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One or more keywords matched the following properties of Asara, John
keywords Proteomics
overview Research activities in the Asara lab focusses on the development of merging tri-omics (proteomics, metabolomics and lipidomics) data. We apply these methods for a personalized medicine approach by analyzing cancer cells and tumor samples in order help make appropriate therapeutic decisions with "smart" drugs. This is accomplished by understanding how cancer cells are signaling for growth and proliferation and how signaling talks to metabolic processes in order to develop mass spec quantitative assays. We are developing hypothesis directed proteomics and gloabl metabolomics and lipidomics strategies to understand the fundamental drivers of disease in cancers such as multiple myeloma, lung cancer and prostate cancer by performing protein-protein interaction studies, immunoprecipitation (IP)-tandem mass spectrometry (MS/MS), quantitative phosphoproteomics, metabolic and lipidomic profiling as well as metabolic flux analyses. Taken together, this information is vital in selecting the appropriate use of newly developed drugs. In addition to our internal research, we are involved in many collaborative projects that are coordinated through our state-of-the-art high resolution mass spectrometry technologies and services through our mass spectrometry facility.
One or more keywords matched the following items that are connected to Asara, John
Item TypeName
Academic Article An automated method for the analysis of stable isotope labeling data in proteomics.
Academic Article Data pre-processing in liquid chromatography-mass spectrometry-based proteomics.
Academic Article In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.
Academic Article Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.
Academic Article Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates.
Academic Article Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.
Academic Article Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
Academic Article Use of a label-free quantitative platform based on MS/MS average TIC to calculate dynamics of protein complexes in insulin signaling.
Academic Article Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells.
Academic Article Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Academic Article Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture.
Academic Article Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease.
Academic Article Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).
Academic Article Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.
Academic Article A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.
Academic Article Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
Academic Article CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Academic Article Characterization and analysis of the composition and dynamics of the mammalian riboproteome.
Academic Article Behavioral extremes of trait anxiety in mice are characterized by distinct metabolic profiles.
Academic Article Gross cystic disease fluid protein-15/prolactin-inducible protein as a biomarker for keratoconus disease.
Academic Article A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.
Academic Article The Lipid Kinase PI5P4Kß Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
Grant High Resolution Mass Spectrometry System
Academic Article An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling.
Academic Article Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.
Academic Article Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics.
Academic Article Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice.
Search Criteria
  • Proteomics
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.