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overview Robert Farese, Jr., is Chair and Professor of the Department of Molecular Metabolism at the Harvard School of Public Health and Professor of Cell Biology at Harvard Medical School, where he has run a laboratory jointly with Dr. Tobias Walther since 2014. Dr. Farese earned a B.S. in chemistry at the University of Florida and an M.D. at Vanderbilt University School of Medicine. He trained in medicine at the University of Colorado School of Medicine, and completed a research fellowship in Endocrinology and Metabolism at the University of California, San Francisco and the Gladstone Institutes. Dr. Farese serves on the board of the Bluefield Project to Cure Frontotemporal Dementia (FTD). He has received numerous honors, including election to the American Society for Clinical Investigation and the Association of American Physicians, the Bristol-Myers Squibb “Freedom to Discover Award”, and the Avanti Award in Lipids. Research The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology. Dr. Farese has made important contributions to our understanding of lipid metabolism. His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. Excessive accumulation of TGs underlies obesity, diabetes, fatty liver, and other metabolic diseases. Since 2007, Dr. Farese’s laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD).
preferred title Professor of Molecular Metabolism
One or more keywords matched the following items that are connected to Farese, Robert
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Academic Article Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.
Academic Article SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Academic Article Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
Academic Article Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein.
Academic Article A guide to analysis of mouse energy metabolism.
Academic Article Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
Academic Article Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Academic Article SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Academic Article DGAT1 mutation is linked to a congenital diarrheal disorder.
Academic Article Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Academic Article Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.
Concept Immunohistochemistry
Concept Carcinoma, Small Cell
Concept Environment
Concept Genes, Insect
Concept Diet
Concept Inclusion Bodies
Concept Sirtuin 3
Concept Silver Staining
Concept Pituitary Gland
Concept Aorta, Thoracic
Concept In Situ Hybridization
Concept Receptors, Retinoic Acid
Concept Diarrhea, Infantile
Concept Caloric Restriction
Concept Thalamus
Concept Encephalitis
Concept Toxoplasma
Concept Type C Phospholipases
Concept Nuclear Receptor Subfamily 1, Group F, Member 1
Concept Cell Differentiation
Concept Fructose
Concept Fasting
Concept Cholesterol, LDL
Concept Cytomegalovirus Infections
Concept Serine Proteases
Concept Single-Cell Analysis
Concept Epidermis
Concept Lipid Metabolism
Concept Microsomes
Concept Proteomics
Concept Yolk Sac
Concept Cell Line
Concept Adenosine Triphosphatases
Concept Base Sequence
Concept Chemokines
Concept MAP Kinase Kinase 3
Concept 3T3 Cells
Concept Thrombin
Concept Cholesterol Esters
Concept Heart Failure
Concept Retinoids
Concept Frontotemporal Dementia
Concept Genetic Predisposition to Disease
Concept Chylomicrons
Concept Palmitic Acid
Concept Cell Adhesion
Concept Mitogen-Activated Protein Kinase Kinases
Concept Golgi Apparatus
Concept Organelles
Concept Brain Chemistry
Concept Adiponectin
Concept Intestinal Absorption
Concept Tumor Cells, Cultured
Concept Chemotaxis, Leukocyte
Concept HEK293 Cells
Concept Adipose Tissue, Brown
Concept Energy Metabolism
Concept Chromatography, Gel
Concept 3-Hydroxybutyric Acid
Concept Mastadenovirus
Concept Coronary Artery Disease
Concept Alzheimer Disease
Concept Phagocytosis
Concept Complement C3b
Concept Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Concept K562 Cells
Concept Amyloid Precursor Protein Secretases
Concept Carcinoma, Hepatocellular
Concept Th1 Cells
Concept Adipocytes, Brown
Concept 3T3-L1 Cells
Concept Phospholipases A1
Concept Sirtuin 2
Concept Genes, Dominant
Concept Turkey
Concept Tretinoin
Concept GTP-Binding Proteins
Concept Genomics
Concept Fatty Acids, Unsaturated
Concept Adipogenesis
Concept Trans Fatty Acids
Concept Aorta
Concept GTP Phosphohydrolases
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Concept Antibodies, Monoclonal
Concept Cell Membrane
Concept Osteoprotegerin
Concept Cytoplasmic Granules
Concept Lipogenesis
Concept ATP-Binding Cassette Transporters
Concept Lithium Chloride
Concept Weight Loss
Concept Gene Knock-In Techniques
Concept Esters
Concept Membrane Fusion
Concept Mice, 129 Strain
Concept Endosomes
Concept Metabolomics
Concept Response Elements
Concept Antioxidants
Concept Fatty Acids
Concept Bucladesine
Concept Mycobacterium bovis
Concept Electroretinography
