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overview My research goals are (i) to further mechanistic understanding of the vascular, interstitial and cellular barriers to the delivery and efficacy of molecular medicine in tumors, (ii) to develop and test new strategies to overcome these barriers for improving detection and treatment of tumors, and (iii) to translate these strategies from bench to bedside and in the process discover new biomarkers and new strategies to improve the outcome further. This tight integration between bench and bedside is a hallmark of my research. My educational goals are to train basic scientists, bioengineers and physicians in the systems biology of cancer. I have had the good fortune of mentoring more than 150 doctoral and postdoctoral fellows from diverse backgrounds including engineering, mathematics, physics, chemistry, molecular and cellular biology, immunology, pathology, radiology, radiation, medical and surgical oncology – listed in the Table in the next section. I have also had productive collaborations with a similar number of basic scientists and clinicians from Harvard, MIT and elsewhere. Findings from these collaborative efforts are summarized in more than 525 publications, seven monographs and six patents. For highlights of our key research findings, please visit: http://steele.mgh.harvard.edu
One or more keywords matched the following items that are connected to Jain, Rakesh
Item TypeName
Mentoring - Completed Student Project Search for the Mechanism of Resistance of HER2-positive Breast Cancer Brain Metastases to Targeted Therapies
Academic Article Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Academic Article Quantitative analysis of 3'-azido-3'-deoxythymidine incorporation into DNA in human colon tumor cells.
Academic Article Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Academic Article Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Academic Article Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Academic Article Tumor angiogenesis and interstitial hypertension.
Academic Article Compatibility and the genesis of residual stress by volumetric growth.
Academic Article Formation of endothelial cell networks.
Academic Article Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Academic Article Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.
Academic Article Photodynamic therapy for cancer.
Academic Article Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Academic Article Zooming in and out with quantum dots.
Academic Article Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Academic Article Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
Academic Article Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
Academic Article Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.
Academic Article Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Academic Article Leukocyte-endothelial adhesion and angiogenesis in tumors.
Academic Article Pedunculated gastric teratoma: a case report with review of literature.
Academic Article Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Academic Article Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Academic Article Understanding barriers to drug delivery: high resolution in vivo imaging is key.
Academic Article Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Academic Article Role of extracellular matrix assembly in interstitial transport in solid tumors.
Academic Article Solid stress inhibits the growth of multicellular tumor spheroids.
Academic Article Effects of needle insertion in tumors on interstitial fluid pressure.
Academic Article Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Academic Article Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Academic Article Openings between defective endothelial cells explain tumor vessel leakiness.
Academic Article Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Academic Article Fractals and cancer.
Academic Article Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Academic Article Vessels of death or life.
Academic Article Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
Academic Article Imaging angiogenesis and the microenvironment.
Academic Article Can engineered bacteria help control cancer?
Academic Article Development. Lymphatics make the break.
Academic Article Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Academic Article Interstitial hypertension in superficial metastatic melanomas in humans.
Academic Article Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Academic Article Direct in vivo measurement of targeted binding in a human tumor xenograft.
Academic Article The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Academic Article Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Academic Article Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Academic Article Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Academic Article Differential transplantability of tumor-associated stromal cells.
Academic Article Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Academic Article VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.
Academic Article Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Academic Article Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Academic Article Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Academic Article Role of nitric oxide in angiogenesis and microcirculation in tumors.
Academic Article A model for temporal heterogeneities of tumor blood flow.
Academic Article During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Academic Article Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Academic Article Characterization of distinct Gal:3-O-sulfotransferase activities in human tumor epithelial cell lines and of calf lymph node GlcNAc : 6-O-sulfotransferase activity.
Academic Article In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Academic Article Pathology: cancer cells compress intratumour vessels.
Academic Article Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Academic Article Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Academic Article Oncotic pressure in solid tumors is elevated.
Academic Article Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Academic Article The biology of brain metastases-translation to new therapies.
