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Item TypeName
Mentoring - Completed Student Project Assessing PRDM16 Protein Stability in Adipose Tissue
Academic Article Adipogenesis and obesity: rounding out the big picture.
Academic Article Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Academic Article Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
Academic Article Terminal differentiation of human breast cancer through PPAR gamma.
Academic Article Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
Academic Article PGC-1beta in the regulation of hepatic glucose and energy metabolism.
Academic Article Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Academic Article Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Academic Article A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.
Academic Article Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Academic Article Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Academic Article Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
Academic Article DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
Academic Article Activation of PPARgamma coactivator-1 through transcription factor docking.
Academic Article PPAR gamma and the molecular control of adipogenesis.
Academic Article ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
Academic Article Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Academic Article Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Academic Article Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Academic Article The role of exercise and PGC1alpha in inflammation and chronic disease.
Academic Article Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Academic Article PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Academic Article Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
Academic Article Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
Academic Article Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.
Academic Article PPARgamma ligands: taking Ppart in chemoprevention.
Academic Article Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Academic Article PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Academic Article An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
Academic Article PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
Academic Article Obesity and the regulation of energy balance.
Academic Article Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.
Academic Article APC-dependent suppression of colon carcinogenesis by PPARgamma.
Academic Article Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
Academic Article Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
Academic Article Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
Academic Article "The adipocyte: a multifunctional cell".
Academic Article Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity.
Academic Article Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation.
Academic Article The perils of putting career before all else.
Academic Article Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
Academic Article A direct role for c-fos in AP-1-dependent gene transcription.
Academic Article Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA.
Academic Article A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Academic Article A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Academic Article Transcriptional regulation of adipogenesis.
Academic Article Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain.
Academic Article Identification of novel genes involved in adipose differentiation by differential display.
Academic Article Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Academic Article Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Academic Article Regulation of alternative pathway activation and C3a production by adipose cells.
Academic Article Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.
Academic Article Adipocytes as regulators of energy balance and glucose homeostasis.
Academic Article Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats.
Academic Article AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Academic Article Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins.
Academic Article DNA-binding activity of Jun is increased through its interaction with Fos.
Academic Article Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Academic Article Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Academic Article Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
Academic Article The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Academic Article PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth.
Academic Article Heparin potentiation of 3T3-adipocyte stimulated angiogenesis: mechanisms of action on endothelial cells.
Academic Article Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function.
Academic Article Hic-5 regulates an epithelial program mediated by PPARgamma.
Academic Article Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Academic Article Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.
Academic Article Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Academic Article Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol.
Academic Article Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Academic Article International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Academic Article Transcriptional control of brown fat determination by PRDM16.
Academic Article Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Academic Article Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Academic Article Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes.
Academic Article Through thick and thin: wasting, obesity, and TNF alpha.
Academic Article Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
Academic Article Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.
Academic Article FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis.
Academic Article Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
Academic Article Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1a/ERR? complex.
Academic Article The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.
Academic Article Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression.
Academic Article Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
Academic Article Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache.
Academic Article Molecular regulation of adipogenesis.
Academic Article Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.
Academic Article Adipsin and an endogenous pathway of complement from adipose cells.
Academic Article Biological control through regulated transcriptional coactivators.
Academic Article Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.
Academic Article TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Academic Article Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
Academic Article A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
Academic Article PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Academic Article QnAs with Bruce M. Spiegelman.
Academic Article A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
Academic Article Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes.
Academic Article Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
Academic Article Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.
Academic Article Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Academic Article Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.
Academic Article Synergy between PPARgamma ligands and platinum-based drugs in cancer.
Academic Article Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Academic Article Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.
Academic Article Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells.
Academic Article Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Academic Article Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Academic Article Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.
Academic Article Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes.
Academic Article C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Academic Article PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.
Academic Article TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Academic Article Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells.
Academic Article Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.
Academic Article Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Academic Article Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy.
Academic Article Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.
Academic Article Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D.
Academic Article A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Academic Article A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.
Academic Article Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
Academic Article Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.
Academic Article Multiple sites for the initiation of microtubule assembly in mammalian cells.
Academic Article A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Academic Article Transgenic mouse models of disease: altering adipose tissue function in vivo.
Academic Article AdipoQ is a novel adipose-specific gene dysregulated in obesity.
Academic Article Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
Academic Article Involvement of fos as a trans-acting factor in adipogenic gene expression.
Academic Article Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Academic Article Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
Academic Article Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.
Academic Article Development of insulin resistance in mice lacking PGC-1a in adipose tissues.
Academic Article Severely impaired adipsin expression in genetic and acquired obesity.
