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Item TypeName
Academic Article Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: a study in miniature swine.
Academic Article Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.
Academic Article Pig to monkey bone marrow and kidney xenotransplantation.
Academic Article Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.
Academic Article Demonstration of multilineage chimerism in a nonhuman primate concordant xenograft model.
Academic Article Coagulation/thrombotic disorders associated with organ and cell xenotransplantation.
Academic Article Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.
Academic Article Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation.
Academic Article alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies.
Academic Article Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC.
Academic Article Characterization of a monoclonal anti-porcine CD3 antibody.
Academic Article Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation.
Academic Article Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 320 aphereses in baboons.
Academic Article Natural antibodies can inhibit bone marrow engraftment in the rat----mouse species combination.
Academic Article The use of tolerance for transplantation across xenogeneic barriers.
Academic Article Apheresis and column absorption for specific removal of Gal-alpha-1,3 Gal natural antibodies in a pig-to-baboon model.
Academic Article Function of porcine adhesion molecules in a human marrow microenvironment.
Academic Article Inhibition of xenoreactive natural antibody production by retroviral gene therapy.
Academic Article Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption.
Academic Article Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen.
Academic Article Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.
Academic Article A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.
Academic Article Effect of pig-specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons.
Academic Article High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.
Academic Article Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts.
Academic Article A study of tolerance in a concordant xenograft model.
Academic Article Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes.
Academic Article Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.
Academic Article Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands.
Academic Article Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.
Academic Article The Imunologic Response to Xenografts.
Academic Article CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons.
Academic Article Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells.
Academic Article Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons.
Academic Article Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism.
Academic Article Mixed chimerism and transplantation tolerance.
Academic Article Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons.
Academic Article Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates.
Academic Article Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation.
Academic Article Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-alphaGal antibody.
Academic Article Composite "thymoheart" transplantation improves cardiac allograft survival.
Academic Article Clearance of mobilized porcine peripheral blood progenitor cells is delayed by depletion of the phagocytic reticuloendothelial system in baboons.
Academic Article Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction.
Academic Article The immunology of xenotransplantation: introduction.
Academic Article Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.
Academic Article Depletion of natural anti-pig antibodies by the continuous infusion of oligosaccharides in a pig-to-baboon model.
Academic Article Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons.
Academic Article Tolerance in a concordant nonhuman primate model.
Academic Article Public stem cell banks: considerations of justice in stem cell research and therapy.
Academic Article A knock-out punch?
Academic Article Xenograft rejection of class I-expressing transgenic skin is CD4-dependent and CD8-independent.
Academic Article Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti-alphaGal antibody in the baboon.
Academic Article Experience with porcine thymic transplantation in baboons.
Academic Article Effect of natural antibody on xenogeneic bone marrow engraftment.
Academic Article Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells.
Academic Article Transplantation.
Academic Article Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons.
Academic Article Immunologic tolerance to organ transplants.
Academic Article Effects of xenogeneic thymic transplantation in baboons.
Academic Article Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress.
Academic Article Rejection of transgenic skin expressing a xeno-class I antigen is CD4-dependent and CD8-independent.
Academic Article Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts.
Academic Article Xenografts, cloning and the immune system.
Academic Article Discordant organ xenotransplantation in primates: world experience and current status.
Academic Article T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model.
Academic Article Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
Academic Article Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction.
Academic Article Xenogeneic thymic transplantation in a pig-to-nonhuman primate model.
Academic Article Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients.
Academic Article Genetic manipulation in pigs.
Academic Article Genetics of the induction of antigen-specific immunity in anti-idiotype-treated mice and derivation of monoclonal Ab3 antibodies.
Academic Article Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine.
Academic Article The pig as a xenograft donor.
Academic Article Skin graft tolerance across a discordant xenogeneic barrier.
Academic Article Enhancement of swine progenitor chimerism in mixed swine/human bone marrow cultures with swine cytokines.
Academic Article The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice.
Academic Article Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation.
Academic Article Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.
Academic Article Approaches to avoid immune responses induced by repeated subcutaneous injections of allogeneic umbilical cord tissue-derived cells.
