Am J Transplant. 2009 Jan; 9(1):105-13. PMID: 19145702; PMCID: PMC3252388.
  169. Meltzer AJ, Weiss MJ, Veillette GR, Sahara H, Ng CY, Cochrane ME, Houser SL, Sachs DH, Rosengard BR, Madsen JC, Wain JC, Allan JS. Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine. Transplantation. 2008 Dec 27; 86(12):1824-9. PMID: 19104429; PMCID: PMC2717556.
  170. Bradley JA, Hardy M, Neuberger J, Sachs D, Suthanthiran M, Wood K, Monaco AP, Morris PJ. Transplantation: a report of progress. Transplantation. 2008 Dec 27; 86(12):1635. PMID: 19104394.
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  171. Sachs DH, Sykes M, Yamada K. Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol. 2009 Jun; 21(2):101-5. PMID: 19059481; PMCID: PMC2805276.
  172. Hisashi Y, Yamada K, Kuwaki K, Tseng YL, Dor FJ, Houser SL, Robson SC, Schuurman HJ, Cooper DK, Sachs DH, Colvin RB, Shimizu A. Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons. Am J Transplant. 2008 Dec; 8(12):2516-26. PMID: 19032222; PMCID: PMC2836186.
  173. Issa NC, Wilkinson RA, Griesemer A, Cooper DK, Yamada K, Sachs DH, Fishman JA. Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation. J Virol. 2008 Dec; 82(24):12441-8. PMID: 18829759; PMCID: PMC2593320.
  174. Griesemer AD, Lamattina JC, Okumi M, Etter JD, Shimizu A, Sachs DH, Yamada K. Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. J Immunol. 2008 Sep 15; 181(6):4027-36. PMID: 18768858; PMCID: PMC2694842.
  175. Sogawa H, Boskovic S, Nadazdin O, Abrahamian G, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Limited efficacy and unacceptable toxicity of cyclophosphamide for the induction of mixed chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 2008 Aug 27; 86(4):615-9. PMID: 18724233; PMCID: PMC2786005.
  176. Sachs DH, Kawai T, Colvin RB, Fishman JA, Sykes M, Cosimi AB. Response to 'Tolerance versus immunosuppression: a perspective'. Am J Transplant. 2008 Aug; 8(8):1573-4. PMID: 18694470.
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  177. Smith RN, Kawai T, Boskovic S, Nadazdin O, Sachs DH, Cosimi AB, Colvin RB. Four stages and lack of stable accommodation in chronic alloantibody-mediated renal allograft rejection in Cynomolgus monkeys. Am J Transplant. 2008 Aug; 8(8):1662-72. PMID: 18557724; PMCID: PMC2796366.
  178. Traum AZ, Kawai T, Vacanti JP, Sachs DH, Cosimi AB, Madsen JC. The need for tolerance in pediatric organ transplantation. Pediatrics. 2008 Jun; 121(6):1258-60. PMID: 18519497.
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  179. Shimizu A, Hisashi Y, Kuwaki K, Tseng YL, Dor FJ, Houser SL, Robson SC, Schuurman HJ, Cooper DK, Sachs DH, Yamada K, Colvin RB. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol. 2008 Jun; 172(6):1471-81. PMID: 18467706; PMCID: PMC2408408.
  180. Hoerbelt R, Benjamin CL, Shoji T, Houser SL, Muniappan A, Hasse RS, Ledgerwood LG, Allan JS, Sachs DH, Madsen JC. The effects of tolerance on allograft damage caused by the innate immune system. Transplantation. 2008 Feb 15; 85(3):314-22. PMID: 18301326; PMCID: PMC2846698.
  181. Sachs DH. Patents and research: friends or foes? Surgery. 2008 Feb; 143(2):191-3. PMID: 18242334.
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  182. Okumi M, Fishbein JM, Griesemer AD, Gianello PR, Hirakata A, Nobori S, Moran S, Samelson-Jones E, Shimizu A, Sachs DH, Yamada K. Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts. Transplantation. 2008 Jan 27; 85(2):270-80. PMID: 18212633; PMCID: PMC2862307.
  183. Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey B, Ko DS, Hertl M, Goes NB, Wong W, Williams WW, Colvin RB, Sykes M, Sachs DH. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008 Jan 24; 358(4):353-61. PMID: 18216355.
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  184. Sachs DH. The lure of transplantation. Clin Transpl. 2008; 287-305. PMID: 19708462.
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  185. Shoji T, Sahara H, Muniappan A, Guenther DA, Wain JC, Houser SL, Bravard MA, Pujara AC, Hasse RS, Sachs DH, Madsen JC, Allan JS. Operational tolerance to class I disparate lungs can be induced despite pretransplant immunization with class I allopeptides. Transplantation. 2007 Dec 15; 84(11):1467-73. PMID: 18091523.
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  186. Cho PS, Messina DJ, Hirsh EL, Chi N, Goldman SN, Lo DP, Harris IR, Popma SH, Sachs DH, Huang CA. Immunogenicity of umbilical cord tissue derived cells. Blood. 2008 Jan 01; 111(1):430-8. PMID: 17909081.
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  187. Cho PS, Lo DP, Wikiel KJ, Rowland HC, Coburn RC, McMorrow IM, Goodrich JG, Arn JS, Billiter RA, Houser SL, Shimizu A, Yang YG, Sachs DH, Huang CA. Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood. 2007 Dec 01; 110(12):3996-4004. PMID: 17702898; PMCID: PMC2190613.
  188. Hongo D, Hadidi S, Damrauer S, Garrigue V, Kraft D, Sachs DH, Nikolic B, Sykes M. Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. J Infect Dis. 2007 Sep 15; 196(6):900-10. PMID: 17703422.
