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One or more keywords matched the following items that are connected to Cole, Philip
Item TypeName
Academic Article HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
Academic Article Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Academic Article Transcriptional coactivator protein p300. Kinetic characterization of its histone acetyltransferase activity.
Academic Article p300/CBP-associated factor histone acetyltransferase processing of a peptide substrate. Kinetic analysis of the catalytic mechanism.
Concept Histone Acetyltransferases
Academic Article Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.
Academic Article Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators.
Academic Article Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.
Academic Article Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor.
Academic Article Regulation of the p300 HAT domain via a novel activation loop.
Academic Article Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
Academic Article The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
Academic Article TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.
Academic Article Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
Academic Article Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
Academic Article Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.
Academic Article Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300.
Academic Article Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis.
Academic Article Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300.
Academic Article p300/CBP-associated factor drives DEK into interchromatin granule clusters.
Academic Article Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs.
Academic Article Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
Academic Article Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer.
Academic Article Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.
Academic Article Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues.
Academic Article Selective HAT inhibitors as mechanistic tools for protein acetylation.
Academic Article Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Academic Article Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase.
Academic Article Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation.
Academic Article Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms.
Academic Article Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Academic Article Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells.
Academic Article Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function.
Academic Article Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Academic Article Regulation of Myf5 Early Enhancer by Histone Acetyltransferase p300 during Stem Cell Differentiation.
Grant Histone Modification Mechanisms and Inhibition
Academic Article The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.
Academic Article Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.
Academic Article MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.
Academic Article Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.
Grant FASEB SRC on Reversible Acetylation in Health and Disease
Search Criteria
  • Histone Acetyltransferases
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.