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Academic Article Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
Academic Article The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus.
Academic Article Antigen-presenting function of the TL antigen and mouse CD1 molecules.
Academic Article Organ-specific disease provoked by systemic autoimmunity.
Academic Article Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription.
Academic Article Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.
Academic Article Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.
Academic Article Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities.
Academic Article Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes.
Academic Article Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire.
Academic Article Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.
Academic Article Inhibition of thymocyte positive selection by natural MHC: peptide ligands.
Academic Article Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes.
Academic Article Cellular and molecular changes accompanying the progression from insulitis to diabetes.
Academic Article Intrathymic delivery of MHC genes using recombinant adenoviruses.
Academic Article Why is clonal deletion of neonatal thymocytes defective?
Academic Article The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed.
Academic Article The K/BxN arthritis model.
Academic Article Transcriptional impact of Aire varies with cell type.
Academic Article Positive and negative selection of the T cell repertoire in MHC class II transgenic mice.
Academic Article Lymphocyte tolerance: central is central.
Academic Article Visualization of CD4/CD8 T cell commitment.
Academic Article Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
Academic Article A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice.
Academic Article The shaping of the T cell repertoire.
Academic Article Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.
Academic Article FOXP3 controls regulatory T cell function through cooperation with NFAT.
Academic Article Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.
Academic Article Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.
Academic Article MHC-linked protection from diabetes dissociated from clonal deletion of T cells.
Academic Article T-cell compartments of prediabetic NOD mice.
Academic Article Genetic influences on the end-stage effector phase of arthritis.
Academic Article Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis.
Academic Article Positive selection of T cells: fastidious or promiscuous?
Academic Article A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
Academic Article How much TCR does a T cell need?
Academic Article beta-Cell death during progression to diabetes.
Academic Article Autoimmunity. The pathogen connection.
Academic Article Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
Academic Article Mast cells in autoimmune disease.
Academic Article Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.
Academic Article Yes, it does.
Academic Article Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells.
Academic Article Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.
Academic Article NF-X, a transcription factor implicated in MHC class II gene regulation.
Academic Article Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.
Academic Article Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.
Academic Article The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.
Academic Article Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant.
Academic Article Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.
Academic Article A plaidoyer for 'systems immunology'.
Academic Article Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.
Academic Article Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.
Academic Article Selection for survival?
Academic Article Autoimmune diabetes. Retrovirus as trigger, precipitator or marker?
Academic Article The cellular mechanism of Aire control of T cell tolerance.
Academic Article Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Academic Article Altered natural killer cells in type 1 diabetic patients.
Academic Article Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.
Academic Article Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
Academic Article Gene expression microarrays: glimpses of the immunological genome.
Academic Article Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.
Academic Article Spotting a killer's target in autoimmune diabetes.
Academic Article Evolutionary variation of the CCAAT-binding transcription factor NF-Y.
Academic Article T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo.
Academic Article A molecular chart of thymocyte positive selection.
Academic Article The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.
Academic Article B-cell signaling: protein kinase Cdelta puts the brakes on.
Academic Article Treg cells, life history, and diversity.
Academic Article Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.
Academic Article Efficient immune responses in mice lacking N-region diversity.
Academic Article T cell receptor specificity and diabetes in nonobese diabetic mice.
Academic Article Following a diabetogenic T cell from genesis through pathogenesis.
Academic Article Defective central tolerance induction in NOD mice: genomics and genetics.
Academic Article Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice.
Academic Article Treg cells: guardians for life.
Academic Article Lack of Foxp3 function and expression in the thymic epithelium.
Academic Article Genomic definition of multiple ex vivo regulatory T cell subphenotypes.
Academic Article Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.
Academic Article The influence of positive selection on RAG expression in thymocytes.
Academic Article Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
Academic Article Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.
Academic Article Positive selection of T cells induced by viral delivery of neopeptides to the thymus.
Academic Article Cell death mediators in autoimmune diabetes--no shortage of suspects.
