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Item TypeName
Academic Article Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression.
Academic Article Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia.
Academic Article Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor.
Academic Article High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.
Academic Article Hyperglycemia-induced oxidative stress in diabetic complications.
Academic Article Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
Academic Article Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
Academic Article Retinopathy in diabetes.
Academic Article Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats.
Academic Article Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Academic Article Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.
Academic Article Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain.
Academic Article Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
Academic Article Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.
Academic Article Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.
Academic Article Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.
Academic Article Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes.
Academic Article The role of protein kinase C activation and the vascular complications of diabetes.
Academic Article Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth.
Academic Article Microvascular complications of diabetes.
Academic Article Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
Academic Article Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
Academic Article Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue.
Academic Article Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Academic Article Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications.
Academic Article Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Academic Article Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells.
Academic Article Applications of inhibitors for protein kinase C and their isoforms.
Academic Article Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.
Academic Article Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
Academic Article Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells.
Academic Article Stimulation of endothelin-1 gene expression by insulin in endothelial cells.
Academic Article Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases.
Academic Article B-cell signaling: protein kinase Cdelta puts the brakes on.
Academic Article Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.
Academic Article The role of inflammatory cytokines in diabetes and its complications.
Academic Article Molecular understanding of hyperglycemia's adverse effects for diabetic complications.
Academic Article Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells.
Academic Article Oxidative stress and antioxidant treatment in diabetes.
Academic Article Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.
Academic Article A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes.
Academic Article Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells.
Academic Article Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice.
Academic Article Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels.
Academic Article Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues.
Academic Article Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.
Academic Article Human vascular smooth muscle cells of diabetic origin exhibit increased proliferation, adhesion, and migration.
Academic Article Diabetic retinopathy.
Academic Article Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes.
Academic Article Vascular dysfunction in diabetes mellitus.
Academic Article Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.
Academic Article Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway.
Academic Article Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.
Academic Article Diabetes Mellitus and its Complications in Asian Americans.
Academic Article Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways.
Academic Article Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.
Academic Article Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Academic Article Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
Academic Article Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications.
Academic Article Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes.
Academic Article Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
Academic Article Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells.
Academic Article Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.
Academic Article Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
Academic Article Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.
Academic Article Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.
Academic Article Activation of protein kinase C isoforms and its impact on diabetic complications.
Academic Article Endothelium-dependent delivery of insulin to muscle interstitium.
Academic Article Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Academic Article PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
Academic Article Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1.
Academic Article A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Academic Article Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells.
Academic Article Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats.
Academic Article Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Academic Article Can VEGF reverse diabetic neuropathy in human subjects?
Academic Article Diabetic retinopathy.
Academic Article Characterization of the receptors for insulin and the insulin-like growth factors on micro- and macrovascular tissues.
Academic Article Diabetic retinopathy.
Academic Article Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice.
Academic Article Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo.
Academic Article Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease.
Academic Article Isolation of genes differentially expressed at the downstream anastomosis of prosthetic arterial grafts with use of mRNA differential display.
Academic Article Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Academic Article Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
Academic Article Kidney complications: factors that protect the diabetic vasculature.
Academic Article Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
Academic Article p38 MAPK is a major regulator of MafA protein stability under oxidative stress.
Academic Article Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).
Academic Article Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders.
Academic Article Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display.
Academic Article Summary statement IV: Obesity and diabetes: opportunities for translation of basic research.
Academic Article Molecular targets of diabetic cardiovascular complications.
Academic Article Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin.
Academic Article Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes.
Academic Article Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
Academic Article Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.
Academic Article Glucose induced genes in bovine aortic smooth muscle cells identified by mRNA differential display.
Academic Article Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Academic Article Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.
Academic Article Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Academic Article Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes.
Academic Article Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells.
Academic Article Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.
Academic Article Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
Academic Article Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.
Academic Article Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.
Academic Article The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients.
Academic Article Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
Academic Article Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor.
Academic Article More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes.
Academic Article Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.
Academic Article Demonstration of receptors for insulin and insulin-like growth factors on Swarm rat chondrosarcoma chondrocytes. Evidence that insulin stimulates proteoglycan synthesis through the insulin receptor.
