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One or more keywords matched the following items that are connected to Walensky, Loren
Item TypeName
Academic Article Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Academic Article BCL-2 in the crosshairs: tipping the balance of life and death.
Academic Article A stapled BID BH3 helix directly binds and activates BAX.
Academic Article Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains.
Academic Article Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains.
Academic Article Interview with Loren D Walensky.
Academic Article The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.
Academic Article Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
Academic Article Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Academic Article From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia.
Academic Article A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.
Academic Article Protein-protein interactions: A PUMA mechanism unfolds.
Academic Article The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.
Concept bcl-X Protein
Concept Proto-Oncogene Proteins c-bcl-2
Academic Article Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3.
Academic Article Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry.
Academic Article Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Academic Article BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress.
Academic Article Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation.
Academic Article Allosteric inhibition of antiapoptotic MCL-1.
Grant Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer
Academic Article Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.
Academic Article Allosteric sensitization of proapoptotic BAX.
Academic Article Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Academic Article Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.
Academic Article Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Academic Article Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Academic Article Cheating Death: New Molecules Block BAX.
Academic Article Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
Academic Article A redox switch regulates the structure and function of anti-apoptotic BFL-1.
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  • Proto Oncogene Proteins c bcl 6
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.