Concept Receptors, CCR5
Concept Puromycin
Concept Fatty Acids, Monounsaturated
Concept Calcium
Concept Cytidine Deaminase
Concept Angiopoietins
Concept Phospholipases A
Concept Fetal Death
Concept Diet, Atherogenic
Concept Chemotaxis
Concept CHO Cells
Concept Blotting, Western
Concept Interleukin-4
Concept Cycloheximide
Concept Farnesyl-Diphosphate Farnesyltransferase
Concept Sirtuins
Concept Genes, Essential
Concept Receptors, Glucocorticoid
Concept Adenoviridae
Concept Sterols
Concept Lithium
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Concept Lysosomes
Concept NIH 3T3 Cells
Concept Genetic Testing
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Concept Corpus Luteum
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Receptors, Lysophosphatidic Acid
Concept Genetic Complementation Test
Concept Hypothalamus
Concept Syndrome
Concept Vitamin E
Concept Palmitates
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Concept Disease Susceptibility
Concept Sterol Regulatory Element Binding Protein 1
Concept Dendritic Cells
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Trans-Activators
Concept Adenosine Triphosphate
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Concept Lipase
Concept Integrin beta Chains
Concept Lipoprotein Lipase
Concept Acyl Coenzyme A
Concept Baculoviridae
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Concept ran GTP-Binding Protein
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Concept Granulosa Cells
Concept Hypothalamo-Hypophyseal System
Concept Wnt Proteins
Concept Enterocytes
Concept Leptin
Concept Corticosterone
Concept 3' Untranslated Regions
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Concept Sterol Esterase
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Concept Complement C1q
Concept Sequence Homology, Amino Acid
Concept N-Acetylglucosaminyltransferases
Concept PPAR gamma
Concept Embryonic Induction
Concept Thermogenesis
Concept Image Processing, Computer-Assisted
Concept Hydroxamic Acids
Concept ADP-Ribosylation Factor 1
Concept Hep G2 Cells
Concept Orphan Nuclear Receptors
Concept Genes, Reporter
Concept Eye Infections, Viral
Concept Fatal Outcome
Concept Synapses
Concept Lipid Metabolism, Inborn Errors
Concept Phospholipases
Concept Body Mass Index
Concept Cytokines
Concept Enzyme-Linked Immunosorbent Assay
Concept Apolipoprotein B-48
Concept Age Factors
Concept Disease Models, Animal
Concept Dexamethasone
Concept Apoptosis
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Concept Temperature
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Concept Body Temperature Regulation
Concept Transforming Growth Factor beta
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Concept RNA, Small Interfering
Concept NF-kappa B
Concept Mycobacterium tuberculosis
Concept Myelin Sheath
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Concept Receptors, Progesterone
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Concept Myostatin
Concept Oleic Acid
Concept Fats
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Concept Alleles
Concept Cyclic AMP
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Concept rab GTP-Binding Proteins
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Concept Agouti Signaling Protein
Concept Cholesterol, Dietary
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Concept Vitamin A
Concept Receptors, Chemokine
Concept MAP Kinase Signaling System
Concept Hepacivirus
Concept Down-Regulation
Concept Cattle
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Concept Frontotemporal Lobar Degeneration
Concept Hyperlipoproteinemia Type II
Concept Receptors, Steroid
Concept History, 20th Century
Concept Apolipoprotein A-I
Concept Amygdala
Concept Carbachol
Concept Lymphocytes
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Concept Cell Death
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Concept Mitochondria
Concept alpha-Tocopherol
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Concept Parkinson Disease
Concept Cholesterol
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Concept Receptor, Insulin
Concept Phosphates
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Concept Magnesium Chloride
Concept Esterification
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Concept Liver Neoplasms
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Concept Foscarnet
Concept Apolipoprotein B-100
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Concept Deoxyribonucleases, Type II Site-Specific
Concept Epistasis, Genetic
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Concept ADP-Ribosylation Factors
Concept Phospholipase D
Concept Drosophila melanogaster
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Concept Hedgehog Proteins
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Concept RANK Ligand
Concept Intestine, Small
Academic Article Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Academic Article A conserved role for atlastin GTPases in regulating lipid droplet size.
