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One or more keywords matched the following properties of Muehlschlegel, Jochen
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overview Research goals My research centers on the impact of genetic variation upon adverse cardiovascular events, and their significance on a functional level. The patients of my clinical practice of cardiac anesthesia are also my research subjects, as they are a group that is profoundly transcriptionally-upregulated, making examination of genetic variation in transcription more readily apparent. I am an investigator in the CABG Genomics study group created by Drs. Body, Shernan, and Collard in 2001 and also the principal investigator of the TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study, initiated by myself in 2009. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. In TRANSCRIBE, my goals are to identify differential expression in human left ventricular myocardium upon exposure to ischemia, examine genetic variants that determine expression changes, and characterize these changes among different disease states. Clinical Contributions: I am a Cardiac Anesthesiologist in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. With extensive subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, I see myself as a perioperative physician guiding the care of very sick patients with cardiovascular disease. While the spectrum of cardiovascular intervention might be shifting from the more invasive operating room to the less invasive catheter-based technologies, as a perioperative cardiovascular physician I see myself involved in all aspects of the care of these dynamic patients for many years to come.
One or more keywords matched the following items that are connected to Muehlschlegel, Jochen
Item TypeName
Award or Honor Receipt Anesthesiology Fellow of the Year
Academic Article Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery.
Academic Article From creatine kinase-MB to troponin: do we really need to differentiate between myocardial injury and infarction?
Academic Article Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting.
Academic Article Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
Academic Article Acute Pulmonary Hypertension and Right Ventricular Failure
Academic Article Comparison of the utility of preoperative versus postoperative B-type natriuretic peptide for predicting hospital length of stay and mortality after primary coronary artery bypass grafting.
Academic Article If a troponin falls in a forest but no one measures it, does it really matter?
Concept Anesthesiology
Academic Article Increased perioperative b-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery.
Academic Article Noteworthy articles in 2013 for cardiothoracic anesthesiologists.
Academic Article GNAS gene variants affect ß-blocker-related survival after coronary artery bypass grafting.
Academic Article Closing the pore on reperfusion injury: myocardial protection with cyclosporine.
Academic Article Noteworthy articles in 2014 for cardiothoracic anesthesiologists.
Academic Article Using next-generation RNA sequencing to examine ischemic changes induced by cold blood cardioplegia on the human left ventricular myocardium transcriptome.
Academic Article Noteworthy Articles in 2015 for the Cardiothoracic Anesthesiologist.
Academic Article Noteworthy Literature Published in 2016 for the Cardiothoracic Anesthesiologist.
Academic Article Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.
Academic Article Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.
Academic Article Noteworthy Literature Published in 2018 for Cardiothoracic Anesthesiologists.
Award or Honor Receipt Distinguished Chair in Anesthesiology
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  • Anesthesiology
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.