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New roles for the major human 3'-5' exonuclease TREX1 in human disease.
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.
Neuropathology and genetics of cerebroretinal vasculopathies.
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia.