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Item TypeName
Academic Article Adipogenesis and obesity: rounding out the big picture.
Academic Article Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity.
Academic Article Brown adipose tissue, beta 3-adrenergic receptors, and obesity.
Academic Article Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.
Academic Article Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
Academic Article Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.
Academic Article Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
Academic Article Chemokine IP-10 expression in cultured human keratinocytes.
Academic Article Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.
Academic Article Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.
Academic Article The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.
Academic Article Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.
Academic Article Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus.
Academic Article Loss of insulin binding and insulin receptor mRNA in a transformed human fetal fibroblast cell line.
Academic Article ADD-1 provides major new insight into the mechanism of insulin action.
Academic Article Obesity after genetic ablation of brown adipose tissue.
Academic Article Mice lacking melanin-concentrating hormone are hypophagic and lean.
Academic Article Attenuation of leptin and insulin signaling by SOCS proteins.
Academic Article UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
Academic Article The organization, promoter analysis, and expression of the human PPARgamma gene.
Academic Article Lowered leptin slims immune response.
Academic Article Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.
Academic Article Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.
Academic Article Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.
Academic Article Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.
Academic Article Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.
Academic Article Leptin expression and action: new experimental paradigms.
Academic Article Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes.
Academic Article Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin.
Academic Article Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress.
Academic Article Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.
Academic Article Receptors for peptide hormones. New insights into the pathophysiology of disease states in man.
Academic Article An introduction to receptors and receptor disorders.
Academic Article The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.
Academic Article Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.
Academic Article Neuroscience. Regulating energy balance: the substrate strikes back.
Academic Article Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.
Academic Article Clinical review 94: What's in a name? In search of leptin's physiologic role.
Academic Article Leptin.
Academic Article Obesity and the regulation of energy balance.
Academic Article Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans.
Academic Article Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice.
Academic Article Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue.
Academic Article Leptin activates neurons in ventrobasal hypothalamus and brainstem.
Academic Article Endocrine function of neuropeptide Y knockout mice.
Academic Article Adipose tissue as an endocrine organ.
Academic Article Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.
Academic Article Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Academic Article Association of Metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes.
Academic Article Expression of leptin receptor isoforms in rat brain microvessels.
Academic Article Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity.
Academic Article Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor.
Academic Article Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring.
Academic Article Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.
Academic Article Lasker lauds leptin.
Academic Article High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats.
Academic Article Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
Academic Article Vanadate regulates glucose transporter (Glut-1) expression in NIH3T3 mouse fibroblasts.
Academic Article Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment.
Academic Article Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans.
Academic Article Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.
Academic Article Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.
Academic Article Direct demonstration that receptor crosslinking or aggregation is important in insulin action.
Academic Article Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
Academic Article Leptin accelerates the onset of puberty in normal female mice.
Academic Article Distributions of leptin receptor mRNA isoforms in the rat brain.
Academic Article Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.
Academic Article Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice.
Academic Article Regulation of neuronal and glial proteins by leptin: implications for brain development.
Academic Article Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways.
Academic Article Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.
Academic Article Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance).
Academic Article Insulin resistance--mechanisms, syndromes, and implications.
Academic Article Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
Academic Article AgRP in energy balance: Will the real AgRP please stand up?
Academic Article Erythrocyte Na,K pump in uremia. Acute correction of a transport defect by hemodialysis.
Academic Article Regulation of glucose-transporter gene expression in vitro and in vivo.
Academic Article Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.
Academic Article Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.
Academic Article Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.
Academic Article Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
Academic Article FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis.
Academic Article Unraveling the central nervous system pathways underlying responses to leptin.
Academic Article Big deal about a little insulin.
Academic Article A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.
Academic Article Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.
Academic Article Diabetes. The missing link with obesity?
Academic Article Receptors, antireceptor antibodies and mechanisms of insulin resistance.
Academic Article Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
Academic Article Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.
Academic Article Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.
Academic Article Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.
Academic Article Energy homeostasis and body weight.
Academic Article In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
Academic Article Obesity and insulin resistance.
