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One or more keywords matched the following properties of Kraft, Peter
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overview My research concentrates on the design and analysis of genetic association studies, with particular emphasis on studies linking variation in germline DNA to cancer risk. I have played a key role in multiple international consortia studying genetics and other exposures in relation to cancer risk over the last ten years: I have been a member of the statistical working group of the Breast and Prostate Cancer Cohort Consortium since its inception, and currently chair the BPC3 steering committee; I played a leading role in the design and analysis of GWAS of breast, prostate and pancreatic cancers as part of the NCI's Cancer Genetic Markers of Susceptibility and PanScan projects; and I chair the Analytic Working Group for the NCI's "post-GWAS" GAME-ON consortium, which aims to better understand the biological mechanisms underlying GWAS-identified cancer risk markers at five cancer sites (including breast and lung) and their public health implications. I am also the contact PI for the epidemiology project of the breast cancer arm of GAME-ON, which focuses on gene-environment interactions and risk prediction. I have been the primary statistical geneticist for the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS) for over ten years, and oversee the genotype databases for both studies, including genome-wide association data on over 20,000 subjects. I have collaborated on numerous analyses in the NHS and HPFS examining associations between genetic markers, behaviors (including diet and smoking), and risk of complex diseases. I have also collaborated with NHS investigators on the analyses of metabolite profiles in a case-control study of pancreatic cancer. My current methodological research focuses on 1) efficient and interpretable "gene x environment interaction" analyses, 2) genetic risk prediction using common and rare genetic variation, biomarkers (including metabolites), and clinical and environmental risk factors, and 3) methods linking low-frequency variation, emerging functional annotation, and risk of complex disease.
One or more keywords matched the following items that are connected to Kraft, Peter
Item TypeName
Academic Article A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
Academic Article Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
Academic Article A genome-wide association study of prognosis in breast cancer.
Academic Article Efficient two-stage genome-wide association designs based on false positive report probabilities.
Academic Article Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.
Academic Article Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration.
Academic Article Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
Academic Article Genome-wide association study identifies new prostate cancer susceptibility loci.
Academic Article Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Academic Article Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Academic Article Powerful SNP-set analysis for case-control genome-wide association studies.
Academic Article Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.
Academic Article Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
Academic Article Common variants of FUT2 are associated with plasma vitamin B12 levels.
Academic Article Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Academic Article Analysis of case-control association studies with known risk variants.
Academic Article Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases.
Academic Article Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.
Academic Article The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk.
Academic Article The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions.
Academic Article Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.
Academic Article Replication in genome-wide association studies.
Academic Article Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.
Academic Article Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Academic Article Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.
Academic Article Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Academic Article Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Academic Article Quality control and quality assurance in genotypic data for genome-wide association studies.
Academic Article Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Academic Article A Bayesian latent class analysis for whole-genome association analyses: an illustration using the GAW15 simulated rheumatoid arthritis dense scan data.
Academic Article Curses--winner's and otherwise--in genetic epidemiology.
Academic Article Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects.
Academic Article Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma.
Academic Article A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
Academic Article Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium.
Academic Article Beyond odds ratios--communicating disease risk based on genetic profiles.
Academic Article Genome-wide association study of tanning phenotype in a population of European ancestry.
Academic Article Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
Academic Article Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Academic Article Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
Academic Article Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Academic Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Academic Article Multiple loci identified in a genome-wide association study of prostate cancer.
Academic Article Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
Academic Article A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
Academic Article ß-Carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descent.
Academic Article Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
Academic Article Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Academic Article Genome-wide association study of relative telomere length.
Academic Article Large-scale fine mapping of the HNF1B locus and prostate cancer risk.
Academic Article A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
Academic Article Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.
Academic Article Artifact due to differential error when cases and controls are imputed from different platforms.
Academic Article Genetic variation in the vitamin d pathway in relation to risk of prostate cancer--results from the breast and prostate cancer cohort consortium.
Academic Article Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Academic Article Genome-wide association study of prostate cancer mortality.
Academic Article Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses' Health Study.
Academic Article Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Academic Article Breast cancer susceptibility loci and mammographic density.
Academic Article Absence of evidence for MHC-dependent mate selection within HapMap populations.
Academic Article Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples.
Academic Article Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes.
Academic Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Academic Article Exploring the genetic architecture of circulating 25-hydroxyvitamin D.
Academic Article Genomic screening in family-based association testing.
Academic Article Identification of ten loci associated with height highlights new biological pathways in human growth.
Academic Article Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Academic Article A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
Academic Article A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
Academic Article Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.
Academic Article Evaluation of polygenic risk scores for predicting breast and prostate cancer risk.
Academic Article Identification of a novel percent mammographic density locus at 12q24.
Academic Article A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication.
Academic Article Genome-wide and candidate gene association study of cigarette smoking behaviors.
Academic Article Genome-wide association scans for secondary traits using case-control samples.
Academic Article Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels.
