Harvard Catalyst Profiles

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One or more keywords matched the following items that are connected to Kufe, Donald
Item TypeName
Academic Article Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia.
Academic Article Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species.
Academic Article 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells.
Academic Article Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.
Academic Article Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.
Academic Article Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.
Academic Article Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH.
Academic Article MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation.
Academic Article Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.
Academic Article The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.
Academic Article The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species.
Academic Article Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress.
Academic Article Targeting of protein kinase C delta to mitochondria in the oxidative stress response.
Academic Article miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death.
Academic Article Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function.
Academic Article MUC1 oncoprotein is a druggable target in human prostate cancer cells.
Academic Article Radiation induction of immediate early genes: effectors of the radiation-stress response.
Academic Article Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells.
Academic Article Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.
Academic Article MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells.
Academic Article Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta -dependent and required for SAPK activation.
Concept Reactive Oxygen Species
Academic Article Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death.
Academic Article Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma.
Academic Article Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells.
Grant Regulation of Oxidative Stress Response by c-Abl and Arg
Grant Differentiating Agents in Hematologic Malignancies
Academic Article Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer.
Academic Article MUC1-C is a target in lenalidomide resistant multiple myeloma.
Academic Article Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma.
Academic Article Role of the MUC1-C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma.
Search Criteria
  • Reactive Oxygen Species
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.