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Last Name

profileBarbara Caldarone, Ph.D.

TitleInstructor in Neurology
InstitutionBrigham and Women's Hospital
AddressBrigham and Womens Hospital
75 Francis St
Boston MA 02115
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  1. Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nat Chem Biol. 2016 Jul; 12(7):559-66. PMID: 27239787; PMCID: PMC4912417 [Available on 11/30/16].
  2. Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT. s1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016 Jul; 12(7):552-8. PMID: 27239788; PMCID: PMC4912403 [Available on 11/30/16].
  3. Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP. Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective a4ß2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III. ACS Chem Neurosci. 2016 06 15; 7(6):811-22. PMID: 27035276.
    View in: PubMed
  4. Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CA. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015 Sep 23; 35(38):13029-42. PMID: 26400934.
    View in: PubMed
  5. Frost JL, Liu B, Rahfeld JU, Kleinschmidt M, O'Nuallain B, Le KX, Lues I, Caldarone BJ, Schilling S, Demuth HU, Lemere CA. An anti-pyroglutamate-3 Aß vaccine reduces plaques and improves cognition in APPswe/PS1?E9 mice. Neurobiol Aging. 2015 Dec; 36(12):3187-99. PMID: 26453001; PMCID: PMC4641825 [Available on 12/01/16].
  6. Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiol Aging. 2015 Mar; 36(3):1316-32. PMID: 25619661.
    View in: PubMed
  7. Caldarone BJ, Zachariou V, King SL. Rodent models of treatment-resistant depression. Eur J Pharmacol. 2015 Apr 15; 753:51-65. PMID: 25460020; PMCID: PMC4423538.
  8. Onajole OK, Eaton JB, Lukas RJ, Brunner D, Thiede L, Caldarone BJ, Kozikowski AP. Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective a4ß2-nAChR Ligands. ACS Med Chem Lett. 2014 Nov 13; 5(11):1196-201. PMID: 25408831; PMCID: PMC4233362.
  9. Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP. Recent developments in novel antidepressants targeting a4ß2-nicotinic acetylcholine receptors. J Med Chem. 2014 Oct 23; 57(20):8204-23. PMID: 24901260; PMCID: PMC4207546.
  10. Stratinaki M, Varidaki A, Mitsi V, Ghose S, Magida J, Dias C, Russo SJ, Vialou V, Caldarone BJ, Tamminga CA, Nestler EJ, Zachariou V. Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8254-9. PMID: 23630294; PMCID: PMC3657820.
  11. Zhang H, Tückmantel W, Eaton JB, Yuen PW, Yu LF, Bajjuri KM, Fedolak A, Wang D, Ghavami A, Caldarone B, Paterson NE, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Chemistry and behavioral studies identify chiral cyclopropanes as selective a4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. J Med Chem. 2012 Jan 26; 55(2):717-24. PMID: 22171543; PMCID: PMC3292870.
  12. Yu LF, Tückmantel W, Eaton JB, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Identification of novel a4ß2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. J Med Chem. 2012 Jan 26; 55(2):812-23. PMID: 22148173; PMCID: PMC3272775.
  13. Liu J, Yu LF, Eaton JB, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D, Ghavami A, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Discovery of isoxazole analogues of sazetidine-A as selective a4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem. 2011 Oct 27; 54(20):7280-8. PMID: 21905669; PMCID: PMC3197876.
  14. Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B. Identification of a glycogen synthase kinase-3ß inhibitor that attenuates hyperactivity in CLOCK mutant mice. ChemMedChem. 2011 Sep 05; 6(9):1593-602. PMID: 21732538; PMCID: PMC3428230.
  15. Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl). 2011 Sep; 217(2):199-210. PMID: 21487659; PMCID: PMC3266849.
  16. Liu J, Eaton JB, Caldarone B, Lukas RJ, Kozikowski AP. Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as a4ß2-nicotinic acetylcholine receptor-selective partial agonists. J Med Chem. 2010 Oct 14; 53(19):6973-85. PMID: 20822184; PMCID: PMC2957884.