Academic Article Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
Academic Article Adipsin and complement factor D activity: an immune-related defect in obesity.
Academic Article Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Academic Article Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha.
Academic Article Transcriptional activation of adipogenesis.
Academic Article Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Academic Article Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity.
Academic Article Peroxisome proliferator-activated receptor gamma and the control of adipogenesis.
Academic Article Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
Academic Article Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation.
Academic Article Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
Academic Article Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Academic Article Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
Academic Article C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Academic Article Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.
Academic Article Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Academic Article CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Academic Article Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Academic Article Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.
Academic Article Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Academic Article Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.
Academic Article ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Academic Article Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Academic Article PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Academic Article Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase.
Academic Article c-fos is not essential for v-abl-induced lymphomagenesis.
Academic Article 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes.
Academic Article A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
Academic Article Adipsin: regulation and dysregulation in obesity and other metabolic states.
Academic Article Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
Academic Article PRDM16 controls a brown fat/skeletal muscle switch.
Academic Article Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Academic Article Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Academic Article NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Academic Article PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination.
Academic Article Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
Academic Article A chemical screen probing the relationship between mitochondrial content and cell size.
Academic Article A PGC-1a isoform induced by resistance training regulates skeletal muscle hypertrophy.
Academic Article Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells.
Academic Article PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Academic Article Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.
Academic Article Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Academic Article A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.
Academic Article Transcriptional control of preadipocyte determination by Zfp423.
Academic Article Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Academic Article Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science.
Academic Article Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.
Academic Article Protooncogene c-fos as a transcription factor.
Academic Article PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
Academic Article PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Academic Article Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.
Academic Article The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex.
Academic Article Metabolic control through the PGC-1 family of transcription coactivators.
Academic Article HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Academic Article Transcriptional control of brown fat development.
Academic Article The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.
Academic Article Fat and beyond: the diverse biology of PPARgamma.
Academic Article Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Academic Article Regulation of gene expression during the differentiation of 3T3-adipocytes.
Academic Article Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Academic Article Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
Academic Article Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Academic Article Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Academic Article PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.
Academic Article ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
Academic Article A rationale for SDS-PAGE of MHC isoforms as a gold standard for determining contractile phenotype.
Academic Article Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
Academic Article Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Academic Article Age-related changes associated with the induction of o-pyrocatechuic acid carboxylase in Aspergillus ornatus.
Academic Article PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
Academic Article Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.
Academic Article Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Academic Article Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.
Academic Article Molecular mechanisms of cancer development in obesity.
Academic Article Adaptive thermogenesis in adipocytes: is beige the new brown?
Academic Article Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Academic Article Behavioral assessment of c-fos mutant mice.
Academic Article p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Academic Article Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
Academic Article Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.
Academic Article IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Academic Article PPAR gamma and the control of adipogenesis.
Academic Article Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.
Academic Article Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.
Academic Article Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Academic Article Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Academic Article Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4).
Academic Article Towards a molecular understanding of adaptive thermogenesis.
Academic Article Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.
Academic Article Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Academic Article Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.
Academic Article Tumor necrosis factor alpha: a key component of the obesity-diabetes link.
Academic Article Differential activation of adipogenesis by multiple PPAR isoforms.
Academic Article Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Academic Article Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Academic Article Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.
Academic Article Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Academic Article Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.
Academic Article For a pragmatic approach to exercise studies.
Academic Article Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Academic Article Identifying novel transcriptional components controlling energy metabolism.
Academic Article fos protooncogene and the regulation of gene expression in adipocyte differentiation.
Academic Article Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
Academic Article Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
Academic Article Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
Academic Article Transcriptional control of energy homeostasis through the PGC1 coactivators.
Academic Article Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
Academic Article A novel therapeutic approach to treating obesity through modulation of TGFß signaling.
Academic Article Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos.
Academic Article Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.