Academic Article Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.
Academic Article Nucleolar organizer regions in cirrhosis and hepatocellular carcinoma.
Academic Article Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Academic Article Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Academic Article Solid stress generated by spheroid growth estimated using a linear poroelasticity model.
Academic Article Measurement of capillary filtration coefficient in a solid tumor.
Academic Article Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Academic Article Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Academic Article Angiogenesis in cancer and other diseases.
Academic Article Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Academic Article Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Academic Article Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Academic Article Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.
Academic Article Mucin biosynthesis revisited. The enzymatic transfer of Gal in beta 1,3 linkage to the GalNAc moiety of the core structure R1-GlcNAc beta 1,6GalNAc alpha-O-R2.
Academic Article Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Academic Article Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Academic Article Localized tenosynovial giant cell tumor of tendon sheath. A case report.
Academic Article Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Academic Article A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Academic Article Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
Academic Article VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
Academic Article Polyhydroxyalkanoates: important in cancer and other drug discovery systems.
Academic Article Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Academic Article Delivering nanomedicine to solid tumors.
Academic Article Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Academic Article Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Academic Article Haemodynamic and transport barriers to the treatment of solid tumours.
Academic Article In: Antiangiogenic Cancer Therapy (Editors: James L. Abbruzzese, Darren W. Davis and Roy S. Herbst), CRC Press, Boca Raton
Academic Article In: Tumor Angiogenesis, R. Bicknell, C. Lewis and N. Ferrara, Eds, Oxford University Press, Oxford
Academic Article Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Academic Article A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Academic Article Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Academic Article Mixed hepatoblastoma diagnosed by fine-needle aspiration biopsy cytology: a case report.
Academic Article Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.
Academic Article Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Academic Article Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Academic Article Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Academic Article Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Academic Article Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Academic Article Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Academic Article In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Academic Article Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
Academic Article Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
Academic Article Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Academic Article Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Academic Article Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Academic Article Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology.
Academic Article TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Academic Article Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
Academic Article Differential gene expression in metastasizing cells shed from kidney tumors.
Academic Article Measurement of macromolecular diffusion coefficients in human tumors.
Academic Article In: Progress in Microcirculation Research, H. Niimi, et al, Eds
Academic Article Differential response of normal and tumor microcirculation to hyperthermia.
Academic Article Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Academic Article Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
Academic Article Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Academic Article Hemangiopericytoma of the head and neck.
Academic Article Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
Academic Article Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Academic Article Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Academic Article Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Academic Article Circulating immune profile in patients with pre-cancer and cancer of the cervix: a cross sectional study among Indian women.
Academic Article Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Academic Article The role of nitric oxide in tumour progression.
Academic Article Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Academic Article Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Academic Article Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Academic Article Ovarian cancer alpha 1,3-L-fucosyltransferase. Differentiation of distinct catalytic species with the unique substrate, 3'-sulfo-N-acetyllactosamine in conjunction with other synthetic acceptors.
Academic Article Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Academic Article Blood flow and heat transfer in Walker 256 mammary carcinoma.
Academic Article Microvascular permeability of normal and neoplastic tissues.
Academic Article BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Academic Article Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Academic Article 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
Academic Article In: Biology and Clinical Applications of IL-2, R.C. Rees, Ed., Oxford University Press, London
Academic Article Dynamics of cancer cell interactions with microvasculature and interstitium.
Academic Article Is vasculogenesis crucial for the regrowth of irradiated tumours?
Academic Article Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Academic Article Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Academic Article Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Academic Article Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Academic Article Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
Academic Article Delivery of molecular and cellular medicine to solid tumors.
Academic Article Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Academic Article Thalamic glioblastoma with cerebrospinal fluid dissemination in the peritoneal cavity.
Academic Article Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Academic Article Neurocutaneous melanosis: an atypical presentation.
Academic Article Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Academic Article Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Academic Article Taming vessels to treat cancer.