Academic Article Specific tolerance across a discordant xenogeneic transplantation barrier.
Academic Article Xenotransplantation.
Academic Article Localized myocardial infarction following pig-to-baboon heart transplantation.
Academic Article Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.
Academic Article Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction.
Academic Article Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides.
Academic Article Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons.
Academic Article Results of gal-knockout porcine thymokidney xenografts.
Academic Article Human monoclonal HLA antibodies reveal interspecies crossreactive swine MHC class I epitopes relevant for xenotransplantation.
Academic Article Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model.
Academic Article Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen.
Academic Article Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation.
Academic Article Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Academic Article Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists.
Academic Article Induction of mixed hematopoietic chimerism in the pig-to-baboon model.
Academic Article Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine.
Academic Article Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen.
Academic Article Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution.
Academic Article Epidermal Langerhans cells are derived from cells originating in bone marrow.
Academic Article Immunogenicity of umbilical cord tissue derived cells.
Academic Article In vivo and in vitro characterization of specific hyporeactivity to skin xenografts in mixed xenogeneically reconstituted mice (B10 + F344 rat----B10).
Academic Article A mixed chimerism approach to renal transplantation between concordant nonhuman primate species.
Academic Article Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts.
Academic Article Xenotransplantation and its implications. Background information for the press.
Academic Article Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance.
Academic Article Human CD4+ T cells mediate rejection of porcine xenografts.
Academic Article Acute humoral xenograft rejection: destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts.
Academic Article Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus.
Academic Article Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs.
Academic Article Activation of cytomegalovirus in pig-to-primate organ xenotransplantation.
Academic Article Lack of variation in alphaGal expression on lymphocytes in miniature swine of different genotypes.
Academic Article Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation.
Academic Article Will the pig solve the transplantation backlog?
Academic Article Histocompatibility relationships between species.
Academic Article Human plasma causes rapid dysfunction in ex vivo pig hearts.
Academic Article Derivation of immortalized swine stromal cell lines.
Academic Article Depletion of anti-Gal(alpha)1-3Gal antibody in baboons by specific alpha-Gal immunoaffinity columns.
Academic Article Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors.
Academic Article Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy.
Academic Article Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate.
Academic Article Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.
Academic Article In vitro and in vivo analysis of bone marrow-derived CD3+, CD4-, CD8-, NK1.1+ cell lines.
Academic Article The pig as a potential xenograft donor.
Academic Article Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen.
Academic Article Tolerance to primarily vascularized allografts in miniature swine.
Academic Article Long-term acceptance of primarily vascularized renal allografts in miniature swine. Systemic tolerance versus graft adaptation.
Academic Article Immunology of xenograft rejection.
Academic Article GalT-KO pigs: is the cup half empty or half full?
Academic Article Natural antibodies against bone marrow cells of a concordant xenogeneic species.
Academic Article Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons.
Academic Article Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.
Academic Article Xenogeneic thymus transplantation in a pig-to-baboon model.
Academic Article Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation.
Academic Article Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.
Academic Article Life-supporting function of genetically modified swine lungs in baboons.
Academic Article Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.
Academic Article Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade.
Academic Article CCETS Basic Science Lecture. Transplantation tolerance.
Academic Article First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome.
Academic Article Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons.
Academic Article Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood.
Academic Article Basic science highlights at the 1990 Congress.
Academic Article Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.
Academic Article Direct and indirect recognition of pig class II antigens by human T cells.
Academic Article Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine. Effect of administration of exogenous IL-2.
Academic Article Effect of selective T cell depletions in mixed xenogeneic reconstitution on specific hyporeactivity to transplantation across a species barrier.
Academic Article Quantification of baboon thymopoiesis in porcine thymokidney xenografts by the signal-joining T-cell receptor excision circle assay.
Academic Article Transplant tolerance: bench to bedside--26th annual Samuel Jason Mixter Lecture.
Academic Article Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Academic Article In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates.
Academic Article Prolonged survival of GalT-KO swine skin on baboons.
Academic Article Pathologic characteristics of transplanted kidney xenografts.
Academic Article Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. I. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component.