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  189. Sachs DH, Yamada K, Robson SC, Fishman JA, Shimizu A, Colvin RB, Sykes M. GalT-KO pigs: is the cup half empty or half full? Transplantation. 2007 Jul 15; 84(1):12-4. PMID: 17627230.
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  190. Shaffer J, Villard J, Means TK, Alexander S, Dombkowski D, Dey BR, McAfee S, Ballen KK, Saidman S, Preffer FI, Sachs DH, Spitzer TR, Sykes M. Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. Exp Hematol. 2007 Jul; 35(7):1140-52. PMID: 17588483; PMCID: PMC2031850.
  191. Dey BR, Shaffer J, Yee AJ, McAfee S, Caron M, Power K, Ting DT, Colby C, Preffer F, Ballen K, Attar E, Saidman S, Tarbell N, Sachs D, Sykes M, Spitzer TR. Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen. Bone Marrow Transplant. 2007 Jul; 40(1):19-27. PMID: 17468773.
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  192. Nguyen BN, Azimzadeh AM, Zhang T, Wu G, Schuurman HJ, Shuurman HJ, Sachs DH, Ayares D, Allan JS, Pierson RN. Life-supporting function of genetically modified swine lungs in baboons. J Thorac Cardiovasc Surg. 2007 May; 133(5):1354-63. PMID: 17467457.
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  193. Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant. 2007 May; 7(5):1055-61. PMID: 17286617; PMCID: PMC3785402.
  194. Houser S, Muniappan A, Allan J, Sachs D, Madsen J. Cardiac allograft vasculopathy: real or a normal morphologic variant? J Heart Lung Transplant. 2007 Feb; 26(2):167-73. PMID: 17258151; PMCID: PMC1802125.
  195. Papeta N, Chen T, Vianello F, Gererty L, Malik A, Mok YT, Tharp WG, Bagley J, Zhao G, Stevceva L, Yoon V, Sykes M, Sachs D, Iacomini J, Poznansky MC. Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation. 2007 Jan 27; 83(2):174-83. PMID: 17264814.
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  196. Doucette K, Dor FJ, Wilkinson RA, Martin SI, Huang CA, Cooper DK, Sachs DH, Fishman JA. Gene expression of porcine lymphotrophic herpesvirus-1 in miniature Swine with posttransplant lymphoproliferative disorder. Transplantation. 2007 Jan 15; 83(1):87-90. PMID: 17220799.
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  197. Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochem Biophys. 2007; 48(2-3):201-7. PMID: 17709890.
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  198. Nobori S, Shimizu A, Okumi M, Samelson-Jones E, Griesemer A, Hirakata A, Sachs DH, Yamada K. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19081-6. PMID: 17148614; PMCID: PMC1748180.
  199. Horner BM, Cina RA, Wikiel KJ, Lima B, Ghazi A, Lo DP, Yamada K, Sachs DH, Huang CA. Predictors of organ allograft tolerance following hematopoietic cell transplantation. Am J Transplant. 2006 Dec; 6(12):2894-902. PMID: 17294522.
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  200. Sahara H, Shoji T, Ng CY, Weiss MJ, Muniappan A, Guenther DA, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantation. Transplant Proc. 2006 Dec; 38(10):3256-8. PMID: 17175241; PMCID: PMC1865568.
  201. Shoji T, Sahara H, Muniappan A, Guenther DA, Houser SL, Pujara AC, Bravard MA, Wain JC, Sachs DH, Madsen JC, Allan JS. An MHC class II disparity raises the threshold for tolerance induction in pulmonary allografts in miniature swine. Transplant Proc. 2006 Dec; 38(10):3268-70. PMID: 17175245; PMCID: PMC1766937.
  202. Sahara H, Weiss MJ, Ng CY, Houser SL, Pujara AC, Sayre JK, Wain JC, Sachs DH, Madsen JC, Allan JS. Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Transplant Proc. 2006 Dec; 38(10):3253-5. PMID: 17175240; PMCID: PMC1865569.
  203. Boskovic S, Kawai T, Smith RN, Wee SL, Nadazdin O, Koyama I, Saidman S, Cardarelli F, Elias N, Sykes M, Strom T, Colvin RB, Sachs DH, Cosimi AB. Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation. 2006 Sep 27; 82(6):819-25. PMID: 17006330.
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  204. Wong BS, Yamada K, Okumi M, Weiner J, O'Malley PE, Tseng YL, Dor FJ, Cooper DK, Saidman SL, Griesemer A, Sachs DH. Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists. Transplantation. 2006 Aug 15; 82(3):314-9. PMID: 16906027.
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  205. Fudaba Y, Spitzer TR, Shaffer J, Kawai T, Fehr T, Delmonico F, Preffer F, Tolkoff-Rubin N, Dey BR, Saidman SL, Kraus A, Bonnefoix T, McAfee S, Power K, Kattleman K, Colvin RB, Sachs DH, Cosimi AB, Sykes M. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant. 2006 Sep; 6(9):2121-33. PMID: 16796719.
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  206. Smith RN, Kawai T, Boskovic S, Nadazdin O, Sachs DH, Cosimi AB, Colvin RB. Chronic antibody mediated rejection of renal allografts: pathological, serological and immunologic features in nonhuman primates. Am J Transplant. 2006 Aug; 6(8):1790-8. PMID: 16780551.
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  207. Tseng YL, Moran K, Dor FJ, Sanderson TM, Li W, Lancos CJ, Schuurman HJ, Sachs DH, Cooper DK. Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs. Transplantation. 2006 Apr 15; 81(7):1058-62. PMID: 16612284.
