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Item TypeName
Award or Honor Receipt Eli Lilly Award for Outstanding Scientific Achievement
Award or Honor Receipt Max Miller Memorial Lecture
Award or Honor Receipt Award for "Outstanding International Contributions to Research in Diabetes Mellitus"
Award or Honor Receipt Capps Scholar in Diabetes
Award or Honor Receipt Research Award
Award or Honor Receipt Mosenthal Award
Academic Article Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle.
Academic Article Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity.
Academic Article Lilly lecture 1995. Glucose transport: pivotal step in insulin action.
Academic Article Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats.
Academic Article Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
Academic Article cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme.
Academic Article Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Academic Article Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle.
Academic Article Molecular characterization of a putative sodium/iodide symporter in the South African clawed frog, Xenopus laevis.
Academic Article Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency.
Academic Article Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning.
Academic Article Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
Academic Article Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.
Academic Article Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice.
Academic Article Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes.
Academic Article Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.
Academic Article Are older breast carcinoma survivors willing to take hormone replacement therapy?
Academic Article Models of insulin action on metabolic and growth response genes.
Academic Article Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects.
Academic Article Peripheral signals set the tone for central regulation of metabolism.
Academic Article Neuronal PTP1B regulates body weight, adiposity and leptin action.
Academic Article Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation.
Academic Article High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect.
Academic Article Exercise, glucose transport, and insulin sensitivity.
Academic Article Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.
Academic Article Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.
Academic Article Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.
Academic Article Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
Academic Article Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.
Academic Article Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Academic Article Effect of aging and obesity on insulin responsiveness and glut-4 glucose transporter content in skeletal muscle of Fischer 344 x Brown Norway rats.
Academic Article Perturbed glucose transport in diabetes mellitus
Academic Article Alterations in glucose transporter expression and function in diabetes: mechanisms for insulin resistance.
Academic Article Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.
Academic Article Type 2 diabetes--who is conducting the orchestra?
Academic Article Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit.
Academic Article Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.
Academic Article Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Academic Article The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents.
Academic Article Rosiglitazone, PPAR?, and type 2 diabetes.
Academic Article Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
Academic Article High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats.
Academic Article Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats.
Academic Article Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds
Academic Article GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase.
Academic Article Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.
Academic Article Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment.
Academic Article High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.
Academic Article Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.
Academic Article Breast cancer in younger women: reproductive and late health effects of treatment.
Academic Article Deletion of cd39/entpd1 results in hepatic insulin resistance.
Academic Article Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter.
Academic Article Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Academic Article Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.
Academic Article Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.
Academic Article Development and validation of a physical examination scale to assess vaginal atrophy and inflammation.
Academic Article Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
Academic Article Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.
Academic Article GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
Academic Article Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
Academic Article Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states.
Academic Article Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.
Academic Article Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
Academic Article Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Academic Article Minimally invasive total hip arthroplasty: a prospective randomized study.
Academic Article Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Academic Article Regulation of glucose-transporter gene expression in vitro and in vivo.
Academic Article Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Academic Article Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport.
Academic Article Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Academic Article Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects.
Academic Article Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass.
Academic Article Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
Academic Article Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes.
Academic Article aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.
Academic Article Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Academic Article CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.
Academic Article AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
Academic Article Impairments in insulin-stimulated muscle glucose uptake and whole-body glucose homeostasis caused by muscle–specific overexpression of LAR or PTP1B are not additive. Presented at the American Diabetes Association Scientific Sessions
Academic Article Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Academic Article Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.
Academic Article Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
Academic Article Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
Academic Article Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats.
Academic Article Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes.
Academic Article In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
Academic Article Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.
Academic Article Obesity and insulin resistance.
Academic Article Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors.
Academic Article Extended longevity in mice lacking the insulin receptor in adipose tissue.
Academic Article AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Academic Article Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.
Academic Article Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Academic Article Paradoxically increased glycogen content in muscle-Glut4 knockout mice may be due to increased levels of glycogen-targeting subunits. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Expression of the GLUT4 glucose transporter in diabetes. In Molecular Biology of Diabetes. B Draznin and D LeRoith eds
Academic Article Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds
Academic Article Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Academic Article Total ankle replacement in patients with rheumatoid arthritis.
Academic Article Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Academic Article Adipocyte function in IRS2-/- mice. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Adipose-specific overexpression of GLUT-4 in transgenic mice alters lipoprotein lipase activity.
Academic Article Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells.
Academic Article Leveraging leptin for type I diabetes?
Academic Article Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Academic Article Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland.
Academic Article A guide to analysis of mouse energy metabolism.
