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One or more keywords matched the following items that are connected to Tenen, Daniel
Item TypeName
Academic Article The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture.
Academic Article PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.
Academic Article Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
Academic Article PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
Academic Article Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation.
Academic Article A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.
Academic Article Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.
Academic Article Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
Academic Article Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment.
Academic Article The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.
Academic Article Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Academic Article Multiple control elements are required for expression of the human CD34 gene.
Academic Article Regulation of the PU.1 gene by distal elements.
Academic Article Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
Academic Article Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.
Academic Article Functional characterization of the promoter for the gene encoding murine CD34.
Academic Article Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression.
Academic Article Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Academic Article Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
Academic Article Characterization of the myeloid-specific CD11b promoter.
Academic Article PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Academic Article 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Academic Article The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.
Academic Article Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.
Academic Article PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL.
Academic Article Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPa.
Academic Article Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line.
Academic Article Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.
Academic Article Distal elements are critical for human CD34 expression in vivo.
Academic Article A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.
Academic Article Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.
Academic Article Regulation of the gene for CD34, a human hematopoietic stem cell antigen, in KG-1 cells.
Academic Article Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.
Academic Article CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.
Academic Article Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Academic Article Transcriptional regulation of the human eosinophil peroxidase genes: characterization of a peroxidase promoter.
Academic Article C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia.
Academic Article Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein ß.
Academic Article The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.
Academic Article c-Myc is a critical target for c/EBPalpha in granulopoiesis.
Academic Article Proteomic analysis of transcription factor interactions in myeloid stem cell development and leukaemia.
Academic Article Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor.
Academic Article Effect of transcription-factor concentrations on leukemic stem cells.
Academic Article The gene for human eosinophil Charcot-Leyden crystal protein directs expression of lysophospholipase activity and spontaneous crystallization in transiently transfected COS cells.
Academic Article ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
Academic Article Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Academic Article Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
Academic Article Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.
Academic Article A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Academic Article Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Academic Article The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.
Academic Article The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.
Academic Article Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Academic Article The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Academic Article Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene.
Academic Article Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
Academic Article Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.
Academic Article Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.
Academic Article PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.
Academic Article RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
Academic Article C/EBPa and DEK coordinately regulate myeloid differentiation.
Academic Article Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response.
Academic Article Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
Academic Article Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9.
Academic Article Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes.
Academic Article Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Academic Article The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.
Academic Article PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Academic Article Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1.
Academic Article Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.
Academic Article C/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations.
Academic Article The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
Academic Article Transgenic targeting with regulatory elements of the human CD34 gene.
Academic Article C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.
Academic Article Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development: identification of a unique cis-element that acts lie an enhancer in regulating activity of the IL-5R alpha promoter.
Academic Article Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor.
Academic Article Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
Academic Article Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation.
Academic Article Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Leukemic
Academic Article SALL4 is a key transcription regulator in normal human hematopoiesis.
Academic Article Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.
Academic Article A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.
Academic Article Transcription factor C/EBPa-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia.
Academic Article Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia.
Academic Article DNMT1-interacting RNAs block gene-specific DNA methylation.
Academic Article Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.
Academic Article NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML.
Academic Article A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
Academic Article The gene signature in CCAAT-enhancer-binding protein a dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors.
Academic Article Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.
Academic Article PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.
Academic Article The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.
Academic Article SALL4 is a new target in endometrial cancer.
Academic Article Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.
Academic Article NF-?B/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.
Academic Article Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.
Academic Article A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation.
Academic Article PML/RARa-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.
Academic Article A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.
Academic Article Non-canonical NF-?B signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Academic Article The histone chaperone CAF-1 safeguards somatic cell identity.
Academic Article Acetylation of C/EBPa inhibits its granulopoietic function.
Academic Article IRF3 promotes adipose inflammation and insulin resistance and represses browning.
Academic Article Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression.
Academic Article Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity.
Academic Article Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.
Academic Article C/EBPß is required for survival of Ly6C- monocytes.
Academic Article ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa.
Academic Article An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer.
Academic Article TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.
Academic Article ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.
Academic Article Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
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  • Gene Expression Regulation
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.