  17. Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. J Pharmacol Exp Ther. 2010 Dec; 335(3):762-70. PMID: 20864506; PMCID: PMC2993553.
  18. Paterson NE, Min W, Hackett A, Lowe D, Hanania T, Caldarone B, Ghavami A. The high-affinity nAChR partial agonists varenicline and sazetidine-A exhibit reinforcing properties in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 01; 34(8):1455-64. PMID: 20708056.
    View in: PubMed
  19. Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B. Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol Biochem Behav. 2010 Jun; 95(4):449-56. PMID: 20346966; PMCID: PMC2880855.
  20. Kozikowski AP, Eaton JB, Bajjuri KM, Chellappan SK, Chen Y, Karadi S, He R, Caldarone B, Manzano M, Yuen PW, Lukas RJ. Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. ChemMedChem. 2009 Aug; 4(8):1279-91. PMID: 19569163; PMCID: PMC2955514.
  21. Cho SJ, Jensen NH, Kurome T, Kadari S, Manzano ML, Malberg JE, Caldarone B, Roth BL, Kozikowski AP. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. J Med Chem. 2009 Apr 09; 52(7):1885-902. PMID: 19284718; PMCID: PMC2832311.
  22. Traynor JR, Terzi D, Caldarone BJ, Zachariou V. RGS9-2: probing an intracellular modulator of behavior as a drug target. Trends Pharmacol Sci. 2009 Mar; 30(3):105-11. PMID: 19211160; PMCID: PMC3394094.
  23. Caldarone BJ, King SL, Picciotto MR. Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice. Neurosci Lett. 2008 Jul 11; 439(2):187-91. PMID: 18524488; PMCID: PMC2491450.
  24. Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. J Am Chem Soc. 2007 Jul 04; 129(26):8328-32. PMID: 17552518.
    View in: PubMed
  25. Lynch WJ, Kiraly DD, Caldarone BJ, Picciotto MR, Taylor JR. Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats. Psychopharmacology (Berl). 2007 Apr; 191(2):263-71. PMID: 17180335.
    View in: PubMed
  26. Rabenstein RL, Caldarone BJ, Picciotto MR. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec; 189(3):395-401. PMID: 17016705.
    View in: PubMed
  27. Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron. 2006 Sep 07; 51(5):587-600. PMID: 16950157.
    View in: PubMed
  28. Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR. Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein. J Neurosci. 2005 Feb 23; 25(8):2138-45. PMID: 15728854; PMCID: PMC1352335.
  29. Harrist A, Beech RD, King SL, Zanardi A, Cleary MA, Caldarone BJ, Eisch A, Zoli M, Picciotto MR. Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor. Synapse. 2004 Dec 15; 54(4):200-6. PMID: 15472930.
    View in: PubMed
  30. Caldarone BJ, Harrist A, Cleary MA, Beech RD, King SL, Picciotto MR. High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biol Psychiatry. 2004 Nov 01; 56(9):657-64. PMID: 15522249.
    View in: PubMed
  31. Desai RA, Maciejewski PK, Dausey DJ, Caldarone BJ, Potenza MN. Health correlates of recreational gambling in older adults. Am J Psychiatry. 2004 Sep; 161(9):1672-9. PMID: 15337659.
    View in: PubMed
  32. King SL, Caldarone BJ, Picciotto MR. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology. 2004; 47 Suppl 1:132-9. PMID: 15464132.
    View in: PubMed
  33. Mongeluzi DL, Rosellini RA, Ley R, Caldarone BJ, Stock HS. The conditioning of dyspneic suffocation fear. Effects of carbon dioxide concentration on behavioral freezing and analgesia. Behav Modif. 2003 Oct; 27(5):620-36. PMID: 14531158.
    View in: PubMed
  34. Caldarone BJ, Karthigeyan K, Harrist A, Hunsberger JG, Wittmack E, King SL, Jatlow P, Picciotto MR. Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice. Psychopharmacology (Berl). 2003 Oct; 170(1):94-101. PMID: 12879206.
