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One or more keywords matched the following items that are connected to Sharpe, Arlene
Item TypeName
Academic Article Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.
Academic Article CD28-independent costimulation of T cells in alloimmune responses.
Academic Article Restoring function in exhausted CD8 T cells during chronic viral infection.
Academic Article Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
Academic Article Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.
Academic Article CTLA-4 regulates induction of anergy in vivo.
Academic Article Paradoxical effect of reduced costimulation in T cell-mediated colitis.
Academic Article Mechanisms of costimulation.
Academic Article Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Academic Article Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.
Academic Article Cutting edge: transplantation tolerance through enhanced CTLA-4 expression.
Academic Article An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Academic Article Prevention and treatment of factor VIII inhibitors in murine hemophilia A.
Academic Article The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens.
Academic Article Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.
Academic Article T-cell stimulation: an abundance of B7s.
Academic Article The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system.
Academic Article Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
Academic Article The ICOS molecule plays a crucial role in the development of mucosal tolerance.
Academic Article Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.
Academic Article CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
Academic Article Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
Academic Article CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis.
Academic Article The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Academic Article Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).
Academic Article Dendritic cells giveth and taketh away.
Academic Article Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
Academic Article CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation.
Academic Article Synergistic costimulation by both B7 molecules regulates colitis pathogenesis.
Academic Article B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
Academic Article Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Academic Article ICOS is critical for CD40-mediated antibody class switching.
Academic Article Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Academic Article B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
Academic Article An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.
Academic Article CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
Academic Article Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
Academic Article B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Academic Article Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells.
Academic Article A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Academic Article Role of PD-1 in regulating acute infections.
Academic Article B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.
Academic Article CTLA-4 regulates cell cycle progression during a primary immune response.
Academic Article The B7 family revisited.
Academic Article The complexity of the B7-CD28/CTLA-4 costimulatory pathway.
Academic Article CTLA-4 and T cell activation.
Academic Article Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus.
Academic Article The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules.
Academic Article Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus.
Academic Article The B7-CD28 superfamily.
Academic Article The role of B7 costimulation in CD4/CD8 T cell homeostasis.
Academic Article Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice.
Academic Article Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis.
Academic Article Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo.
Academic Article Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
Academic Article CD28 costimulation regulates genome-wide effects on alternative splicing.
Academic Article Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.
Academic Article Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Academic Article ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Academic Article The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.
Academic Article The role of CTLA-4 in regulating Th2 differentiation.
Academic Article Negative co-receptors on lymphocytes.
Academic Article Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
Academic Article B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
Academic Article B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Academic Article ICOS contributes to T cell expansion in CTLA-4 deficient mice.
Academic Article The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Concept Antigens, Differentiation, Myelomonocytic
Concept Antigens, Differentiation, B-Lymphocyte
Concept Antigens, Differentiation, T-Lymphocyte
Concept Antigens, Differentiation
Search Criteria
  • Antigens Differentiation
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.