Academic Article Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
Academic Article Short-term hyperthyroidism has no effect on leptin levels in man.
Academic Article A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty.
Academic Article The immunology of the insulin receptor.
Academic Article Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.
Academic Article Pushing the envelope on lipodystrophy.
Academic Article Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells.
Academic Article Endogenous digitalis-like activity in the plasma of the toad Bufo marinus.
Academic Article Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.
Academic Article A good night's sleep: future antidote to the obesity epidemic?
Academic Article PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.
Academic Article Obesity is a fibroblast growth factor 21 (FGF21)-resistant state.
Academic Article Characteristics of in vitro steroidogenesis in a woman with hyperandrogenism, a granulosa cell tumor and polycystic ovary disease. A case report.
Academic Article Obesity wars: molecular progress confronts an expanding epidemic.
Academic Article Divergent roles of SHP-2 in ERK activation by leptin receptors.
Academic Article Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes.
Academic Article Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.
Academic Article Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects.
Academic Article Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat.
Academic Article Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).
Academic Article Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells.
Academic Article Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance.
Academic Article Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor.
Academic Article Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
Academic Article The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia.
Academic Article Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary.
Academic Article Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.
Academic Article Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.
Academic Article Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM.
Academic Article Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor.
Academic Article Gut check: testing a role for the intestinal microbiome in human obesity.
Academic Article Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification.
Academic Article Metabolic importance of acanthosis nigricans.
Academic Article Molecular cloning of two small GTP-binding proteins from human skeletal muscle.
Academic Article Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy.
Academic Article Creating a Nobel culture.
Academic Article Severely impaired adipsin expression in genetic and acquired obesity.
Academic Article The adipocyte as an active participant in energy balance and metabolism.
Academic Article Nasal absorption of insulin: enhancement by hydrophobic bile salts.
Academic Article Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
Academic Article Insulin resistance: the clinical spectrum.
Academic Article Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.
Academic Article Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.
Academic Article Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain.
Academic Article Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns.
Academic Article Obesity research springs a proton leak.
Academic Article Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.
Academic Article The role of SOCS-3 in leptin signaling and leptin resistance.
Academic Article Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again.
Academic Article Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.
Academic Article Adipose tissue as an endocrine organ.
Academic Article Identification of SOCS-3 as a potential mediator of central leptin resistance.
Academic Article The gut and energy balance: visceral allies in the obesity wars.
Academic Article Divergent signaling capacities of the long and short isoforms of the leptin receptor.
Academic Article IP-10 mRNA expression in cultured keratinocytes is suppressed by inhibition of protein kinase-C and tyrosine kinase and elevation of cAMP.
Academic Article Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia.
Academic Article SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
Academic Article Editorial: leptin as a therapeutic agent--trials and tribulations.
Academic Article Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues.
Academic Article Physiology: is brain sympathetic to bone?
Academic Article Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.
Academic Article Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep.
Academic Article Obesity and the hypothalamus: novel peptides for new pathways.
Academic Article Leptin regulation of neuroendocrine systems.
Academic Article The stomach speaks--ghrelin and weight regulation.
Academic Article Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.
Academic Article U-500 insulin in the treatment of antibody-mediated insulin resistance.
Academic Article Muscle-specific expression of human insulin receptor in transgenic mice.
Academic Article Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man.
Academic Article Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia.
Academic Article Energetic pursuit of leptin function.
Academic Article Leptin concentrations in the polycystic ovary syndrome.
Academic Article Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids.
Academic Article Sex differences in circulating human leptin pulse amplitude: clinical implications.
Academic Article Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
Academic Article Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.
Academic Article Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.
Academic Article Adipsin: regulation and dysregulation in obesity and other metabolic states.
Academic Article Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
Academic Article Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
Academic Article Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.
Academic Article Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA.
Academic Article Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
Academic Article Insulin stimulation of aminoisobutyric acid transport in human skin fibroblasts is mediated through both insulin and type I insulin-like growth factor receptors.
Academic Article Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.