    View in: PubMed
  35. King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR. Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. J Neurosci. 2003 May 01; 23(9):3837-43. PMID: 12736354.
    View in: PubMed
  36. Picciotto MR, Brunzell DH, Caldarone BJ. Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport. 2002 Jul 02; 13(9):1097-106. PMID: 12151749.
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  37. Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O, De Camilli P. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron. 2002 Feb 28; 33(5):789-804. PMID: 11879655.
    View in: PubMed
  38. Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther. 2001 Nov-Dec; 92(2-3):89-108. PMID: 11916531.
    View in: PubMed
  39. Zachariou V, Caldarone BJ, Weathers-Lowin A, George TP, Elsworth JD, Roth RH, Changeux JP, Picciotto MR. Nicotine receptor inactivation decreases sensitivity to cocaine. Neuropsychopharmacology. 2001 May; 24(5):576-89. PMID: 11282258.
    View in: PubMed
  40. Stock HS, Caldarone B, Abrahamsen G, Mongeluzi D, Wilson MA, Rosellini RA. Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia. Physiol Behav. 2001 Feb; 72(3):439-47. PMID: 11274689.
    View in: PubMed
  41. Caldarone BJ, Duman CH, Picciotto MR. Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology. 2000 Oct; 39(13):2779-84. PMID: 11044747.
    View in: PubMed
  42. Caldarone BJ, George TP, Zachariou V, Picciotto MR. Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacol Biochem Behav. 2000 Aug; 66(4):811-7. PMID: 10973520.
    View in: PubMed
  43. Bolivar VJ, Caldarone BJ, Reilly AA, Flaherty L. Habituation of activity in an open field: A survey of inbred strains and F1 hybrids. Behav Genet. 2000 Jul; 30(4):285-93. PMID: 11206083.
    View in: PubMed
  44. Picciotto MR, Caldarone BJ, King SL, Zachariou V. Nicotinic receptors in the brain. Links between molecular biology and behavior. Neuropsychopharmacology. 2000 May; 22(5):451-65. PMID: 10731620.
    View in: PubMed
  45. Caldarone B, Saavedra C, Tartaglia K, Wehner JM, Dudek BC, Flaherty L. Quantitative trait loci analysis affecting contextual conditioning in mice. Nat Genet. 1997 Nov; 17(3):335-7. PMID: 9354801.
    View in: PubMed
  46. Caldarone BJ, Abrahamsen GC, Stock HS, Mongeluzi DL, Rossellini RA. Enhancement of morphine analgesia in rats following removal from contextual conditioned fear cues. Prog Neuropsychopharmacol Biol Psychiatry. 1997 Aug; 21(6):981-95. PMID: 9380793.
    View in: PubMed
  47. Mongeluzi DL, Rosellini RA, Caldarone BJ, Stock HS, Abrahamsen GC. Pavlovian aversive context conditioning using carbon dioxide as the unconditional stimulus. J Exp Psychol Anim Behav Process. 1996 Jul; 22(3):244-57. PMID: 8691156.
    View in: PubMed
  48. Abrahamsen GC, Caldarone BJ, Stock HS, Schutz AD, Rosellini RA. Conditioned fear exacerbates acute morphine dependence. Pharmacol Biochem Behav. 1995 Jun-Jul; 51(2-3):407-13. PMID: 7667361.
    View in: PubMed
  49. Rosellini RA, Abrahamsen GC, Stock HS, Caldarone BJ. Modulation of hypoalgesia by morphine and number of shock trials: covariation of a measure of context fear and hypoalgesia. Physiol Behav. 1994 Jul; 56(1):183-8. PMID: 8084899.
    View in: PubMed
  50. Abrahamsen GC, Stock HS, Caldarone BJ, Rosellini RA. Learned helplessness inducing foot shock can exacerbate morphine responsiveness. Physiol Behav. 1993 Aug; 54(2):289-94. PMID: 8372123.
    View in: PubMed
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