Academic Article Do adipocytes contain high affinity sulfonylurea receptors.
Academic Article Diet-induced obesity (DIO) causes resistance to leptin action on AMP-activated protein kinase (AMPK) in skeletal muscle. Presented at the American Diabetes Association Annual Scientific Session
Academic Article Knockout of GLUT4 simultaneously from both muscle and fat causes hyperglycemia and hyperinsulinemia. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity.
Academic Article High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.
Academic Article A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Academic Article Tissue specific regulation of glucose transporters in adipose cells and muscle of obese Zucker rats
Academic Article Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis?
Academic Article Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4.
Academic Article Cell biology of insulin action on glucose transport and its perturbation in diabetes mellitus. In Diabetes Mellitus: Pathophysiology and Therapy. W. Creutzfeldt and P. Lefebvre, editors
Academic Article Regulation of glucose transport in diabetes. In Frontiers of Diabetes Research: Current Trends in Non-insulin-dependent Diabetes Mellitus. KGMM Alberti, RS Mazze, editors
Academic Article Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes.
Academic Article Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
Academic Article Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion.
Academic Article Paradoxically increased glycogen content in muscle-Glut4 knockout mice may be due to increased levels of glycogen-targeting subunits. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Leptin stimulates fatty acid oxidation directly in white adipose tissue through activation of AMP-activated protein kinase. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance.
Academic Article Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases.
Academic Article Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes.
Academic Article Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
Academic Article Tissue specific regulation of the glyceraldehyde-3-phosphate dehydrogenase gene by insulin correlates with the induction of an insulin-sensitive transcription factor during differentiation of 3T3 adipocytes
Academic Article Biology of adipose tissue. In Joslin’s Diabetes Mellitus. CR Kahn, GC Weir, GL King, AC Moses, RJ Smith, AM Jacobson eds
Academic Article Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
Academic Article Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.
Academic Article Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
Academic Article Perioperative morbidity following total knee arthroplasty among obese patients.
Academic Article The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes.
Academic Article Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
Academic Article Use of recombinant adenovirus-mediated gene transfer to study insulin action in 3T3L1 adipocytes
Academic Article Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.
Academic Article Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial.
Academic Article Characteristics and natural history of transient postoperative pseudosubluxation after total hip arthroplasty.
Academic Article Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
Academic Article Tissue-specific regulation of glucose transporters in different forms of obesity.
Academic Article Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Academic Article AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Academic Article Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
Academic Article Role of glucose transporters in diabetes. In Diabetes 1991. H Rifkin, JA Colwell and SI Taylor eds
Academic Article Cell biology of insulin's stimulatory action on glucose transport and its perturbation in altered metabolic states.
Academic Article Targeted disruption of the beta 3-adrenergic receptor gene.
Academic Article Cathepsin L activity controls adipogenesis and glucose tolerance.
Academic Article Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.
Academic Article Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool.
Academic Article Lessons on conditional gene targeting in mouse adipose tissue.
Academic Article Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Academic Article mTOR tells the brain that the body is hungry.
Academic Article Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.
Academic Article Transgenic models of insulin resistance: a focus on the manipulation of the distal glucose transport step
Academic Article Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.
Academic Article Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling.
Academic Article GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
Academic Article Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Academic Article Cellular defects in glucose transport: lessons from animal models and implications for human insulin resistance. In Insulin Resistance DE Moller ed
Academic Article Glucose transporters in diabetes and related disorders
Academic Article Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
Academic Article Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study.
Academic Article Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans.
Academic Article Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states.
Academic Article Adipose-specific overexpression of Glut4 restores insulin sensitivity in mice with muscle-specific knockout of Glut4 without restoring glucose transporters in muscle. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2.
Academic Article Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.
Academic Article Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Academic Article p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
Academic Article Adipose-specific overexpression of Glut4 selectively enhances insulin action on Akt and MAPK. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Role of the AMP-activated protein kinase as an energy sensor in the hypothalamus. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Nutrient sensor links obesity with diabetes risk.
Academic Article The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance.
Academic Article Hypothalamic AMP kinase (AMPK) regulates food intake, body weight and expression of orexigenic neuropeptides. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
Academic Article Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Academic Article Increased insulin-stimulated glucose uptake in athletes: the importance of GLUT4 mRNA, GLUT4 protein and fibre type composition of skeletal muscle.
Academic Article Overexpression of Glut4 in adipose tissue “rescues” insulin resistance and glucose intolerance in muscle-specific Glut4 knockout mice. Presented at the Keystone conference on Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies. Keystone, CO
Academic Article Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds
Academic Article Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis.
Academic Article Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue.