Academic Article Malignant cells facilitate lung metastasis by bringing their own soil.
Academic Article Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Academic Article Spontaneous nonthymic tumors in SCID mice.
Academic Article Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.
Academic Article Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Academic Article Interstitial hypertension in human breast and colorectal tumors.
Academic Article Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Academic Article Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Academic Article Trends in Molecular Medicine
Academic Article Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Academic Article Angiogenesis in brain tumours.
Academic Article LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Academic Article Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Academic Article What brings pericytes to tumor vessels?
Academic Article The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Academic Article Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
Academic Article Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Academic Article Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Academic Article Antiangiogenic agents for the treatment of glioblastoma.
Academic Article Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Academic Article Response criteria for glioma.
Academic Article A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Academic Article Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade.
Academic Article Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Academic Article Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Academic Article Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
Academic Article Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Academic Article Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Academic Article Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Academic Article Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Academic Article Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Academic Article Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
Academic Article Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Academic Article A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
Academic Article TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Academic Article Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Academic Article Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Academic Article Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Academic Article Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Academic Article Role of perfusion CT in glioma grading and comparison with conventional MR imaging features.
Academic Article VEGFR3: a new target for antiangiogenesis therapy?
Academic Article Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?
Academic Article Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Academic Article Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Academic Article Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Academic Article Barriers to drug delivery in solid tumors.
Academic Article Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Academic Article Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Academic Article Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Academic Article Lung window preparation in mice.
Academic Article Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Academic Article C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Academic Article Visualizing anti-tumor immune responses in vivo.
Academic Article Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Academic Article VEGFR1-activity-independent metastasis formation.
Academic Article Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Academic Article In vivo wide-area cellular imaging by side-view endomicroscopy.
Academic Article In vivo imaging of tumors.
Academic Article A semi-Markov model for the average length of stay in transient states and its application.
Academic Article Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Academic Article Mechanical compression drives cancer cells toward invasive phenotype.
Academic Article Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
Academic Article Mammary fat pad tumor preparation in mice.
Academic Article Unilateral expression of multiple glomus tumors. An unusual occurrence.
Academic Article Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Academic Article Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Academic Article Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Academic Article VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Academic Article Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Academic Article PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Academic Article Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Academic Article Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Academic Article Corneal pocket assay in rabbits.
Academic Article Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Academic Article Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Academic Article Pharmacokinetics of methotrexate in solid tumors.
Academic Article Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
Academic Article Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Academic Article Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Academic Article Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
Academic Article Cancer, angiogenesis and fractals.
Academic Article Interstitial fluid pressure in intracranial tumours in patients and in rodents.
Academic Article Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
Academic Article In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
Academic Article Integrative pathophysiology of solid tumors: role in detection and treatment.
Academic Article CT-guided preoperative needle localization of MR imaging-detected mammographically occult lesions.
Academic Article Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Academic Article Microvascular network architecture in a mammary carcinoma.
Academic Article Tumor induction of VEGF promoter activity in stromal cells.
Academic Article Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Academic Article Lymphatic metastasis in the absence of functional intratumor lymphatics.
Academic Article Molecular regulation of vessel maturation.
Academic Article HSV-IgA serum antibodies in cervical intraepithelial neoplasia and invasive cancer patients, and in their spouses: a case control study.
Academic Article Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Academic Article Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
Academic Article Delivery of molecular and cellular medicine to solid tumors.
Academic Article Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Academic Article Vascular permeability in a human tumour xenograft: molecular charge dependence.
Academic Article Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Academic Article Advances in Cancer Research
Academic Article Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Academic Article Antiangiogenic therapy for cancer: current and emerging concepts.
Academic Article Transport of molecules across tumor vasculature.
Academic Article Extravascular diffusion in normal and neoplastic tissues.
Academic Article Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Academic Article Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Academic Article The next frontier of molecular medicine: delivery of therapeutics.
Academic Article Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Academic Article Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Academic Article Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Academic Article Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Academic Article Dissecting tumour pathophysiology using intravital microscopy.
