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Multiple niches for Notch in cancer: context is everything.
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Myc-induced T cell leukemia in transgenic zebrafish.
Notch signaling in leukemia.
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.
NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Activating Notch1 mutations in mouse models of T-ALL.
T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.
A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.
Leukemia-Lymphoma, Adult T-Cell
Leukemia Lymphoma Adult T Cell