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One or more keywords matched the following items that are connected to Zhao, Jean
Item TypeName
Academic Article Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.
Academic Article PI3 kinases in cancer: from oncogene artifact to leading cancer target.
Academic Article Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention.
Academic Article Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
Academic Article Targeting the phosphoinositide 3-kinase pathway in cancer.
Academic Article Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Academic Article Surveillance mechanism linking Bub1 loss to the p53 pathway.
Academic Article COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Academic Article Should individual PI3 kinase isoforms be targeted in cancer?
Academic Article Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Academic Article The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.
Academic Article PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.
Academic Article 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Academic Article The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.
Academic Article Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Academic Article Functional characterization of an isoform-selective inhibitor of PI3K-p110ß as a potential anticancer agent.
Academic Article A genetic screen for candidate tumor suppressors identifies REST.
Academic Article A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.
Concept Class Ia Phosphatidylinositol 3-Kinase
Concept Mitogen-Activated Protein Kinase Kinases
Concept MAP Kinase Kinase Kinases
Concept Phosphatidylinositol 3-Kinase
Concept Cyclin-Dependent Kinase 3
Concept Protein Kinase Inhibitors
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept I-kappa B Kinase
Concept Cyclin-Dependent Kinase 8
Concept Cyclin-Dependent Kinase 6
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Cyclin-Dependent Kinase 4
Concept MAP Kinase Signaling System
Concept MAP Kinase Kinase Kinase 1
Academic Article Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Academic Article Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.
Mentoring - Completed Student Project Targeting NUAK2, an AMPK-related kinase, for breast cancer
Academic Article Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.
Academic Article The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.
Academic Article A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Academic Article Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a.
Academic Article PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.
Academic Article MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Academic Article Cyclin C is a haploinsufficient tumour suppressor.
Academic Article PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.
Academic Article Role of phosphoinositide 3-OH kinase p110ß in skeletal myogenesis.
Academic Article Class IA Phosphatidylinositol 3-Kinase Isoform p110a Mediates Vascular Remodeling.
Academic Article The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.
Academic Article Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.
Academic Article Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases.
Academic Article Tyrosine receptor kinase B is a drug target in astrocytomas.
Academic Article Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Grant Targeting the p110beta Isoform of PI3 Kinase in Pten Null Tumors
Grant SPORE: Targeted Therapies for Glioma
Grant Targeting the p110beta isoform of PI3 kinase in prostate cancer
Grant Developing novel targeted therapeutics integrated with immunotherapy-based approaches to make breakthroughs in metastatic breast cancer
Academic Article Rac1-mediated membrane raft localization of PI3K/p110ß is required for its activation by GPCRs or PTEN loss.
Academic Article CDK4/6 inhibition: the late harvest cycle begins.
Academic Article PI3K-p110a mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85a.
Academic Article CDK4/6 inhibition triggers anti-tumour immunity.
Academic Article CRKL Mediates p110ß-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.
Academic Article A cell-based quantitative high-throughput image screening identified novel autophagy modulators.
Academic Article Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells.
Academic Article Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer.
Academic Article Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Academic Article Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.
Academic Article CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest.
Academic Article Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
Academic Article PI3 kinase alpha and delta promote hematopoietic stem cell activation.
Academic Article Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.
Academic Article A sequential methodology for the rapid identification and characterization of breast cancer-associated functional SNPs.
Academic Article PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-a inhibition.
Search Criteria
  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.