Academic Article Licorice-induced hypermineralocorticoidism.
Academic Article Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans.
Academic Article Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Academic Article Limited stage small cell lung cancer: analysis of clinical prognostic factors.
Academic Article Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.
Academic Article Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.
Academic Article DGAT and triglyceride synthesis: a new target for obesity treatment?
Academic Article A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
Academic Article A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice.
Academic Article The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.
Academic Article Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.
Academic Article Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Academic Article MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
Academic Article Cholesterol metabolism and embryogenesis.
Academic Article The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase.
Academic Article Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
Academic Article Apolipoprotein B gene mutations affecting cholesterol levels.
Academic Article The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development.
Academic Article Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.
Academic Article DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.
Academic Article Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway.
Academic Article Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
Academic Article Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.
Academic Article Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.
Academic Article Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.
Academic Article Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.
Academic Article Determination of adipocyte size by computer image analysis.
Academic Article Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Academic Article Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.
Academic Article Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.
Academic Article Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis.
Academic Article Acyl CoA:cholesterol acyltransferase genes and knockout mice.
Academic Article Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.
Academic Article Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.
Academic Article Turning WAT into BAT gets rid of fat.
Academic Article Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.
Academic Article Mammalian acyl-CoA:cholesterol acyltransferases.
Academic Article Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.
Academic Article Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.
Academic Article Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
Academic Article The enzymes of neutral lipid synthesis.
Academic Article Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
Academic Article Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.
Academic Article The life of lipid droplets.
Academic Article A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.
Academic Article Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.
Academic Article Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Academic Article Lipopenia and skin barrier abnormalities in DGAT2-deficient mice.
Academic Article Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Academic Article Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.
Academic Article Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
Academic Article Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
Academic Article Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
Academic Article Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia.
Academic Article Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
Academic Article Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Academic Article ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
Academic Article The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).
Academic Article Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
Academic Article Cellular fatty acid metabolism and cancer.
Academic Article Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
Academic Article Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.
Academic Article The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.
Academic Article Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.
Academic Article Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.
Academic Article A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.
Academic Article Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation.
Academic Article DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
Academic Article Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.
Academic Article LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).
Academic Article Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Academic Article Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.
Academic Article Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48.
Academic Article Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
Academic Article ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.
Academic Article Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.
Academic Article Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
Academic Article Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
Academic Article Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.
Academic Article The nine lives of ACAT inhibitors.
Academic Article Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
Academic Article Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.
Academic Article ACAT inhibition and the progression of coronary atherosclerosis.
Academic Article Lipid droplets finally get a little R-E-S-P-E-C-T.
Academic Article Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
Academic Article Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Academic Article Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.
Academic Article Lipid droplets at a glance.
Academic Article The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
Academic Article The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface.
Academic Article Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.
Academic Article Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.
Academic Article Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages.
Academic Article Cholesterol homeostasis: a role for oxysterols.
Academic Article Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
Academic Article DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
Academic Article MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.
Academic Article The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.
Academic Article SnapShot: Lipid Droplets.
Academic Article Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
Academic Article Balancing the fat: lipid droplets and human disease.
Academic Article Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Academic Article Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
Academic Article A new way to look at fat.
Academic Article Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity.
Academic Article The biophysics and cell biology of lipid droplets.
Academic Article DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.
Academic Article Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
Academic Article Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
Academic Article Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
Academic Article Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
Academic Article A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Academic Article Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Academic Article Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.
Academic Article Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
Academic Article Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
Academic Article Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
Academic Article Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
Academic Article Progranulin: at the interface of neurodegenerative and metabolic diseases.
Academic Article Protein correlation profiles identify lipid droplet proteins with high confidence.
Academic Article Lipid droplets and cellular lipid metabolism.
Academic Article Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.
Academic Article In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.
Academic Article Lipid droplet biogenesis.
Academic Article Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Academic Article Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models.
Academic Article Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
Academic Article MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.
