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Item TypeName
Academic Article Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression.
Academic Article Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor.
Academic Article Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
Academic Article Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Academic Article Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.
Academic Article Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain.
Academic Article Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
Academic Article Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.
Academic Article Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.
Academic Article The role of protein kinase C activation and the vascular complications of diabetes.
Academic Article Microvascular complications of diabetes.
Academic Article Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
Academic Article Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Academic Article Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Academic Article Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells.
Academic Article Applications of inhibitors for protein kinase C and their isoforms.
Academic Article Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.
Academic Article Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
Academic Article Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells.
Academic Article Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases.
Academic Article B-cell signaling: protein kinase Cdelta puts the brakes on.
Academic Article Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.
Academic Article Molecular understanding of hyperglycemia's adverse effects for diabetic complications.
Academic Article Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues.
Academic Article Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway.
Academic Article Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.
Academic Article Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways.
Academic Article Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.
Academic Article Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Academic Article Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
Academic Article Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.
Academic Article Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.
Academic Article Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.
Academic Article Activation of protein kinase C isoforms and its impact on diabetic complications.
Academic Article Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Academic Article PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
Academic Article Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Academic Article Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo.
Academic Article Isolation of genes differentially expressed at the downstream anastomosis of prosthetic arterial grafts with use of mRNA differential display.
Academic Article Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Academic Article Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
Academic Article Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
Academic Article p38 MAPK is a major regulator of MafA protein stability under oxidative stress.
Academic Article Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).
Academic Article Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy.
Academic Article Molecular targets of diabetic cardiovascular complications.
Academic Article Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin.
Academic Article Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
Academic Article Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Academic Article Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
Academic Article Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
Academic Article Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.
Academic Article Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes.
Concept Mitogen-Activated Protein Kinase 3
Concept Class Ia Phosphatidylinositol 3-Kinase
Concept Diacylglycerol Kinase
Concept Creatine Kinase
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Kinase C-alpha
Concept Protein Kinase Inhibitors
Concept Mitogen-Activated Protein Kinase 1
Concept Glycogen Synthase Kinase 3
Concept Protein Kinase C-delta
Concept Protein Kinase C
Concept Protein Kinase C-epsilon
Concept Pyruvate Kinase
Academic Article Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Academic Article Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium.
Academic Article Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.
Academic Article Protein kinase C and myocardial biology and function.
Academic Article Regulation of receptor-mediated endocytosis by phorbol esters.
Academic Article Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.
Academic Article Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.
Academic Article Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
Academic Article Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues.
Academic Article Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus.
Academic Article Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Academic Article Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C.
Academic Article Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.
Academic Article Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications?
Academic Article The cellular and molecular mechanisms of diabetic complications.
Academic Article Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Academic Article In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
Academic Article The role of protein kinase C activation in diabetic nephropathy.
Academic Article d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.
Academic Article Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol.
Academic Article d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway.
Academic Article Protein kinase C activation and the development of diabetic complications.
Academic Article Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Academic Article Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.
Academic Article Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation.
Academic Article Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes.
Academic Article Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
Academic Article Protein kinase C and the development of diabetic vascular complications.
Academic Article Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.
Academic Article Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.
Academic Article Protein kinase C activation and its pharmacological inhibition in vascular disease.
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels.
Academic Article Identification of PKC-isoform-specific biological actions using pharmacological approaches.
Academic Article Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes.
Academic Article The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes.
Academic Article The role of protein kinase C activation in the pathogenesis of diabetic vascular complications.
Academic Article Biochemical and molecular mechanisms in the development of diabetic vascular complications.
Academic Article PKC-ß activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis.
Academic Article PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.
Grant Monocyte VEGF &PKC, Markers for Diabetic Complications
Grant ENDOTHELIN EFFECTS ON RETINAL CELLS AND BLOOD FLOW
Grant PKC Activation and Cardiovascular Disease in Diabetes
Grant PROTEIN KINASE C ACTIVATION AND DIABETIC CARDIOMYOPATHY
Grant CELL BIOLOGY APPROACH TO DIABETIC RETINOPATHY
Grant Cell Biology of Diabetic Microvascular Complications
Grant Protective Factors Against the Development of Microvascular Complications
Grant Pyruvate kinase M2 levels and activation as protective factors for diabetic nephropathy
Academic Article Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications.
Academic Article Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Academic Article Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation.
Academic Article Obesity-associated Gingival Vascular Inflammation and Insulin Resistance.
Academic Article Role of protein kinase C in diabetic complications.
Academic Article Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
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  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.