Academic Article Genetic control of diabetes progression.
Academic Article The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Academic Article Interleukin-4 deficiency does not exacerbate disease in NOD mice.
Academic Article Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.
Academic Article Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells.
Academic Article Restricted assembly of MHC class II molecules in transgenic mice.
Academic Article Commercially available outbred mice for genome-wide association studies.
Academic Article Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog.
Academic Article I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides.
Academic Article A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice.
Academic Article IL-17-producing T cells can augment autoantibody-induced arthritis.
Academic Article Fine-tuning of MHC class II gene expression in defined microenvironments.
Academic Article Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism.
Academic Article Evidence for a single-niche model of positive selection.
Academic Article Another view of the selective model of thymocyte selection.
Academic Article T-cell development: a new marker of differentiation state.
Academic Article Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.
Academic Article Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
Academic Article Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells.
Academic Article Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.
Academic Article Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
Academic Article Aire's partners in the molecular control of immunological tolerance.
Academic Article Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.
Academic Article Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Academic Article Environmental modulation of the autonomy of cytotoxic T lymphocytes.
Academic Article Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems.
Academic Article Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes.
Academic Article Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.
Academic Article Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits.
Academic Article Immunology at Asilomar: from molecules to mice.
Academic Article Back to central tolerance.
Academic Article CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.
Academic Article Imaging inflammation of the pancreatic islets in type 1 diabetes.
Academic Article A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.
Academic Article A decade of AIRE.
Academic Article Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected.
Academic Article Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
Academic Article The molecular program induced in T cells undergoing homeostatic proliferation.
Academic Article Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
Academic Article Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
Academic Article Delineation of antigen contact residues on an MHC class II molecule.
Academic Article Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.
Academic Article New B-lymphocyte-specific enhancer-binding protein.
Academic Article Stability of the regulatory T cell lineage in vivo.
Academic Article Immunometabolism: an emerging frontier.
Academic Article Modifier loci condition autoimmunity provoked by Aire deficiency.
Academic Article Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.
Academic Article A shared gene-expression signature in innate-like lymphocytes.
Academic Article Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Academic Article Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Academic Article A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.
Academic Article T helper cell subsets in insulin-dependent diabetes.
Academic Article Mice lacking TdT: mature animals with an immature lymphocyte repertoire.
Academic Article A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Academic Article B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.
Academic Article A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.
Academic Article Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis.
Academic Article Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints.
Academic Article Regulatory T cells: recommendations to simplify the nomenclature.
Academic Article The immune system of mice lacking conventional MHC class II molecules.
Academic Article Mice lacking the MHC class II-associated invariant chain.
Academic Article Knock-out mice: a new tool for transplantation immunologists.
Academic Article Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.
Academic Article Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.
Academic Article Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
Academic Article Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.
Academic Article PPAR-? is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Academic Article The immune system's involvement in obesity-driven type 2 diabetes.
Academic Article Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
Academic Article Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Academic Article Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.
Academic Article Altered I-J phenotype in E alpha transgenic mice.
Academic Article How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.
Academic Article The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse.
Academic Article The enhancer in an MHC class II gene, in vitro and in mouso.
Academic Article The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding.
Academic Article The NOD mouse.
Academic Article Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.
Academic Article An influence of CD5 on the selection of CD4-lineage T cells.
Academic Article Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand.
Academic Article Good riddance: Thymocyte clonal deletion prevents autoimmunity.
Academic Article Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.
Academic Article A comprehensive review of interventions in the NOD mouse and implications for translation.
Academic Article Endocrine self and gut non-self intersect in the pancreatic lymph nodes.
Academic Article Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
Academic Article Thymic negative selection is functional in NOD mice.
Academic Article CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells.
Academic Article Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units.
Academic Article Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.
Academic Article Arthritogenic monoclonal antibodies from K/BxN mice.
Academic Article The SV40 early region TATA box is required for accurate in vitro initiation of transcription.
