Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Mignot, Emmanuel
Item TypeName
Academic Article Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.
Academic Article The diurnal rhythm of hypocretin in young and old F344 rats.
Academic Article Relationship between CSF hypocretin levels and hypocretin neuronal loss.
Academic Article The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats.
Academic Article Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy.
Academic Article The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension.
Academic Article APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study.
Academic Article History of the development of sleep medicine in the United States.
Concept Sleep Stages
Concept Sleep Apnea Syndromes
Concept Sleep Apnea, Obstructive
Concept Sleep Deprivation
Concept Sleep
Concept Sleep Paralysis
Concept Sleep, REM
Concept REM Sleep Behavior Disorder
Concept Sleep Initiation and Maintenance Disorders
Concept Sleep Disorders, Circadian Rhythm
Academic Article CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture.
Academic Article Challenges in diagnosing narcolepsy without cataplexy: a consensus statement.
Academic Article The structured diagnostic interview for sleep patterns and disorders: rationale and initial evaluation.
Academic Article Voxel-based morphometry in hypocretin-deficient narcolepsy.
Academic Article Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area.
Academic Article Slow wave sleep disruption increases cerebrospinal fluid amyloid-ß levels.
Academic Article HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.
Academic Article HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.
Academic Article Dual cases of type 1 narcolepsy with schizophrenia and other psychotic disorders.
Academic Article CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?
Academic Article Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.
Academic Article Sodium oxybate is an effective and safe treatment for narcolepsy.
Academic Article The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A).
Academic Article English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary.
Academic Article Knowledge Gaps in the Perioperative Management of Adults With Narcolepsy: A Call for Further Research.
Academic Article Treatment of narcolepsy with natalizumab.
Academic Article COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence.
Academic Article An update on the pharmacotherapy of excessive daytime sleepiness and cataplexy.
Academic Article Modafinil binds to the dopamine uptake carrier site with low affinity.
Academic Article Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults.
Academic Article Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: a study of D- and L-derivatives in canine narcolepsy.
Academic Article DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics.
Academic Article The treatment of sleep disorders.
Academic Article Sleep and EEG features in genetic models of Down syndrome.
Academic Article Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture.
Academic Article Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy.
Academic Article Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children.
Academic Article A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
Academic Article The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients.
Academic Article Narcoleptic canines display periodic leg movements during sleep.
Academic Article Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins.
Academic Article Factors associated with fatigue in patients with insomnia.
Academic Article The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.
Academic Article A year in review--basic science, narcolepsy, and sleep in neurologic diseases.
Academic Article Dopamine D2 mechanisms in canine narcolepsy.
Academic Article Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Academic Article The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study.
Academic Article Genetic studies in the sleep disorder narcolepsy.
Academic Article Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepiness.
Academic Article Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy.
Academic Article Controversies in the diagnosis of narcolepsy.
Academic Article Proteomic biomarkers of sleep apnea.
Academic Article Hypocretin deficiency in Prader-Willi syndrome.
Academic Article Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey.
Academic Article Increased EEG Theta Spectral Power in Sleep in Myotonic Dystrophy Type 1.
Academic Article Letter to the editor regarding our previous publication: "Secondary narcolepsy in children with brain tumors," SLEEP 2002; 25:435-439.
Academic Article Exploring the cytokine and endocrine involvement in narcolepsy.
Academic Article Nocturnal Sleep Dynamics Identify Narcolepsy Type 1.
Academic Article Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.
Academic Article Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity.
Academic Article Drug treatment of patients with insomnia and excessive daytime sleepiness: pharmacokinetic considerations.
Academic Article Automatic detection of cortical arousals in sleep and their contribution to daytime sleepiness.
Academic Article HLA and hypocretin studies in Korean patients with narcolepsy.
Academic Article Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.
Academic Article Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans.
Academic Article Locus coeruleus neurons: cessation of activity during cataplexy.
Academic Article A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
Academic Article Month of birth as a risk factor for narcolepsy.
Academic Article Narcolepsy in African Americans.
Academic Article Thalidomide, immune modulation and narcolepsy.
Academic Article Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans.
Academic Article Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Academic Article Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy.
Academic Article Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives.
Academic Article Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods.
Academic Article Presentations of primary hypersomnia in Chinese children.