Concept Diabetes Mellitus, Experimental
Concept Immunohistochemistry
Concept Mitogen-Activated Protein Kinase Phosphatases
Concept 5' Untranslated Regions
Concept Epithelium
Concept Nuclear Respiratory Factors
Concept Diet
Concept Colonic Neoplasms
Concept Complement C3
Concept Simian virus 40
Concept In Situ Hybridization
Concept Risk Factors
Concept Myogenic Regulatory Factors
Concept Receptors, Tumor Necrosis Factor, Type II
Concept Flavonoids
Concept Electrophysiological Phenomena
Concept Receptors, Retinoic Acid
Concept Cell Lineage
Concept Second Messenger Systems
Concept Cell Survival
Concept Caloric Restriction
Concept Prostaglandin D2
Concept Kininogens
Concept Cell Biology
Concept Fibroblast Growth Factors
Concept Sphingomyelin Phosphodiesterase
Concept Islets of Langerhans Transplantation
Concept Adenocarcinoma
Concept Cell Differentiation
Concept Fasting
Concept DNA, Mitochondrial
Concept Single-Cell Analysis
Concept Intermediate Filament Proteins
Concept Animals, Newborn
Concept Muscle Proteins
Concept Cyclin-Dependent Kinase 5
Concept Dopamine beta-Hydroxylase
Concept Lipid Metabolism
Concept Aurothioglucose
Concept Adenocarcinoma, Follicular
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Concept Apolipoproteins A
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Concept Enhancer Elements, Genetic
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Concept Proto-Oncogene Proteins c-jun
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Concept NIH 3T3 Cells
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Concept Complement Factor D
Concept Drug Evaluation, Preclinical
Concept Adipokines
Concept Hypoxia-Inducible Factor 1
Concept Orphan Nuclear Receptors
Concept Genes, Reporter
Concept MAP Kinase Kinase 2
Concept Cyclic AMP Response Element-Binding Protein
Concept Retinoblastoma-Binding Protein 1
Concept Phosphoenolpyruvate Carboxykinase (GTP)
Concept Parathyroid Hormone-Related Protein
Concept Alprostadil
Concept Regulatory Elements, Transcriptional
Concept Body Mass Index
Concept Cytokines
Concept Nuclear Receptor Subfamily 1, Group D, Member 1
Concept Coenzymes
Concept Muscle, Smooth, Vascular
Concept Vascular Endothelial Growth Factor A
Concept Griseofulvin
Concept Enzyme-Linked Immunosorbent Assay
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Complement Activating Enzymes
Concept Extracellular Matrix
Concept Genes, Lethal
Concept Age Factors
Concept Disease Models, Animal
Concept Dexamethasone
Concept Apoptosis
Concept Y-Box-Binding Protein 1
Concept Mice, Inbred mdx
Concept Tubulin Modulators
Concept Hepatocyte Nuclear Factor 4
Concept Temperature
Concept Body Temperature Regulation
Concept Selenium
Concept PPAR alpha
Concept Maleimides
Concept Early Growth Response Protein 2
Concept Amyloid beta-Protein Precursor
Concept Ionomycin
Concept Transforming Growth Factor beta
Concept Feedback
Concept Chromans
Concept RNA, Small Interfering
Concept CCAAT-Enhancer-Binding Protein-alpha
Concept Transcription Factor CHOP
Concept Dicumarol
Concept NF-kappa B
Concept Heat-Shock Proteins
Concept Adrenergic beta-Agonists
Concept Activating Transcription Factor 6
Concept Neuromuscular Junction
Concept Cell Line, Tumor
Concept Brain-Derived Neurotrophic Factor
Concept Molecular Sequence Data
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Receptors, Cytoplasmic and Nuclear
Concept Prostaglandins
Concept Genes, APC
Concept Repressor Proteins
Concept Cell Enlargement
Concept Myostatin
Concept Endothelium
Concept Arachidonic Acids
Concept Fats
Concept Alleles
Concept Chromatin Assembly and Disassembly
Concept Zebrafish
Concept Bone Morphogenetic Protein 2
Concept Cyclic AMP
Concept Cold Temperature
Concept Gene Silencing
Concept Butyric Acid
Concept Immune Sera
Concept Patch-Clamp Techniques
Concept Exons
Concept Seizures
Concept Diabetes Mellitus, Type 2
Concept Basal Metabolism
Concept NF-E2-Related Factor 1
Concept Genes, ras
Concept Complement System Proteins
Concept CCAAT-Enhancer-Binding Protein-beta
Concept Carboxypeptidase H
Concept Microvascular Angina
Concept Mitochondrial ADP, ATP Translocases
Concept Agouti Signaling Protein
Concept Bone Morphogenetic Proteins
Concept Nuclear Respiratory Factor 1
Concept Enzyme Activation
Concept Computational Biology
Concept Mitochondria, Liver
Concept Insulin-Secreting Cells
Concept Cells, Cultured
Concept Evolution, Molecular
Concept Fluorescein Angiography
