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One or more keywords matched the following items that are connected to Alt, Frederick
Item TypeName
Academic Article Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.
Academic Article Chromatin dynamics and locus accessibility in the immune system.
Academic Article Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family.
Academic Article Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.
Academic Article Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Academic Article Germline transcription and recombination of a murine VDJmudeltagamma1 transgene.
Academic Article Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro.
Academic Article Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.
Academic Article Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Academic Article myc family oncogenes in the development of normal and neoplastic cells.
Academic Article Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.
Academic Article Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
Academic Article E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.
Academic Article Potential regulatory elements for germline transcription in or near murine Sgamma1.
Academic Article Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.
Academic Article Mechanism and control of class-switch recombination.
Academic Article Mechanisms that control antigen receptor variable region gene assembly.
Academic Article Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors.
Academic Article Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.
Academic Article Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.
Academic Article The influence of transcriptional orientation on endogenous switch region function.
Academic Article Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.
Academic Article Regulation of immunoglobulin variable-region gene assembly.
Academic Article T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.
Academic Article Class-switch recombination: interplay of transcription, DNA deamination and DNA repair.
Academic Article Differential regulation of the N-myc gene in transfected cells and transgenic mice.
Academic Article S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.
Academic Article Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.
Academic Article A class switch control region at the 3' end of the immunoglobulin heavy chain locus.
Academic Article LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells.
Academic Article A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
Academic Article Structure and expression of the murine L-myc gene.
Academic Article Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.
Academic Article Structure and expression of germ line immunoglobulin gamma 2b transcripts.
Academic Article Transcriptional down-regulation of N-myc expression during B-cell development.
Academic Article Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.
Academic Article Control of immunoglobulin heavy chain constant region gene expression.
Academic Article An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.
Academic Article The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.
Academic Article Transcription-targeted DNA deamination by the AID antibody diversification enzyme.
Academic Article The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
Academic Article Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients.
Academic Article A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.
Academic Article Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Academic Article Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
Academic Article Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.
Academic Article Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.
Academic Article Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching.
Academic Article A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.
Academic Article Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.
Academic Article Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.
Academic Article Structure and expression of human germline VH transcripts.
Academic Article CTCF-binding elements mediate control of V(D)J recombination.
Academic Article Expression and function of myc family genes.
Academic Article Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.
Academic Article Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.
Academic Article Function of the TCR alpha enhancer in alphabeta and gammadelta T cells.
Academic Article Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.
Academic Article S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.
Academic Article Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.
Academic Article The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Academic Article Recombination between immunoglobulin variable region gene segments is enhanced by transcription.
Academic Article The molecular events in heavy chain class-switching.
Academic Article Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Academic Article Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements.
Concept Transcription, Genetic
Academic Article Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.
Academic Article Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.
Academic Article Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.
Search Criteria
  • Transcription Genetic
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.