Academic Article Reduced activity of the red-cell sodium-potassium pump in human obesity.
Academic Article Targeted disruption of the beta 3-adrenergic receptor gene.
Academic Article The adipocyte: storage depot or node on the energy information superhighway?
Academic Article Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.
Academic Article Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells.
Academic Article Health care reform: without a correct diagnosis, there is no cure.
Academic Article Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
Academic Article Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.
Academic Article Leptin, nutrition, and reproduction: timing is everything.
Academic Article A transgenic model of visceral obesity and the metabolic syndrome.
Academic Article Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.
Academic Article Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.
Academic Article Insulin receptors and insulin resistance.
Academic Article The potential significance of beta 3 adrenergic receptors.
Academic Article Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.
Academic Article Neuroscience. The fat-brain axis enters a new dimension.
Academic Article Problems of insulin resistance.
Academic Article Platelet-derived growth factor regulates glucose transporter expression.
Academic Article Leptin regulation of the mesoaccumbens dopamine pathway.
Academic Article Diseases caused by antibodies to receptors.
Academic Article Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.
Academic Article Characterization of insulin-like growth factor binding to human granulosa cells obtained during in vitro fertilization.
Academic Article Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization.
Academic Article Effect of sucrose overfeeding on Na,K-ATPase-mediated 86Rb uptake in normal and ob/ob mice.
Academic Article Functionally abnormal Na+-K+ pump in erythrocytes of a morbidly obese patient.
Academic Article Characterization of the insulin resistance of aging.
Academic Article Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
Academic Article Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
Academic Article Role of leptin in the neuroendocrine response to fasting.
Academic Article Lasker lauds leptin.
Academic Article Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.
Academic Article Impaired in vivo insulin clearance in patients with severe target-cell resistance to insulin.
Academic Article Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
Academic Article TLR4 links innate immunity and fatty acid-induced insulin resistance.
Academic Article Biological activity of nasally administered insulin in normal subjects.
Academic Article What fuels fat.
Academic Article Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
Academic Article Principles of receptor identification.
Academic Article Effect of diet upon the erythrocyte Na,K pump.
Academic Article Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.
Academic Article Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance.
Academic Article Absence of mutations in the human OB gene in obese/diabetic subjects.
Academic Article Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Academic Article Immunosuppression by alpha blockade.
Academic Article Treatment by plasma exchange of a patient with autoantibodies to the insulin receptor.
Academic Article Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice.
Academic Article Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.
Academic Article Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance.
Academic Article Insulin-resistant diabetes with insulin receptor autoantibodies in a male patient without acanghosis nigricans.
Academic Article Insulin receptors, receptor antibodies, and the mechanism of insulin action.
Academic Article Specific insulin binding sites in human ovary.
Academic Article Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
Academic Article The underlying insulin receptor in patients with antireceptor autoantibodies: demonstration of normal binding and immunological properties.
Academic Article Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.
Academic Article Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant.
Academic Article Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Academic Article Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.
Academic Article Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Academic Article Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.
Academic Article Familial insulin resistance with acanthosis nigricans, acral hypertrophy, and muscle cramps.
Academic Article Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function.
Academic Article The stimulation of pp42mapkinase by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin receptors.
Academic Article Ligand-binding properties of the two isoforms of the human insulin receptor.
Academic Article Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Academic Article Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats.
Academic Article Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.
Academic Article Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice.
Academic Article Insulin-mediated hypokalemia and paralysis in familial hypokalemic periodic paralysis.
Academic Article Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes.
Academic Article Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.
Academic Article Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action.
Academic Article Insulin-like growth factor I (rhIGF-I) as a therapeutic agent for hyperinsulinemic insulin-resistant diabetes mellitus.
Academic Article The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.
Academic Article Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.
Academic Article Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene.
Academic Article Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.
Academic Article Cell biology. Chewing the fat--ACC and energy balance.
Academic Article Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells.
Academic Article Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression.
Academic Article Multiple factors influence insulin-like growth factor-I binding to human skin fibroblasts.