Academic Article The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.
Academic Article Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.
Academic Article Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
Academic Article Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini.
Academic Article Inhibition of cholesterol side chain cleavage by cyanoketone.
Academic Article Gonadotropin-releasing hormone rapidly alters polyphosphoinositide metabolism in rat granulosa cells.
Academic Article Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.
Academic Article Human chorionic gonadotropin activates the inositol 1,4,5-trisphosphate-Ca2+ intracellular signalling system in bovine luteal cells.
Academic Article Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells.
Academic Article Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone.
Academic Article The GARP complex is required for cellular sphingolipid homeostasis.
Academic Article BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1a in livers of obese and type 2 diabetic humans.
Academic Article Contraction stimulates muscle glucose uptake independent of atypical PKC.
Academic Article Lipid droplets go nuclear.
Academic Article Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.
Academic Article Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.
Academic Article Compensation for PKM? in long-term potentiation and spatial long-term memory in mutant mice.
Academic Article High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.
Academic Article Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.
Academic Article Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.
Academic Article Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1a and Increases in Aß1-40/42 and Phospho-Tau May Abet Alzheimer Development.
Grant The Mechanisms of Lipid Droplet Formation and Regulation
Grant Functional Analysis of MGAT Enzymes
Grant Triglyceride Synthesis and Lipotoxicity
Grant Role of DGAT in Triacyglycerol Metabolism
Grant Enhancing Progranulin Expression - a Therapy for Frontotemporal Dementia
Grant Identification of Genes that Regulate Cellular Lipid Storage
Grant Role of DGAT in Triacyglycerol Metabolism
Grant Activation of Atypical PKC by Insulin and Other Agonists
Grant 2014 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Semina
Grant Physiology of Lipid Droplets and Triglyceride Storage
Grant LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
Grant LIPID REGULATED KINASES IN INSULIN ACTION
Academic Article Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.
Academic Article Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
Academic Article Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity.
Academic Article Seipin is required for converting nascent to mature lipid droplets.
Academic Article Effects of Adenoviral Gene Transfer of Wild-Type, Constitutively Active, and Kinase-Defective Protein Kinase C-? on Insulin-Stimulated Glucose Transport in L6 Myotubes* * This work was supported by funds from the Department of Veterans Affairs Merit Review Program and NIH Research Grant 2R01-DK- 38079-09A1.
Academic Article Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-?/? by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats.
Academic Article Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-?, and Glucose Transport in 3T3/L1 Adipocytes.
Academic Article Evidence for Involvement of Protein Kinase C (PKC)-? and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes.
Academic Article Effects of Knockout of the Protein Kinase C ß Gene on Glucose Transport and Glucose Homeostasis1.
Academic Article Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
Academic Article Lipid droplets and liver disease: from basic biology to clinical implications.
Academic Article Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
Academic Article Lipid Droplet Biogenesis.
Grant Mechanisms of Lipid Droplet Formation
Academic Article Atypical PKC, PKC?/?, activates ß-secretase and increases Aß1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
Academic Article An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.
Academic Article Coordinated regulation of hepatic FoxO1, PGC-1a and SREBP-1c facilitates insulin action and resistance.
Academic Article Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.
Academic Article Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.
Academic Article Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
Academic Article Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.
Academic Article Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Academic Article Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Academic Article Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
Academic Article Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.
Academic Article Atypical PKC: therapeutic target for Alzheimer's?
Academic Article Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Academic Article Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
Academic Article The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
Academic Article Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
Academic Article Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.
Academic Article LDAF1 and Seipin Form a Lipid Droplet Assembly Complex.
Academic Article Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.
Grant Lipid Droplets and Transcriptional Regulation of Metabolism
Academic Article Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Academic Article Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
Grant FASEB's The Lipid Droplets Conference
Academic Article Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
Academic Article Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Academic Article FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
Academic Article A Systematic Protein Turnover Map for Decoding Protein Degradation.
Academic Article Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.
Academic Article The power of two: lessons from a scientific partnership.
Grant Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
Academic Article Conditional targeting of phosphatidylserine decarboxylase to lipid droplets.
Grant Lipotoxic Protective Response of the Endoplasmic Reticulum
Academic Article An open-access volume electron microscopy atlas of whole cells and tissues.
Academic Article The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.