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One or more keywords matched the following properties of Daskalakis, Nikolaos
overview Nikolaos P. Daskalakis, MD, PhD, is the director of the Neurogenomics and Translational Bioinformatics Laboratory at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. He is also an affiliate member of the Broad Institute, MIT Computer Science and Artificial Intelligence Laboratory, and the National Center for PTSD. Dr. Daskalakis received his MD from the University of Athens, his PhD in neuropsychopharmacology from Leiden University, and completed post-doctoral research fellowships in clinical neuroendocrinology at Leiden University and in systems biology at the Icahn School of Medicine. Dr. Daskalakis focuses on the interaction between stress and the brain, conducting translational studies and following an integrative systems biology approach. His lab uses transcriptomic and epigenomic profiling of brain and blood samples to identify gene networks associated with vulnerability and resilience to PTSD. Dr. Daskalakis leads the Systems Biology working group of the Psychiatric Genomics Consortium for PTSD. He is an editor for Brain Sciences, Frontiers (in Behavioral Neuroscience, Endocrinology, Neuroscience, and Psychiatry) and Neurobiology of Stress.
One or more keywords matched the following items that are connected to Daskalakis, Nikolaos
Item TypeName
Concept Stress, Psychological
Concept Stress Disorders, Post-Traumatic
Concept Stress, Physiological
Academic Article Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.
Grant Psychiatric Genomics Consortium for PTSD
Academic Article Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation.
Academic Article Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder.
Academic Article New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility.
Academic Article Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder.
Academic Article The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.
Academic Article Animal models in translational studies of PTSD.
Academic Article Recent Genetics and Epigenetics Approaches to PTSD.
Grant Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics
Academic Article Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
Academic Article Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment.
Grant Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital
Academic Article Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.
Academic Article PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools.
Academic Article Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development.
Academic Article Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity.
Academic Article Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory.
Academic Article Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction.
Academic Article Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans.
Academic Article Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors.
Academic Article Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment.
Academic Article Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring.
Academic Article Early maternal influences on stress circuitry: implications for resilience and susceptibility to physical and mental disorders.
Academic Article Elevation of 11ß-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure.
Academic Article The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion.
Academic Article Defeat stress in rodents: From behavior to molecules.
Academic Article Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes.
Academic Article Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example.
Academic Article Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences.
Academic Article Driving Progress in Posttraumatic Stress Disorder Biomarkers.
Academic Article International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
Academic Article Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress.
Academic Article An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Academic Article Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation.
Academic Article PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.
Academic Article Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.
Academic Article Klotho, PTSD, and advanced epigenetic age in cortical tissue.
Academic Article Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes.
Academic Article Cross-platform comparison of highly sensitive immunoassay technologies for cytokine markers: Platform performance in post-traumatic stress disorder and Parkinson's disease.
Academic Article Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents.
Academic Article Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review.
Academic Article Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Academic Article From genetics to systems biology of stress-related mental disorders.
Academic Article Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD.
Search Criteria
  • Stress
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.