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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.
Systemic stimulation of TLR2 impairs neonatal mouse brain development.
Adenosine Shapes Neonatal Toll-like Receptor Function