My research centers on the impact of genetic variation upon adverse cardiovascular events, and their significance on a functional level. The patients of my clinical practice of cardiac anesthesia are also my research subjects, as they are a group that is profoundly transcriptionally-upregulated, making examination of genetic variation in transcription more readily apparent. I am an investigator in the CABG Genomics study group created by Drs. Body, Shernan, and Collard in 2001 and also the principal investigator of the TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study, initiated by myself in 2009. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. In TRANSCRIBE, my goals are to identify differential expression in human left ventricular myocardium upon exposure to ischemia, examine genetic variants that determine expression changes, and characterize these changes among different disease states.
I am a Cardiac Anesthesiologist in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. With extensive subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, I see myself as a perioperative physician guiding the care of very sick patients with cardiovascular disease. While the spectrum of cardiovascular intervention might be shifting from the more invasive operating room to the less invasive catheter-based technologies, as a perioperative cardiovascular physician I see myself involved in all aspects of the care of these dynamic patients for many years to come.