Concept Protons
Concept Muscle Fibers, Fast-Twitch
Concept Receptors, Thyroid Hormone
Concept Deoxyglucose
Concept Vimentin
Concept Amyloid beta-Peptides
Concept Carboxypeptidases
Concept Deoxyribonuclease I
Concept Nutritional Status
Concept Receptors, Estrogen
Concept Dimerization
Concept Tumor Necrosis Factor-alpha
Concept Muscle Fibers, Slow-Twitch
Concept Chimera
Concept Plasminogen Activators
Concept Eating
Concept Glycolysis
Concept Appetite Regulation
Concept Sulfides
Concept Epinephrine
Concept Hippocampus
Concept Activin Receptors, Type II
Concept Proteasome Endopeptidase Complex
Concept Culture Media, Serum-Free
Concept Promoter Regions, Genetic
Concept Glucokinase
Concept Weight Gain
Concept Antigens, Differentiation, B-Lymphocyte
Concept Metalloendopeptidases
Concept Cell Line, Transformed
Concept DNA Primers
Concept Endopeptidases
Concept GA-Binding Protein Transcription Factor
Concept Cysteine
Concept Vascular Endothelial Growth Factors
Concept Epilepsy
Concept Histocytochemistry
Concept Collagen Type III
Concept Paired Box Transcription Factors
Concept Survival Rate
Concept Genes, Regulator
Concept MAP Kinase Signaling System
Concept PPAR delta
Concept Gluconeogenesis
Concept Antigens, Differentiation, T-Lymphocyte
Concept Down-Regulation
Concept Body Fluids
Concept Cattle
Concept Transgenes
Concept MyoD Protein
Concept Organ Size
Concept Cell Movement
Concept beta Catenin
Concept Keratins
Concept History, 20th Century
Concept Linoleic Acids
Concept Plasma
Concept Retinoid X Receptors
Concept Sirtuin 1
Concept Adrenergic beta-3 Receptor Agonists
Concept Peroxisome Proliferator-Activated Receptors
Concept Dual-Specificity Phosphatases
Concept Fatty Acids, Nonesterified
Concept Dactinomycin
Concept Adaptor Proteins, Signal Transducing
Concept Glucose Transporter Type 4
Concept Cell Dedifferentiation
Concept Cell Death
Concept Multigene Family
Concept Mitochondria
Concept Flow Cytometry
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 4
Concept Cytochromes c
Concept Culture Media, Conditioned
Concept Corpus Striatum
Concept Exercise Test
Concept Cholesterol
Concept Monocytes
Concept Cell Proliferation
Concept Tetradecanoylphorbol Acetate
Concept Receptor, Insulin
Concept T-Lymphocytes
Concept Calcineurin
Concept Estrogen Receptor alpha
Concept Drug Synergism
Concept Organ Culture Techniques
Concept Genes, Immediate-Early
Concept Antigens, CD
Concept Cell Hypoxia
Concept 8-Bromo Cyclic Adenosine Monophosphate
Concept CREB-Binding Protein
Concept Oleic Acids
Concept Fructose-Bisphosphate Aldolase
Concept Cell Separation
Concept Exercise
Concept Troponin I
Concept Transforming Growth Factor beta1
Concept Denmark
Concept Adrenergic beta-1 Receptor Agonists
Concept Liver Neoplasms
Concept Cytoplasm
Concept Signal Transduction
Concept Oxygen
Concept Chickens
Concept Adipose Tissue, White
Concept Tumor Suppressor Protein p53
Concept Prostatic Neoplasms
Concept Phosphoprotein Phosphatases
Concept Dobutamine
Concept Antigens, Polyomavirus Transforming
Concept HeLa Cells
Concept Genes, Tumor Suppressor
Concept Insulin Receptor Substrate Proteins
Concept Exodeoxyribonucleases
Concept Oncogenes
Concept Embryo, Mammalian
Concept Lactic Acid
Concept Cachexia
Concept Cell Nucleus
Concept Cell Division
Concept Diptera
Concept Cardiac Output, Low
Concept Interleukin-13
Concept Culture Techniques
Concept Presynaptic Terminals
Concept Antigens, Differentiation
Concept Adipose Tissue
Concept Drug Design
Concept Drug Resistance, Microbial
Concept ADP-Ribosylation Factors
Concept Actins
Concept Glycosylation
Concept COS Cells
Concept Growth Differentiation Factor 3
Concept Membrane Potentials
Concept Cell Communication
Concept Forkhead Transcription Factors
Concept Dietary Fats
Concept RNA Interference
Concept Isoproterenol
Concept Sterol Regulatory Element Binding Protein 2
Concept PC12 Cells
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Body Weight
Concept Blood
Concept Disease Progression
Concept Creatine
Concept Antigen-Antibody Complex
Concept Nuclear Receptor Subfamily 4, Group A, Member 2
Concept Phosphoenolpyruvate Carboxykinase (ATP)
Concept Ceramides
Concept Amyotrophic Lateral Sclerosis
Concept Receptor, Parathyroid Hormone, Type 1
Concept Endothelium, Vascular
Concept Axons
Concept Glycerol Kinase
Concept NFI Transcription Factors
Academic Article Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease.
