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One or more keywords matched the following properties of Hla, Timothy
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overview Tim Hla's laboratory has been investigating the role of lipid mediators, sphingosine 1-phosphate (S1P) and prostanoids in vascular biology and disease. In the 1990s, we cloned the inducible cyclooxygenase (COX-2) and the first S1P receptor. Our work defined how the COX-2 pathway regulates angiogenesis, cancer and inflammatory disease. Recently, we are examining molecular mechanisms by which prostanoids interact with other lipid signaling systems to protect the vascular system and maintain health. Secondly, since our discovery of the S1P receptor, we have been working on how this novel signaling pathway regulates vascular development, homeostasis and is dysregulated in vascular diseases. In addition, our work contributed to the development of S1P receptor inhibitors, which are being used for the treatment of a number of autoimmune diseases. Recently, we discovered that HDL-bound S1P activates vascular S1P receptors to inhibit vascular injury and disease. We also showed that proteins that bind to S1P, such as the HDL-bound apolipoprotein M (ApoM), direct specific biological functions of S1P by activating S1P receptors in unique ways. This mode of signaling, termed as, chaperone-dependent S1P signaling, may be a general mechanism for lipid mediators that are poorly soluble in water. We are also examining novel mechanisms of S1P metabolism, export into the extracellular environment, capture and signaling by novel chaperones, receptor-dependent signaling mechanisms and cross-talk with other cytokine, growth factor signaling pathways. Such mechanistic information is useful not only to achieve a deeper understanding of vascular health and disease but also to develop new therapeutic entities. In fact, our laboratory is developing novel small molecules as well as protein biotherapeutics to modulate heart disease, stroke, autoimmune diseases, eye disease and cancer.
One or more keywords matched the following items that are connected to Hla, Timothy
Item TypeName
Academic Article Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Academic Article Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.
Academic Article Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration.
Academic Article Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.
Academic Article Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Academic Article Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
Academic Article Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.
Academic Article Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference.
Academic Article S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.
Academic Article Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?
Academic Article Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2.
Academic Article Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.
Academic Article Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.
Academic Article Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors.
Academic Article Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.
Academic Article Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway.
Academic Article S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor.
Academic Article Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
Academic Article Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.
Academic Article Lysophospholipids--receptor revelations.
Academic Article Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells.
Concept Sphingosine
Concept Sphingosine N-Acyltransferase
Academic Article S1P and the birth of platelets.
Academic Article HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.
Academic Article HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Academic Article Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.
Academic Article Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.
Academic Article Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions.
Academic Article Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.
Academic Article Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.
Academic Article Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development.
Academic Article Sphingosine kinases are not required for inflammatory responses in macrophages.
Academic Article Engagement of S1P1-degradative mechanisms leads to vascular leak in mice.
Academic Article Vascular endothelium as a contributor of plasma sphingosine 1-phosphate.
Academic Article Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity.
Academic Article Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.
Academic Article Constitutive expression of the S1P1 receptor in adult tissues.
Academic Article Deafness and stria vascularis defects in S1P2 receptor-null mice.
Academic Article Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.
Academic Article C16:0-ceramide signals insulin resistance.
Academic Article Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.
Academic Article Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.
Academic Article Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.
Academic Article S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity.
Academic Article Immunology. Dietary factors and immunological consequences.
Academic Article Sphingosine 1-phosphate signalling.
Academic Article Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
Academic Article Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.
Academic Article Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
Academic Article Sphingosine kinases are not required for inflammatory responses in macrophages.
Academic Article Sphingosine-1-phosphate signaling in endothelial activation.
Academic Article Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model.
Academic Article A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC).
Academic Article Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.
Academic Article Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.
Academic Article Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.
Academic Article Sphingolipid modulation of angiogenic factor expression in neuroblastoma.
Academic Article Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.
Academic Article TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Academic Article Point-counterpoint of sphingosine 1-phosphate metabolism.
Academic Article Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Academic Article Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-?B ligand (RANKL) expression in rheumatoid arthritis.
Academic Article Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells.
Academic Article Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.
Academic Article Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice.
Academic Article Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation.
Academic Article Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.
Academic Article FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.
Academic Article The vascular S1P gradient-cellular sources and biological significance.
Academic Article Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
Academic Article FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
Academic Article S1P control of endothelial integrity.
Academic Article An update on the biology of sphingosine 1-phosphate receptors.
Academic Article Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.
Academic Article Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis.
Academic Article Physiological and pathological actions of sphingosine 1-phosphate.
Academic Article Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Academic Article Signaling and biological actions of sphingosine 1-phosphate.
Academic Article The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.
Academic Article Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome.
Academic Article Cell biology. The ABCs of lipophile transport.
Academic Article Inhibition of gene expression in vivo using multiplex siRNA.
Academic Article Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis.
Academic Article Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.
Academic Article Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.
Academic Article S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
Academic Article Sphingosine 1-phosphate in coagulation and inflammation.
Academic Article HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver.
Academic Article Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.
Academic Article Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell.
Academic Article Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Academic Article Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.
Academic Article S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.
Grant Mechanisms of sphingolipid signaling in vascular health and disease
Academic Article Correction: TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Academic Article An engineered S1P chaperone attenuates hypertension and ischemic injury.
Academic Article The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis.
Academic Article Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Academic Article Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury.
Academic Article Bioactive lysolipids in cancer and angiogenesis.
Academic Article Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation.
Academic Article CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.
Academic Article Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells.
Academic Article Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Academic Article Sphingosine 1-phosphate and inflammation.
Academic Article Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes.
Academic Article Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.
Academic Article Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation.
Academic Article Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.
Academic Article Sphingosine 1-phosphate: Lipid signaling in pathology and therapy.
Academic Article Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest.
Academic Article Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy.
Academic Article Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization.
Academic Article Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
Academic Article Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
Academic Article Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival.
Academic Article Sphingosine 1-phosphate receptors.
Academic Article Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors.
Academic Article Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins.
Academic Article Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
Academic Article Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.
Academic Article Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells.
Academic Article Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.
Academic Article Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.
Academic Article Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.
Academic Article Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
Search Criteria
  • Sphingosine
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.