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One or more keywords matched the following items that are connected to Jain, Rakesh
Item TypeName
Academic Article 1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Academic Article Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.
Academic Article Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Academic Article Hindered diffusion in agarose gels: test of effective medium model.
Academic Article Compatibility and the genesis of residual stress by volumetric growth.
Academic Article Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Academic Article A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Academic Article Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Academic Article Role of extracellular matrix assembly in interstitial transport in solid tumors.
Academic Article Solid stress inhibits the growth of multicellular tumor spheroids.
Academic Article Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
Academic Article Fractals and cancer.
Academic Article Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Academic Article Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Academic Article Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.
Academic Article Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Academic Article Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.
Academic Article Nuclease P1-mediated fluorescence postlabeling assay of AAF modified DNA model d(TACGTA) and calf-thymus DNA.
Academic Article Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Academic Article Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Academic Article Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Academic Article A model for temporal heterogeneities of tumor blood flow.
Academic Article Chemical synthesis of sulfated oligosaccharides with a beta-D-Gal-(1-->3).
Academic Article Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Academic Article The biology of brain metastases-translation to new therapies.
Academic Article Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Academic Article Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
Academic Article Solid stress generated by spheroid growth estimated using a linear poroelasticity model.
Academic Article Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Academic Article Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Academic Article Application of ARIMA model in adjustment of seasonal and non-seasonal variations in births of Ontario.
Academic Article A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Academic Article Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Academic Article Transport of molecules, particles, and cells in solid tumors.
Academic Article A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Academic Article Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Academic Article Angiogenesis in the huPBL-SCID model of human transplant rejection.
Academic Article Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Academic Article Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Academic Article A potential murine model for flap-related investigations.
Academic Article Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Academic Article TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Academic Article Neuro-Oncology Published online
Academic Article Biophysical Journal
Academic Article Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
Academic Article Anti-vascular endothelial growth factor therapy for malignant glioma.
Academic Article PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.
Academic Article Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Academic Article Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Academic Article Inhibition of L- and P-selectin by a rationally synthesized novel core 2-like branched structure containing GalNAc-Lewisx and Neu5Acalpha2-3Galbeta1-3GalNAc sequences.
Academic Article Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Academic Article Microvascular permeability of normal and neoplastic tissues.
Academic Article Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
Academic Article Plastic and Reconstructive Surgery
Academic Article Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Academic Article Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
Academic Article Delivery of molecular and cellular medicine to solid tumors.
Academic Article Non-reducing terminal linkage position determination in intact and permethylated synthetic oligosaccharides having a penultimate amino sugar: fast atom bombardment ionization, collisional-induced dissociation and tandem mass spectrometry.
Academic Article Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Academic Article A protocol for a lung neovascularization model in rodents.
Academic Article Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Academic Article Quantitative angiogenesis assays: progress and problems.
Academic Article Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Academic Article Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Academic Article A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
Academic Article Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Academic Article Biophysical Journal
Academic Article J. Theor. Biol
Academic Article Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
Academic Article Fucosylation of disaccharide precursors of sialyl LewisX inhibit selectin-mediated cell adhesion.
Academic Article Robust 3-D modeling of vasculature imagery using superellipsoids.
Academic Article TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Academic Article Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?
Academic Article Journal of Pharmacokinetics and Biopharmaceutics
Academic Article Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Academic Article An isolated tumor perfusion model in mice.
Academic Article Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Academic Article p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Academic Article Painful diabetic neuropathy is more than pain alone: examining the role of anxiety and depression as mediators and complicators.
Academic Article Visualizing anti-tumor immune responses in vivo.
Academic Article In vivo wide-area cellular imaging by side-view endomicroscopy.
Academic Article A semi-Markov model for the average length of stay in transient states and its application.
Academic Article Mechanical compression drives cancer cells toward invasive phenotype.
Academic Article Mammary fat pad tumor preparation in mice.
Academic Article Journal of Applied Physiology
Academic Article Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Academic Article Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Academic Article Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Academic Article Corneal pocket assay in rabbits.
Academic Article Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Academic Article Journal of Pharmaceutical Sciences
Academic Article A transient parabiosis skin transplantation model in mice.
Academic Article Anti-invasive activity of alkaloids and polyphenolics in vitro.
Academic Article Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
Academic Article Cancer, angiogenesis and fractals.
Academic Article Return of lymphatic function after flap transfer for acute lymphedema.
Academic Article Integrative pathophysiology of solid tumors: role in detection and treatment.
Academic Article Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone.
Academic Article Microvascular network architecture in a mammary carcinoma.
Academic Article J. Thermal Biology
Academic Article Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Academic Article Transplantation
Academic Article In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
Academic Article Vascular permeability in a human tumour xenograft: molecular charge dependence.
Academic Article Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Academic Article Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Academic Article Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Academic Article Transport of molecules across tumor vasculature.
Academic Article Microvascular Research
Academic Article Characterization of sialyloligosaccharide binding by recombinant soluble and native cell-associated CD22. Evidence for a minimal structural recognition motif and the potential importance of multisite binding.
Academic Article Dissecting tumour pathophysiology using intravital microscopy.
Academic Article Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Academic Article Structure-activity relationship of antiestrogens: a study using triarylbutenone, benzofuran, and triarylfuran analogues as models for triarylethylenes and triarylpropenones.