Academic Article Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells.
Academic Article The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats.
Academic Article Characterization of type I IGF receptor and IGF-I mRNA expression in cultured human and bovine glomerular cells.
Academic Article von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes.
Academic Article Insulin receptors, receptor antibodies, and the mechanism of insulin action.
Academic Article Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells.
Academic Article Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.
Academic Article Vascular complications of diabetes: mechanisms of injury and protective factors.
Academic Article Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps.
Academic Article Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
Academic Article Vascular endothelial growth factor expression in canine peripheral vein bypass grafts.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
Academic Article Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
Academic Article Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.
Academic Article Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study.
Academic Article Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes.
Concept Immunohistochemistry
Concept Vinblastine
Concept Structure-Activity Relationship
Concept Proto-Oncogene Proteins c-myc
Concept Monosaccharide Transport Proteins
Concept Biological Evolution
Concept Interleukin-18
Concept Carotid Arteries
Concept Aorta, Thoracic
Concept Sequence Homology, Nucleic Acid
Concept Young Adult
Concept Blood Circulation
Concept Flavonoids
Concept Cohort Studies
Concept von Willebrand Factor
Concept Mitogen-Activated Protein Kinase 3
Concept Mice
Concept Substrate Specificity
Concept Plasminogen Activator Inhibitor 1
Concept Health Knowledge, Attitudes, Practice
Concept U937 Cells
Concept Diffusion of Innovation
Concept Transcription, Genetic
Concept Fasting
Concept Vasoconstriction
Concept Phorbol 12,13-Dibutyrate
Concept Oxidative Phosphorylation
Concept Class Ia Phosphatidylinositol 3-Kinase
Concept Iron-Sulfur Proteins
Concept Receptor, Endothelin A
Concept Boston
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Concept Insulin Antibodies
Concept Threonine
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Concept Vasodilation
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Concept Proto-Oncogene Proteins c-fos
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Concept Oligonucleotide Array Sequence Analysis
Concept B-Lymphocytes
Concept Metformin
Concept Acarbose
Concept Osteocalcin
Concept Thrombin
Concept Renin-Angiotensin System
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Concept Sodium-Potassium-Exchanging ATPase
Concept DNA Fragmentation
Concept Phosphotyrosine
Concept Receptors, Purinergic P1
Concept Diabetic Nephropathies
Concept Immunoglobulins
Concept Dental Plaque Index
Concept Up-Regulation
Concept Fibrinolysis
Concept Obesity
Concept Chromatography, Gel
Concept Diffusion
Concept Cerebrovascular Disorders
Concept Receptors, Angiotensin
Concept Aspirin
Concept Insulin-Like Growth Factor II
Concept Immunoglobulin Heavy Chains
Concept Oligonucleotides, Antisense
Concept Cytochalasin D
Concept Protein Kinase C-alpha
Concept Binding Sites
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Concept Rats, Inbred Lew
Concept GTP-Binding Proteins
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Concept Transcription Factor AP-1
Concept Protein Multimerization
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Concept Chymotrypsin
Concept Lipogenesis
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Concept Analysis of Variance
Concept Aorta, Abdominal
Concept Virulence Factors, Bordetella
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Feeding Behavior
Concept Atherosclerosis
Concept Chromosomes, Human, Pair 1
Concept Mice, 129 Strain
Concept Metabolomics
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Concept Oxidation-Reduction
Concept Bucladesine
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Concept Phospholipases A
Concept Coronary Vessels
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Concept Hydrogen Peroxide
Concept Cyclic AMP-Dependent Protein Kinases
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Concept Ascorbic Acid
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Concept Receptor, IGF Type 1
Academic Article Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Academic Article New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia.
Academic Article Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium.
Academic Article Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes.
Academic Article Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.
Academic Article Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.
Academic Article Protein kinase C and myocardial biology and function.
Academic Article A cell biology approach to the study of diabetic vascular complications.
