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One or more keywords matched the following items that are connected to Kuchroo, Vijay
Item TypeName
Mentoring - Completed Student Project Induction of T regulatory type 1-like phenotype in CD4+ T cells by interleukin-27 and interferon-á
Academic Article Protective autoimmunity is a physiological response to CNS trauma.
Academic Article IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.
Academic Article Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Academic Article Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi.
Academic Article Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis.
Academic Article IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice.
Academic Article Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines.
Academic Article Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.
Academic Article Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells.
Academic Article IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice.
Academic Article Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis.
Academic Article Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.
Academic Article Tim3 binding to galectin-9 stimulates antimicrobial immunity.
Academic Article Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
Academic Article T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production.
Academic Article Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.
Academic Article B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.
Academic Article IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.
Academic Article Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Academic Article Role of Th1 and Th17 cells in organ-specific autoimmunity.
Academic Article Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.
Academic Article Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
Academic Article B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Academic Article Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
Academic Article Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
Academic Article Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Academic Article Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Academic Article Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Academic Article The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Academic Article IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.
Academic Article IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation.
Academic Article Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Academic Article IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis.
Academic Article Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
Academic Article Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells.
Academic Article Immunology. The yin and yang of follicular helper T cells.
Academic Article ?d T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.
Academic Article MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Academic Article IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
Academic Article IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.
Academic Article Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.
Academic Article Type 1 regulatory T cells (Tr1) in autoimmunity.
Academic Article Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
Academic Article Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.
Academic Article Interplay between effector Th17 and regulatory T cells.
Academic Article IL-17-producing human peripheral regulatory T cells retain suppressive function.
Academic Article IL-1ß promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
Academic Article The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.
Academic Article Control of TH17 cells occurs in the small intestine.
Academic Article B7-2 (CD86) is essential for the development of IL-4-producing T cells.
Academic Article Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.
Academic Article Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.
Academic Article QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2.
Academic Article Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Academic Article IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Academic Article Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets.
Academic Article Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
Academic Article The TIM gene family: emerging roles in immunity and disease.
Academic Article Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.
Academic Article IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Academic Article Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.
Academic Article A model for how signal duration can determine distinct outcomes of gene transcription programs.
Academic Article Induction and molecular signature of pathogenic TH17 cells.
Academic Article IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together.
Academic Article Th17 cells: effector T cells with inflammatory properties.
Academic Article Dynamic regulatory network controlling TH17 cell differentiation.
Academic Article Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.
Academic Article IL-12 family cytokines: immunological playmakers.
Academic Article Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice.
Academic Article Induction and effector functions of T(H)17 cells.
Academic Article Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
Academic Article A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Academic Article Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Academic Article Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity.
Academic Article Interleukin-17 and type 17 helper T cells.
Academic Article Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.
Academic Article The many faces of Th17 cells.
Academic Article IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
Academic Article TGF-beta induces IL-9 production from human Th17 cells.
Academic Article IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Academic Article Th17 cells: from precursors to players in inflammation and infection.
Academic Article Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.
Academic Article Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity.
Academic Article Th17: the third member of the effector T cell trilogy.
Academic Article IL-17 and Th17 Cells.
Academic Article Proinflammatory T helper type 17 cells are effective B-cell helpers.
Academic Article Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Academic Article Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.
Academic Article T(H)-17 cells in the circle of immunity and autoimmunity.
Academic Article Functional Th1 cells are required for surgical adhesion formation in a murine model.
Academic Article The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Academic Article Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Concept Receptors, Interleukin
Concept Interleukin-5
Concept Interleukin-12 Receptor beta 1 Subunit
Concept Interleukin-2 Receptor alpha Subunit
Concept Interleukin-12
Concept Receptors, Interleukin-2
Concept Interleukin-23 Subunit p19
Concept Interleukin-17
Concept Receptors, Interleukin-6
Concept Interleukin-1beta
Concept Interleukin-4
Concept Interleukin-23
Concept Interleukin-6
Concept Receptors, Interleukin-12
Concept Interleukin-21 Receptor alpha Subunit
Concept Interleukin-10
Concept Receptors, Interleukin-1
Concept Interleukins
Concept Receptors, Interleukin-17
Concept Interleukin-16
Concept Interleukin-1
Concept Interleukin-9
Concept Interleukin-2
Concept Interleukin-3
Concept Interleukin-13
Academic Article Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.
Academic Article How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases.
Academic Article T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
Academic Article IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Academic Article T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice.
Academic Article The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
Academic Article Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.
Academic Article Unexpected targets and triggers of autoimmunity.
Academic Article Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.
Academic Article An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
Academic Article DUBA-UBR5 axis: other than transactivation.
Academic Article Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.
Academic Article TIM-1 signaling is required for maintenance and induction of regulatory B cells.
Academic Article A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.
Academic Article Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity.
Academic Article Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Academic Article Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Academic Article Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment.
Academic Article IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.
Academic Article IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling.
Academic Article Oct1 and OCA-B are selectively required for CD4 memory T cell function.
Academic Article TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.
Academic Article Differentiation and Characterization of Tr1 Cells.
Academic Article RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.
Academic Article IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
Academic Article Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.
Academic Article IL-17 Blockade in Psoriasis.
Academic Article The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
Academic Article Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.
Academic Article Induction and transcriptional regulation of the co-inhibitory gene module in T cells.
Academic Article T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Academic Article Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.
Academic Article Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.
Academic Article Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.
Academic Article Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
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  • Interleukins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.