Academic Article The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.
Academic Article Green T(R) cells.
Academic Article Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells.
Academic Article Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.
Academic Article Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.
Academic Article Arthritis critically dependent on innate immune system players.
Academic Article Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells.
Academic Article Mast cells: a cellular link between autoantibodies and inflammatory arthritis.
Academic Article Projection of an immunological self shadow within the thymus by the aire protein.
Academic Article Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.
Academic Article Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.
Academic Article Levees of immunological tolerance.
Academic Article A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.
Academic Article How defects in central tolerance impinge on a deficiency in regulatory T cells.
Academic Article The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.
Academic Article Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity.
Academic Article Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.
Academic Article HMG proteins (1 + 2) form beaded structures when complexed with closed circular DNA.
Academic Article Graft rejection across transgene-encoded MHC class II molecules.
Academic Article In favor of the selective model of positive selection.
Academic Article The K/BxN mouse model of inflammatory arthritis: theory and practice.
Academic Article Aire.
Academic Article Positive selection of the T cell repertoire: where and when does it occur?
Academic Article Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.
Academic Article Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.
Academic Article Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.
Academic Article Mice lacking MHC class II molecules.
Academic Article How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease.
Academic Article Properties of a CCAAT box-binding protein.
Academic Article Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice.
Academic Article Slot-machine mutagenesis of a polymorphic residue on the A kappa alpha-chain.
Academic Article Consortium biology in immunology: the perspective from the Immunological Genome Project.
Academic Article AIRE and APECED: molecular insights into an autoimmune disease.
Academic Article Chromosomal clustering of genes controlled by the aire transcription factor.
Academic Article Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice.
Academic Article Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Academic Article Defects in antigen presentation of mutant influenza haemagglutinins are reversed by mutations in the MHC class II molecule.
Academic Article Regulatory T-cell differentiation: Committed to control: a precocious choice?
Academic Article TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.
Academic Article A molecular basis for the Ia.2 and Ia.19 antigenic determinants.
Academic Article T-cell recognition of superantigens: inside or outside the groove?
Academic Article Anatomy of a new B-cell-specific enhancer.
Academic Article Structure of transcribing chromatin.
Academic Article Independent modes of natural killing distinguished in mice lacking Lag3.
Academic Article I-A alpha polymorphic residues that determine alloreactive T cell recognition.
Academic Article Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
Academic Article Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists?
Academic Article An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.
Academic Article Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice.
Academic Article Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.
Academic Article Gut immune maturation depends on colonization with a host-specific microbiota.
Academic Article Microbiota and autoimmune disease: the hosted self.
Academic Article The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.
Academic Article Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.
Academic Article Danger-free autoimmune disease in Aire-deficient mice.
Academic Article The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation.
Academic Article Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.
Academic Article Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells.
Academic Article Dominant negative analogs of NF-YA.
Academic Article A single amino acid substitution in the Ak molecule fortuitously provokes an alloresponse.
Academic Article Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity.
Academic Article Interleukin-4 can be a key positive regulator of inflammatory arthritis.
Academic Article Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements.
Academic Article Cassette vectors directing expression of T cell receptor genes in transgenic mice.
Academic Article Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain.
Academic Article The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.
Academic Article Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.
Academic Article Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.
Academic Article Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model.
Academic Article A broad analysis of IL1 polymorphism and rheumatoid arthritis.
Academic Article Superantigens interact with MHC class II molecules outside of the antigen groove.
Academic Article The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.
Academic Article Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model.
Academic Article The influence of invariant chain on the positive selection of single T cell receptor specificities.
Academic Article Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules.
Academic Article The level of N-region diversity in T cell receptors is not pre-ordained in the stem cell.
Academic Article CD4/CD8 lineage commitment: matching fate with competence.
Academic Article The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis.
Academic Article Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.
Academic Article Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.
Academic Article Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Academic Article Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.