Academic Article Autoantibodies to insulin receptors in man: immunological determinants and mechanism of action.
Academic Article Regulation of receptor-mediated endocytosis by phorbol esters.
Academic Article Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex.
Academic Article Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.
Academic Article [B17-D-leucine]insulin and [B17-norleucine]insulin: synthesis and biological properties.
Academic Article Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.
Academic Article Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
Academic Article Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues.
Academic Article Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus.
Academic Article Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Academic Article Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells.
Academic Article Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C.
Academic Article Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor.
Academic Article Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester.
Academic Article Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.
Academic Article The potential use of glutathionyl hemoglobin as a clinical marker of oxidative stress.
Academic Article Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Academic Article Processing and release of insulin and insulin-like growth factor I by macro- and microvascular endothelial cells.
Academic Article Non-parallel evolution of metabolic and growth-promoting functions of insulin.
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
Academic Article The cellular and molecular mechanisms of diabetic complications.
Academic Article Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Academic Article Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells.
Academic Article Processing of insulin by bovine endothelial cells in culture. Internalization without degradation.
Academic Article In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
Academic Article Pigment-epithelium-derived factor--a key coordinator of retinal neuronal and vascular functions.
Academic Article The role of protein kinase C activation in diabetic nephropathy.
Academic Article d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.
Academic Article Regulation of vascular permeability in cell culture.
Academic Article A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes.
Academic Article Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester.
Academic Article Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol.
Academic Article d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway.
Academic Article Protein kinase C activation and the development of diabetic complications.
Academic Article Intracellular pathways of insulin transport across vascular endothelial cells.
Academic Article Characterization and partial purification of an endothelial cell growth factor from human platelets.
Academic Article Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Academic Article Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.
Academic Article Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation.
Academic Article Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes.
Academic Article Modulation of the insulin receptor by insulin receptor autoantibodies.
Academic Article Processing and transport of insulin by vascular endothelial cells. Effects of sulfonylureas on insulin receptors.
Academic Article Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
Academic Article Hyperglycemia and the pathogenesis of diabetic retinopathy.
Academic Article Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells.
Academic Article Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells.
Academic Article Protein kinase C and the development of diabetic vascular complications.
Academic Article Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.
Academic Article Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.
Academic Article Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I.
Academic Article Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes.
Academic Article Protein kinase C activation and its pharmacological inhibition in vascular disease.
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels.
Academic Article Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor.
Academic Article The human erythrocyte insulin-like growth factor I receptor: characterization and demonstration of ligand-stimulated autophosphorylation.
Academic Article Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide.
Academic Article Identification of PKC-isoform-specific biological actions using pharmacological approaches.
Academic Article Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes.
Academic Article Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus.
Academic Article The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes.
Academic Article [B22-D-arginine]insulin: synthesis and biological properties.
Academic Article The role of protein kinase C activation in the pathogenesis of diabetic vascular complications.
Academic Article Biochemical and molecular mechanisms in the development of diabetic vascular complications.
Academic Article PKC-ß activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis.
Academic Article Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study.
Academic Article PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.
Academic Article Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture.
Grant Validation of Potential Protective Factors from Diabetic Complications
Grant Retinal imaging tests for microvascular functions
Grant Biomarkers for protection against complications and beta-cell destruction
Grant ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
Grant Selective Insulin Resistance- Diabetic Cardiovascular Diseases
Grant Protective Factors Against the Development of Microvascular Complications
Academic Article Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop".
Academic Article Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications.
Academic Article Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Academic Article Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation.
Academic Article High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes.
Academic Article Association of Glycemic Control With Reduced Risk for Large-Vessel Disease After More Than 50 Years of Type 1 Diabetes.
Academic Article Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.
Academic Article Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function.
Academic Article Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.
Academic Article Cell biology as an approach to the study of the vascular complications of diabetes.
Academic Article Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications.
Academic Article Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Academic Article Residual ß cell function and monogenic variants in long-duration type 1 diabetes patients.
Academic Article Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy.
Academic Article Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.
Academic Article High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.