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One or more keywords matched the following items that are connected to Gladyshev, Vadim
Item TypeName
Academic Article Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii.
Academic Article Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines.
Academic Article Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.
Academic Article Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds.
Academic Article The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development.
Academic Article SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.
Academic Article Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.
Academic Article Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues.
Academic Article Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods.
Academic Article Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.
Academic Article Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.
Academic Article Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
Academic Article Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.
Academic Article Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases.
Academic Article Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast.
Academic Article Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.
Academic Article New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.
Academic Article Dietary selenium affects host selenoproteome expression by influencing the gut microbiota.
Academic Article Functions and evolution of selenoprotein methionine sulfoxide reductases.
Academic Article Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase.
Academic Article Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution.
Academic Article Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases.
Academic Article Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
Academic Article Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy.
Academic Article Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis.
Academic Article Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins.
Academic Article Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif.
Academic Article Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA.
Academic Article Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.
Academic Article Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.
Academic Article Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
Academic Article Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis.
Academic Article An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes.
Academic Article A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.
Academic Article Recharging oxidative protein repair: catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates.
Academic Article Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.
Academic Article Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.
Academic Article Reduced reliance on the trace element selenium during evolution of mammals.
Academic Article Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.
Academic Article Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.
Academic Article Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality.
Academic Article Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.
Academic Article Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.
Academic Article Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases.
Academic Article Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase.
Academic Article Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.
Academic Article The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
Academic Article NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus.
Academic Article Methionine sulfoxide reduction and the aging process.
Academic Article Understanding selenoprotein function and regulation through the use of rodent models.
Academic Article Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.
Academic Article Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.
Academic Article SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.
Academic Article Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.
Academic Article Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa.
Academic Article Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice.
Academic Article The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A.
Academic Article Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
Academic Article Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing.
Academic Article Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance.
Academic Article Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase.
Academic Article High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.
Academic Article Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
Academic Article Selenocysteine in thiol/disulfide-like exchange reactions.
Academic Article Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases.
Academic Article Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism.
Academic Article Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
Academic Article Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses.
Academic Article A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines.
Academic Article Selenoprotein expression is essential in endothelial cell development and cardiac muscle function.
Academic Article MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.
Academic Article 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2.
Academic Article Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.
Academic Article Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.
Academic Article Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology.
Academic Article Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.
Academic Article Genetic and functional analysis of mammalian Sep15 selenoprotein.
Academic Article Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.
Academic Article Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals.
Academic Article Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression.
Academic Article Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.
Concept Selenoprotein W
Concept Methionine Sulfoxide Reductases
Concept Selenoprotein P
Academic Article MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.
Academic Article Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide.
Academic Article SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.
Academic Article SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.
Academic Article Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein.
Academic Article Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Academic Article Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.
Academic Article The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
Academic Article Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.
Academic Article Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.
Academic Article Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.
Grant Selenoproteins as targets for cancer prevention
Grant Redox mechanism of cancer prevention by selenium
Grant Identity and Function of Selenoprotein Genes
Grant Methionine sulfoxide reduction, selenium and aging
Grant Functions of Mammalian Thioredoxin Reductases
Grant Function of thioredoxin glutathione reductase
Academic Article Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
Academic Article Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.
Academic Article Selenoprotein Gene Nomenclature.
Academic Article Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.
Academic Article Regulated methionine oxidation by monooxygenases.
Academic Article Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.
Academic Article Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.
Academic Article Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.
Academic Article Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.
Academic Article Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.
Academic Article Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.
Grant Systems level understanding of selenoprotein biosynthesis
Academic Article Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.
Academic Article Tolerance to Selenoprotein Loss Differs between Human and Mouse.
Academic Article An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo.
Search Criteria
  • Methionine Sulfoxide Reductases
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.