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One or more keywords matched the following items that are connected to Levy, Ofer
Item TypeName
Academic Article Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.
Academic Article Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists.
Academic Article The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.
Academic Article Neonatal innate immunity in allergy development.
Academic Article Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.
Academic Article Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly.
Academic Article Plasma-mediated immune suppression: a neonatal perspective.
Academic Article Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo.
Academic Article Neonatal babesiosis: case report and review of the literature.
Academic Article Innate immunity of the newborn: basic mechanisms and clinical correlates.
Academic Article Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo.
Academic Article Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivo.
Academic Article A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses.
Academic Article Role of innate host defenses in susceptibility to early-onset neonatal sepsis.
Academic Article The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.
Academic Article Neonatal immune responses to coagulase-negative staphylococci.
Academic Article Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.
Academic Article Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates.
Academic Article Neonatal vaccination: a once in a lifetime opportunity.
Academic Article Role of innate immunity in neonatal infection.
Academic Article Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.
Academic Article Impaired innate immunity at birth: deficiency of bactericidal/permeability-increasing protein (BPI) in the neutrophils of newborns.
Academic Article Genetic screening for susceptibility to infection in the NICU setting.
Academic Article Challenges in infant immunity: implications for responses to infection and vaccines.
Academic Article Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation.
Academic Article Development of newborn and infant vaccines.
Academic Article Developmental biology of the innate immune response: implications for neonatal and infant vaccine development.
Academic Article Safety and efficacy of neonatal vaccination.
Academic Article Newborn cord blood demonstrates impaired TNF responses to multiple pathogen-assocaited molecular pattern molecules (PAMPs) despite normal expression of monocyte Toll-like receptos 1 and 2, MD-2, MyD88 and TIRAP
Academic Article Systemic stimulation of TLR2 impairs neonatal mouse brain development.
Academic Article Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors.
Academic Article Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
Academic Article Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities.
Concept Infant, Newborn
Concept Animals, Newborn
Academic Article Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.
Academic Article Immune response to vaccine adjuvants during the first year of life.
Academic Article Vaccine-induced immunity in early life.
Academic Article Neonatal host defense against Staphylococcal infections.
Academic Article A prime time for trained immunity: innate immune memory in newborns and infants.
Academic Article Ontogeny of early life immunity.
Academic Article Infection-induced inflammation and cerebral injury in preterm infants.
Academic Article The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.
Academic Article Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways.
Academic Article Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs.
Academic Article Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity.
Academic Article Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.
Academic Article In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.
Academic Article Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.
Grant Adenosine Shapes Neonatal Toll-like Receptor Function
Grant Determinants of Innate Immunity to Group B Streptococci
Academic Article Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
Academic Article Human newborn B cells mount an interferon-a/ß receptor-dependent humoral response to respiratory syncytial virus.
Academic Article Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.
Academic Article Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.
Academic Article TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.
Academic Article Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.
Academic Article Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis.
Academic Article Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.
Academic Article Neonatal Immunization: Rationale, Current State, and Future Prospects.
Academic Article Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.
Academic Article Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro.
Academic Article Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
Search Criteria
  • Infant Newborn
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.