Academic Article Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells.
Academic Article Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
Academic Article Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes.
Concept Acanthosis Nigricans
Concept Immunohistochemistry
Concept GTPase-Activating Proteins
Concept Hypothalamus, Middle
Concept Structure-Activity Relationship
Concept Zinc Fingers
Concept Monosaccharide Transport Proteins
Concept Receptors, Adrenergic, beta-1
Concept Cell Shape
Concept Biological Evolution
Concept Pituitary Gland
Concept Sequence Homology, Nucleic Acid
Concept Interdisciplinary Studies
Concept Nuclear Envelope
Concept Nonsuppressible Insulin-Like Activity
Concept Estrus
Concept Massachusetts
Concept Mitogen-Activated Protein Kinase 3
Concept Choroid Plexus
Concept Administration, Intranasal
Concept Mice
Concept Prostaglandin D2
Concept Antibodies
Concept Curriculum
Concept alpha-MSH
Concept Hypertrophy, Left Ventricular
Concept Transcription, Genetic
Concept Thyroxine
Concept Fasting
Concept Absorption
Concept Molecular Mimicry
Concept Remission, Spontaneous
Concept Anti-Obesity Agents
Concept Insulin Antibodies
Concept Threonine
Concept Biology
Concept DNA Replication
Concept Ephedrine
Concept Resistin
Concept Cell Membrane Permeability
Concept Digitalis Glycosides
Concept RNA Splicing
Concept Enteric Nervous System
Concept Rats, Wistar
Concept Base Sequence
Concept Mice, Inbred DBA
Concept Proto-Oncogene Proteins c-fos
Concept RNA, Ribosomal, 16S
Concept STAT1 Transcription Factor
Concept Oligonucleotide Array Sequence Analysis
Concept Metformin
Concept 11-beta-Hydroxysteroid Dehydrogenase Type 2
Concept Polycystic Ovary Syndrome
Concept Lipopolysaccharides
Concept Enhancer Elements, Genetic
Concept Cricetulus
Concept Caffeine
Concept Renin-Angiotensin System
Concept Neurites
Concept Sodium-Potassium-Exchanging ATPase
Concept Diphtheria Toxin
Concept Calcitriol
Concept Lipotropic Agents
Concept Pyrrolidonecarboxylic Acid
Concept Avian Sarcoma Viruses
Concept Echocardiography
Concept Brain Chemistry
Concept Phosphotyrosine
Concept Triiodothyronine
Concept National Institutes of Health (U.S.)
Concept Microtubules
Concept 11-beta-Hydroxysteroid Dehydrogenase Type 1
Concept Sleep Deprivation
Concept Biopsy
Concept Immunoglobulins
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 11
Concept Serial Publications
Concept Chromatography, Liquid
Concept Adipose Tissue, Brown
Concept Obesity
Concept Chromatography, Gel
Concept Prealbumin
Concept Animal Feed
Concept Cerebral Ventricles
Concept Sodium Glutamate
Concept Blood Chemical Analysis
Concept Oligonucleotides, Antisense
Concept Dynamin I
Concept Carcinoma, Hepatocellular
Concept Binding Sites
Concept Antibody Affinity
Concept Molecular Conformation
Concept Erythrocyte Membrane
Concept Models, Structural
Concept Cell Transformation, Neoplastic
Concept Adipocytes, Brown
Concept GTP-Binding Proteins
Concept Cricetinae
Concept Estrus Detection
Concept Bufo marinus
Concept Adipogenesis
Concept Mice, Inbred NOD
Concept Leucine
Concept Chromosomes, Human, Pair 11
Concept Mitochondria, Muscle
Concept Antibodies, Monoclonal
Concept Health Care Costs
Concept Corticotropin-Releasing Hormone
Concept Meninges
Concept Lipogenesis
Concept Complement Factor B
Concept Allosteric Regulation
Concept Lithium Chloride
Concept ras Proteins
Concept Analysis of Variance
Concept Weight Loss
Concept Fenofibrate
Concept Feeding Behavior
Concept Hypolipidemic Agents
Concept Sheep
Concept Fibroblast Growth Factor 10
Concept Vanadates
Concept Disclosure
Concept Cerebrovascular Circulation