Academic Article Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
Academic Article Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.
Concept Diabetes Mellitus, Experimental
Concept Immunohistochemistry
Concept Trypsin
Concept Gastritis
Concept Epithelium
Concept Transcription Factor RelA
Concept Diet
Concept Genetics, Population
Concept Colonic Neoplasms
Concept Complement C3
Concept Interleukin-18
Concept Simian virus 40
Concept Tumor Necrosis Factors
Concept Receptors, Calcitonin Gene-Related Peptide
Concept In Situ Hybridization
Concept Risk Factors
Concept Receptors, Tumor Necrosis Factor, Type II
Concept Interleukin-5
Concept Immunogenetics
Concept Cohort Studies
Concept Receptors, Retinoic Acid
Concept Bacteroidaceae Infections
Concept Cell Lineage
Concept Clone Cells
Concept Cell Survival
Concept Hybridomas
Concept Mitogen-Activated Protein Kinase 3
Concept CD4 Lymphocyte Count
Concept Islets of Langerhans Transplantation
Concept Dextrans
Concept Inflammatory Bowel Diseases
Concept Cell Differentiation
Concept Nuclear Receptor Subfamily 1, Group F, Member 3
Concept Single-Cell Analysis
Concept Animals, Newborn
Concept Interleukin-2 Receptor alpha Subunit
Concept Genome-Wide Association Study
Concept Immunization
Concept Prediabetic State
Concept Interleukin-12
Concept DNA Replication
Concept Multiple Sclerosis
Concept Lyme Disease Vaccines
Concept Proteomics
Concept Th2 Cells
Concept Bacterial Infections
Concept Cell Line
Concept Nematospiroides dubius
Concept Base Sequence
Concept Chemokines
Concept Interferon Type I
Concept DNA Restriction Enzymes
Concept Serine Endopeptidases
Concept Chromosome Deletion
Concept Cell Compartmentation
Concept B-Lymphocytes
Concept DNA, Circular
Concept Enhancer Elements, Genetic
Concept Diabetes Mellitus
Concept Heart Defects, Congenital
Concept Genetic Predisposition to Disease
Concept Palmitic Acid
Concept Cell Adhesion
Concept Operon
Concept T-Lymphocytes, Helper-Inducer
Concept Carboxypeptidases A
Concept T-Lymphocyte Subsets
Concept Lymphotoxin beta Receptor
Concept Diabetic Nephropathies
Concept Tumor Cells, Cultured
Concept Citrobacter rodentium
Concept Mitosis
Concept HEK293 Cells
Concept Adipose Tissue, Brown
Concept Lymphocytes, Tumor-Infiltrating
Concept Cathepsin L
Concept Cysteine Endopeptidases
Concept Leukocyte Count
Concept Energy Metabolism
Concept Chromosome Inversion
Concept Chromatin
Concept Rheumatic Fever
Concept Alzheimer Disease
Concept Receptors, Interleukin-8B
Concept Protein Tyrosine Phosphatases
Concept Receptors, Tumor Necrosis Factor, Type I
Concept Salmonella Infections
Concept K562 Cells
Concept Magnetite Nanoparticles
Concept Th1 Cells
Concept Cyclophosphamide
Concept DNA Probes
Concept Ribosomes
Concept Serotonin
Concept Genes, Dominant
Concept Tretinoin
Concept Genomics
Concept TATA Box
Concept Adipogenesis
Concept Transcription Factor AP-1
Concept Microsatellite Repeats
Concept Histological Techniques
Concept Interleukin-17
Concept Antibodies, Monoclonal
Concept Cell Membrane
Concept Epigenesis, Genetic
Concept Coculture Techniques
Concept Crystallography, X-Ray
Concept Cathepsins
Concept Cluster Analysis
Concept ATP-Binding Cassette Transporters
Concept Sialoglycoproteins
Concept Green Fluorescent Proteins
Concept Receptor, Anaphylatoxin C5a
Concept Biodiversity
Concept Horses
Concept Gene Knock-In Techniques
Concept Esters
Concept Micrococcal Nuclease
Concept Zea mays
Concept Interleukin-1beta
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Concept Lymphotoxin-alpha
Concept RNA Polymerase II
Concept Glucocorticoid-Induced TNFR-Related Protein
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Concept Stem Cell Factor
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Concept Genes, T-Cell Receptor
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Concept Cyclic AMP-Dependent Protein Kinases
Concept Antibodies, Viral
Concept Laparoscopy
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Concept T-Lymphocytes, Regulatory
