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Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes.
Constitutive cellular expression of PI 3-kinase is distinct from transient expression.
A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.
Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway.
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts.
Tyrosine phosphorylation in signal transduction.
Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.
Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways.
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase.
Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
Platelet-Derived Growth Factor
Receptors, Platelet-Derived Growth Factor
Xenograft Model Antitumor Assays
K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.
PI3K-p110a mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
Dana-Farber/Harvard Cancer Center SPORE in Breast Cancer
The Role of PTEN and the PI3K Pathway in Prostate Cancer
AMOEBOID MOTILITY--A CELLULAR AND GENETIC APPROACH
Molecular mechanisms and therapeutic targeting of PI3K-p110beta/PTEN signaling in breast cancer and cancer immunity