Academic Article Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Academic Article Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Academic Article Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Academic Article Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Academic Article Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Academic Article Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Academic Article Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.
Academic Article Genetic evidence for a tumor suppressor role of HIF-2alpha.
Academic Article Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Academic Article Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
Academic Article Scaling rules for diffusive drug delivery in tumor and normal tissues.
Academic Article Normalization of the vasculature for treatment of cancer and other diseases.
Academic Article Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Academic Article Liver tumor preparation in mice.
Academic Article Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Academic Article Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Academic Article In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ
Academic Article Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Academic Article Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Academic Article Delivery of molecular medicine to solid tumors.
Academic Article Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.
Academic Article Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Academic Article Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Academic Article Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Academic Article Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
Academic Article Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Academic Article Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
Academic Article Dehydro-alpha-lapachone, a plant product with antivascular activity.
Academic Article Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Academic Article Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Academic Article Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.
Academic Article Rabbit ear chambers.
Academic Article Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Academic Article Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Academic Article Targeted therapy in rectal cancer.
Academic Article Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Academic Article Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Academic Article Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Academic Article Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Academic Article Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Academic Article Transport of molecules in the tumor interstitium: a review.
Academic Article Fluorescence postlabeling assay of DNA damage induced by N-methyl-N-nitrosourea.
Academic Article Determinants of tumor blood flow: a review.
Academic Article Lessons from the adjuvant bevacizumab trial on colon cancer: what next?
Academic Article Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Academic Article T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.
Academic Article Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Academic Article AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Academic Article Tumor physiology and antibody delivery.
Academic Article Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required?
Academic Article Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Academic Article SnapShot: Tumor angiogenesis.
Academic Article Pancreatic tumor preparation in mice.
Academic Article Measuring angiogenesis and hemodynamics in mice.
Academic Article Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Academic Article Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
Academic Article Ewing's sarcoma of rib presenting as paraplegia of acute onset (case report).
Academic Article Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Academic Article Perivascular nitric oxide gradients normalize tumor vasculature.
Academic Article Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Academic Article A comparative study of low dose weekly paclitaxel versus cisplatin with concurrent radiation in the treatment of locally advanced head and neck cancers.
Academic Article Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Academic Article A new target for tumor therapy.
Academic Article Marine life: new hope for cancer drugs.
Academic Article Anti-invasive activity of 3,7-dimethoxyflavone in vitro.
Academic Article Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Academic Article Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Academic Article Oxygenation in tumors by modified hemoglobins.
Academic Article Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
Academic Article Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
Academic Article Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment.
Academic Article Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
Academic Article Cancer Research
Academic Article Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Academic Article Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Academic Article Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Academic Article In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Academic Article Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Academic Article Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Academic Article Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Academic Article Transvascular and interstitial transport in tumors.
Academic Article HCC and angiogenesis: possible targets and future directions.
Academic Article Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Academic Article Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Academic Article Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.
Academic Article Hyperthermia in Cancer Therapy
Academic Article Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
Academic Article Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Academic Article In: Biologic Therapy of Cancer: Principles and Practice, S. Rosenberg, Ed., Lippincott, Williams and Watkins, Philadelphia
Academic Article Extensive verrucosis, squamous cell carcinoma, and immunologic abnormality in Klinefelter's syndrome.
Academic Article Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Academic Article Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Academic Article Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Academic Article Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan.
Academic Article Biomarkers of response and resistance to antiangiogenic therapy.
Academic Article Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Academic Article Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Academic Article In: Monoclonal Antibody-Based Therapy of Cancer, M.L. Grossbard, Ed., Marcel Dekker, Inc., New York
Academic Article Extravascular transport in normal and tumor tissues.
Academic Article Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Academic Article Vasculogenic mimicry: how convincing, how novel, and how significant?
Academic Article Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.
Academic Article Squamous cell carcinoma complicating chronic discoid lupus erythematosus (CDLE).
Academic Article Temperature gradients and local perfusion in a mammary carcinoma.
