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Search Results to Leonard Ira Zon, M.D.

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Item TypeName
Academic Article Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways.
Academic Article The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis.
Academic Article Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation.
Academic Article Cloning and genetic mapping of zebrafish BMP-2.
Academic Article Mutant-specific gene programs in the zebrafish.
Academic Article Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.
Academic Article Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis.
Academic Article The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis.
Academic Article Organogenesis--heart and blood formation from the zebrafish point of view.
Academic Article Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators.
Academic Article The pu.1 promoter drives myeloid gene expression in zebrafish.
Academic Article Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish.
Academic Article Molecular insights into early hematopoiesis.
Academic Article An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio.
Academic Article SCL specifies hematopoietic mesoderm in Xenopus embryos.
Academic Article Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.
Academic Article Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.
Academic Article A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro.
Academic Article Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK.
Academic Article SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.
Academic Article Dissecting hematopoiesis and disease using the zebrafish.
Academic Article Hematopoietic development in the zebrafish.
Academic Article Characterization of embryonic globin genes of the zebrafish.
Academic Article Vascular and blood gene expression.
Academic Article Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis.
Academic Article Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2.
Academic Article Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.
Academic Article The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1).
Academic Article The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis.
Academic Article Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.
Academic Article LPS response and tolerance in the zebrafish (Danio rerio).
Academic Article BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis.
Academic Article Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).
Academic Article Small molecules that delay S phase suppress a zebrafish bmyb mutant.
Academic Article Zebrafish kidney stromal cell lines support multilineage hematopoiesis.
Academic Article Mitoferrin is essential for erythroid iron assimilation.
Academic Article Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.
Academic Article Zebrafish orthologs of human muscular dystrophy genes.
Academic Article T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Academic Article Ageing: Stem cells on a stress-busting diet.
Academic Article Ferroportin1 is required for normal iron cycling in zebrafish.
Academic Article Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins.
Academic Article Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes.
Academic Article The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.
Academic Article Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.
Academic Article Isolation and characterization of zebrafish NFE2.
Academic Article The zebrafish runzel muscular dystrophy is linked to the titin gene.
Academic Article Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.
Academic Article cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.
Academic Article Modeling human hematopoietic and cardiovascular diseases in zebrafish.
Academic Article Combinatorial regulation of novel erythroid gene expression in zebrafish.
Academic Article The zebrafish klf gene family.
Academic Article Interaction of retinoic acid and scl controls primitive blood development.
Academic Article cpsf1 is required for definitive HSC survival in zebrafish.
Academic Article Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
Academic Article TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Academic Article Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.
Academic Article Functional conservation of erythropoietin signaling in zebrafish.
Academic Article Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters.
Academic Article Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.
Academic Article Transplantation in zebrafish.
Academic Article The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.
Academic Article CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
Academic Article Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish.
Academic Article Myelopoiesis in the zebrafish, Danio rerio.
Academic Article GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.
Academic Article Transcriptional regulation of blood formation during Xenopus development.
Academic Article Zebrafish scl functions independently in hematopoietic and endothelial development.
Academic Article SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis.
Academic Article Development. Endothelium--chicken soup for the endoderm.
Academic Article Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish.
Academic Article A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.
Academic Article Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Academic Article Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.
Academic Article Transferrin-a modulates hepcidin expression in zebrafish embryos.
Academic Article A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis.
Academic Article Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation.
Academic Article Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.
Academic Article Effects of RAS on the genesis of embryonal rhabdomyosarcoma.
Academic Article Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.
Academic Article Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen.
Academic Article Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR.
Academic Article Zebrafish models of p53 functions.
Academic Article Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Academic Article The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1.
Academic Article Hematopoietic stem cell fate is established by the Notch-Runx pathway.
Academic Article Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.
Academic Article The ERGonomics of hematopoietic stem cell self-renewal.
Academic Article DHODH modulates transcriptional elongation in the neural crest and melanoma.
Academic Article Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.
Academic Article Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.
Academic Article Analysis of hematopoietic development in the zebrafish.
Academic Article Transcriptional regulation of hematopoietic stem cell development in zebrafish.
Academic Article The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis.
Academic Article Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis.
Academic Article Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
Academic Article Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis.
Academic Article An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Academic Article Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos.
Academic Article BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.
Academic Article Developmental biology of hematopoiesis.
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Leukemic
Academic Article The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.
Academic Article Hematopoiesis.
Academic Article A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.
Academic Article Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.
Academic Article The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance.
Academic Article Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.
Academic Article A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis.
Academic Article Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.
Academic Article Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
Academic Article Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.
Academic Article Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.
Academic Article A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
Academic Article DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.
Academic Article Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.
Academic Article Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.
Academic Article Chamber identity programs drive early functional partitioning of the heart.
Academic Article A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.
Academic Article Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
Academic Article Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.
Academic Article CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development.
Academic Article KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.
Academic Article Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis.

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