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One or more keywords matched the following items that are connected to Engen, John
Item TypeName
Academic Article Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.
Academic Article Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Academic Article Allosteric interactions between the myristate- and ATP-site of the Abl kinase.
Concept Spectrometry, Mass, Electrospray Ionization
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Gas Chromatography-Mass Spectrometry
Concept Tandem Mass Spectrometry
Concept Mass Spectrometry
Academic Article Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.
Academic Article Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.
Academic Article Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.
Academic Article Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Academic Article Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe.
Academic Article KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.
Academic Article Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry.
Academic Article Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.
Academic Article Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.
Academic Article Applications of hydrogen/deuterium exchange MS from 2012 to 2014.
Academic Article Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations.
Academic Article Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.
Academic Article Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis.
Academic Article Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data.
Academic Article Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
Academic Article Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements.
Academic Article Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Academic Article Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry.
Academic Article Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi.
Academic Article A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.
Academic Article Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.
Academic Article Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange.
Academic Article Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.
Academic Article GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding.
Academic Article Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry.
Academic Article Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.
Academic Article Protein interactions probed with mass spectrometry.
Academic Article ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements.
Academic Article Escherichia coli processivity clamp ß from DNA polymerase III is dynamic in solution.
Academic Article Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein.
Academic Article Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes.
Academic Article Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry.
Academic Article Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding.
Academic Article Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry.
Academic Article Considerations in the analysis of hydrogen exchange mass spectrometry data.
Academic Article Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
Academic Article What mass spectrometry can reveal about protein function.
Academic Article A conformational investigation of propeptide binding to the integral membrane protein ?-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry.
Academic Article Hydrogen exchange mass spectrometry: are we out of the quicksand?
Academic Article Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
Academic Article Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra.
Academic Article Hydrogen exchange mass spectrometry: what is it and what can it tell us?
Academic Article Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching.
Academic Article Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.
Academic Article An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.
Academic Article Semi-automated data processing of hydrogen exchange mass spectra using HX-Express.
Academic Article Using stable-isotope-labeled proteins for hydrogen exchange studies in complex mixtures.
Academic Article Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry.
Academic Article Investigating the higher order structure of proteins. Hydrogen exchange, proteolytic fragmentation, and mass spectrometry.
Academic Article Hydrogen exchange mass spectrometry for the analysis of protein dynamics.
Academic Article Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation.
Academic Article Abl N-terminal cap stabilization of SH3 domain dynamics.
Academic Article Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry.
Academic Article Analysis of protein complexes with hydrogen exchange and mass spectrometry.
Academic Article Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry.
Academic Article On the solution conformation and dynamics of the HIV-1 viral infectivity factor.
Academic Article Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry.
Academic Article Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.
Academic Article Accessing the reproducibility and specificity of pepsin and other aspartic proteases.
Academic Article Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS.
Academic Article Partial unfolding of diverse SH3 domains on a wide timescale.
Academic Article Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs.
Academic Article Investigating protein structure and dynamics by hydrogen exchange MS.
Academic Article Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip.
Academic Article High-speed and high-resolution UPLC separation at zero degrees Celsius.
Academic Article Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?
Academic Article Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers.
Academic Article Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.
Academic Article Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.
Academic Article Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP.
Academic Article The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.
Academic Article Post-translational modifications differentially affect IgG1 conformation and receptor binding.
Academic Article Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry.
Academic Article Utilizing Microchip Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry.
Academic Article Analytical Aspects of Hydrogen Exchange Mass Spectrometry.
Academic Article Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.
Academic Article Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation.
Academic Article Fetal alcohol exposure alters neurosteroid levels in the developing rat brain.
Academic Article Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.
Academic Article Dynamics of the Tec-family tyrosine kinase SH3 domains.
Academic Article Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.
Academic Article The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies.
Academic Article Replication in bioanalytical studies with HDX MS: aim as high as possible.
Grant Protein conformational change upon membrane association
Grant Structural Dynamics of Src-Family Kinase Activation
Grant Extending the applications of hydrogen exchange mass spectrometry
Grant Conformational Regulation and Therapeutic Targeting of Oncogenic KRAS
Academic Article Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy.
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  • Mass Spectrometry
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.