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One or more keywords matched the following items that are connected to Seidman, Jonathan
Item TypeName
Academic Article Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
Academic Article Altered regulatory function of two familial hypertrophic cardiomyopathy troponin T mutants.
Academic Article Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.
Academic Article Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy.
Academic Article Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Academic Article Development of left ventricular hypertrophy in adults in hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations.
Academic Article The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article Mutations in cardiac myosin heavy chain genes cause familial hypertrophic cardiomyopathy.
Academic Article Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.
Academic Article Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.
Academic Article Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function.
Academic Article Molecular genetic studies of familial hypertrophic cardiomyopathy.
Academic Article Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Academic Article Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Academic Article Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.
Academic Article Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy.
Academic Article An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.
Academic Article Phenotypic diversity in hypertrophic cardiomyopathy.
Academic Article Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.
Academic Article Proposal for contemporary screening strategies in families with hypertrophic cardiomyopathy.
Academic Article Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
Academic Article The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation.
Academic Article Progress in familial hypertrophic cardiomyopathy: molecular genetic analyses in the original family studied by Teare.
Academic Article Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts.
Academic Article Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
Academic Article Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.
Academic Article Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.
Academic Article Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1.
Academic Article Comparison of two murine models of familial hypertrophic cardiomyopathy.
Academic Article The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms.
Academic Article Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
Academic Article Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy.
Academic Article Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy.
Academic Article The genetic basis for cardiac remodeling.
Academic Article Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics.
Academic Article Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes.
Academic Article The PTPN11 gene is not implicated in nonsyndromic hypertrophic cardiomyopathy.
Academic Article A mouse model of familial hypertrophic cardiomyopathy.
Academic Article Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy.
Academic Article Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
Academic Article Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
Academic Article Genetics of hypertrophic cardiomyopathy.
Academic Article Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy.
Academic Article The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.
Academic Article Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
Academic Article Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome.
Academic Article Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.
Academic Article A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy.
Academic Article A de novo mutation in alpha-tropomyosin that causes hypertrophic cardiomyopathy.
Academic Article A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation.
Academic Article Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Academic Article Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Academic Article Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-ß.
Academic Article [Using molecular genetics to guide the diagnosis and treatment of hypertrophic cardiomyopathy].
Academic Article Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.
Academic Article Familial hypertrophic cardiomyopathy: a genetic model of cardiac hypertrophy.
Academic Article Novel locus for an inherited cardiomyopathy maps to chromosome 7.
Academic Article A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene.
Academic Article Short communication: the cardiac myosin binding protein C Arg502Trp mutation: a common cause of hypertrophic cardiomyopathy.
Academic Article Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history.
Academic Article Molecular epidemiology of hypertrophic cardiomyopathy.
Academic Article Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.
Academic Article Gene mutations in apical hypertrophic cardiomyopathy.
Academic Article A dinucleotide repeat polymorphism in the MYBPH gene.
Academic Article An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations.
Academic Article Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy.
Academic Article Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics.
Academic Article Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling.
Academic Article Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy.
Academic Article Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.
Academic Article Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy.
Academic Article Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.
Academic Article QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice.
Academic Article Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy.
Academic Article A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3.
Academic Article Sarcomere gene mutations in hypertrophy and heart failure.
Academic Article Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy.
Academic Article Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Academic Article Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Concept Cardiomyopathy, Hypertrophic, Familial
Concept Cardiomyopathy, Hypertrophic
Academic Article Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy.
Academic Article ß-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.
Academic Article Nationwide study on hypertrophic cardiomyopathy in Iceland: evidence of a MYBPC3 founder mutation.
Academic Article Merits and pitfalls of genetic testing in a hypertrophic cardiomyopathy clinic.
Academic Article Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.
Academic Article Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity.
Academic Article A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Academic Article CORRIGENDUM: Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity.
Academic Article A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.
Grant SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
Grant MOLECULAR CAUSE OF FAMILIAL HYPERTROPHIC CARDIOMYOPATHY
Grant GENOMICS OF CARDIOVASCULAR DEVELOPMENT, ADAPTION
Grant Genetic Signals in Ventricular Hypertrophy
Grant Molecular Biology of Cardiac Disease
Academic Article Early remodeling of repolarizing K+ currents in the aMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Academic Article Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Academic Article Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.
Academic Article Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.
Academic Article Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy.
Academic Article Telomere shortening is a hallmark of genetic cardiomyopathies.
Academic Article The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy.
Academic Article Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Academic Article Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.
Academic Article Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Academic Article Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers.
Academic Article Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.
Search Criteria
  • Hypertrophic Cardiomyopathy
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.