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One or more keywords matched the following items that are connected to Roberts, Thomas
Item TypeName
Academic Article Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes.
Academic Article Constitutive cellular expression of PI 3-kinase is distinct from transient expression.
Academic Article A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.
Academic Article Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway.
Academic Article Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
Academic Article Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts.
Academic Article Tyrosine phosphorylation in signal transduction.
Academic Article Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.
Academic Article Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways.
Academic Article Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase.
Academic Article Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.
Academic Article DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
Concept Platelet-Derived Growth Factor
Concept Receptors, Platelet-Derived Growth Factor
Concept Xenograft Model Antitumor Assays
Academic Article K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
Academic Article Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a.
Academic Article Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Academic Article Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.
Academic Article PI3K-p110a mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
Grant Dana-Farber/Harvard Cancer Center SPORE in Breast Cancer
Grant The Role of PTEN and the PI3K Pathway in Prostate Cancer
Grant AMOEBOID MOTILITY--A CELLULAR AND GENETIC APPROACH
Grant Molecular mechanisms and therapeutic targeting of PI3K-p110beta/PTEN signaling in breast cancer and cancer immunity
Search Criteria
  • primary
  • derived
  • xenograft
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.