Academic Article Normalization of the vasculature for treatment of cancer and other diseases.
Academic Article Liver tumor preparation in mice.
Academic Article Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Academic Article In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ
Academic Article Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Academic Article Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Academic Article Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Academic Article Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Academic Article Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Academic Article Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Academic Article Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Academic Article Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Academic Article AIChE Symposium Series
Academic Article Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Academic Article A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Academic Article Physiological adaptations and tolerance towards higher concentration of selenite (Se(+4)) in Enterobacter sp. AR-4, Bacillus sp. AR-6 and Delftia tsuruhatensis AR-7.
Academic Article Pancreatic tumor preparation in mice.
Academic Article Measuring angiogenesis and hemodynamics in mice.
Academic Article Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Academic Article A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Academic Article Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Academic Article Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
Academic Article Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Academic Article Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Academic Article Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Academic Article In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Academic Article Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Academic Article Transvascular and interstitial transport in tumors.
Academic Article Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Academic Article Hyperthermia in Cancer Therapy
Academic Article Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Academic Article Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
Academic Article Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Academic Article Extravascular transport in normal and tumor tissues.
Academic Article Two-compartment model for plasma pharmacokinetics in individual blood vessels.
Academic Article Preliminary model for streptozocin metabolism in mice.
Academic Article Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Academic Article Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
Academic Article Dynamics of neovascularization in normal tissue.
Academic Article Physiologically based pharmacokinetic modeling: principles and applications.
Academic Article Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Academic Article CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Academic Article Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Academic Article Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Academic Article Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Academic Article Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Academic Article Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Academic Article Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model.
Academic Article J. Bioengineering
Concept Models, Chemical
Concept Models, Molecular
Concept Models, Theoretical
Concept Models, Structural
Concept Models, Animal
Concept Models, Genetic
Concept Models, Immunological
Concept Models, Cardiovascular
Concept Linear Models
Concept Disease Models, Animal
Concept Models, Statistical
Concept Models, Biological
Concept Xenograft Model Antitumor Assays
Concept Proportional Hazards Models
Academic Article Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.
Academic Article A theoretical model for water flux through the artery wall.
Academic Article Stability of membrane systems modeled as multilayered viscoelastic films.
Academic Article Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Academic Article Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells.
Academic Article Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?
Academic Article Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2.
Academic Article Transgenic mice for cGMP imaging.
Academic Article Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse.
Academic Article Horizontal gene transfer among genomes: the complexity hypothesis.
Academic Article Influence of plate design on cortical bone perfusion and fracture healing in canine segmental tibial fractures.
Academic Article In vivo assessment of second generation implantable laser Doppler flowmetry fibres for bone blood flow determination.
Academic Article Combining two strategies to improve perfusion and drug delivery in solid tumors.
Academic Article Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Academic Article A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer.
Academic Article Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.
Academic Article Study on incidence of bleeding in hospitalized patients after antithrombotic therapy at a tertiary care hospital.
Academic Article The role of mechanical forces in tumor growth and therapy.
Academic Article Letter to the editor regarding recent article by Wu et al. [J. Theor. Biol. 355 (2014) pp. 194-207].
Academic Article Using tumour phylogenetics to identify the roots of metastasis in humans.
Academic Article Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Academic Article PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Academic Article Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Academic Article An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Academic Article Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
Academic Article Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
Academic Article Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
Academic Article A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Academic Article Texture Feature Ratios from Relative CBV Maps of Perfusion MRI Are Associated with Patient Survival in Glioblastoma.
Academic Article Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Academic Article Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.
Academic Article Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.
Grant Integrative Biology of Tumor Metastasis
Grant Probing Tumor Microenvironment Using Nanotechnology
Grant Dissecting Pediatric Brain Tumor Microenvironment to Improve Treatment
Grant Integrative Pathophysiology of Solid Tumors
Academic Article Role of vascular normalization in benefit from metronomic chemotherapy.
Academic Article Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.
Academic Article Origins of lymphatic and distant metastases in human colorectal cancer.
Grant Reengineering obesity-induced abnormal microenvironment to improve PDAC treatment
Academic Article YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.
Academic Article Anti-VEGF treatment improves neurological function in tumors of the nervous system.
Grant Reprogramming PDAC tumor microenvironment to improve immunotherapy
Academic Article A cerebellar window for intravital imaging of normal and disease states in mice.
Academic Article Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.
Academic Article MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma.
Academic Article Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.
Academic Article Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.
Academic Article Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Academic Article Quantifying solid stress and elastic energy from excised or in situ tumors.
Academic Article Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Mentoring - Current Student Opportunity Tumor Angiogenesis, Metastasis and Microenvironment
Academic Article Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.
Academic Article Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Academic Article Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Academic Article A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Academic Article Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
Academic Article Vessel co-option in glioblastoma: emerging insights and opportunities.
Academic Article CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Academic Article Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.
Academic Article Combining microenvironment normalization strategies to improve cancer immunotherapy.
Academic Article Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
Academic Article A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
Academic Article Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Academic Article In silico dynamics of COVID-19 phenotypes for optimizing clinical management.
Mentoring - Current Student Opportunity Targeting the tumor microenvironment - from bench to bedside
Academic Article Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Grant Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism
Academic Article Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas.
Academic Article Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.
Grant Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistance
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.