Academic Article Carcinoma of the supraglottic larynx in a girl of 11 years of age.
Academic Article Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Academic Article Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Academic Article Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
Academic Article Peripheral blood lymphocyte subpopulations in Indian women with cervical intraepithelial neoplasia and invasive cancer--an immunocytochemical study using monoclonal antibodies.
Academic Article Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Academic Article Tissue-isolated human tumor xenografts in athymic nude mice.
Academic Article Osteoid osteoma of the mandible.
Academic Article Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Academic Article Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Academic Article Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Academic Article CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Academic Article Current Colorectal Cancer Reports
Academic Article Use of sialylated or sulfated derivatives and acrylamide copolymers of Gal beta 1,3GalNAc alpha- and GalNAc alpha- to determine the specificities of blood group T- and Tn-specific lectins and the copolymers to measure anti-T and anti-Tn antibody levels in cancer patients.
Academic Article Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Academic Article Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Academic Article Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Academic Article 2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Academic Article Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Academic Article Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Academic Article Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
Academic Article Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Academic Article Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Academic Article Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).
Academic Article Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Academic Article Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model.
Academic Article In: Angiogenesis: Mechanisms and Cancer Therapy (Editors: Dieter Marmé and Norbert E. Fusenig), Springer-Verlag, Berlin
Academic Article Osteoid osteoma of the mandible.
Academic Article Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
Academic Article Capillary electrophoretic separation and laser-induced fluorescence detection of the major DNA adducts of cisplatin and carboplatin.
Academic Article Mesenteric plexiform neurofibroma: computed tomography appearance.
Academic Article Specificity analysis of three clonal and five non-clonal alpha 1,3-L-fucosyltransferases with sulfated, sialylated, or fucosylated synthetic carbohydrates as acceptors in relation to the assembly of 3'-sialyl-6'-sulfo Lewis x (the L-selectin ligand) and related complex structures.
Concept Colonic Neoplasms
Concept Mouth Neoplasms
Concept Neoplasms, Neuroepithelial
Concept Hypopharyngeal Neoplasms
Concept Breast Neoplasms
Concept Stomach Neoplasms
Concept Bone Neoplasms
Concept Chemotherapy, Cancer, Regional Perfusion
Concept Thymus Neoplasms
Concept Neoplasms, Hormone-Dependent
Concept Head and Neck Neoplasms
Concept Bile Duct Neoplasms
Concept Neoplasms, Experimental
Concept Immunotherapy, Adoptive
Concept Peripheral Nervous System Neoplasms
Concept Laryngeal Neoplasms
Concept Meningeal Neoplasms
Concept Maxillary Neoplasms
Concept Colorectal Neoplasms
Concept Pancreatic Neoplasms
Concept Lip Neoplasms
Concept Gallbladder Neoplasms
Concept Ovarian Neoplasms
Concept Mammary Neoplasms, Animal
Concept Kidney Neoplasms
Concept Pleural Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Muscle Neoplasms
Concept Immunotherapy
Concept Esophageal Neoplasms
Concept Brain Neoplasms
Concept Lung Neoplasms
Concept Rectal Neoplasms
Concept Skin Neoplasms
Concept National Cancer Institute (U.S.)
Concept Intestinal Neoplasms
Concept Peritoneal Neoplasms
Concept Neoplasms
Concept Pharyngeal Neoplasms
Concept Mandibular Neoplasms
Concept Early Detection of Cancer
Concept Central Nervous System Neoplasms
Concept Uterine Cervical Neoplasms
Concept Liver Neoplasms, Experimental
Concept Soft Tissue Neoplasms
Concept Liver Neoplasms
Concept Facial Neoplasms
Concept Prostatic Neoplasms
Concept Ear Neoplasms
Concept Uveal Neoplasms
Concept Cerebellar Neoplasms
Academic Article Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.