Concept Antioxidants
Concept Oxidation-Reduction
Concept Cytoskeleton
Concept Lipid Peroxidation
Concept Phenytoin
Concept Precipitin Tests
Concept Cyclic AMP-Dependent Protein Kinases
Concept STAT3 Transcription Factor
Concept Blotting, Western
Concept Cytochalasin B
Concept Synaptophysin
Concept Complement C3a
Concept Endocrinology
Concept Bromodeoxyuridine
Concept Biological Science Disciplines
Concept Chemokines, CXC
Concept Lysosomes
Concept Hemolysis
Concept Oncogene Protein p21(ras)
Concept Excitatory Amino Acid Transporter 1
Concept Periodicity
Concept Dogs
Concept Chromones
Concept Erythrocytes
Concept Choline Deficiency
Concept Binding, Competitive
Concept Blotting, Northern
Concept Physiology
Concept Hormones, Ectopic
Concept Hypothalamus
Concept Thiazolidinediones
Concept Ovarian Follicle
Concept Mitogen-Activated Protein Kinase 1
Concept Disease Susceptibility
Concept Sterol Regulatory Element Binding Protein 1
Concept Aged
Concept Platelet-Derived Growth Factor
Concept Synaptic Transmission
Concept Adenosine Triphosphate
Concept Protein Biosynthesis
Concept Amino Acid Sequence
Concept Insulin-Like Growth Factor I
Concept Lipase
Concept Neurogenesis
Concept Lipoprotein Lipase
Concept Mice, Knockout
Concept Microcirculation
Concept Chemokine CCL2
Concept Mice, Inbred Strains
Concept CCAAT-Enhancer-Binding Proteins
Concept Obesity, Morbid
Concept Extracellular Signal-Regulated MAP Kinases
Concept Cell Size
Concept Antibody Specificity
Concept Ovary
Concept Ketosis
Concept Granulosa Cells
Concept Aminoisobutyric Acids
Concept Hypothalamo-Hypophyseal System
Concept Cell Transformation, Viral
Concept Leptin
Concept Malonyl Coenzyme A
Concept Microbodies
Concept Adipocytes, White
Concept Cross-Sectional Studies
Concept Rats
Concept Sequence Homology, Amino Acid
Concept Brain Stem
Concept Diabetes Mellitus, Type 1
Concept Proto-Oncogene Proteins p21(ras)
Concept Autoradiography
Concept Thermogenesis
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept Complement Factor D
Concept Kinetics
Concept Blood Specimen Collection
Concept Biological Transport, Active
Concept Hypothalamic Area, Lateral
Concept Manuscripts as Topic
Concept Nucleic Acid Hybridization
Concept Ventricular Function, Left
Concept Cyclic AMP Response Element-Binding Protein
Concept Autoantibodies
Concept Phosphoenolpyruvate Carboxykinase (GTP)
Concept Confidentiality
Concept Body Mass Index
Concept Tandem Mass Spectrometry
Concept Diagnosis, Differential
Concept Blotting, Southern
Concept Cross Reactions
Concept Chemokine CCL7
Concept Enzyme-Linked Immunosorbent Assay
Concept Protein Binding
Concept Third Ventricle
Concept Apoptosis
Concept Receptors, Adrenergic, beta-2
Concept Antisense Elements (Genetics)
Concept Graves Disease
Concept Chemokine CXCL11
Concept Ki-67 Antigen
Concept Interleukin-10
Concept Temperature
Concept Central Nervous System
Concept Thinness
Concept Body Temperature Regulation
Concept Methionine
Concept Thiazoles
Concept Phentolamine
Concept Terminology as Topic
Concept Motor Activity
Concept Feedback
Concept Chromans
Concept RNA, Small Interfering
Concept Hemagglutinins
Concept ras GTPase-Activating Proteins
Concept CCAAT-Enhancer-Binding Protein-alpha
Concept Androgens
Concept Blood-Brain Barrier
Concept Diabetes Mellitus, Lipoatrophic
Concept Data Interpretation, Statistical
Concept Ouabain
Concept Myasthenia Gravis
Concept Protein Processing, Post-Translational
Concept Adrenergic beta-Agonists
Concept Cell Count
Concept Somatomedins
Concept Clorgyline
Concept Ventromedial Hypothalamic Nucleus
Concept Immunoglobulin Fab Fragments