Academic Article Genetic studies in narcolepsy, a disorder affecting REM sleep.
Academic Article CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans.
Academic Article Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy.
Academic Article Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.
Academic Article Behavioural and neurophysiological correlates of human cataplexy: a video-polygraphic study.
Academic Article Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.
Academic Article Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring.
Academic Article Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602.
Academic Article Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness.
Academic Article REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.
Academic Article Narcolepsy risk and COVID-19.
Academic Article Stability of cataplexy over several months--information for the design of therapeutic trials.
Academic Article Narcolepsy with cataplexy mimicry: the strange case of two sisters.
Academic Article Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE.
Academic Article Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort.
Academic Article Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.
Academic Article Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome.
Academic Article Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys.
Academic Article Perspectives in narcolepsy research and therapy.
Academic Article Serum prolactin response to a D2 antagonist in narcoleptic and control canines.
Academic Article Towards a Flexible Deep Learning Method for Automatic Detection of Clinically Relevant Multi-Modal Events in the Polysomnogram.
Academic Article Central administration of vitamin B12 aggravates cataplexy in canine narcolepsy.
Academic Article Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort.
Academic Article The hypocretin neurotransmission system in myotonic dystrophy type 1.
Academic Article Familial Kleine-Levin Syndrome: A Specific Entity?
Academic Article Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
Academic Article Deep residual networks for automatic sleep stage classification of raw polysomnographic waveforms.
Academic Article Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts.
Academic Article Kleine-Levin syndrome: a systematic study of 108 patients.
Academic Article Low cerebrospinal fluid hypocretin levels found in familial narcolepsy.
Academic Article Sleep, sleep disorders and hypocretin (orexin).
Academic Article The month-of-birth pattern in narcolepsy is moderated by cataplexy severity and may be independent of HLA-DQB1*0602.
Academic Article Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602.
Academic Article Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.
Academic Article A novel HLA DR17,DQ1 (DQA1-0102/DQB1-0602 positive) haplotype predisposing to narcolepsy in Caucasians.
Academic Article An immunoglobulin switchlike sequence is linked with canine narcolepsy.
Academic Article Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin.
Academic Article CSF hypocretin-1 assessment in sleep and neurological disorders.
Academic Article CSF hypocretin levels are normal in Huntington's disease patients.
Academic Article CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies.
Academic Article Sleep spindle alterations in patients with Parkinson's disease.
Academic Article Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey.
Academic Article Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls.
Academic Article Post-H1N1 narcolepsy-cataplexy.
Academic Article Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.
Academic Article Article reviewed: Plasma orexin-A is lower in patients with narcolepsy.
Academic Article DOSED: A deep learning approach to detect multiple sleep micro-events in EEG signal.
Academic Article TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
Academic Article Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.
Academic Article Hypersomnolence and increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma.
Academic Article Inter-expert and intra-expert reliability in sleep spindle scoring.
Academic Article Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults.
Academic Article A CLOCK polymorphism associated with human diurnal preference.
Academic Article Hypocretin/orexin, sleep and narcolepsy.
Academic Article Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy.
Academic Article On the value of measuring CSF hypocretin-1 in diagnosing narcolepsy.
Academic Article Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected].
Academic Article Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy.
Academic Article Serum cytokine levels in Kleine-Levin syndrome.
Academic Article PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.
Academic Article Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C.
Academic Article Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy.
Academic Article Correlates of serum C-reactive protein (CRP)--no association with sleep duration or sleep disordered breathing.
Academic Article Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants.
Academic Article Association of low ferritin with PLM in the Wisconsin Sleep Cohort.
Academic Article Narcolepsy research: past, present, and future perspectives.
Academic Article Neuropharmacology and neurochemistry of canine narcolepsy.
Academic Article Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension.
Academic Article Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy.
Academic Article DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.
Academic Article History of narcolepsy at Stanford University.
Academic Article Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.
Academic Article The genetics of sleep disorders.
Academic Article Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs.
Academic Article Transient total sleep loss in cerebral Whipple's disease: a longitudinal study.
Academic Article Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease.
Academic Article Body mass index-independent metabolic alterations in narcolepsy with cataplexy.
Academic Article Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine.
Academic Article Effect of the prion 129 polymorphism on nocturnal sleep and insomnia complaints: a population-based study.
