Harvard Catalyst Profiles

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Item TypeName
Academic Article Multiple niches for Notch in cancer: context is everything.
Academic Article c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Academic Article The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.
Academic Article Consequences of Notch-mediated inhibition of the transcription factor E47.
Academic Article Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.
Academic Article Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Academic Article Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.
Academic Article BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
Academic Article Calcium depletion dissociates and activates heterodimeric notch receptors.
Academic Article Notch signaling in cancer.
Academic Article An invitation to T and more: notch signaling in lymphopoiesis.
Academic Article Cutaneous ß-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.
Academic Article Notch signaling in leukemia.
Academic Article Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
Academic Article Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.
Academic Article F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Academic Article Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
Academic Article Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Academic Article Targeting the Notch pathway: twists and turns on the road to rational therapeutics.
Academic Article Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Academic Article Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
Academic Article Direct inhibition of the NOTCH transcription factor complex.
Academic Article A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.
Academic Article Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
Academic Article Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.
Academic Article Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.
Academic Article Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.
Academic Article Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
Academic Article High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
Academic Article Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.
Academic Article NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Academic Article Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
Academic Article Notch signaling as a therapeutic target.
Academic Article Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.
Academic Article Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Academic Article Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Academic Article Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
Academic Article High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas.
Academic Article Modulated expression of notch1 during thymocyte development.
Academic Article Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.
Academic Article Notch signaling in leukemia.
Academic Article Molecular biology of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma.
Academic Article No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.
Academic Article The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.
Academic Article Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.
Academic Article Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Academic Article Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Academic Article Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
Academic Article Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Academic Article Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Academic Article T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.
Academic Article The multifaceted role of Notch in cancer.
Academic Article Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.
Academic Article Notch signaling in hematopoiesis and early lymphocyte development.
Academic Article Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Academic Article The double-edged sword of Notch signaling in cancer.
Academic Article Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
Academic Article Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Academic Article Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Academic Article Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.
Academic Article Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Academic Article Delta-like 4 induces notch signaling in macrophages: implications for inflammation.
Academic Article Notch signaling controls the generation and differentiation of early T lineage progenitors.
Academic Article NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Academic Article Notch dimerization is required for leukemogenesis and T-cell development.
Academic Article T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
Academic Article NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-? and reactive oxygen species.
Concept Signal Transduction
Academic Article Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.
Academic Article In brief: Notch signalling in health and disease.
Academic Article NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
Academic Article An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
Academic Article Application and evaluation of anti-Notch antibodies to modulate Notch signaling.
Academic Article NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
Academic Article Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.
Academic Article Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
Academic Article Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.
Academic Article The role of Notch receptors in transcriptional regulation.
Academic Article A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies.
Academic Article Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Academic Article Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.
Academic Article Metabolic Mechanisms of Drug Resistance in Leukemia.
Academic Article Comprehensive analyses of tumor immunity: implications for cancer immunotherapy.
Grant Abnormalities/Signal Transduction/Hematopoietic Disease
Academic Article Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.
Academic Article Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Academic Article Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
Academic Article The Varied Roles of Notch in Cancer.
Academic Article Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.
Academic Article The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.
Academic Article A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.
Search Criteria
  • Pathway Signal Transduction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.