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One or more keywords matched the following items that are connected to Cleary, Michael
Item TypeName
Concept Histone-Lysine N-Methyltransferase
Academic Article Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.
Academic Article Epigenetic roles of MLL oncoproteins are dependent on NF-?B.
Academic Article A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.
Academic Article Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.
Academic Article The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.
Academic Article A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Academic Article Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.
Academic Article Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias.
Academic Article Common mechanism for oncogenic activation of MLL by forkhead family proteins.
Academic Article MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.
Academic Article MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice.
Academic Article ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Academic Article Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
Academic Article Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.
Academic Article Menin critically links MLL proteins with LEDGF on cancer-associated target genes.
Academic Article The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.
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  • Histone Lysine N Methyltransferase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.