Academic Article Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Academic Article Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.
Academic Article Benign focal melanotic lesions of the oral mucosa.
Academic Article Measuring interstitial pH and pO2 in mouse tumors.
Academic Article Outcome after disarticulation of the hip for sarcomas.
Academic Article Giant congenital melanocytic nevus with choroid plexus papilloma: case report and review of literature.
Academic Article Lacrimal drainage surgery in patients with rare nasal diseases.
Academic Article A comparative study of fuzzy classification methods on breast cancer data.
Academic Article Permeability estimates in histopathology-proved treatment-induced necrosis using perfusion CT: can these add to other perfusion parameters in differentiating from recurrent/progressive tumors?
Academic Article Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?
Academic Article In vivo correlation of tumor blood volume and permeability with histologic and molecular angiogenic markers in gliomas.
Academic Article Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers.
Academic Article Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.
Academic Article Morphologic magnetic resonance imaging features of therapy-induced cerebral necrosis.
Academic Article An update on natural occurrence and biological activity of chromones.
Academic Article A randomised, double-blind, placebo-controlled phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma.
Academic Article Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.
Academic Article Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Academic Article Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse.
Academic Article Perfusion CT imaging of brain tumors: an overview.
Academic Article Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Academic Article Correlation of perfusion parameters with genes related to angiogenesis regulation in glioblastoma: a feasibility study.
Academic Article Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma.
Academic Article Strategies for advancing cancer nanomedicine.
Academic Article Combining two strategies to improve perfusion and drug delivery in solid tumors.
Academic Article Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Academic Article Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Academic Article A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer.
Academic Article Benefits of vascular normalization are dose and time dependent--letter.
Academic Article mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
Academic Article Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation.
Academic Article Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.
Academic Article An indirect way to tame cancer.
Academic Article Hypermutable DNA chronicles the evolution of human colon cancer.
Academic Article A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.
Academic Article Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure.
Academic Article Proliferating cell nuclear antigen immunostaining in breast carcinoma and its relationship to clinical and pathological variables.
Academic Article Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
Academic Article Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Academic Article Letter to the editor regarding recent article by Wu et al. [J. Theor. Biol. 355 (2014) pp. 194-207].
Academic Article CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Academic Article Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.
Academic Article Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.
Academic Article Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
Academic Article Emerging strategies for treating brain metastases from breast cancer.
Academic Article Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.
Academic Article Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
Academic Article Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Academic Article Using tumour phylogenetics to identify the roots of metastasis in humans.
Academic Article Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Academic Article PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Academic Article Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Academic Article An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Academic Article Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.
Academic Article From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Academic Article A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Academic Article A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.
Academic Article Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
Academic Article Design considerations for nanotherapeutics in oncology.
Academic Article Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Academic Article Glioma Angiogenesis and Perfusion Imaging: Understanding the Relationship between Tumor Blood Volume and Leakiness with Increasing Glioma Grade.
Academic Article Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
Academic Article A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Academic Article Texture Feature Ratios from Relative CBV Maps of Perfusion MRI Are Associated with Patient Survival in Glioblastoma.
Academic Article Concurrent functional and metabolic assessment of brain tumors using hybrid PET/MR imaging.
Academic Article Assessing the utilization of functional imaging in multiparametric prostate MRI in routine clinical practice.
Academic Article Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Academic Article Obesity and Cancer: An Angiogenic and Inflammatory Link.
Academic Article PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.
Academic Article Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Academic Article Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.
Academic Article Closing the gap: astrocytes and brain metastasis.
