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Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.
Carbonic anhydrase II is an AP-1 target gene in osteoclasts.
Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass.
Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus.
Transcription Factor AP-1
Both NPY-Expressing and CART-Expressing Neurons Increase Energy Expenditure and Trabecular Bone Mass in Response to AP1 Antagonism, But Have Opposite Effects on Bone Resorption.
Transcription Factor AP 2