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overview I am an Assistant Professor of Medicine at the HMS and an associate physiologist at the Division of Sleep and Circadian Disorders (DSCD), BWH. I also serve as the Research Director of the Medical Biodynamics Program, a cross-disciplinary research and training program whose major goal is to promote translational research in sleep medicine and facilitate interdisciplinary collaborations. Research Interests: My research interests span multidisciplinary areas in sleep/circadian physiology and aging. The goal of my work is to promote health and well-being by designing new tools to understand and predict disease progression, monitor health status, guide health lifestyle, and evaluate interventions or treatments of diseases. Since my PhD, I have been fascinated by how complex patterns in spontaneous fluctuations of physiological output can be linked to innate physiological or bodily functions such as autonomic function and circadian system, and associated with health outcomes. I have developed and applied many nonlinear algorithms for harnessing changes in physiological signals that are better connected to adverse outcomes than traditional analytical approaches. My study has also demonstrated that various circadian function degradations predict the risk of Alzheimer’s dementia years ahead of cognitive symptoms occur and progress in parallel with cognitive decline. I am keen to apply my expertise to promote a proactive strategy for early detection of individuals with elevated risk of cognitive symptoms or brain pathology, to achieve healthy aging especially healthy cognitive aging, which means even more in vulnerable populations such as people living with HIV infection (PLWH). Society Memberships: IEEE Engineering in Medicine and Biology Society Sleep Research Society American Academy of Sleep Medicine American Heart Association The Alzheimer's Association International Society to Advance Alzheimer Research and Treatment (ISTAART) Society for Neuroscience Mentor: Kun Hu, Ph.D., 2016-present (Primary) Monty A. Montano, Ph.D., 2020-present (Co-mentor on HIV and Aging) Ingrid T. Katz, MD, 2020-present (Co-mentor on clinical management of PLWH) Trainees: Research Assistants (*indicates a trainee for whom I was/am a co-mentor) *Chelsea Hu, B.S., 2017-2019 *Longchang Cui, B.S., 2019-2020 *Arlen Gaba, B.S., 2019-present *Ma Cherrysse Ulsa, B.S., 2020-present Xi Zheng, M.S., 2020-present Postdoctoral Fellows Chenlu Gao, Ph.D., 2021-present
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  • Neurobehavioral Manifestations
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.