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One or more keywords matched the following properties of Murphy, George
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overview Dr. Murphy’s program in funded basic investigation has been ongoing continuously since 1984 in the form of R01 grants and via participation in Program Project initiatives. The current focus of Dr. Murphy's research is elucidation of the cellular and molecular mechanisms responsible for cutaneous cytotoxic reactions, including graft-versus-host disease subsequent to allogeneic stem cell transplantation for childhood and adult leukemia/lymphoma. In addition, a major collaboration involving Brigham Plastic and Reconstructive Surgery and the MIT Biomaterials Department focuses on tissue stem cell biology and cutaneous regenerative medicine. One goal of this work is to define pathways responsible for scarless regeneration that typifies fetal, but not post-natal, human skin. Dr. Murphy also serves as the Director of the Tissue and Cell Analysis Core for the Harvard Skin Disease Research Center (SDRC) as well as for the Biospecimen Access and Analysis Core for the Harvard Specialized Program for Research Excellence (SPORE) in skin cancer. For research contributions concerning Langerhans cell histiocytosis, he received the Benjamin Castleman Award of the International Academy of Pathology. In 1991, he was elected into the American Society for Clinical Investigation for which he also served as an Institutional Representative. His work in the area of neuropeptide regulation of Langerhans cell function was recognized as one of the 50 most significant scientific breakthroughs worldwide for the year 1993 by the magazine, Discover. His most recent collaborative interaction with the laboratory of Dr. Markus Frank of Boston’s Children’s Hospital has recently fostered the first biomarker identification and therapeutically relevant targeting of melanoma stem cells (January 2008 cover article, Nature). He has served as a regular term member of the General Medicine A Study Section for the NIH.
One or more keywords matched the following items that are connected to Murphy, George
Item TypeName
Academic Article Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease.
Academic Article T cells require TRAIL for optimal graft-versus-tumor activity.
Academic Article CCR2 is required for CD8-induced graft-versus-host disease.
Academic Article Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model.
Academic Article Experimental induction and ultrastructural characterization of apoptosis in murine acute cutaneous graft-versus-host disease.
Academic Article Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier.
Academic Article Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with epithelial tissue infiltrate.
Academic Article Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease.
Academic Article An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression.
Academic Article Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease.
Academic Article Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation.
Academic Article Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response.
Academic Article Evolution of responding CD4+ and CD8+ T-cell repertoires during the development of graft-versus-host disease directed to minor histocompatibility antigens.
Academic Article T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.
Academic Article IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease.
Academic Article Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case.
Academic Article Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.
Academic Article Significance of selectively targeted apoptotic rete cells in graft-versus-host disease.
Academic Article Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells.
Academic Article Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.
Academic Article Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation.
Academic Article Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in a murine model. Evidence that large granular lymphocytes are effector cells in the immune response.
Academic Article Depletion and repopulation of epidermal dendritic cells after allogeneic bone marrow transplantation in humans.
Academic Article Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses.
Academic Article Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
Academic Article Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease.
Academic Article Fas-deficient lpr mice are more susceptible to graft-versus-host disease.
Academic Article Kinetics of gene expression in murine cutaneous graft-versus-host disease.
Academic Article A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model.
Academic Article Cytotoxic folliculitis in GvHD. Evidence of follicular stem cell injury and recovery.
Academic Article Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions.
Academic Article Target cells in graft-versus-host disease: implications for cancer therapy.
Academic Article Specific donor Vbeta-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens.
Academic Article Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine.
Academic Article Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype.
Academic Article Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.
Academic Article Organ-derived dendritic cells have differential effects on alloreactive T cells.
Academic Article Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody.
Academic Article Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth.
Academic Article Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation.
Academic Article Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells.
Academic Article Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease.
Academic Article T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease.
Academic Article Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease.
Academic Article Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease.
Academic Article Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Academic Article NOD2 regulates hematopoietic cell function during graft-versus-host disease.
Concept Graft vs Host Disease
Academic Article Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.
Academic Article PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD.
Academic Article A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.
Academic Article Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
Academic Article Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Grant BIOLOGIC &CLINICAL PROPERTIES OF CD4 STRUCTURAL ANALOGS
Grant Cellular Pathology of Graft Versus Host Disease
Grant CELLULAR PATHOLOGY OF GRAFT VERSUS HOST DISEASE
Grant Immune Modulation/Hematopoietic Cell Transplantation
Academic Article Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
Academic Article Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study.
Academic Article Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Academic Article COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters).
Search Criteria
  • Graft vs Host Disease
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.