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  208. Yamamoto S, Teranishi K, Kamano C, Samelson-Jones E, Arakawa H, Nobori S, Okumi M, Houser S, Shimizu A, Sachs DH, Yamada K. Role of the thymus in transplantation tolerance in miniature swine: V. Deficiency of the graft-to-thymus pathway of tolerance induction in recipients of cardiac transplants. Transplantation. 2006 Feb 27; 81(4):607-13. PMID: 16495810.
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  209. Nobori S, Samelson-Jones E, Shimizu A, Hisashi Y, Yamamoto S, Kamano C, Teranishi K, Vagefi PA, Nuhn M, Okumi M, Wong B, Houser S, Sachs DH, Yamada K. Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation. 2006 Jan 15; 81(1):26-35. PMID: 16421473.
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  210. Kawai T, Sachs DH, Sykes M, Spitzer T, Tolkoff-Rubin N, Saidman S, Ko D, Dey B, Colvin RB, Cosimi AB. My most interesting cases. Clin Transpl. 2006; 580-2. PMID: 18365443.
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  211. Yamamoto S, Lavelle JM, Vagefi PA, Arakawa H, Samelson-Jones E, Moran S, Teranishi K, Kamano C, Fishman J, Awwad M, Neville DM, Shimizu A, Sykes M, Sachs DH, Yamada K. Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation. 2005 Dec 27; 80(12):1783-90. PMID: 16378075.
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  212. Sachs DH. A knock-out punch? Nat Med. 2005 Dec; 11(12):1271. PMID: 16333259.
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  213. Tseng YL, Kuwaki K, Dor FJ, Shimizu A, Houser S, Hisashi Y, Yamada K, Robson SC, Awwad M, Schuurman HJ, Sachs DH, Cooper DK. alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation. 2005 Nov 27; 80(10):1493-500. PMID: 16340796.
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  214. Mathes DW, Solari MG, Randolph MA, Gazelle GS, Yamada K, Huang CA, Sachs DH, Lee WP. Long-term acceptance of renal allografts following prenatal inoculation with adult bone marrow. Transplantation. 2005 Nov 15; 80(9):1300-8. PMID: 16314799.
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  215. Hoerbelt R, Johnston DR, Shoji T, Houser SL, Hasse RS, Ledgerwood LG, Iribarne A, Allan JS, Sayegh MH, Sachs DH, Madsen JC. Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine. Transplantation. 2005 Nov 15; 80(9):1275-82. PMID: 16314796.
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  216. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Sachs DH, Cooper DK. Localized myocardial infarction following pig-to-baboon heart transplantation. Xenotransplantation. 2005 Nov; 12(6):489-91. PMID: 16202073.
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  217. Rodríguez-Barbosa JI, Haller GW, Zhao G, Sachs DH, Sykes M. Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice. Transpl Immunol. 2005 Oct; 15(1):25-33. PMID: 16223670.
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  218. Johnston DR, Muniappan A, Hoerbelt R, Guenther DA, Shoji T, Houser SL, Sachs DH, Madsen JC. Heart and en-bloc thymus transplantation in miniature swine. J Thorac Cardiovasc Surg. 2005 Aug; 130(2):554-9. PMID: 16077427.
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  219. Shimizu A, Yamada K, Yamamoto S, Lavelle JM, Barth RN, Robson SC, Sachs DH, Colvin RB. Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol. 2005 Sep; 16(9):2732-45. PMID: 16049072.
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  220. Shoji T, Wain JC, Houser SL, Benjamin LC, Johnston DR, Hoerbelt R, Hasse RS, Lee RS, Muniappan A, Guenther DA, Bravard MA, Ledgerwood LG, Sachs DH, Sayegh MH, Madsen JC, Allan JS. Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine. Am J Transplant. 2005 Jul; 5(7):1626-34. PMID: 15943620.
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  221. Mezrich JD, Benjamin LC, Sachs JA, Houser SL, Vagefi PA, Sachs DH, Madsen JC, Yamada K. Role of the thymus and kidney graft in the maintenance of tolerance to heart grafts in miniature swine. Transplantation. 2005 Jun 27; 79(12):1663-73. PMID: 15973167.
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  222. Lee PW, Cina RA, Randolph MA, Arellano R, Goodrich J, Rowland H, Huang CA, Sachs DH, Kim HB. In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in Swine. Transplantation. 2005 May 15; 79(9):1084-90. PMID: 15880048.
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  223. Lee PW, Cina RA, Randolph MA, Goodrich J, Rowland H, Arellano R, Kim HB, Sachs DH, Huang CA. Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs. Exp Hematol. 2005 Mar; 33(3):371-9. PMID: 15730861.
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  224. Dey BR, McAfee S, Colby C, Cieply K, Caron M, Saidman S, Preffer F, Shaffer J, Tarbell N, Sackstein R, Sachs D, Sykes M, Spitzer TR. Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 2005 Feb; 128(3):351-9. PMID: 15667537.
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  225. Tseng YL, Tseng YL, Sachs DH, Cooper DK. Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress. Transplantation. 2005 Jan 15; 79(1):1-9. PMID: 15714161.
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  226. Mueller NJ, Kuwaki K, Knosalla C, Dor FJ, Gollackner B, Wilkinson RA, Arn S, Sachs DH, Cooper DK, Fishman JA. Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus. Xenotransplantation. 2005 Jan; 12(1):59-62. PMID: 15598274.
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  227. Shoji T, Muniappan A, Guenther DA, Wain JC, Houser SL, Hoerbelt R, Benjamin LC, Hasse RS, Bravard MA, Sachs DH, Madsen JC, Allan JS. Long-term acceptance of porcine pulmonary allografts without chronic rejection. Transplant Proc. 2005 Jan-Feb; 37(1):72-4. PMID: 15808551.