Academic Article The protein level of PGC-1a, a key metabolic regulator, is controlled by NADH-NQO1.
Academic Article Fat cells directly sense temperature to activate thermogenesis.
Academic Article Time window expansion for HDX analysis of an intrinsically disordered protein.
Academic Article Exercise induces hippocampal BDNF through a PGC-1a/FNDC5 pathway.
Academic Article ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors.
Academic Article What we talk about when we talk about fat.
Academic Article Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Academic Article A conversation with Bruce Spiegelman. Interviewed by Ushma Neill.
Academic Article Irisin ERKs the fat.
Academic Article A smooth muscle-like origin for beige adipocytes.
Academic Article Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Academic Article Adipsin is an adipokine that improves ß cell function in diabetes.
Academic Article IRF4 is a key thermogenic transcriptional partner of PGC-1a.
Academic Article Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
Academic Article Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.
Academic Article G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
Academic Article Thrap3 docks on phosphoserine 273 of PPAR? and controls diabetic gene programming.
Academic Article miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Academic Article An ERK/Cdk5 axis controls the diabetogenic actions of PPAR?.
Academic Article Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPAR? effects.
Academic Article Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.
Academic Article Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.
Academic Article The future of brown adipose tissues in the treatment of type 2 diabetes.
Academic Article Brown and Beige Fat: Physiological Roles beyond Heat Generation.
Academic Article Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
Academic Article A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.
Academic Article A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.
Academic Article PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Academic Article Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Academic Article Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Academic Article The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.
Academic Article Cell biology of fat storage.
Academic Article Attenuated PGC-1a Isoforms following Endurance Exercise with Blood Flow Restriction.
Academic Article CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.
Grant Control of Adipocyte Gene Expression and Physiology
Grant Conference on the PPARs
Grant Regulation of Brown Fat: Toward New Therapy for Human Obesity
Grant DF/HCC SPORE in Prostate Cancer
Grant PGC1 proteins, meteorin-like and energy homeostasis
Grant PGC-1a and the Energetics of Heart Function and Disease
Grant Chemical Biology of Mitochondria and Diabetes
Grant PGC1alpha and Irisin in the Control of Diabetes and Obesity
Academic Article Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.
Academic Article The Cancer Drug Dasatinib Increases PGC-1a in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.
Academic Article Cell Differentiation.
Academic Article Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.
Academic Article UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Academic Article Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Academic Article Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.
Academic Article Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Academic Article Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.
Academic Article Cachexia and Brown Fat: A Burning Issue in Cancer.
Academic Article Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.
Academic Article Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.
Academic Article Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.
Academic Article Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Academic Article Irisin Mediates Effects on Bone and Fat via aV Integrin Receptors.
Grant Identification of Novel Protein Kinases Dependent on Phosphocreatine Rather than ATP
Academic Article Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.
Academic Article New Advances in Adaptive Thermogenesis: UCP1 and Beyond.
Grant Control of PGC1alpha Translation and Function
Academic Article Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis.
Academic Article An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.
Academic Article Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.
Academic Article H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Academic Article Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
Grant Cellular and Biochemical Pathways of Adipose Metabolism and Thermogenesis
Academic Article ?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
Academic Article Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Academic Article Confounding issues in the "humanized" BAT of mice.
Academic Article A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity.
Academic Article CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
Academic Article Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Academic Article Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Academic Article Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo.
Academic Article Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Academic Article Mechanism of futile creatine cycling in thermogenesis.
Academic Article No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians.
Academic Article Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis.
Academic Article Creatine kinase B controls futile creatine cycling in thermogenic fat.
Academic Article Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Academic Article Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
Academic Article Exercise hormone irisin is a critical regulator of cognitive function.
Academic Article Author Correction: Exercise hormone irisin is a critical regulator of cognitive function.
Search Criteria
  • metabolism
  • type
  • 2
  • diabetes
  • adipose tissue
  • small
  • molecules
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.