Academic Article Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
Academic Article Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Academic Article A genome-wide association search for type 2 diabetes genes in African Americans.
Academic Article Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Academic Article Meta-analysis of new genome-wide association studies of colorectal cancer risk.
Academic Article Drinking from the fire hose--statistical issues in genomewide association studies.
Academic Article Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes.
Academic Article Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Academic Article Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer.
Academic Article A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.
Academic Article Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
Academic Article A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies.
Academic Article Genetic risk prediction--are we there yet?
Academic Article Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
Academic Article Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.
Academic Article Study designs for genome-wide association studies.
Academic Article Genome-wide association study of circulating vitamin D levels.
Academic Article Genome-wide association study of circulating retinol levels.
Academic Article Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Academic Article A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Academic Article A genome-wide association study of early menopause and the combined impact of identified variants.
Academic Article Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.
Academic Article Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
Academic Article Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade.
Academic Article Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Academic Article Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
Academic Article Performance of common genetic variants in breast-cancer risk models.
Academic Article Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Academic Article Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Academic Article Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Academic Article Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Academic Article A genome-wide association study of depressive symptoms.
Academic Article Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
Concept Genome-Wide Association Study
Concept Genome
Concept Genome, Human
Concept Genome, Mitochondrial
Academic Article Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
Academic Article Genome-wide association study identifies two susceptibility loci for osteosarcoma.
Academic Article Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Academic Article Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.
Academic Article Improved ancestry inference using weights from external reference panels.
Academic Article One thousand genomes imputation in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium aggressive prostate cancer genome-wide association study.
Academic Article A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes.
Academic Article Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
Academic Article Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
Academic Article Genome-wide association study of endometrial cancer in E2C2.
Academic Article Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.
Academic Article Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Academic Article Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
Academic Article Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.
Academic Article A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer.
Academic Article Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies.
Academic Article Exome-wide association study of endometrial cancer in a multiethnic population.
Academic Article Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.
Academic Article Identification of a melanoma susceptibility locus and somatic mutation in TET2.
Academic Article COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration.
Academic Article Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.
Academic Article Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Academic Article Genome-wide interaction study of smoking and bladder cancer risk.
Academic Article Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types.
Academic Article Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women.
Academic Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Academic Article A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Academic Article Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Academic Article Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.
Academic Article The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.
Academic Article Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Academic Article Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Academic Article Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium.
Academic Article Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Academic Article A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Academic Article Characterization of large structural genetic mosaicism in human autosomes.
Academic Article Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).
Academic Article A genome-wide pleiotropy scan for prostate cancer risk.
Academic Article Genome-wide association study of selenium concentrations.
Academic Article Adjusting for heritable covariates can bias effect estimates in genome-wide association studies.
Academic Article Multilocus heterozygosity and coronary heart disease: nested case-control studies in men and women.
Academic Article Integrating functional data to prioritize causal variants in statistical fine-mapping studies.
Academic Article Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
Academic Article Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Academic Article Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Academic Article Summarizing polygenic risks for complex diseases in a clinical whole-genome report.
Academic Article Common germline polymorphisms associated with breast cancer-specific survival.
Academic Article Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
Academic Article Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Academic Article Corrigendum: genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Academic Article Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.
Academic Article Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.
Academic Article Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
Academic Article Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.
Academic Article Genome-wide association study of prostate cancer-specific survival.
Academic Article Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Academic Article Body Mass Index Genetic Risk Score and Endometrial Cancer Risk.
Academic Article Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Academic Article Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Academic Article Reclassification of genetic-based risk predictions as GWAS data accumulate.
Academic Article Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Academic Article Response to Day et al.
Academic Article Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
Academic Article Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.
Academic Article Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry.
Academic Article A targeted genetic association study of epithelial ovarian cancer susceptibility.
Academic Article GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.
Academic Article Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Academic Article Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Academic Article A genome-wide investigation of food addiction.
Academic Article Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Academic Article Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.
Academic Article Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Academic Article Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study.
Academic Article Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Academic Article Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Academic Article Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Grant Discovery, Biology and Risk of Inherited Variants in Breast Cancer
Academic Article Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.
Academic Article Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Academic Article Interactions of established risk factors and a GWAS-based genetic risk score on the risk of venous thromboembolism.
Academic Article Telomere structure and maintenance gene variants and risk of five cancer types.
Academic Article The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.
Academic Article Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities.
Academic Article Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.
Academic Article GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
Academic Article Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Academic Article Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Academic Article Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Academic Article Sniffing out significant "Pee values": genome wide association study of asparagus anosmia.
Academic Article Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Academic Article Genome-Wide Association Studies of Multiple Keratinocyte Cancers.
Academic Article Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Academic Article Testing calibration of risk models at extremes of disease risk.
Academic Article A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts.
Academic Article Leveraging family history in population-based case-control association studies.
Academic Article Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.
Academic Article Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Academic Article Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Academic Article An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Academic Article Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Academic Article Quantifying the Genetic Correlation between Multiple Cancer Types.
Academic Article Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.
Academic Article Investigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics.
Academic Article Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.
