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One or more keywords matched the following items that are connected to Kuchroo, Vijay
Item TypeName
Academic Article Dysregulated T cell expression of TIM3 in multiple sclerosis.
Academic Article Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation.
Academic Article An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Academic Article Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions.
Academic Article Emerging Tim-3 functions in antimicrobial and tumor immunity.
Academic Article TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.
Academic Article Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Academic Article Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.
Academic Article TIM-4 expressed on APCs induces T cell expansion and survival.
Academic Article Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Academic Article Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts.
Academic Article T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Academic Article TIM-3 and its regulatory role in immune responses.
Academic Article TIM family of genes in immunity and tolerance.
Academic Article Tim protein structures reveal a unique face for ligand binding.
Academic Article The costimulatory role of TIM molecules.
Academic Article Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.
Academic Article Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
Academic Article Cytosolic phospholipase A2a blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Academic Article Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand.
Academic Article Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
Academic Article The TIM gene family: emerging roles in immunity and disease.
Academic Article TIMs: central regulators of immune responses.
Academic Article Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.
Academic Article TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.
Academic Article T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.
Academic Article Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.
Academic Article The TIM gene family regulates autoimmune and allergic diseases.
Academic Article Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
Academic Article CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.
Academic Article Tim-2 regulates T helper type 2 responses and autoimmunity.
Academic Article Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells.
Academic Article Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Academic Article Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Academic Article Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Concept Membrane Proteins
Academic Article Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.
Academic Article PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8? T cells induced by melanoma vaccines.
Academic Article Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.
Academic Article TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.
Academic Article Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.
Academic Article Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.
Academic Article Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.
Academic Article T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury.
Academic Article CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Academic Article Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.
Academic Article KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Academic Article TIM-1 signaling is required for maintenance and induction of regulatory B cells.
Academic Article Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.
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  • Membrane Proteins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.