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Search Results to Bruce Michael Spiegelman, Ph.D.

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Item TypeName
Academic Article Adipogenesis and obesity: rounding out the big picture.
Academic Article Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Academic Article Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
Academic Article Terminal differentiation of human breast cancer through PPAR gamma.
Academic Article Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
Academic Article Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Academic Article Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Academic Article Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Academic Article ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.
Academic Article Activation of PPARgamma coactivator-1 through transcription factor docking.
Academic Article Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Academic Article Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Academic Article PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Academic Article Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
Academic Article Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
Academic Article Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.
Academic Article Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Academic Article Adipocyte differentiation: a transcriptional regulatory cascade.
Academic Article An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
Academic Article An adipogenic cofactor bound by the differentiation domain of PPARgamma.
Academic Article Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.
Academic Article Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
Academic Article Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity.
Academic Article Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
Academic Article Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA.
Academic Article Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.
Academic Article A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Academic Article Transcriptional regulation of adipogenesis.
Academic Article Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Academic Article Regulation of alternative pathway activation and C3a production by adipose cells.
Academic Article AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Academic Article Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Academic Article Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.
Academic Article Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Academic Article Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Academic Article Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function.
Academic Article Hic-5 regulates an epithelial program mediated by PPARgamma.
Academic Article Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Academic Article Transcriptional control of brown fat determination by PRDM16.
Academic Article Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Academic Article Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes.
Academic Article FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis.
Academic Article The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.
Academic Article Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma.
Academic Article Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
Academic Article Biological control through regulated transcriptional coactivators.
Academic Article TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Academic Article A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
Academic Article PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Academic Article Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes.
Academic Article Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
Academic Article Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Academic Article Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Academic Article Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Academic Article C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Academic Article Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.
Academic Article Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Academic Article Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.
Academic Article A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Academic Article A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Academic Article AdipoQ is a novel adipose-specific gene dysregulated in obesity.
Academic Article Involvement of fos as a trans-acting factor in adipogenic gene expression.
Academic Article PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.
Academic Article Adipsin and complement factor D activity: an immune-related defect in obesity.
Academic Article Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Academic Article Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
Academic Article Peroxisome proliferator-activated receptor gamma and the control of adipogenesis.
Academic Article Regulation of gene expression of catecholamine biosynthetic enzymes by stress.
Academic Article Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
Academic Article Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
Academic Article C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Academic Article Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Academic Article CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Academic Article Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
Academic Article A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
Academic Article Adipsin: regulation and dysregulation in obesity and other metabolic states.
Academic Article PRDM16 controls a brown fat/skeletal muscle switch.
Academic Article Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Academic Article Normal peripheral T-cell function in c-Fos-deficient mice.
Academic Article PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Academic Article Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Academic Article Transcriptional control of preadipocyte determination by Zfp423.
Academic Article Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.
Academic Article Protooncogene c-fos as a transcription factor.
Academic Article The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex.
Academic Article HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Academic Article Transcriptional control of brown fat development.
Academic Article Regulation of gene expression during the differentiation of 3T3-adipocytes.
Academic Article Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Academic Article Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Academic Article PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.
Academic Article Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
Academic Article Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Academic Article PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
Academic Article Adaptive thermogenesis in adipocytes: is beige the new brown?
Academic Article Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Academic Article Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.
Academic Article p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Academic Article Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Academic Article Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.
Academic Article Towards a molecular understanding of adaptive thermogenesis.
Academic Article Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Academic Article Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Academic Article Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Academic Article Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Academic Article Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.
Academic Article Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Academic Article fos protooncogene and the regulation of gene expression in adipocyte differentiation.
Academic Article Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
Academic Article Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
Academic Article Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos.
Academic Article mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Academic Article Exercise induces hippocampal BDNF through a PGC-1a/FNDC5 pathway.
Academic Article ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors.
Academic Article Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
Academic Article G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
Academic Article Thrap3 docks on phosphoserine 273 of PPAR? and controls diabetic gene programming.
Academic Article PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Academic Article Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.

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