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  228. Dor FJ, Kuwaki K, Tseng YL, Shimizu A, Houser SL, Yamada K, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Sachs DH, Schuurman HJ, Cooper DK. Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons. Transplant Proc. 2005 Jan-Feb; 37(1):489-90. PMID: 15808685.
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  229. Schroeder C, Allan JS, Nguyen BN, Wu G, Zhang T, Azimzadeh AM, Madsen JC, Schuurman HJ, Sachs DH, Pierson RN. Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood. Transplant Proc. 2005 Jan-Feb; 37(1):512-3. PMID: 15808693.
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  230. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med. 2005 Jan; 11(1):29-31. PMID: 15619628.
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  231. Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, Sachs DH. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med. 2005 Jan; 11(1):32-4. PMID: 15619627.
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  232. Eguchi H, Knosalla C, Lan P, Cheng J, Diouf B, Wang L, Abe M, Schuurman HJ, Sachs DH, Sykes M, Cooper DK, Yang YG. T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation. 2004 Dec 15; 78(11):1609-17. PMID: 15591949.
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  233. Mueller NJ, Kuwaki K, Dor FJ, Knosalla C, Gollackner B, Wilkinson RA, Sachs DH, Cooper DK, Fishman JA. Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation. Transplantation. 2004 Nov 27; 78(10):1449-53. PMID: 15599308.
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  234. Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith RN, Wee SL, Andrews D, Nadazdin O, Koyama I, Sykes M, Winn HJ, Colvin RB, Sachs DH, Cosimi AB. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant. 2004 Sep; 4(9):1391-8. PMID: 15307826.
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  235. Cho PS, Mueller NJ, Cameron AM, Cina RA, Coburn RC, Hettiaratchy S, Melendy E, Neville DM, Patience C, Fishman JA, Sachs DH, Huang CA. Risk factors for the development of post-transplant lymphoproliferative disorder in a large animal model. Am J Transplant. 2004 Aug; 4(8):1274-82. PMID: 15268728.
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  236. Dor FJ, Tseng YL, Cheng J, Moran K, Sanderson TM, Lancos CJ, Shimizu A, Yamada K, Awwad M, Sachs DH, Hawley RJ, Schuurman HJ, Cooper DK. alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies. Transplantation. 2004 Jul 15; 78(1):15-20. PMID: 15257033.
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  237. Dickler M, Rugo H, Caravelli J, Brogi E, Sachs D, Panageas K, Flores S, Moasser M, Norton L, Hudis C. Phase II trial of erlotinib (OSI-774), an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, and bevacizumab, a recombinant humanized monoclonal antibody to vascular endothelial growth factor (VEGF), in patients (pts) with metastatic breast cancer (MBC). J Clin Oncol. 2004 Jul 15; 22(14_suppl):2001. PMID: 28015792.
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  238. Tseng YL, Dor FJ, Kuwaki K, Ryan D, Wood J, Denaro M, Giovino M, Yamada K, Hawley R, Patience C, Schuurman HJ, Awwad M, Sachs DH, Cooper DK. Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Xenotransplantation. 2004 Jul; 11(4):361-70. PMID: 15196131.
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  239. Knosalla C, Ryan DJ, Moran K, Gollackner B, Schuler W, Sachs DH, Awwad M, Schuurman HJ, Cooper DK. Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation. Xenotransplantation. 2004 Jul; 11(4):353-60. PMID: 15196130.
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  240. Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, Betthauser J, Carter DB, Greenstein JL, Hao Y, Im GS, Liu Z, Mell GD, Murphy CN, Park KW, Rieke A, Ryan DJ, Sachs DH, Forsberg EJ, Prather RS, Hawley RJ. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7335-40. PMID: 15123792; PMCID: PMC409919.
  241. Mezrich J, Yamada K, Sachs DH, Madsen JC. Regulatory T cells generated by the kidney may mediate the beneficial immune effects of combining kidney with heart transplantation. Surgery. 2004 May; 135(5):473-8. PMID: 15118583.
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  242. Mueller NJ, Livingston C, Knosalla C, Barth RN, Yamamoto S, Gollackner B, Dor FJ, Buhler L, Sachs DH, Yamada K, Cooper DK, Fishman JA. Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation. J Infect Dis. 2004 May 01; 189(9):1628-33. PMID: 15116299.
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  243. Vagefi PA, Ierino FL, Gianello PR, Shimizu A, Kamano C, Sachs DH, Yamada K. Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance. Transplantation. 2004 Apr 15; 77(7):979-85. PMID: 15087757.
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  244. Cosimi AB, Sachs DH. Mixed chimerism and transplantation tolerance. Transplantation. 2004 Mar 27; 77(6):943-6. PMID: 15077044.
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  245. Kamano C, Vagefi PA, Kumagai N, Yamamoto S, Barth RN, LaMattina JC, Moran SG, Sachs DH, Yamada K. Vascularized thymic lobe transplantation in miniature swine: thymopoiesis and tolerance induction across fully MHC-mismatched barriers. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3827-32. PMID: 15007168; PMCID: PMC374329.
  246. Wood JC, Quinn G, Suling KM, Oldmixon BA, Van Tine BA, Cina R, Arn S, Huang CA, Scobie L, Onions DE, Sachs DH, Schuurman HJ, Fishman JA, Patience C. Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine. J Virol. 2004 Mar; 78(5):2494-501. PMID: 14963150; PMCID: PMC369241.
  247. Kuwaki K, Knosalla C, Dor FJ, Gollackner B, Tseng YL, Houser S, Mueller N, Prabharasuth D, Alt A, Moran K, Cheng J, Behdad A, Sachs DH, Fishman JA, Schuurman HJ, Awwad M, Cooper DK. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am J Transplant. 2004 Mar; 4(3):363-72. PMID: 14961988.