Academic Article Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Academic Article Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions.
Academic Article Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.
Academic Article Covariate selection for association screening in multiphenotype genetic studies.
Academic Article Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Academic Article Cross-Cancer Analysis Reveals Novel Pleiotropic Associations-Response.
Academic Article Association analysis identifies 65 new breast cancer risk loci.
Academic Article Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
Academic Article GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.
Academic Article Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.
Academic Article Use of deep whole-genome sequencing data to identify structure risk variants in breast cancer susceptibility genes.
Academic Article Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Academic Article Quantifying the Polygenic Contribution to Cutaneous Squamous Cell Carcinoma Risk.
Academic Article A test for gene-environment interaction in the presence of measurement error in the environmental variable.
Academic Article Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Academic Article Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
Academic Article Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk.
Academic Article HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.
Academic Article Transcriptome-wide association studies accounting for colocalization using Egger regression.
Academic Article A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Academic Article Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Academic Article Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Academic Article Polygenic risk score of shorter telomere length and risk of depression and anxiety in women.
Academic Article A genome-wide association study of energy intake and expenditure.
Academic Article Identification of nine new susceptibility loci for endometrial cancer.
Academic Article The case-only test for gene-environment interaction is not uniformly powerful: an empirical example.
Academic Article The genetics of vitamin D.
Academic Article Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Academic Article Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
Academic Article Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Academic Article Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
Academic Article Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies.
Academic Article Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.
Academic Article Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan.
Academic Article Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.
Academic Article A large-scale exome array analysis of venous thromboembolism.
Academic Article Shared heritability and functional enrichment across six solid cancers.
Academic Article Genome-wide association study of germline variants and breast cancer-specific mortality.
Academic Article Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.
Academic Article Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes.
Academic Article A genome-wide association study of bitter and sweet beverage consumption.
Academic Article Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.
Academic Article Erratum: A genome-wide association study of bitter and sweet beverage consumption.
Academic Article Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.
Academic Article Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.
Academic Article Sex specific associations in genome wide association analysis of renal cell carcinoma.
Academic Article Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.
Academic Article Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
Academic Article Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways.
Academic Article Genome-Wide Association Study for Urinary and Fecal Incontinence in Women.
Academic Article Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
Academic Article A Mendelian randomization analysis of circulating lipid traits and breast cancer risk.
Academic Article A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.
Academic Article Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Academic Article A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Academic Article The Association of Modifiable Breast Cancer Risk Factors and Somatic Genomic Alterations in Breast Tumors: The Cancer Genome Atlas Network.
Academic Article Allergy, asthma, and the risk of breast and prostate cancer: a Mendelian randomization study.
Academic Article Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma.
Academic Article Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.
Academic Article Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.
Academic Article Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia.
Academic Article Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Academic Article Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
Academic Article Genome-wide association study identifies 48 common genetic variants associated with handedness.
Academic Article Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.
Academic Article Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.
Academic Article Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Academic Article Improved methods for multi-trait fine mapping of pleiotropic risk loci.
Academic Article Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop.
Academic Article Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228?951 Women of European Descent.
Academic Article Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma.
Academic Article Using principal components of genetic variation for robust and powerful detection of gene-gene interactions in case-control and case-only studies.
Academic Article The PhenX Toolkit: get the most from your measures.
Academic Article Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
Academic Article Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.
Academic Article Analyses of genome-wide association scans for additional outcomes.
Academic Article VEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis.
Academic Article Fine Tuning the Risk of Hereditary Cancer Using Genome-Wide Association Studies.
Academic Article Heritability in the genome-wide association era.
Academic Article Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report.
Academic Article Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.
Academic Article A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants.
Academic Article High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.
Academic Article Unidentified genetic variants influence pancreatic cancer risk: an analysis of polygenic susceptibility in the PanScan study.
Academic Article Novel genetic markers of breast cancer survival identified by a genome-wide association study.
Academic Article GWAS identifies a common breast cancer risk allele among BRCA1 carriers.
Academic Article Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.
Academic Article Associations between smoking behavior-related alleles and the risk of melanoma.
Academic Article Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Academic Article Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Academic Article Re-ranking sequencing variants in the post-GWAS era for accurate causal variant identification.
Academic Article Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
Academic Article Lessons Learned From Past Gene-Environment Interaction Successes.
Academic Article CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
Academic Article A Genome-Wide Association Study of Childhood Body Fatness.
Grant Evaluating the Clinical Validity of Novel Gene-Environment Risk Profiles
Grant Sequencing regions assoc with breast cancer risk in European and African American
Grant Leveraging cross-cancer shared heritability to better understand the genetic architecture of cancer
Grant Leveraging GxE interaction to understand pancreatic cancer and altered metabolism
Academic Article A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Academic Article Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
Academic Article Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.
Academic Article Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies.
Academic Article Multitrait transcriptome-wide association study (TWAS) tests.
Academic Article Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.
Academic Article Genetic insights into biological mechanisms governing human ovarian ageing.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.