Concept Crohn Disease
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Concept Quantitative Trait Loci
Concept Adenoviridae
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Concept Case-Control Studies
Concept Salmonella enterica
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Concept Lysosomes
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Concept NIH 3T3 Cells
Concept Interferon Regulatory Factors
Concept Transcription Initiation Site
Concept Endoplasmic Reticulum
Concept Lymphocyte Function-Associated Antigen-1
Concept Open Reading Frames
Concept Glucose-6-Phosphate Isomerase
Concept Erythrocytes
Concept Genetic Complementation Test
Concept Stearic Acids
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Concept Mitogen-Activated Protein Kinase 1
Concept Histamine
Concept Disease Susceptibility
Concept Dendritic Cells
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Concept Encephalomyelitis, Autoimmune, Experimental
Concept Chronic Disease
Concept Chromosomal Proteins, Non-Histone
Concept Genes, RAG-1
Concept STAT5 Transcription Factor
Concept Trans-Activators
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Concept Chemokine CCL2
Concept CCAAT-Enhancer-Binding Proteins
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Concept Cytochrome c Group
Concept DNA Breaks, Double-Stranded
Concept Fluorescence
Concept Extracellular Signal-Regulated MAP Kinases
Concept CD4-Positive T-Lymphocytes
Concept Succinic Acid
Concept Data Display
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Concept beta 2-Microglobulin
Concept Sequence Homology, Amino Acid
Concept Chelating Agents
Concept Diabetes Mellitus, Type 1
Concept PPAR gamma
Concept I-kappa B Proteins
Concept Interleukin-6
Concept Thermogenesis
Concept Image Processing, Computer-Assisted
Concept Serum
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Concept Lymphopoiesis
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Concept Extracellular Matrix
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Concept DNA Methylation
Concept Apoptosis
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Concept Muramidase
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Concept Cell Line, Tumor
Concept Chromosomes, Human, Pair 2
Concept Molecular Sequence Data
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Concept Hypoxia-Inducible Factor 1, alpha Subunit
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Concept Lymphocyte Subsets
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Concept Chromatin Assembly and Disassembly
Concept Cyclic AMP
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Concept Diabetes Mellitus, Type 2
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Concept Nuclear Receptor Subfamily 4, Group A, Member 1
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Concept DNA-Directed RNA Polymerases
Concept Ankle
Concept Hippocampus
Concept DNA Repair
Concept Ovalbumin
Concept Diarrhea
Concept Promoter Regions, Genetic
Concept Antigens, Differentiation, B-Lymphocyte
Concept Chromosomes, Human, Pair 6
Concept DNA Primers
Concept Nucleosomes
Concept Genes, Regulator
Concept MAP Kinase Signaling System
Concept Interleukin-1alpha
Concept Antigens, Differentiation, T-Lymphocyte
Concept Down-Regulation
Concept Chromosomes, Human, Pair 12
Concept Jurkat Cells
Concept Cattle
Concept Receptors, CXCR3
Concept Transgenes
Concept Ikaros Transcription Factor
Concept Cell Movement
Concept Homeodomain Proteins
Concept CpG Islands
Concept DNA, Bacterial
Concept Fibrinogen
Concept Immunoglobulin A
Concept Interleukin-1
Concept Lymphocytes
Concept Receptors, Interleukin-7
Concept Cell Death
Concept Major Histocompatibility Complex
Concept Receptors, Lymphocyte Homing
Concept Multigene Family
Concept Mitochondria
Concept Lymphoid Enhancer-Binding Factor 1
Concept Osteopontin
Concept Flow Cytometry
Concept Lyme Disease
Concept Enterovirus B, Human