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  248. Hettiaratchy S, Melendy E, Randolph MA, Coburn RC, Neville DM, Sachs DH, Huang CA, Lee WP. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation. 2004 Feb 27; 77(4):514-21. PMID: 15084927.
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  249. Koyama I, Kawai T, Andrews D, Boskovic S, Nadazdin O, Wee SL, Sogawa H, Wu DL, Smith RN, Colvin RB, Sachs DH, Cosimi AB. Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates. Transplantation. 2004 Feb 15; 77(3):460-2. PMID: 14966427.
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  250. Wu A, Yamada K, Baron C, Mathes DW, Monajati LM, Vagefi PA, Sachs DH. Detection of regulatory cells as an assay for allograft tolerance in miniature swine. J Heart Lung Transplant. 2004 Feb; 23(2):210-7. PMID: 14761769.
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  251. Lan P, Wang L, Diouf B, Eguchi H, Su H, Bronson R, Sachs DH, Sykes M, Yang YG. Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood. 2004 May 15; 103(10):3964-9. PMID: 14739221.
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  252. Menard MT, Schwarze ML, Allan JS, Johnston DR, Mawulawde K, Shimizu A, Yamada K, Houser SL, Allison KS, Sachs DH, Madsen JC. Composite "thymoheart" transplantation improves cardiac allograft survival. Am J Transplant. 2004 Jan; 4(1):79-86. PMID: 14678037.
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  253. Houser SL, McMorrow IM, LeGuern C, Schwarze ML, Fuchimoto Y, Sachs DH, Madsen JC. Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine. J Heart Lung Transplant. 2004 Jan; 23(1):50-60. PMID: 14734127.
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  254. Quinn G, Wood J, Suling K, Arn S, Sachs DH, Schuurman HJ, Patience C. Genotyping of porcine endogenous retroviruses from a family of miniature swine. J Virol. 2004 Jan; 78(1):314-9. PMID: 14671113; PMCID: PMC303422.
  255. Knosalla C, Gollackner B, Bühler L, Mueller NJ, Houser S, Mauiyyedi S, Sachs DH, Robson SC, Fishman J, Schuurman HJ, Awwad M, Cooper DK. Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons. Am J Transplant. 2003 Dec; 3(12):1510-9. PMID: 14629281.
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  256. Faden RR, Dawson L, Bateman-House AS, Agnew DM, Bok H, Brock DW, Chakravarti A, Gao XJ, Greene M, Hansen JA, King PA, O'Brien SJ, Sachs DH, Schill KE, Siegel A, Solter D, Suter SM, Verfaillie CM, Walters LB, Gearhart JD. Public stem cell banks: considerations of justice in stem cell research and therapy. Hastings Cent Rep. 2003 Nov-Dec; 33(6):13-27. PMID: 14983554.
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  257. Gollackner B, Knosalla C, Houser S, Mauiyyedi S, Buhler L, Kawai T, Duggan M, Sachs DH, Awwad M, Cooper DK. Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate. Xenotransplantation. 2003 Nov; 10(6):606-14. PMID: 14708529.
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  258. Dawson L, Bateman-House AS, Mueller Agnew D, Bok H, Brock DW, Chakravarti A, Greene M, King PA, O'Brien SJ, Sachs DH, Schill KE, Siegel A, Solter D, Suter SM, Verfaillie CM, Walters LB, Gearhart JD, Faden RR. Safety issues in cell-based intervention trials. Fertil Steril. 2003 Nov; 80(5):1077-85. PMID: 14607552.
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  259. Le Guern AC, Giovino MA, Abe M, Theodore PR, Qi J, Down JD, Sachs DH, Sykes M, Yang YG. Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol. 2003 Sep; 31(9):833-40. PMID: 12962730.
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  260. Mezrich JD, Kesselheim JA, Johnston DR, Yamada K, Sachs DH, Madsen JC. The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation. Am J Transplant. 2003 Sep; 3(9):1107-15. PMID: 12919090.
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  261. Lima B, Gleit ZL, Cameron AM, Germana S, Murphy MC, Consorti R, Chang Q, Down JD, LeGuern C, Sachs DH, Huang CA. Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine. Biol Blood Marrow Transplant. 2003 Sep; 9(9):571-82. PMID: 14506659.
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  262. Mueller NJ, Sulling K, Gollackner B, Yamamoto S, Knosalla C, Wilkinson RA, Kaur A, Sachs DH, Yamada K, Cooper DK, Patience C, Fishman JA. Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation. Am J Transplant. 2003 Sep; 3(9):1057-64. PMID: 12919084.
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  263. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Benjamin LC, Schwarze ML, Maloney ME, Amoah HC, Houser SL, Sachs DH, Madsen JC. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation. 2003 Aug 27; 76(4):625-31. PMID: 12973099.
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  264. Yamada K, Vagefi PA, Utsugi R, Kitamura H, Barth RN, LaMattina JC, Sachs DH. Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers. Transplantation. 2003 Aug 15; 76(3):530-6. PMID: 12923439.
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  265. Teranishi K, Alwayn IP, Bühler L, Gollackner B, Knosalla C, Huck J, Duthaler R, Katopodis A, Sachs DH, Schuurman HJ, Awwad M, Cooper DK. Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons. Xenotransplantation. 2003 Jul; 10(4):357-67. PMID: 12795685.
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  266. Wu A, Yamada K, Ierino FL, Vagefi PA, Sachs DH. Regulatory mechanism of peripheral tolerance: in vitro evidence for dominant suppression of host responses during the maintenance phase of tolerance to renal allografts in miniature swine. Transpl Immunol. 2003 Jul-Sep; 11(3-4):367-74. PMID: 12967789.