Grant Integrative Biology of Tumor Metastasis
Grant Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside &Back
Grant Training Program in Integrative Pathophysiology of Solid Tumors
Grant MACROMOLECULAR TRANSPORT IN NEOPLASTIC CAPILLARY BEDS
Grant Probing Tumor Microenvironment Using Nanotechnology
Grant HETEROGENEOUS DISTRIBUTION OF ANTIBODIES IN TUMORS
Grant BIOLOGY OF TUMOR ANGIOGENESIS, INVASION AND METASTASIS
Grant Integrative Pathophysiology of Solid Tumors
Grant Conference on Angiogenesis in Cancer and Other Diseases
Grant PATHOPHYSIOLOGY OF EXPERIMENTAL AND HUMAN TUMORS
Grant Role of BMDCs in Solid Tumor Growth and Relapse
Academic Article Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Academic Article Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients.
Academic Article Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.
Academic Article Improving treatment of liver metastases by targeting nonangiogenic mechanisms.
Academic Article Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Academic Article Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer.
Academic Article New Directions in Anti-Angiogenic Therapy for Glioblastoma.
Academic Article Stress granule-associated protein G3BP2 regulates breast tumor initiation.
Academic Article Role of vascular normalization in benefit from metronomic chemotherapy.
Academic Article A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.
Academic Article Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Academic Article Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
Academic Article Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Academic Article Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer.
Academic Article CD4+ T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?
Academic Article Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma.
Academic Article Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
Academic Article Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.
Academic Article Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors.
Academic Article Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Academic Article Origins of lymphatic and distant metastases in human colorectal cancer.
Grant Improving treatment of brain metastases from HER2-positive breast cancer
Academic Article Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.
Academic Article Anti-VEGF treatment improves neurological function in tumors of the nervous system.
Grant Reprogramming PDAC tumor microenvironment to improve immunotherapy
Academic Article Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis.
Academic Article Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.
Academic Article Engineering and physical sciences in oncology: challenges and opportunities.
Academic Article MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma.
Academic Article The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Academic Article Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.
Academic Article Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.
Academic Article Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.
Academic Article Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Academic Article Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Academic Article Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.
Academic Article Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Academic Article A Physical View of Cancer.
Academic Article Renin-Angiotensin System Inhibitors to Mitigate Cancer Treatment-Related Adverse Events.
Academic Article Quantifying solid stress and elastic energy from excised or in situ tumors.
Academic Article A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Academic Article Understanding the tumor immune microenvironment (TIME) for effective therapy.
Academic Article Consensus guidelines for the use and interpretation of angiogenesis assays.
Academic Article Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Academic Article Phase I and Biomarker Study of Plerixafor and Bevacizumab in Recurrent High-Grade Glioma.
Academic Article Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Academic Article A Phase II and Biomarker Study of Sorafenib Combined with Modified FOLFOX in Patients with Advanced Hepatocellular Carcinoma.
Academic Article Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study.
Academic Article A homing system targets therapeutic T cells to brain cancer.
Mentoring - Current Student Opportunity Tumor Angiogenesis, Metastasis and Microenvironment
Academic Article Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.
Mentoring - Current Student Opportunity Targeting the tumor microenvironment - from bench to bedside
Academic Article Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.
Academic Article Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Academic Article Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Academic Article Mapping Physical Tumor Microenvironment and Drug Delivery.
Academic Article Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
Academic Article Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
Academic Article Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
Academic Article Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.
Academic Article Retraction Note: A homing system targets therapeutic T cells to brain cancer.
Academic Article Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Academic Article FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
Academic Article Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
Academic Article Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Academic Article Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.
Academic Article Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
Academic Article Vascular regulation of antitumor immunity.
Academic Article A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases.
Academic Article Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma.
Academic Article The blood-brain barrier and blood-tumour barrier in brain tumours and metastases.
Academic Article CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Academic Article A framework for advancing our understanding of cancer-associated fibroblasts.
Academic Article Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.
Academic Article Combining microenvironment normalization strategies to improve cancer immunotherapy.
Academic Article Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Academic Article Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Academic Article Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
Academic Article In vivo compression and imaging in mouse brain to measure the effects of solid stress.
Academic Article Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55a Complex the Answer?
Academic Article Physical traits of cancer.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.