Concept Neuromuscular Junction
Concept Carbohydrate Metabolism
Concept Anorexia
Concept RNA-Binding Proteins
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Concept Binding Sites, Antibody
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Concept RNA, Antisense
Concept Cyclic AMP
Concept Cold Temperature
Concept Immune Sera
Concept Tryptophan
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Concept Capillaries
Concept Monocyte Chemoattractant Proteins
Concept Exons
Concept Receptors, Adrenergic, beta
Concept Diabetes Mellitus, Type 2
Concept Carboxypeptidase H
Concept Codon
Concept Anethole Trithione
Concept Mice, Inbred C57BL
Concept Dorsomedial Hypothalamic Nucleus
Concept Deoxycholic Acid
Concept Repetitive Sequences, Nucleic Acid
Concept Indians, North American
Concept Proto-Oncogene Proteins c-akt
Concept Enzyme Activation
Concept Mitochondria, Liver
Concept Insulin-Secreting Cells
Concept Nucleus Accumbens
Concept 11-beta-Hydroxysteroid Dehydrogenases
Concept Ventral Tegmental Area
Concept Chemokine CXCL10
Concept Adiposity
Concept Amphetamine
Concept Mice, Mutant Strains
Concept Body Composition
Concept Adaptation, Physiological
Concept Leukocytes
Concept Plasmapheresis
Concept Tumor Necrosis Factor-alpha
Concept Middle Aged
Concept Glycolysis
Concept Rats, Sprague-Dawley
Concept Acromegaly
Concept beta-Galactosidase
Concept Receptor, Melanocortin, Type 4
Concept United States
Concept Carboxylic Ester Hydrolases
Concept Aging
Concept Janus Kinase 2
Concept Promoter Regions, Genetic
Concept Weight Gain
Concept Rats, Zucker
Concept Cell Line, Transformed
Concept Alanine
Concept Coated Pits, Cell-Membrane
Concept Mitogen-Activated Protein Kinase 6
Concept Arizona
Concept Receptors, Adrenergic, beta-3
Concept Awards and Prizes
Concept MAP Kinase Signaling System
Concept Nobel Prize
Concept Humans
Concept Autoimmune Diseases
Concept Cerebellum
Concept Gluconeogenesis
Concept Down-Regulation
Concept Organ Size
Concept Melanins
Concept Chromatography, Ion Exchange
Concept alpha 1-Antitrypsin
Concept Suppressor of Cytokine Signaling Proteins
Concept Body Temperature
Concept Escherichia coli
Concept Rabbits
Concept Membrane Transport Proteins
Concept Lipolysis
Concept Glucose Transporter Type 1
Concept Adaptor Proteins, Signal Transducing
Concept RNA Processing, Post-Transcriptional
Concept Glucose Transporter Type 4
Concept Adrenergic alpha-Antagonists
Concept Glucose Tolerance Test
Concept Smoking
Concept Electrophoresis, Polyacrylamide Gel
Concept Lymphocytes
Concept Longitudinal Studies
Concept Restriction Mapping
Concept Erythroid Precursor Cells
Concept Mitochondria
Concept Brain
Concept Protein Conformation
Concept Serine
Concept Colon
Concept Cholesterol
Concept Aerosols
Concept Monocytes
Concept Early Growth Response Protein 1
Concept Mice, Transgenic
Concept Tyrosine
Concept T-Lymphocytes
Concept Cardiac Glycosides
Concept Activity Cycles
Concept Authorship
Concept Phosphorylation
Concept Skinfold Thickness
Concept Immunoglobulin G
Concept Nucleic Acid Conformation
Concept Arteriosclerosis
Concept Signal Transduction
Concept Biomedical Research
Concept Adipose Tissue, White
Concept Circadian Rhythm
Concept Information Dissemination
Concept Introns
Concept Excitatory Postsynaptic Potentials
Concept Paraventricular Hypothalamic Nucleus
Concept Drug Discovery
Concept Insulin Receptor Substrate Proteins
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Rats, Inbred Strains
Concept Cell Nucleus
Concept Sodium Chloride
Concept Ion Channels
Concept Cell Division
Concept Receptors, Melanocortin
Concept Adipose Tissue