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  267. Zhao Y, Rodriguez-Barbosa JI, Shimizu A, Sachs DH, Sykes M. Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity. Transplantation. 2003 Jun 15; 75(11):1832-40. PMID: 12811242.
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  268. Gollackner B, Dor FJ, Knosalla C, Buhler L, Duggan M, Huang CA, Houser SL, Sachs DH, Kawai T, Ko DS, Cooper DK. Spleen transplantation in miniature swine: surgical technique and results in major histocompatibility complex-matched donor and recipient pairs. Transplantation. 2003 Jun 15; 75(11):1799-806. PMID: 12811237.
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  269. Gollackner B, Mueller NJ, Houser S, Qawi I, Soizic D, Knosalla C, Buhler L, Dor FJ, Awwad M, Sachs DH, Cooper DK, Robson SC, Fishman JA. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation. 2003 Jun 15; 75(11):1841-7. PMID: 12811243.
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  270. Sachs DH. Tolerance: of mice and men. J Clin Invest. 2003 Jun; 111(12):1819-21. PMID: 12813017; PMCID: PMC161433.
  271. Daly A, McAfee S, Dey B, Colby C, Schulte L, Yeap B, Sackstein R, Tarbell NJ, Sachs D, Sykes M, Spitzer TR. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant. 2003 Jun; 9(6):373-82. PMID: 12813445.
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  272. Barth RN, Yamamoto S, LaMattina JC, Kumagai N, Kitamura H, Vagefi PA, Awwad M, Colvin RB, Cooper DK, Sykes M, Sachs DH, Yamada K. Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness. Transplantation. 2003 May 27; 75(10):1615-24. PMID: 12777846.
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  273. Spitzer TR, McAfee SL, Dey BR, Colby C, Hope J, Grossberg H, Preffer F, Shaffer J, Alexander SI, Sachs DH, Sykes M. Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation. 2003 May 27; 75(10):1748-51. PMID: 12777868.
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  274. Dey BR, McAfee S, Colby C, Sackstein R, Saidman S, Tarbell N, Sachs DH, Sykes M, Spitzer TR. Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2003 May; 9(5):320-9. PMID: 12766882.
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  275. Mezrich JD, Haller GW, Arn JS, Houser SL, Madsen JC, Sachs DH. Histocompatible miniature swine: an inbred large-animal model. Transplantation. 2003 Mar 27; 75(6):904-7. PMID: 12660524.
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  276. Wu A, Yamada K, Neville DM, Awwad M, Wain JC, Shimizu A, Gojo S, Kitamura H, Colvin RB, Cooper DK, Sykes M, Sachs DH. Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation. 2003 Feb 15; 75(3):282-91. PMID: 12589146.
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  277. Mathes DW, Randolph MA, Solari MG, Nazzal JA, Nielsen GP, Arn JS, Sachs DH, Lee WP. Split tolerance to a composite tissue allograft in a swine model. Transplantation. 2003 Jan 15; 75(1):25-31. PMID: 12544866.
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  278. Shimada H, Germana S, Hayashi H, Sachs DH, LeGuern C. Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes. Surg Today. 2003; 33(3):183-9. PMID: 12658383.
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  279. Gleit ZL, Fuchimoto Y, Yamada K, Melendy E, Scheier-Dolberg R, Monajati L, Coburn RC, Neville DM, Sachs DH, Huang CA. Variable relationship between chimerism and tolerance after hematopoietic cell transplantation without myelosuppressive conditioning. Transplantation. 2002 Dec 15; 74(11):1535-44. PMID: 12490786.
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  280. Bühler LH, Spitzer TR, Sykes M, Sachs DH, Delmonico FL, Tolkoff-Rubin N, Saidman SL, Sackstein R, McAfee S, Dey B, Colby C, Cosimi AB. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 2002 Nov 27; 74(10):1405-9. PMID: 12451240.
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  281. Bagley J, Tian C, Sachs DH, Iacomini J. T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients. Transplantation. 2002 Nov 27; 74(10):1454-60. PMID: 12451248.
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  282. Gleit ZL, Cameron AM, Fuchimoto Y, Melendy E, Monajati L, Coburn RC, Sachs DH, Huang CA. Persistent chimerism despite antidonor MHC in vitro responses in miniature swine following allogeneic hematopoietic cell transplantation. Transplantation. 2002 Nov 15; 74(9):1260-6. PMID: 12451263.
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  283. Kumagai N, O'Neil JJ, Barth RN, LaMattina JC, Utsugi R, Moran SG, Yamamoto S, Vagefi PA, Kitamura H, Kamano C, Sachs DH, Yamada K. Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys. Transplantation. 2002 Nov 15; 74(9):1223-30. PMID: 12451257.
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  284. Teranishi K, Alwayn IP, Bühler L, Gollackner B, Knosalla C, Correa L, Down JD, White-Scharf ME, Sachs DH, Duthaler R, Katopodis A, Awwad M, Cooper DK. Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model. Transplant Proc. 2002 Nov; 34(7):2757-8. PMID: 12431597.
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  285. Kumagai N, LaMattina JC, Kamano C, Vagefi PA, Barth RN, O'Neil JJ, Yamamoto S, Moran SG, Utsugi R, Sachs DH, Yamada K. Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy. Diabetes. 2002 Nov; 51(11):3220-8. PMID: 12401713.
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  286. Bühler L, Kurilla-Mahon B, Chang Q, Abraham S, Alwayn IP, Appel JZ, Newman D, Awwad M, White-Scharf ME, Sackstein R, Sachs DH, Cooper DK, Down JD. Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells. Transplantation. 2002 Oct 27; 74(8):1159-66. PMID: 12438964.