Concept Eosinophils
Concept Parkinson Disease
Concept Colon
Concept Monocytes
Concept Severity of Illness Index
Concept Cell Proliferation
Concept Tetradecanoylphorbol Acetate
Concept Capsid
Concept Interleukin-2
Concept T-Lymphocytes
Concept Drug Synergism
Concept Genes, MHC Class I
Concept Organ Culture Techniques
Concept Natural Killer T-Cells
Concept Antigens, CD
Concept Interleukin-3
Concept Boron Compounds
Concept Succinates
Concept Keratitis, Herpetic
Concept TATA-Box Binding Protein
Concept Heligmosomatoidea
Concept Cell Separation
Concept Transcription Factor TFIID
Concept Transforming Growth Factor beta1
Concept Cytoplasm
Concept Signal Transduction
Concept Chickens
Concept Hematopoietic Stem Cell Transplantation
Concept Incidence
Concept Tumor Suppressor Protein p53
Concept Brain Diseases
Concept Introns
Concept Clostridium
Concept HeLa Cells
Concept DNA Topoisomerases, Type II
Concept Embryo, Mammalian
Concept DNA-Activated Protein Kinase
Concept Cell Nucleus
Concept Cell Division
Concept Nippostrongylus
Concept Antigens, Differentiation
Concept Adipose Tissue
Concept Age of Onset
Concept Genes, MHC Class II
Concept High Mobility Group Proteins
Concept Diabetes Complications
Concept Bacterial Vaccines
Concept Cell Communication
Concept Forkhead Transcription Factors
Concept RNA Interference
Concept Fluorescent Dyes
Concept Arthritis, Experimental
Concept DNA Topoisomerases, Type I
Concept Ethnic Groups
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Cell Degranulation
Concept Interleukin-15
Concept Blood
Concept CD8-Positive T-Lymphocytes
Concept Disease Progression
Concept Lymphocyte Count
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 22
Concept Antigen-Antibody Complex
Concept Adenoviruses, Human
Concept Immunoglobulin D
Concept B-Lymphocyte Subsets
Concept Lymphocytic Choriomeningitis
Concept Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Concept Endothelium, Vascular
Academic Article Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.
Academic Article The transcriptional landscape of aß T cell differentiation.
Academic Article Identification of transcriptional regulators in the mouse immune system.
Academic Article Soluble factors secreted by T cells promote ß-cell proliferation.
Academic Article Differential splicing across immune system lineages.
Academic Article Regulatory T cells in nonlymphoid tissues.
Academic Article Differential response of regulatory and conventional CD4? lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?
Academic Article Immunological goings-on in visceral adipose tissue.
Academic Article A gut feeling about arthritis.
Academic Article Restoration of the unfolded protein response in pancreatic ß cells protects mice against type 1 diabetes.
Academic Article A special population of regulatory T cells potentiates muscle repair.
Academic Article Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Academic Article An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.
Academic Article Interindividual variation in human T regulatory cells.
Academic Article Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Academic Article Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.
Academic Article Fluorescent exendin-4 derivatives for pancreatic ß-cell analysis.
Academic Article Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Academic Article Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Academic Article Intersection of population variation and autoimmunity genetics in human T cell activation.
Academic Article Transgenic mice: 'new wave' immunogenetics.
Academic Article Type 1 diabetes in NOD mice unaffected by mast cell deficiency.
Academic Article Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.
Academic Article Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.
Academic Article Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and ß cells.
Academic Article Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.
