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One or more keywords matched the following properties of Ashrafali, Mohamed Ismail
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overview Our focus is to study the evolution of human adenoviruses associated with epidemic keratoconjunctivitis- a severe eye infection. We employ phylogenetics, recombination detection tools and in silico structural predictions for genetic characterization of novel adenoviruses. To study the differential viral gene regulation, I am mapping transcription factors occupancy across the genome by chromatin Immunoprecipitation and high throughput sequencing (ChIP-Seq). I am also studying adenovirus interactome by Affinity purification and Mass spectrometry methods. Studying viral DNA sensors and immune evasion strategies are my other current interests.
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  • Keratoconjunctivitis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.