Academic Article Challenges and opportunities of defining clinical leptin resistance.
Academic Article Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.
Academic Article Glucose transporters and diabetes. Seminars in Cell and Developmental Biology
Academic Article Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.
Academic Article Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
Academic Article Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
Academic Article Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Academic Article A high-fat, ketogenic diet induces a unique metabolic state in mice.
Academic Article Insulin sensitivity in cystic fibrosis.
Academic Article Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity.
Academic Article Glucose transport in adipose tissue is essential for the acute effect of â3 adrenergic agonists on glucose homeostasis. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Deletion of PPARã in adipose tissues of mice leads to impaired lipid deposition. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.
Academic Article Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
Academic Article Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
Academic Article Muscle-specific knock out of GLUT4 down-regulates signaling. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Mechanism for markedly hyperresponsive insulin-stimulated glucose transport activity in adipose cells from insulin-treated streptozotocin diabetic rats. Evidence for increased glucose transporter intrinsic activity.
Academic Article Regulatory role of glucose and melancortin-4 receptor in AMP-activity protein kinase activity in the hypothalamus: association with feeding behavior. Presented at the American Diabetes Association Scientific Sessions
Academic Article Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.
Academic Article Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Academic Article Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.
Academic Article Exercise capacity is impaired in mice with muscle-specific GLUT4 knock out but is normal with cardiac-specific GLUT4 knock out. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.
Academic Article Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo.
Academic Article Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats.
Academic Article Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.
Academic Article Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay.
Academic Article Dietary regulation of glucose transporter gene expression: tissue specific effects in adipose cells and muscle.
Academic Article Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Academic Article PTP1B regulates leptin signal transduction in vivo.
Academic Article Leptin signaling in the central nervous system and the periphery.
Academic Article AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.
Academic Article Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle.
Academic Article Regulation of gluconeogenesis by Krüppel-like factor 15.
Academic Article Overexpression of Glut4 in fat “rescues” glucose intolerance in muscle-specific Glut4 knockout mice. Presented at the American Diabetes Association Annual Scientific Sessions
Academic Article Recent advances in understanding the molecular basis for insulin stimulated glucose transport
Concept Diabetes Mellitus, Experimental
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Concept Myostatin
Concept Alleles
Concept Cyclic AMP
Concept Gene Silencing
Concept Immune Sera
Concept Patch-Clamp Techniques
Concept Estrogens
Concept Exons
Concept rab GTP-Binding Proteins
Concept Glucose Metabolism Disorders
Concept Diabetes Mellitus, Type 2
Concept Glucose Transporter Type 2
Concept Genes, ras
Concept Proto-Oncogene Proteins c-kit
Concept Cell Fractionation
Concept Lectins, C-Type
Concept Retrospective Studies
Concept Toll-Like Receptor 2
Concept Enzyme Activation
Concept Computational Biology
Concept Neural Cell Adhesion Molecule L1
Concept Insulin-Secreting Cells
Concept Cells, Cultured
Concept Clathrin-Coated Vesicles
Concept Bone Morphogenetic Protein 4
Concept Deoxyglucose
Concept Adenylate Kinase
Concept R-SNARE Proteins
Concept Cystinyl Aminopeptidase
Concept Cytosol
Concept Nutritional Status
Concept Neural Cell Adhesion Molecules
Concept Follow-Up Studies
Concept Stearates
Concept Deoxycytidine
Concept Colitis
Concept Tumor Necrosis Factor-alpha
Concept Eating
Concept Glycolysis
Concept Acromegaly
Concept beta-Galactosidase
Concept Epinephrine
Concept Cromolyn Sodium
Concept Hippocampus
Concept Janus Kinase 2
Concept Comorbidity
Concept Promoter Regions, Genetic
Concept Weight Gain
Concept DNA Primers
Concept Calmodulin
Concept Vitamin A
Concept Hydroxy Acids
Concept MAP Kinase Signaling System
Concept Palmitic Acids
Concept Gluconeogenesis
Concept Doxorubicin
Concept Down-Regulation
Concept Adrenergic Antagonists
Concept Transgenes
Concept Organ Size
Concept Ornithine Decarboxylase
Concept Consensus Development Conferences, NIH as Topic
Concept Pancreas Transplantation
Concept Doxycycline
Concept Sirtuin 1
Concept Fatty Acids, Nonesterified
Concept Portal Vein
Concept Glucose Transporter Type 1
Concept Adaptor Proteins, Signal Transducing
Concept Glucose Transporter Type 4
Concept Cardiomegaly
Concept Adrenergic alpha-Antagonists
Concept Longitudinal Studies
Concept Erythroid Precursor Cells
Concept Multigene Family
Concept Mitochondria
Concept Carbon
Concept Steroidogenic Factor 1
Concept Duodenum
Concept Early Growth Response Protein 1
Concept Cell Proliferation
Concept Tetradecanoylphorbol Acetate
Concept Receptor, Insulin
Concept Hunger
Concept T-Lymphocytes
Concept Phosphorus
Concept Antigens, CD
Concept Diagnostic Errors
Concept Nitric Oxide Synthase Type III
Concept Liver Neoplasms, Experimental
Concept Injections, Intraperitoneal
Concept Cell Separation