Concept Age of Onset
Concept Lighting
Concept Actins
Concept Fatty Acid-Binding Proteins
Concept Basal Ganglia
Concept Fetal Blood
Concept Glycosylation
Concept COS Cells
Concept Membrane Potentials
Concept Bone and Bones
Concept Receptors, Adrenergic
Concept Receptors, Neuropeptide Y
Concept Isoproterenol
Concept Mice, Inbred BALB C
Concept Interleukin-15
Concept Body Weight
Concept Blood
Concept Cyclic Nucleotide Phosphodiesterases, Type 4
Concept Mice, Obese
Concept Antigen-Antibody Complex
Concept Biological Availability
Concept Birth Weight
Concept Alcohol Drinking
Concept Receptor, IGF Type 1
Concept Axons
Concept Intestine, Small
Academic Article a-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
Academic Article Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.
Academic Article Adipsin is an adipokine that improves ß cell function in diabetes.
Academic Article Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Academic Article Status of the red cell Na,K-pump in hyper- and hypothyroidism.
Academic Article Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.
Academic Article Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.
Academic Article Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.
Grant Boston Nutrition Obesity Research Center
Grant Nonhuman Primate Housing Infrastructure and Caging
Grant New England Primate Research Center Base Grant
Grant REGULATING BODY COMPOSITION BY INSULIN &IGF-I RECEPTORS
Grant LEPTIN-- SIGNALING, TARGETS AND RESISTANCE
Grant New England Primate Research Center Base Grant
Academic Article Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport.
Academic Article Developing Core Competencies for the Prevention and Management of Prescription Drug Misuse: A Medical Education Collaboration in Massachusetts.
Academic Article Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus.
Academic Article Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia1.
Academic Article Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity.
Academic Article Characterization of Expression of Hypothalamic Appetite-Regulating Peptides in Obese Hyperleptinemic Brown Adipose Tissue-Deficient (Uncoupling Protein-Promoter-Driven Diphtheria Toxin A) Mice* *This work was supported by a grant from Eli Lilly & Co. (to E.M.F.), NIH Grant DK-R37-28082 (to J.S.F.), and NIH Grant MH-56537 (to J.K.E.).
Academic Article Expression of Leptin Receptor Isoforms in Rat Brain Microvessels.
Academic Article Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.
Academic Article Functional Properties of Leptin Receptor Isoforms Containing the Gln?Pro Extracellular Domain Mutation of the Fatty Rat.
Academic Article Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells.
Academic Article Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach.
Academic Article Faculty promotion must assess reproducibility.
Academic Article Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.
Academic Article Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet.
Academic Article Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin.
Academic Article Academia and industry: allocating credit for discovery and development of new therapies.
Academic Article Credit and Priority in Scientific Discovery: A Scientist's Perspective.
Academic Article C. Ronald Kahn: The Louisville Slugger of metabolic science.
Academic Article Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis.
Academic Article Might ß3-adrenergic receptor agonists be useful in disorders of glucose homeostasis?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.