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One or more keywords matched the following properties of Kostic, Aleksandar
keywords Microbiome
overview Our research combines computational and experimental expertise to probe the relationship between the human microbiome and type 1 diabetes. We strive to generate a high-level understanding of how the molecular interactions between the immune system and our indigenous microbiome regulate human health. We have worked to characterize the developing infant gut microbiome in dense, longitudinal metagenomic analyses of birth cohorts at risk for type 1 diabetes, including mechanistic evidence by which the human microbiome may directly influence immune development and progression to type 1 diabetes. The ultimate goal of our lab is to develop new methods to diagnose and treat type 1 diabetes by deepening our understanding of the immunomodulatory effects of the diverse constituents of the symbiotic microbiota and their impact on autoimmunity.
One or more keywords matched the following items that are connected to Kostic, Aleksandar
Item TypeName
Academic Article Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.
Concept Metagenome
Academic Article Exploring host-microbiota interactions in animal models and humans.
Academic Article The treatment-naive microbiome in new-onset Crohn's disease.
Academic Article The microbiome in inflammatory bowel disease: current status and the future ahead.
Academic Article Microbes and inflammation in colorectal cancer.
Academic Article Inflammatory bowel disease as a model for translating the microbiome.
Academic Article The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.
Academic Article An integrative view of microbiome-host interactions in inflammatory bowel diseases.
Academic Article Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Academic Article Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.
Academic Article Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Academic Article Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.
Academic Article A Microbiome Foundation for the Study of Crohn's Disease.
Academic Article Gut Microbiota: Small Molecules Modulate Host Cellular Functions.
Academic Article Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
Academic Article Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing.
Academic Article Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.
Academic Article Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.
Academic Article Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences.
Academic Article The Landscape of Genetic Content in the Gut and Oral Human Microbiome.
Academic Article CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content.
Academic Article An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
Academic Article Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators.
Academic Article Reconstruction of ancient microbial genomes from the human gut.
Search Criteria
  • Microbiota
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.