Academic Article Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency.
Academic Article High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy.
Academic Article Emerging therapies in narcolepsy-cataplexy.
Academic Article Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy.
Academic Article Validation of a cataplexy questionnaire in 983 sleep-disorders patients.
Academic Article Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog.
Academic Article Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomnia.
Academic Article Association of sleep disordered breathing and cognitive deficit in APOE e4 carriers.
Academic Article Validation of Multiple Sleep Latency Test for the diagnosis of pediatric narcolepsy type 1.
Academic Article Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep.
Academic Article ß2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study.
Academic Article Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Academic Article Resting our cortices by going DOWN to sleep.
Academic Article Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy.
Academic Article Familial aspects of narcolepsy-cataplexy in the Czech Republic.
Academic Article A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness.
Academic Article A circadian sleep disorder reveals a complex clock.
Academic Article DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue.
Academic Article A commentary on the neurobiology of the hypocretin/orexin system.
Academic Article Normal hypocretin-1 (orexin-A) cerebrospinal fluid level in a previously reported case of severe, life-long insomnia with motor hyperactivity.
Academic Article Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep.
Academic Article Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish.
Academic Article The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions.
Academic Article Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release.
Academic Article Effect of liraglutide 3.0?mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial.
Academic Article Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
Academic Article The Burden of Narcolepsy Disease (BOND) study: health-care utilization and cost findings.
Academic Article Excessive daytime sleepiness: population and etiology versus nosology.
Academic Article Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders.
Academic Article Non-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology.
Academic Article A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy.
Academic Article Clinical aspects of narcolepsy-cataplexy across ethnic groups.
Academic Article Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy.
Academic Article The role of hypocretins (orexins) in sleep regulation and narcolepsy.
Academic Article Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
Academic Article Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation.
Academic Article Sympathetic and cardiovascular activity during cataplexy in narcolepsy.
Academic Article Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1.
Academic Article Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study.
Academic Article Physiology. The perfect hypnotic?
Academic Article A link between short sleep and obesity: building the evidence for causation.
Academic Article Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study.
Academic Article Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorder of rapid eye movement sleep.
Academic Article Why we sleep: the temporal organization of recovery.
Academic Article Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds.
Academic Article Genetics of narcolepsy and other sleep disorders.
Academic Article Disrupted nighttime sleep in narcolepsy.
Academic Article HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.
Academic Article Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea.
Academic Article Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.
Academic Article Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status.
Academic Article Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts.
Academic Article Depression: relationships to sleep paralysis and other sleep disturbances in a community sample.
Academic Article Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset.
Academic Article Modafinil and ?-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep.
Grant Center for Narcolepsy and Related Disorders (P50)
Grant Molecular Genetics of Kleine-Levin Syndrome
Grant Sleep Disordered Breathing, APOE and Lipid Metabolism
Grant Role of Hypocretin in Metabolic Effects of Sleep Loss
Grant Sleep promotion in zebrafish by hypocretin neuronal networks
Grant Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders
Academic Article Association of Rapid Eye Movement Sleep With Mortality in Middle-aged and Older Adults.
Academic Article Automatic sleep stage classification with deep residual networks in a mixed-cohort setting.
Academic Article PSG Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device.
Academic Article Predicting Age with Deep Neural Networks from Polysomnograms.
Academic Article Cortical arousal frequency is increased in narcolepsy type 1.
Grant Proteomic and Transcriptomic Biomarkers of Circadian Timing
Academic Article Greatest changes in objective sleep architecture during COVID-19 lockdown in night owls with increased REM sleep.
Academic Article Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency.
Academic Article Arousal Characteristics in Patients with Parkinson's Disease and Isolated Rapid Eye Movement Sleep Behavior Disorder.
Academic Article Acoustic stimulation time-locked to the beginning of sleep apnea events reduces oxygen desaturations: a pilot-study.
Academic Article Genetic risk for subjective reports of insomnia associate only weakly with polygraphic measures of insomnia in 2,770 adults.
Academic Article Disrupted nighttime sleep and sleep instability in narcolepsy.
Academic Article Longitudinal associations of hypersomnolence and depression in the Wisconsin Sleep Cohort Study.
Search Criteria
  • sleep
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.