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Last Name

profileMiriam Moscovitch-Lopatin, Ph.D.

TitleInstructor in Neurology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
MIND, Room 2350
114 16th Street
Charlestown MA 02129
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  1. Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Jan; 14(1):39-47. PMID: 25467848.
    View in: PubMed
  2. Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM. HTRF analysis of soluble huntingtin in PHAROS PBMCs. Neurology. 2013 Sep 24; 81(13):1134-40. PMID: 23966247; PMCID: PMC3795598.
  3. Moscovitch-Lopatin M, Weiss A, Rosas HD, Ritch J, Doros G, Kegel KB, Difiglia M, Kuhn R, Bilbe G, Paganetti P, Hersch S. Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease. PLoS Curr. 2010 Dec 29; 2:RRN1205. PMID: 21278900; PMCID: PMC3015780.
  4. Weiss A, Grueninger S, Abramowski D, Giorgio FP, Lopatin MM, Rosas HD, Hersch S, Paganetti P. Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count. Anal Biochem. 2011 Mar 15; 410(2):304-6. PMID: 21134349.
    View in: PubMed
  5. Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB. IL-2 knockout recipient mice reject islet cell allografts. J Immunol. 1995 Jul 01; 155(1):489-98. PMID: 7602120.
    View in: PubMed
  6. Stevens C, Lipman M, Fabry S, Moscovitch-Lopatin M, Almawi W, Keresztes S, Peppercorn MA, Strom TB. 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. J Pharmacol Exp Ther. 1995 Jan; 272(1):399-406. PMID: 7815356.
    View in: PubMed
  7. Díaz-Gallo C, Moscovitch-Lopatin M, Strom TB, Kelley VR. An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8656-60. PMID: 1528876; PMCID: PMC49979.
  8. Moscovitch-Lopatin M, Petrillo RJ, Pankewycz OG, Hadro E, Bleackley CR, Strom TB, Wieder KJ. Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo. Eur J Immunol. 1991 Jun; 21(6):1439-44. PMID: 1646113.
    View in: PubMed
  9. Walz G, Zanker B, Wieder K, Hadro E, Moscovitch-Lopatin M, Smith BR, Strom TB. Similar effects of cyclosporine and verapamil on lymphokine, interleukin 2 receptor, and proto-oncogene expression. Transplantation. 1989 Feb; 47(2):331-4. PMID: 2645720.
    View in: PubMed
  10. Melton LB, Lakkis F, Moscovitch-Lopatin M, Smith BR, Williams JM, Rosoff PM, Strom TB. Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells. Clin Immunol Immunopathol. 1989 Feb; 50(2):171-83. PMID: 2521583.
    View in: PubMed
  11. Zanker B, Walz G, Wieder KJ, Moscovitch-Lopatin M, Smith BR, Strom TB. Verapamil selectively inhibits expression of interleukin-2 messenger RNA in mitogen activated mononuclear blood cells. Transplant Proc. 1989 Feb; 21(1 Pt 1):85-7. PMID: 2784906.
    View in: PubMed
  12. Moscovitch M, Grossman Z, Rosen D, Berke G. Maturation of cytolytic T lymphocytes. Cell Immunol. 1986 Oct 01; 102(1):52-67. PMID: 3492278.
    View in: PubMed
  13. Kaufmann Y, Moscovitch M, Robb RJ, Rosenberg SA, Berke G. Antigen/mitogen induced cytolytic activity and IL-2 secretion in memory-like CTL-hybridomas. Adv Exp Med Biol. 1985; 184:535-50. PMID: 3929574.
    View in: PubMed
  14. Moscovitch M, Kaufmann Y, Berke G. Memory CTL-hybridoma: a model system to analyze the anamnestic response of cytolytic T lymphocytes. J Immunol. 1984 Nov; 133(5):2369-74. PMID: 6332847.
    View in: PubMed
  15. Moscovitch M, Slavin S. Anti-tumor effects of allogeneic bone marrow transplantation in (NZB X NZW)F1 hybrids with spontaneous lymphosarcoma. J Immunol. 1984 Feb; 132(2):997-1000. PMID: 6361137.
    View in: PubMed
  16. Berke G, Rosen D, Moscovitch M. T lymphocyte-mediated cytolysis. III. Delineation of mechanisms whereby mitogenic and non-mitogenic lectins mediate lymphocyte-target interaction. Immunology. 1983 Aug; 49(4):585-92. PMID: 6603417; PMCID: PMC1454315.
  17. Moscovitch M, Slavin S. Regulation of the immune response in experimental models of autoimmune disorders. II. Induction of suppressor cells of the mixed lymphocyte culture in adult (NZB x NZW)F1 mice using total lymphoid irradiation. J Clin Lab Immunol. 1983 Jun; 11(2):67-74. PMID: 6224019.
    View in: PubMed
  18. Moscovitch M, Slavin S. Regulation of the immune response in experimental models of autoimmune disorders: I. Immunocompetence and transplantation tolerance in female (NZB X NZW)F1 hybrid mice immunosuppressed with total lymphoid irradiation and in reconstituted bone marrow chimeras. J Clin Lab Immunol. 1983 Apr; 10(4):185-91. PMID: 6345783.
    View in: PubMed
  19. Zan-Bar I, Barzilay M, Moscovitch M, Slavin S. Regulation of the immune response in experimental models of autoimmune disorders: resistance of (NZB X NZW)F1 mice to tolerance induction in vivo. Clin Exp Immunol. 1983 Mar; 51(3):558-64. PMID: 6851246; PMCID: PMC1536798.
  20. Moscovitch M, Rosenmann E, Neeman Z, Slavin S. Successful treatment of autoimmune manifestations in MRL/l and MRL/n mice using total lymphoid irradiation (TLI). Exp Mol Pathol. 1983 Feb; 38(1):33-47. PMID: 6339270.
    View in: PubMed
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