Academic Article Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Academic Article Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.
Academic Article Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Academic Article Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPAR? effects.
Academic Article Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.
Academic Article ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.
Academic Article Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Academic Article Aire controls gene expression in the thymic epithelium with ordered stochasticity.
Academic Article MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells.
Academic Article Rapid, high efficiency isolation of pancreatic ß-cells.
Academic Article Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.
Academic Article Immunological contributions to adipose tissue homeostasis.
Academic Article Parsing the Interferon Transcriptional Network and Its Disease Associations.
Academic Article Unstable FoxP3+ T regulatory cells in NZW mice.
Academic Article Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.
Academic Article Promiscuity Promotes Tolerance.
Academic Article Tissue Tregs.
Academic Article IL-33, Imprimatur of Adipocyte Thermogenesis.
Academic Article Network pharmacology of JAK inhibitors.
Grant Cellular and Molecular Effectors of Synovitis
Grant The molecular mechanism of Aire
Grant Training Grant in Diabetes and Metabolism
Grant Gene Expression and Regulatory Networks in Human Leukocytes
Grant Aire, A Zinc-Finger Protein That Controls Autoimmunity
Grant Adipose-tissue Tregs: important players in immunological control of metabolism
Grant Aire, a zinc-finger protein that controls autoimmunity
Grant Initiation of autoimmune diabetes
Grant Genetics of arthritis susceptibility in outbred HS mice
Grant Diabetes Research Center
Grant Arthritogenic Igs
Grant Muscle Tregs in health and disease
Grant Imaging Autoimmune Disease
Academic Article Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing ?d T Cells to Promote Immunologic Tolerance.
Academic Article Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes.
Academic Article Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice.
Academic Article The transcriptional regulator Aire binds to and activates super-enhancers.
Academic Article Mining the Human Gut Microbiota for Immunomodulatory Organisms.
Academic Article An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
Academic Article Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
Academic Article Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Academic Article Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.
Academic Article Different molecular complexes that mediate transcriptional induction and repression by FoxP3.
Academic Article FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.
Academic Article Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Academic Article Treg cells limit IFN-? production to control macrophage accrual and phenotype during skeletal muscle regeneration.
Grant Generation of a Cellular Atlas of Adipose Tissue in Mouse and Man
Academic Article Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Academic Article TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.
Academic Article Molecular diversification of regulatory T cells in nonlymphoid tissues.
Academic Article Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.
Academic Article Methods of Isolation and Analysis of TREG Immune Infiltrates from Injured and Dystrophic Skeletal Muscle.
Academic Article Organismal immunometabolism: advances in both directions.
Academic Article T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.
Academic Article Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.
Academic Article PAHSAs attenuate immune responses and promote ß cell survival in autoimmune diabetic mice.
Academic Article Developmental and cellular age direct conversion of CD4+ T cells into ROR?+ or Helios+ colon Treg cells.
Academic Article T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.
Academic Article Microbial bile acid metabolites modulate gut ROR?+ regulatory T cell homeostasis.
Academic Article ?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
Academic Article Sex-specific adipose tissue imprinting of regulatory T cells.
Academic Article Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.
Academic Article Visceral adipose tissue Tregs and the cells that nurture them.
Academic Article Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance.
Academic Article An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
Academic Article Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
Academic Article pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Academic Article Profound Treg perturbations correlate with COVID-19 severity.
Academic Article Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
Academic Article Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells.
Academic Article Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
Academic Article PPAR? marks splenic precursors of multiple nonlymphoid-tissue Treg compartments.
Academic Article Publisher Correction: Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
Academic Article Tissue regulatory T cells: regulatory chameleons.
Academic Article Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.
Academic Article Interferon-a-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.
Academic Article Profound Treg perturbations correlate with COVID-19 severity.
Academic Article Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers.
Search Criteria
  • metabolism
  • type
  • 2
  • diabetes
  • adipose tissue
  • small
  • molecules
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.