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One or more keywords matched the following items that are connected to Tenen, Daniel
Item TypeName
Academic Article The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture.
Academic Article AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.
Academic Article Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.
Academic Article Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment.
Academic Article Multiple control elements are required for expression of the human CD34 gene.
Academic Article Regulation of the PU.1 gene by distal elements.
Academic Article Cloning and analysis of the CD18 promoter.
Academic Article Use of a promoterless Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation.
Academic Article Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.
Academic Article Functional characterization of the promoter for the gene encoding murine CD34.
Academic Article Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1.
Academic Article Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.
Academic Article Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
Academic Article Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression.
Academic Article Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Academic Article Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
Academic Article Characterization of the myeloid-specific CD11b promoter.
Academic Article Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.
Academic Article 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Academic Article PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL.
Academic Article Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene.
Academic Article Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line.
Academic Article A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.
Academic Article CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing.
Academic Article T antigen repression of SV40 early transcription from two promoters.
Academic Article Functional characterization of the promoter for the gene encoding human eosinophil peroxidase.
Academic Article Transcriptional regulation of the human eosinophil peroxidase genes: characterization of a peroxidase promoter.
Academic Article PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Academic Article Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
Academic Article C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia.
Academic Article Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein ß.
Academic Article The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.
Academic Article c-Myc is a critical target for c/EBPalpha in granulopoiesis.
Academic Article Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor.
Academic Article c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.
Academic Article The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.
Academic Article Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.
Academic Article Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Academic Article Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c.
Academic Article Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Academic Article PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.
Academic Article The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.
Academic Article The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.
Academic Article c-Jun homodimers can function as a context-specific coactivator.
Academic Article The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
Academic Article Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.
Academic Article Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene.
Academic Article Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.
Academic Article The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.
Academic Article PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.
Academic Article Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response.
Academic Article Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
Academic Article Sp1 is a critical factor for the monocytic specific expression of human CD14.
Academic Article The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.
Academic Article PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Academic Article Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b.
Academic Article Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.
Academic Article Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.
Academic Article CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.
Academic Article The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
Academic Article Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
Academic Article Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter.
Academic Article Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development: identification of a unique cis-element that acts lie an enhancer in regulating activity of the IL-5R alpha promoter.
Academic Article Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
Academic Article Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
Concept Promoter Regions, Genetic
Academic Article A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.
Academic Article The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.
Academic Article Non-canonical NF-?B signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Academic Article EVI2B is a C/EBPa target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.
Academic Article ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa.
Search Criteria
  • Promoter Regions Genetic
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.