Academic Article Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Academic Article The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat.
Academic Article Xenotransplantation--caution, but no moratorium.
Academic Article The mechanism of xenogeneic cell-mediated lympholysis between human and pig cells.
Academic Article Tolerance and xenograft survival.
Academic Article Immortalized bone-marrow derived pig endothelial cells.
Academic Article Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.
Academic Article Stem cell activity of porcine c-kit+ hematopoietic cells.
Academic Article Humoral tolerance in mixed xenogeneic chimeras prepared by a nonmyeloablative conditioning regimen.
Academic Article The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells.
Academic Article Induction of tolerance to pig antigens in mice grafted with fetal pig thymus/liver grafts.
Academic Article Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection.
Academic Article Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity.
Academic Article Mixed chimerism.
Academic Article Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity.
Academic Article alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months.
Academic Article Xenograft tolerance.
Academic Article Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells.
Concept Transplantation, Heterologous
Concept Antibodies, Monoclonal, Murine-Derived
Concept Xenograft Model Antitumor Assays
Academic Article Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells.
Academic Article Increased levels of anti-non-Gal IgG following pig-to-baboon bone marrow transplantation correlate with failure of engraftment.
Academic Article Production of cloned NIBS (Nippon Institute for Biological Science) and a-1, 3-galactosyltransferase knockout MGH miniature pigs by somatic cell nuclear transfer using the NIBS breed as surrogates.
Academic Article Lack of cross-sensitization between a-1,3-galactosyltransferase knockout porcine and allogeneic skin grafts permits serial grafting.
Academic Article Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.
Academic Article Increased transfusion-free survival following auxiliary pig liver xenotransplantation.
Academic Article Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation.
Academic Article High incidence of xenogenic bone marrow engraftment in pig-to-baboon intra-bone bone marrow transplantation.
Academic Article Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.
Academic Article [[¹¹C]choline as a pharmacodynamic marker for docetaxel therapy. Response assessment in a LNCaP prostate cancer xenograft mouse model].
Academic Article Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization.
Academic Article The Medawar Prize acceptance speech 2014.
Academic Article Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons.
Academic Article Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure.
Academic Article Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.
Academic Article Progress towards inducing tolerance of pig-to-primate xenografts.
Academic Article The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation.
Academic Article A Bridge to Somewhere: 25-day Survival After Pig-to-Baboon Liver Xenotransplantation.
Academic Article Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants.
Grant A Tolerance Approach to Xenotransplantation
Grant GVL without GVHD across HLA barriers: Translational Studies
Grant Xenogeneic Stem Cell and Thymic Replacement in AIDS
Grant GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts
Grant Training in Transplantation Biology
Grant GalT-KO Pigs Expressing Primate CD47 to Facilitate Organ Xenografts
Academic Article Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47.
Academic Article Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation.
Academic Article Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons.
Academic Article Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade.
Academic Article Ontak-like human IL-2 fusion toxin.
Academic Article Skin grafts from genetically modified a-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts.
Academic Article Regulation of Clinical Xenotransplantation-Time for a Reappraisal.
Academic Article Tolerance in xenotransplantation.
Academic Article Comparison of [¹¹C]choline ([¹¹C]CHO) and S(+)-ß-methyl-[¹¹C]choline ([¹¹C]SMC) as imaging probes for prostate cancer in a PC-3 prostate cancer xenograft model.
Academic Article Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.
Academic Article Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation.
Academic Article Joint FDA-IXA Symposium, September 20, 2017.
Academic Article GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.
Academic Article Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo.
Academic Article Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study.
Academic Article Transplantation tolerance through mixed chimerism: From allo to xeno.
Academic Article Amino acid and lipid profiles following pig-to-primate liver xenotransplantation.
Academic Article Xenogeneic Heterotopic Auxiliary Liver transplantation (XHALT) promotes native liver regeneration in a Post-Hepatectomy Liver failure model.
Academic Article Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages.
Academic Article Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival.
Grant Composite porcine islet-kidney xenotransplants to cure diabetes and renal failure
Academic Article Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons.
Academic Article Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.