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  287. Haller GW, Lima B, Kunisaki SM, Germana S, Leguern C, Huang CA, Sachs DH. MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses. J Immunol. 2002 Oct 01; 169(7):3613-21. PMID: 12244152.
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  288. Mapara MY, Kim YM, Wang SP, Bronson R, Sachs DH, Sykes M. Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. Blood. 2002 Sep 01; 100(5):1903-9. PMID: 12176915.
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  289. Kunisaki SM, Haller GW, Shimizu A, Kitamura H, Colvin RB, Sachs DH. Autologous graft-versus-host disease in a porcine bone marrow transplant model. Transplantation. 2002 Aug 27; 74(4):465-71. PMID: 12352903.
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  290. Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul; 30(7):809-15. PMID: 12135680.
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  291. Mathes DW, Randolph MA, Bourget JL, Nielsen GP, Ferrera VR, Arn JS, Sachs DH, Lee WP. Recipient bone marrow engraftment in donor tissue after long-term tolerance to a composite tissue allograft. Transplantation. 2002 Jun 27; 73(12):1880-5. PMID: 12131681.
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  292. Bagley J, Tian C, Sachs DH, Iacomini J. Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy. Blood. 2002 Jun 15; 99(12):4394-9. PMID: 12036867.
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  293. Mezrich JD, Sachs DH, Madsen JC. Combined heart and kidney transplantation: are two organs better than one? J Heart Lung Transplant. 2002 Jun; 21(6):714-6. PMID: 12057709.
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  294. Shimizu A, Yamada K, Sachs DH, Colvin RB. Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine. Lab Invest. 2002 Jun; 82(6):673-86. PMID: 12065677.
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  295. Schmidtko J, Wang R, Wu CL, Mauiyyedi S, Harris NL, Della Pelle P, Brousaides N, Zagachin L, Ferry JA, Wang F, Kawai T, Sachs DH, Cosimi BA, Colvin RB. Posttransplant lymphoproliferative disorder associated with an Epstein-Barr-related virus in cynomolgus monkeys. Transplantation. 2002 May 15; 73(9):1431-9. PMID: 12023621.
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  296. Shimizu A, Yamada K, Sachs DH, Colvin RB. Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis. Kidney Int. 2002 May; 61(5):1867-79. PMID: 11967039.
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  297. Mueller NJ, Barth RN, Yamamoto S, Kitamura H, Patience C, Yamada K, Cooper DK, Sachs DH, Kaur A, Fishman JA. Activation of cytomegalovirus in pig-to-primate organ xenotransplantation. J Virol. 2002 May; 76(10):4734-40. PMID: 11967290; PMCID: PMC136166.
  298. Goltz M, Ericsson T, Patience C, Huang CA, Noack S, Sachs DH, Ehlers B. Sequence analysis of the genome of porcine lymphotropic herpesvirus 1 and gene expression during posttransplant lymphoproliferative disease of pigs. Virology. 2002 Mar 15; 294(2):383-93. PMID: 12009880.
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  299. LaMattina JC, Kumagai N, Barth RN, Yamamoto S, Kitamura H, Moran SG, Mezrich JD, Sachs DH, Yamada K. Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesis. Transplantation. 2002 Mar 15; 73(5):826-31. PMID: 11907438.
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  300. McMorrow IM, Buhler L, Treter S, Neethling FA, Alwayn IP, Comrack CA, Kitamura H, Awwad M, DerSimonian H, Cooper DK, Sachs DH, LeGuern C. Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies. Xenotransplantation. 2002 Mar; 9(2):106-14. PMID: 11897003.
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  301. Allan JS, Wain JC, Schwarze ML, Houser SL, Benjamin LC, Madsen JC, Sachs DH. Modeling chronic lung allograft rejection in miniature swine. Transplantation. 2002 Feb 15; 73(3):447-53. PMID: 11884943.
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  302. Bühler L, Awwad M, Treter S, Chang Q, Basker M, Alwayn IP, Teranishi K, Ericsson T, Moran K, Harper D, Kurilla-Mahon B, Huang CA, Sackstein R, Sykes M, White-Scharf ME, Sachs DH, Down JD, Cooper DK. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation. 2002 Jan 15; 73(1):12-22. PMID: 11792972.
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  303. Teranishi K, Gollackner B, Bühler L, Knosalla C, Correa L, Down JD, White-Scharf ME, Sachs DH, Awwad M, Cooper DK. Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides. Transplantation. 2002 Jan 15; 73(1):129-39. PMID: 11792992.
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  304. McMorrow IM, Narayan K, Sachs DH, LeGuern C. New intra-renal graft genes associated with tolerance or rejection. Kidney Int. 2002 Jan; 61(1 Suppl):S85-93. PMID: 11841619.
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  305. Cooper DK, Gollackner B, Sachs DH. Will the pig solve the transplantation backlog? Annu Rev Med. 2002; 53:133-47. PMID: 11818467.
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  306. Bühler L, Deng S, O'Neil J, Kitamura H, Koulmanda M, Baldi A, Rahier J, Alwayn IP, Appel JZ, Awwad M, Sachs DH, Weir G, Squifflet JP, Cooper DK, Morel P. Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade. Xenotransplantation. 2002 Jan; 9(1):3-13. PMID: 12005102.
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  307. Bühler L, Yamada K, Kitamura H, Alwayn IP, Basker M, Appel JZ, Colvin RB, White-Scharf ME, Sachs DH, Robson SC, Awwad M, Cooper DK. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation. 2001 Dec 15; 72(11):1743-52. PMID: 11740383.