Concept Exercise
Concept Signal Transduction
Concept Phosphoric Monoester Hydrolases
Concept Oxygen
Concept Adipose Tissue, White
Concept Prostatic Neoplasms
Concept Phosphoprotein Phosphatases
Concept Paraventricular Hypothalamic Nucleus
Concept Recurrence
Concept Drug Discovery
Concept Insulin Receptor Substrate Proteins
Concept PTEN Phosphohydrolase
Concept Lactic Acid
Concept Injections, Intraventricular
Concept Cell Nucleus
Concept Cell Division
Concept Receptors, Melanocortin
Concept Antigens, Differentiation
Concept Adipose Tissue
Concept Age of Onset
Concept Dietary Sucrose
Concept Actins
Concept COS Cells
Concept Macrophage Activation
Concept Growth Differentiation Factor 3
Concept Pelvic Bones
Concept Cell Communication
Concept Infusions, Intraventricular
Concept Dietary Fats
Concept RNA Interference
Concept Lactates
Concept Isoproterenol
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Body Weight
Concept Phosphoenolpyruvate Carboxykinase (ATP)
Concept Receptor, IGF Type 1
Concept Intestine, Small
Academic Article Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.
Academic Article Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study.
Academic Article Leptin, GABA, and glucose control.
Academic Article Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.
Academic Article Application of combined omics platforms to accelerate biomedical discovery in diabesity.
Academic Article Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.
Academic Article Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Academic Article RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.
Academic Article Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer.
Academic Article Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.
Academic Article Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
Academic Article Data-driven synthesis of proteolysis-resistant peptide hormones.
Academic Article Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.
Academic Article Leptin and insulin act on POMC neurons to promote the browning of white fat.
Academic Article Novel role for retinol-binding protein 4 in the regulation of blood pressure.
Academic Article PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.
Academic Article Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature.
Academic Article AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
Academic Article Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.
Academic Article Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.
Academic Article GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.
Academic Article A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons.
Academic Article Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.
Grant A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
Grant Glucose Transporter Regulation in Obesity and Diabetes
Grant Mechanisms for regulation of a novel class of anti-diabetic lipids
Grant Integrated Endocrine and Metabolic Research Training
Grant Boston Area Diabetes Endocrinology Research Center
Academic Article A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids.
Academic Article Lipid Extraction from Mouse Feces.
Academic Article Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.
Academic Article Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids.
Academic Article Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.
Academic Article Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.
Academic Article Self-assembling phospholipid filaments.
Academic Article Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Academic Article GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle.
Academic Article Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.
Academic Article Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.
Academic Article Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.
Academic Article Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Academic Article Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.
Academic Article Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.
Academic Article Metabolites as regulators of insulin sensitivity and metabolism.
Academic Article Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
Academic Article Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.
Academic Article Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture.
Academic Article Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.
Award or Honor Receipt Nelson Goldberg Lecture In Signal Transduction and Metabolism
Award or Honor Receipt Research discoveries featured in the publication "NIDDK: Recent Advances and Emerging Opportunities"
Award or Honor Receipt Beth Zaruby Lectureship at the Julia McFarlane Diabetes Research Center
Award or Honor Receipt Journal of Lipid Research Lectureship Award
Award or Honor Receipt Banting Medal for Outstanding Scientific Achievement
Award or Honor Receipt 23rd Dewitt Goodman Lectureship
Award or Honor Receipt Charles Hollenberg Lectureship
Academic Article PAHSAs attenuate immune responses and promote ß cell survival in autoimmune diabetic mice.
Academic Article PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.
Academic Article RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women.
Academic Article Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Academic Article Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4.
Academic Article BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.
Academic Article Insulin action in adipocytes, adipose remodeling, and systemic effects.
Academic Article Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle.
Academic Article Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
Search Criteria
  • metabolism
  • type
  • 2
  • diabetes
  • adipose tissue
  • small
  • molecules
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.