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  308. Bühler L, Alwayn IP, Basker M, Oravec G, Thall A, White-Scharf ME, Sachs DH, Awwad M, Cooper DK. CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons. Transplantation. 2001 Dec 15; 72(11):1759-68. PMID: 11740385.
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  309. Basker M, Alwayn IP, Buhler L, Harper D, Abraham S, Kruger Gray H, DeAngelis H, Awwad M, Down J, Rieben R, White-Scharf ME, Sachs DH, Thall A, Cooper DK. Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons. Transplantation. 2001 Oct 15; 72(7):1278-85. PMID: 11602856.
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  310. Rodriguez-Barbosa JI, Zhao Y, Barth R, Zhao G, Arn JS, Sachs DH, Sykes M. Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells. Transplantation. 2001 Oct 15; 72(7):1223-31. PMID: 11602846.
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  311. Baron C, McMorrow I, Sachs DH, LeGuern C. Persistence of dominant T cell clones in accepted solid organ transplants. J Immunol. 2001 Oct 15; 167(8):4154-60. PMID: 11591735.
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  312. Gargollo P, Yamada K, Esnaola N, Fuchimoto Y, Newell KL, Sachs DH, Huang CA. Neuropathy in miniature swine after administration of the mutant diphtheria toxin-based immunotoxin, pCD3-CRM9. Transplantation. 2001 Sep 15; 72(5):818-22. PMID: 11571443.
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  313. Kunisaki SM, Haller GW, Fuchimoto Y, Huang CA, Sachs DH. Peripheral regulation of graft-versus-host alloreactivity in mixed chimeric miniature swine. Transplantation. 2001 Aug 15; 72(3):523-6. PMID: 11502986.
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  314. Alwayn IP, Xu Y, Basker M, Wu C, Buhler L, Lambrigts D, Treter S, Harper D, Kitamura H, Vitetta ES, Abraham S, Awwad M, White-Scharf ME, Sachs DH, Thall A, Cooper DK. Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody. Xenotransplantation. 2001 Aug; 8(3):157-71. PMID: 11472623.
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  315. Kawai T, Sogawa H, Koulmanda M, Smith RN, O'Neil JJ, Wee SL, Boskovic S, Sykes M, Colvin RB, Sachs DH, Auchincloss H, Cosimi AB, C Ko DS. Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation. 2001 Jul 27; 72(2):351-4. PMID: 11477369.
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  316. Fuchimoto Y, Gleit ZL, Huang CA, Kitamura H, Schwarze ML, Menard MT, Mawulawde K, Madsen JC, Sachs DH. Skin-specific alloantigens in miniature swine. Transplantation. 2001 Jul 15; 72(1):122-6. PMID: 11468546.
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  317. Marghoob AA, Blum R, Nossa R, Busam KJ, Sachs D, Halpern A. Agminated atypical (dysplastic) nevi: case report and review of the literature. Arch Dermatol. 2001 Jul; 137(7):917-20. PMID: 11453811.
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  318. Brander C, Matter-Reissmann UB, Jones NG, Walker BD, Sachs DH, Seebach JD. Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride. J Immunol Methods. 2001 Jun 01; 252(1-2):1-14. PMID: 11334960.
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  319. Bühler L, Goepfert C, Kitamura H, Basker M, Gojo S, Alwayn IP, Chang Q, Down JD, Tsai H, Wise R, Sachs DH, Cooper DK, Robson SC, Sackstein R. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant. 2001 Jun; 27(12):1227-36. PMID: 11548840.
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  320. Sykes M, Sachs DH. Mixed chimerism. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):707-26. PMID: 11375074; PMCID: PMC1088458.
  321. Utsugi R, Barth RN, Lee RS, Kitamura H, LaMattina JC, Ambroz J, Sachs DH, Yamada K. Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully mhc-mismatched kidney allografts in miniature swine. Transplantation. 2001 May 27; 71(10):1368-79. PMID: 11391221.
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  322. Lee WP, Rubin JP, Bourget JL, Cober SR, Randolph MA, Nielsen GP, Ierino FL, Sachs DH. Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens. Plast Reconstr Surg. 2001 May; 107(6):1482-90; discussion 1491-2. PMID: 11335822.
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  323. Bourget JL, Mathes DW, Nielsen GP, Randolph MA, Tanabe YN, Ferrara VR, Wu A, Arn S, Sachs DH, Lee WP. Tolerance to musculoskeletal allografts with transient lymphocyte chimerism in miniature swine. Transplantation. 2001 Apr 15; 71(7):851-6. PMID: 11349715.
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  324. Huang CA, Fuchimoto Y, Gleit ZL, Ericsson T, Griesemer A, Scheier-Dolberg R, Melendy E, Kitamura H, Fishman JA, Ferry JA, Harris NL, Patience C, Sachs DH. Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus. Blood. 2001 Mar 01; 97(5):1467-73. PMID: 11222395.
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  325. Baron C, Sachs DH, LeGuern C. A particular TCR beta variable region used by T cells infiltrating kidney transplants. J Immunol. 2001 Feb 15; 166(4):2589-96. PMID: 11160320.
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  326. Mezrich JD, Yamada K, Lee RS, Mawulawde K, Houser SL, Schwarze ML, Maloney ME, Amoah HC, Pillsbury EP, Sachs DH, Madsen JC. Mechanisms of tolerance induction in the heart/kidney model in miniature swine. J Heart Lung Transplant. 2001 Feb; 20(2):172-173. PMID: 11250274.
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  327. Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. Transplant Proc. 2001 Feb-Mar; 33(1-2):88-9. PMID: 11266718.
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  328. Utsugi R, Barth RN, Kitamura H, Ambroz J, Sachs DH, Yamada K. Tolerance across a two-haplotype, fully MHC-mismatched barrier induced in miniat